Research Summary

Dr. Ryan Gill is a surgical pathologist who specializes in the diagnosis and evaluation of adult and pediatric liver disease, inflammatory bowel disease, and cancers of the liver and gastrointestinal (GI) tract. His expertise also includes liver transplantation.

In his research, Gill focuses on advancing diagnostic and prognostic methods as well as treatment options for patients with liver and GI diseases.

Gill received his medical and doctoral degrees at the University of Kansas in Kansas City, Kansas. At UCSF, he completed a combined residency in anatomic and clinical pathology, followed by a fellowship in hematopathology and a fellowship in liver and gastrointestinal pathology.

Gill is a member of many professional organizations, including the Alpha Omega Alpha Honor Medical Society, College of American Pathologists, Hans Popper Hepatopathology Society, Rodger C. Haggitt Gastrointestinal Pathology Society and United States and Canadian Academy of Pathology. He has received several awards, including the American Society for Investigative Pathology Merit Award and a research award from the UCSF Department of Laboratory Medicine.

Gill has published numerous book chapters on surgical pathology, and he lectures around the country.

Education

University of Kansas, Kansas City, KS, PhD, 2003, Pathology
University of Kansas, Kansas City, KS, MD, 2005, Medicine
University of California, San Francisco, Resident, 2006, Laboratory Medicine
University of California, San Francisco, Resident, 2008, Pathology
University of California, San Francisco, Chief Resident, 2009, Laboratory Medicine
University of California, San Francisco, Fellow, 2010, Hematopathology
University of California, San Francisco, Fellow, 2011, Gastrointestinal/Liver Pathology

Honors & Awards

  • 2003
    Merit Award, American Society for Investigative Pathology
  • 2006
    Resident Research Award, UCSF Department of Laboratory Medicine
  • 2009
    Diplomate, Anatomic and Clinical Pathology, American Board of Pathology
  • 2010
    Diplomate, Hematology, American Board of Pathology

Selected Publications

  1. Bahceci D, Hameed B, Gill RM. Granulomatous hepatitis, a mystery solved. J Hepatol. 2024 Nov; 81(5):e215-e217.  View on PubMed
  2. Samala N, Xin Y, Wilson LA, Yates K, Loomba R, Hoofnagle JH, Chalasani N, NASH Clinical Research Network. Non-Hispanic Black Persons With Nonalcoholic Fatty Liver Disease Have Lower Rates of Advanced Fibrosis, Cirrhosis, and Liver-Related Events Even After Controlling for Clinical Risk Factors and PNPLA3 Genotype. Am J Gastroenterol. 2024 Sep 01; 119(9):1857-1865.  View on PubMed
  3. Kikuchi AT, Akanuma N, Choi WT, Gill RM, Kakar S. Assessment of large droplet fat in frozen sections of donor liver biopsies: utility and interobserver variability of the newly described Banff method compared to a simplified Average of Fields method. J Clin Pathol. 2024 Feb 19; 77(3):151-156.  View on PubMed
  4. Jain AK, Buchannan P, Yates KP, Belt P, Schwimmer JB, Rosenthal P, Murray KF, Molleston JP, Scheimann A, Xanthakos SA, Behling CA, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Nutrition assessment and MASH severity in children using the Healthy Eating Index. Hepatol Commun. 2023 12 01; 7(12).  View on PubMed
  5. Hassan OT, Behr SC, Ohliger MA, Fowler KJ, Gill RM, Fidelman N, Mehta N, Choi HH. Per-patient Negative Predictive Value of the CT and MRI Liver Imaging Reporting and Data System Version 2018 Treatment Response Algorithm for Hepatocellular Carcinoma. Radiology. 2023 12; 309(3):e222776.  View on PubMed
  6. Desai N, Kudose S, Remotti HE, Del Portillo A, Fazlollahi L, Lee MJ, Xiong Y, Moreira RK, Salomao M, Fiel MI, Gonzalez RS, Misdraji J, Gill RM, Hart J, Kleiner DE, Drebber U, Bellizzi AM, Lagana SM. Erythrophagocytosis is not a reproducible finding in liver biopsies, and is not associated with clinical diagnosis of hemophagocytic lymphohistiocytosis. Virchows Arch. 2024 Jan; 484(1):61-69.  View on PubMed
  7. Maldonado SS, Cedars MI, Yates KP, Wilson LA, Gill R, Terrault NA, Suzuki A, Sarkar MA. Antimullerian Hormone, a Marker of Ovarian Reserve, Is Protective Against Presence and Severity of NASH in Premenopausal Women. Clin Gastroenterol Hepatol. 2024 02; 22(2):339-346.e5.  View on PubMed
  8. Hoffman D, Shui A, Gill R, Syed S, Mehta N. Resected Tumor Outcome and Recurrence (RESTORE) Index for Hepatocellular Carcinoma Recurrence after Resection. Cancers (Basel). 2023 Apr 24; 15(9).  View on PubMed
  9. Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal P. Shorter leukocyte telomere length protects against NAFLD progression in children. Sci Rep. 2023 04 03; 13(1):5446.  View on PubMed
  10. Gill RM, Allende D, Belt PH, Behling CA, Cummings OW, Guy CD, Carpenter D, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J, Van Natta ML, Wilson LA, Yamada G, Yeh M, Kleiner DE, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance. Hepatol Commun. 2023 02 01; 7(2):e0033.  View on PubMed
  11. Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM. Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap. Mod Pathol. 2023 03; 36(3):100065.  View on PubMed
  12. Lennerz JK, Pantanowitz L, Amin MB, Eltoum IE, Hameed MR, Kalof AN, Khanafshar E, Kunju LP, Lazenby AJ, Montone KT, Otis CN, Reid MD, Staats PN, Whitney-Miller CL, Abendroth CS, Aron M, Birdsong GG, Bleiweiss IJ, Bronner MP, Chapman J, Cipriani NA, de la Roza G, Esposito MJ, Fadare O, Ferrer K, Fletcher CD, Frishberg DP, Garcia FU, Geldenhuys L, Gill RM, Gui D, Halat S, Hameed O, Hornick JL, Huber AR, Jain D, Jhala N, Jorda M, Jorns JM, Kaplan J, Khalifa MA, Khan A, Kim GE, Lee EY, LiVolsi VA, Longacre T, Magi-Galluzzi C, McCall SJ, McPhaul L, Mehta V, Merzianu M, Miller SB, Molberg KH, Moreira AL, Naini BV, Nosé V, O'Toole K, Picken M, Prieto VG, Pullman JM, Quick CM, Reynolds JP, Rosenberg AE, Schnitt SJ, Schwartz MR, Sekosan M, Smith MT, Sohani A, Stowman A, Vanguri VK, Wang B, Watts JC, Wei S, Whitney K, Younes M, Zee S, Bracamonte ER. Ensuring remote diagnostics for pathologists: an open letter to the US Congress. Nat Med. 2022 12; 28(12):2453-2455.  View on PubMed
  13. Zahir A, Li M, Gill RM, Brandman D. Diagnosis and Management of Drug-Induced Liver Injury After the Use of Polygonum multiflorum. ACG Case Rep J. 2022 Oct; 9(10):e00884.  View on PubMed
  14. Balitzer D, Tsai JH, Gill RM. Clinicopathologic features of de novo non-alcoholic steatohepatitis in the post-transplant setting. Diagn Pathol. 2022 Aug 10; 17(1):65.  View on PubMed
  15. Wu CH, Wang L, Yang CY, Wen KW, Hinds B, Gill R, McCormick F, Moasser M, Pincus L, Ai WZ. Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models. Blood Adv. 2022 04 12; 6(7):2290-2302.  View on PubMed
  16. Joseph NM, Blank A, Shain AH, Gill RM, Umetsu SE, Shafizadeh N, Torbenson MS, Kakar S. Hepatocellular neoplasms with loss of liver fatty acid binding protein: Clinicopathologic features and molecular profiling. Hum Pathol. 2022 04; 122:60-71.  View on PubMed
  17. Gill RM, Theise ND. Rappaport, Glisson, Hering, and Mall-Champions of Liver Microanatomy: Microscopic and Ultramicroscopic Anatomy of the Liver Into the Modern Age. Clin Liver Dis (Hoboken). 2021 Oct; 18(Suppl 1):76-92.  View on PubMed
  18. Rowan DJ, Allende DS, Bellizzi AM, Gill RM, Liu X, McKenzie CA, Moreira RK, Mounajjed T, Said S, Westerhoff M, Jenkins SM, Batts KP, Burgart LJ, Lamps LW, Graham RP. Diagnostic challenges of focal nodular hyperplasia: interobserver variability, accuracy, and the utility of glutamine synthetase immunohistochemistry. Histopathology. 2021 Nov; 79(5):791-800.  View on PubMed
  19. Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D. The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity. Nat Metab. 2021 02; 3(2):244-257.  View on PubMed
  20. Allende DS, Gawrieh S, Cummings OW, Belt P, Wilson L, Van Natta M, Behling CA, Carpenter D, Gill RM, Kleiner DE, Yeh MM, Chalasani N, Guy CD, NASH Clinical Research Network. Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis. Liver Int. 2021 05; 41(5):996-1011.  View on PubMed

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