Research Summary

Cancer, fundamentally, is a disease of disordered gene expression. Cancer cells rely on deregulated expression of oncogenic and tumor suppressive pathways to initiate and maintain the transformation process. Thus, delineating how cancer cells achieve such pathologic gene expression states is a crucial step towards understanding and ultimately treating cancer as a disease. Towards achieving this goal, my laboratory employs a systems biological and multidisciplinary approach that integrates computational and experimental strategies to identify and characterize key regulatory programs that underlie cancer progression. The systems-level frameworks implemented in our lab ensure a truly unbiased and systematic approach to studying this key biological challenge. Such bottom-up and agnostic approaches are crucial for discovering pathways that fall outside of our prior knowledge of regulatory interactions and would otherwise remain hidden in a top-down reductionist framework.

Lab website: http://goodarzilab.ucsf.edu

Research Funding

  • July 1, 2019 - June 30, 2024 - An antisense RNA-mediated regulatory program that drives cancer metastasis, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA240984
  • September 1, 2017 - August 31, 2022 - Targeted regulation of transcript stability through RNA methylation and intron retention, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM123977
  • May 1, 2016 - April 30, 2019 - Systematic dissection of an aberrant splicing program driving cancer metastasis, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R00CA194077
  • July 21, 2015 - June 30, 2017 - Structural RNA elements and their roles in post-transcriptional regulation, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: K99CA194077

Education

University of Tehran, B.S., 2006, Biotechnology
Princeton University, Ph.D., 2010, Molecular Biology
Princeton University, Postdoctoral Associate, 2012, Systems Biology
Rockefeller University, Postdoctoral Fellow, 2016, Cancer Systems Biology

Honors & Awards

  • 2017
    2017 AAAS Martin and Rose Wachtel Cancer Research Award
  • 2015
    Blavatnik Regional Awards for Young Scientists
  • 2015
    NIH K99/R00 Pathway to Independence Award
  • 2015
    Tri-Institutional Breakout Prize for Junior Investigators
  • 2014
    Ruth L. Kirschstein National Research Service Award (T32CA009673)
  • 2014
    RUCCTS/CDDS/SCBN Pilot Project Award
  • 2012
    Anderson Cancer Center Postdoctoral Fellowship at Rockefeller University
  • 2006
    William G. Bowen Merit Fellowship
  • 2005
    Top undergraduate student in the Department of Biotechnology (University of Tehran)
  • 2002
    University of Tehran fellowship for IBO medalists
  • 2002
    Silver medal in the 13th International Biology Olympiad in Riga, Latvia
  • 2001
    Gold medal in the 4th National Biology Olympiad in Tehran, Iran
  • 2001
    Member, Young Scholar’s Club (Tehran, Iran)

Selected Publications

  1. Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen HCB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements.  View on PubMed
  2. Jennifer Blaze, Hannah Phillips, Soeren Heissel, Albertas Navickas, Amara Plaza-Jennings, Marcus Foo, Christopher Katanski, Christopher Watkins, Zachary Pennington, Behnam Javidfar, Sergio Espeso-Gil, Henrik Molina, Denise Cai, Tao Pan, Wei-Dong Yao, Hani Goodarzi, Fatemeh Haghighi, Schahram Akbarian Neuronal Nsun2 Deficiency is Associated With Codon-Specific Epitranscriptomic Dysregulation of Gly-Trnas and Corresponding Proteomic Shift Impacting Synaptic Signaling and Behavior.  View on PubMed
  3. Huh D, Passarelli MC, Gao J, Dusmatova SN, Goin C, Fish L, Pinzaru AM, Molina H, Ren Z, McMillan EA, Asgharian H, Goodarzi H, Tavazoie SF A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression.  View on PubMed
  4. Abdulhay NJ, McNally CP, Hsieh LJ, Kasinathan S, Keith A, Estes LS, Karimzadeh M, Underwood JG, Goodarzi H, Narlikar GJ, Ramani V Massively multiplex single-molecule oligonucleosome footprinting.  View on PubMed
  5. Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.  View on PubMed
  6. Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.  View on PubMed
  7. Tavora B, Mederer T, Wessel KJ, Ruffing S, Sadjadi M, Missmahl M, Ostendorf BN, Liu X, Kim JY, Olsen O, Welm AL, Goodarzi H, Tavazoie SF Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.  View on PubMed
  8. Keshavarzi Arshadi A, Webb J, Salem M, Cruz E, Calad-Thomson S, Ghadirian N, Collins J, Diez-Cecilia E, Kelly B, Goodarzi H, Yuan JS Artificial Intelligence for COVID-19 Drug Discovery and Vaccine Development.  View on PubMed
  9. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY The DNA methylation landscape of advanced prostate cancer.  View on PubMed
  10. Yu J, Navickas A, Asgharian H, Culbertson B, Fish L, Garcia K, Olegario JP, Dermit M, Dodel M, Hänisch B, Luo Y, Weinberg EM, Dienstmann R, Warren RS, Mardakheh FK, Goodarzi H RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon.  View on PubMed
  11. Ghazizadeh Z, Majd H, Richter M, Samuel R, Zekavat SM, Asgharian H, Farahvashi S, Kalantari A, Ramirez J, Zhao H, Natarajan P, Goodarzi H, Fattahi F Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.  View on PubMed
  12. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.  View on PubMed
  13. Yamaguchi N, Weinberg EM, Nguyen A, Liberti MV, Goodarzi H, Janjigian YY, Paty PB, Saltz LB, Kingham TP, Loo JM, de Stanchina E, Tavazoie SF PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis.  View on PubMed
  14. Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.  View on PubMed
  15. Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.  View on PubMed
  16. Hani Goodarzi, Robert S. Warren, Johnny Yu, Lisa Fish A regulatory program that promotes metastasis in colorectal cancer (CRC) through modulation of mRNA stability.  View on PubMed
  17. Mauer J, Sindelar M, Despic V, Guez T, Hawley BR, Vasseur JJ, Rentmeister A, Gross SS, Pellizzoni L, Debart F, Goodarzi H, Jaffrey SR FTO controls reversible m6Am RNA methylation during snRNA biogenesis.  View on PubMed
  18. Fish L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A, Goodarzi H Cancer cells exploit an orphan RNA to drive metastatic progression.  View on PubMed
  19. Alkallas R, Fish L, Goodarzi H, Najafabadi HS Publisher Correction: Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease.  View on PubMed
  20. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.  View on PubMed

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