Research Funding

  • May 1, 2020 - April 30, 2025 - Understanding breast cancer progression as a defect in the mechanics of tissue self-organization, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA244109
  • July 3, 2018 - June 30, 2023 - Uncovering Mechanisms of Regulation and Dependency on Fatty Acid Oxidation in MYC-Driven Tumors, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA223817
  • August 1, 2012 - May 31, 2016 - In Vivo Metabolic Catastrophe Is Induced By Acute Oncogene Inhibition (PQ #22), Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA170447
  • April 19, 2010 - January 31, 2015 - Targeting the MYC Oncogene with CDK Inhibitors, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA136717

Education

University of California, Los Angeles, B.S., 1986-1990, Cell and Molecular Biology
University of California, Los Angeles, M.D., 1990-1997, Medicine
University of California, Los Angeles, Ph.D., 1990-1997, Molecular Biology
University of California, San Francisco, 1997-1999, Internal Medicine
University of California, San Francisco, 1999-2003, Medical Oncology

Honors & Awards

  • 1990-1997
    N.I.H. Medical Scientist Training Fellowship
  • 1997
    Emil Bogen Research Award, (most outstanding graduate research) UCLA School of Medicine
  • 1997
    UCSF Molecular Medicine Fellow
  • 2001-2004
    Howard Hughes Medical Institute Physician-Scientist Fellowship – NCI K08 Mentored Physician-Scientist Fellowship Award
  • 2008
    Susan G. Komen Scholar Award
  • 2009
    V-Foundation Scholar
  • 2011
    Elected Member of the American Society for Clinical Investigation (ASCI)

Selected Publications

  1. Madonna MC, Duer JE, Lee JV, Williams J, Avsaroglu B, Zhu C, Deutsch R, Wang R, Crouch BT, Hirschey MD, Goga A, Ramanujam N In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.  View on PubMed
  2. Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.  View on PubMed
  3. Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.  View on PubMed
  4. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.  View on PubMed
  5. Fish L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A, Goodarzi H Cancer cells exploit an orphan RNA to drive metastatic progression.  View on PubMed
  6. Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.  View on PubMed
  7. Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.  View on PubMed
  8. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.  View on PubMed
  9. Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.  View on PubMed
  10. Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M, Butte AJ Comprehensive analysis of normal adjacent to tumor transcriptomes.  View on PubMed
  11. Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.  View on PubMed
  12. Camarda R, Williams J, Goga A In vivo Reprogramming of Cancer Metabolism by MYC.  View on PubMed
  13. Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.  View on PubMed
  14. Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.  View on PubMed
  15. Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.  View on PubMed
  16. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.  View on PubMed
  17. Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.  View on PubMed
  18. Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.  View on PubMed
  19. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.  View on PubMed
  20. Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.  View on PubMed

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