Nalin Gupta, MD, PhD

Benioff UCSF Professorship in Children's Health; and Dennis Bruce Dettmer Endowed Chair in Pediatric Neurosurgery, UCSF

Professor, Departments of Neurological Surgery and Pediatrics, UCSF; Chief, Division of Pediatric Neurosurgery, UCSF

Cancer Center Program Membership

Pediatric Malignancies

Research Summary

Nalin Gupta is Chief of the Division of Pediatric Neurosurgery at UCSF, and a Professor in the Departments of Neurological Surgery and Pediatrics. His clinical and research interests are directed towards neuro-oncology and congenital anomalies. He was the lead neurosurgeon at UCSF for a randomized clinical trials examining the effectiveness of fetal surgery for myelomeningocele. He also participated in a phase I clinical study examining the safety of stem cell transplantation for a disorder of myelination in humans. He is currently clinical PI of a phase I study examining the safety of gene therapy for children with primary AADC deficiency.

Research Funding

  • July 1, 2020 - June 30, 2025 - Myeloid cells and radiation-induced memory deficits in rodent glioma model: sex and age effects, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA246722
  • January 1, 2019 - December 31, 2021 - Use of a Long Non-coding RNA (lncRNA) as a Therapeutic Target in DIPG, Co-Investigator. Sponsor: Michael Mosier Defeat DIPG Foundation, Sponsor Award ID: A132437
  • April 15, 2016 - October 15, 2019 - Convection-enhanced delivery of nanoliposomal CPT-11 for the treatment of newly diagnosed children with diffuse intrinsic pontine glioma (DIPG), . Sponsor: V Foundation, Sponsor Award ID: 02016-007
  • April 19, 2006 - February 28, 2011 - Macrophage and Microglial Activation in Glioma-Associated Inflammation, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K08NS055061

Education

Faculty of Science, McGill University, Montreal, Canada, 1981-1983, Program in Biology
Faculty of Medicine, University of Toronto, Canada, MD, 1987, Medicine
Mt. Sinai Hospital, Faculty of Medicine, University of Toronto, Canada, Internship, 1987-1988, Surgery
Dept. of Surgery, University of Ottawa and University of Toronto, Canada, Residency, 1988-1996, Neurosurgery
University of California, San Francisco, PhD, 1996, Biochemistry / Biophysics
Hospital for Sick Children, Toronto, Canada, 1997-98, Peds Neurosurgery

Honors & Awards

  • 1981
    J.W. McConnell Scholarship, McGill University
  • 1988
    Outstanding Intern, Department of Emergency Medicine, Mount Sinai Hospital
  • 1989
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1994
    Student Travel Award, Radiation Research Society
  • 1995
    Junior Scientist Travel Award, International Congress of Radiation Research
  • 1995
    T.P. Morley Resident Research Award, Division of Neurosurgery, University of Toronto
  • 1997
    Resident Teaching Award, St. Michael's Hospital, Toronto
  • 1997
    Alan Hudson Resident Teaching Award, Division of Neurosurgery, University of Toronto
  • 2003
    Hellman Family Research Award for Junior Faculty, UCSF
  • 2004
    Career Development Award, SPORE Grant, UCSF

Selected Publications

  1. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.  View on PubMed
  2. Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.  View on PubMed
  3. Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.  View on PubMed
  4. Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.  View on PubMed
  5. Bot GM, Burkhardt JK, Gupta N, Lawton MT Superficial temporal artery-to-middle cerebral artery bypass in combination with indirect revascularization in moyamoya patients = 3 years of age.  View on PubMed
  6. Feng X, Liu S, Chen D, Rosi S, Gupta N Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model.  View on PubMed
  7. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.  View on PubMed
  8. Safaee MM, Jonzzon S, López GY, Asaikar S, Tihan T, Glenn OA, Gupta N Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features.  View on PubMed
  9. Panditharatna E, Kilburn LB, Aboian MS, Kambhampati M, Gordish-Dressman H, Magge SN, Gupta N, Myseros JS, Hwang EI, Kline C, Crawford JR, Warren KE, Cha S, Liang WS, Berens ME, Packer RJ, Resnick AC, Prados M, Mueller S, Nazarian J Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy.  View on PubMed
  10. Gupta N, Goumnerova LC, Manley P, Chi SN, Neuberg D, Puligandla M, Fangusaro J, Goldman S, Tomita T, Alden T, DiPatri A, Rubin JB, Gauvain K, Limbrick D, Leonard J, Geyer JR, Leary S, Browd S, Wang Z, Sood S, Bendel A, Nagib M, Gardner S, Karajannis MA, Harter D, Ayyanar K, Gump W, Bowers DC, Weprin B, MacDonald TJ, Aguilera D, Brahma B, Robison NJ, Kiehna E, Krieger M, Sandler E, Aldana P, Khatib Z, Ragheb J, Bhatia S, Mueller S, Banerjee A, Bredlau AL, Gururangan S, Fuchs H, Cohen KJ, Jallo G, Dorris K, Handler M, Comito M, Dias M, Nazemi K, Baird L, Murray J, Lindeman N, Hornick JL, Malkin H, Sinai C, Greenspan L, Wright KD, Prados M, Bandopadhayay P, Ligon KL, Kieran MW Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma.  View on PubMed
  11. Kline C, Liu SJ, Duriseti S, Banerjee A, Nicolaides T, Raber S, Gupta N, Haas-Kogan D, Braunstein S, Mueller S Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience.  View on PubMed
  12. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA The genetic landscape of gliomas arising after therapeutic radiation.  View on PubMed
  13. Rocque BG, Agee BS, Thompson EM, Piedra M, Baird LC, Selden NR, Greene S, Deibert CP, Hankinson TC, Lew SM, Iskandar BJ, Bragg TM, Frim D, Grant G, Gupta N, Auguste KI, Nikas DC, Vassilyadi M, Muh CR, Wetjen NM, Lam SK Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study.  View on PubMed
  14. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA The genetic landscape of ganglioglioma.  View on PubMed
  15. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.  View on PubMed
  16. Farmer DL, Thom EA, Brock JW, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Gupta N, Adzick NS The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes.  View on PubMed
  17. Louis N, Liu S, He X, Drummond DC, Noble CO, Goldman S, Mueller S, Bankiewicz K, Gupta N, Hashizume R New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model.  View on PubMed
  18. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex.  View on PubMed
  19. Gupta N Surgical techniques for open fetal repair of myelomeningocele.  View on PubMed
  20. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.  View on PubMed

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