Research Summary
I am Professor of Otolaryngology-Head and Neck Surgery and Associate Vice Chancellor for Clinical and Translational Research at UCSF, where I also direct the Clinical and Translational Science Institute (CTSI). My own research efforts are focused on elucidating and targeting key signaling pathways in head and neck cancer. I directed the head and neck cancer program at the University of Pittsburgh Cancer Institute from 1998-2014 and in this capacity facilitated collaborations between clinicians and investigators with an emphasis of developing a robust research infrastructure to support translational cancer studies. I served as PI of the SPORE in Head and Neck Cancer at the University of Pittsburgh from 2002-2014 and now serve as Co-PI of that SPORE in a multi-PI structure. I am a member of the Developmental Therapeutics Program at the HDFCCC and facilitate interactions between the cancer center and the CTSI.
Research Funding
August 15, 2018 - July 31, 2025 - Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R35CA231998
August 13, 2019 - May 31, 2024 - Targeting STAT3 to enhance anti-tumor immunity, Co-Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE028289
May 1, 2014 - May 31, 2024 - PI3K Pathway Mutations in Head and Neck Cancer, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE023685
July 18, 2016 - May 31, 2021 - Clinical and Translational Science Institute, Principal Investigator. Sponsor: NIH/NCATS, Sponsor Award ID: UL1TR001872
Education
Swarthmore College, BA, Biology, 1982
Swarthmore College, BA, Art History, 1982
University of Pittsburgh, M.D., School of Medicine, 1987
University of Pittsburgh, Residency, School of Medicine, Surgery, 1988
University of Pittsburgh, Research Fellowship, School of Medicine, Infections Disease, 1992
University of Pittsburgh, Residency, School of Medicine, Otolaryngology, 1993