Research Summary

Dr. Faddegon is a board certified clinical medical physics who is internationally recognized for his research in developing and using Monte Carlo methods for treatment head simulation and dose calculation and his development of new technology to improve accuracy and precision in radiotherapy. The overall objective of Dr. Faddegon’s research is to allow for more aggressive treatment in sites where side effects, local control, and even metastases are a problem through cost-effective solutions to improve the therapeutic ratio.

Current research includes developing TOPAS, the Tool for Particle Simulation, a collaboration of UCSF, MGH and SLAC supported by NIH to improve advanced simulation of radiotherapy in conjunction with the open source Geant4 Monte Carlo simulation toolkit. The initial grant focussed on proton therapy. The renewal grant focused on organ and cell radiobiology. The current NIH U24 grant is through the NCI Informatics Technology for Cancer Research (ITCR) to extend TOPAS to conventional radiotherapy and imaging. Work in parallel is being done to develop TOPAS-nBio with enhanced track structure simulation capabilities in conjunction with Geant4-DNA for physicists, chemists and biologists to better establish the relationship between ionization deposition details, radiation chemistry, and biological effect.

Dr. Faddegons clinical responsibility is physics support of radiotherapy. This includes installation, commissioning, maintenance and quality assurance of equipment and procedures used in radiation treatment planning and delivery. Highlights of Dr. Faddegon’s published clinical development work at UCSF include developing new x-ray targets that are implemented on linacs worldwide for low-dose megavoltage imaging and to reduce downtime, developing the means to treat the whole body over a short distance (3 meters), implementing high precision graticules for patient localization, and determining the means to detect and correct defective circuitry in treatments using virtual wedges.

Research Funding

  • June 4, 2018 - May 31, 2023 - The TOPAS Tool for Particle Simulation, a Monte Carlo Simulation Tool for Physics, Biology and Clinical Research, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U24CA215123
  • April 1, 2015 - March 31, 2019 - TOPAS-nBio, A Monte Carlo tool for radiation biology research, Co-Investigator. Sponsor: NIH, Sponsor Award ID: R01 CA187003
  • April 15, 2017 - April 14, 2018 - PRISM: Precision Radiotherapy and Imaging of Small Mammals, Principal Investigator. Sponsor: NIH, Sponsor Award ID: S10OD021818
  • February 10, 2015 - January 31, 2017 - NAPTA: Optimizing clinical trial design & delivery of particle therapy for cancer, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P20CA183640

Education

University of Victoria, Victoria, Canada, B.Sc., 1977, Physics (honors)
University of British Columbia, Vancouver, Canada, M.Sc., 1983, Physics (radiobiology)
Carleton University, Ottawa, Canada, Ph.D., 1990, Physics (radiotherapy)

Qualified Medical Physicist by the standards of Cancer Care Ontario (1987)
Certified clinical physicist as member (1987) by Canadian College of Physicists in Medicine

Honors & Awards

  • 1980
    National Science and Engineering Research Council of Canada (NSERC) scholarship for M.Sc. studies
  • 1982
    NSERC scholarship for Ph.D. studies - declined
  • 1986
    Ontario Cancer Foundation fellowship for Ph.D. studies
  • 1988
    Ontario Graduate Scholarship for Ph.D. studies
  • 1989
    American Association Physicists in Medicine (AAPM) Young Investigator's Award, Second Prize
  • 1991
    Farrington Daniels Award (AAPM)
  • 1992
    Runner-up to Sylvia Fedoruk Prize (Canadian Organization of Medical Physics)
  • 1996
    Elected Fellow of the Canadian College of Physicists in Medicine
  • 2007
    Appointed Fellow of the American Association of Physicists in Medicine

Selected Publications

  1. Tran HN, Ramos-Méndez J, Shin WG, Perrot Y, Faddegon B, Okada S, Karamitros M, Davídková M, Štepán V, Incerti S, Villagrasa C Assessment of DNA damage with an adapted Independent Reaction Time approach implemented in Geant4-DNA for the simulation of diffusion-controlled reactions between radio-induced reactive species and a chromatin fiber.  View on PubMed
  2. Ramos-Méndez J, Domínguez-Kondo N, Schuemann J, McNamara A, Moreno-Barbosa E, Faddegon B LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy.  View on PubMed
  3. Ramos-Méndez J, Shin WG, Karamitros M, Domínguez-Kondo J, Tran NH, Incerti S, Villagrasa C, Perrot Y, Štepán V, Okada S, Moreno-Barbosa E, Faddegon B Independent reaction times method in Geant4-DNA: Implementation and performance.  View on PubMed
  4. Lee K, Scholey J, Norman EB, Daftari IK, Mishra KK, Faddegon BA, Maharbiz MM, Anwar M A Millimeter-scale Single Charged Particle Dosimeter for Cancer Radiotherapy.  View on PubMed
  5. Carrasco-Hernández J, Ramos-Méndez J, Faddegon B, Jalilian AR, Moranchel M, Ávila-Rodríguez MA Monte Carlo track-structure for the radionuclide Copper-64: characterization of S-values, nanodosimetry and quantification of direct damage to DNA.  View on PubMed
  6. Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio.  View on PubMed
  7. Arce P, Bolst D, Bordage MC, Brown JMC, Cirrone P, Cortés-Giraldo MA, Cutajar D, Cuttone G, Desorgher L, Dondero P, Dotti A, Faddegon B, Fedon C, Guatelli S, Incerti S, Ivanchenko V, Konstantinov D, Kyriakou I, Latyshev G, Le A, Mancini-Terracciano C, Maire M, Mantero A, Novak M, Omachi C, Pandola L, Perales A, Perrot Y, Petringa G, Quesada JM, Ramos-Méndez J, Romano F, Rosenfeld AB, Sarmiento LG, Sakata D, Sasaki T, Sechopoulos I, Simpson EC, Toshito T, Wright DH Report on G4-Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group.  View on PubMed
  8. Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio.  View on PubMed
  9. Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research.  View on PubMed
  10. Ma CMC, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li J, Seuntjens J, Siebers JV, Traneus E Beam modeling and beam model commissioning for Monte Carlo dose calculation-based radiation therapy treatment planning: Report of AAPM Task Group 157.  View on PubMed
  11. Blakely EA, Faddegon B, Tinkle C, Bloch C, Dominello M, Griffin RJ, Joiner MC, Burmeister J Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility.  View on PubMed
  12. Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery.  View on PubMed
  13. Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H The microdosimetric extension in TOPAS: development and comparison with published data.  View on PubMed
  14. Burigo LN, Ramos-Méndez J, Bangert M, Schulte RW, Faddegon B Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions.  View on PubMed
  15. Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology.  View on PubMed
  16. Ramos-Méndez J, Burigo LN, Schulte R, Chuang C, Faddegon B Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy.  View on PubMed
  17. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ A New Standard DNA Damage (SDD) Data Format.  View on PubMed
  18. Lazar AA, Schulte R, Faddegon B, Blakely EA, Roach M Clinical trials involving carbon-ion radiation therapy and the path forward.  View on PubMed
  19. McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit.  View on PubMed
  20. Piersimoni P, Faddegon BA, Méndez JR, Schulte RW, Volz L, Seco J Helium CT: Monte Carlo simulation results for an ideal source and detector with comparison to proton CT.  View on PubMed

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