Research Summary

I have been heavily involved in the field salivary gland cancer research since my postdoctoral experience during residency in the lab of Drs. David Sidransky and Joseph Califano. I joined the Johns Hopkins Department of Otolaryngology as a faculty member in 2006 and chose to focus my research efforts on salivary gland tumors, with several NIH and foundation grants awarded since 2007. My focus is on the epigenetic mechanisms of adenoid cystic carcinoma, and the pathways that might lead to its development. I have published many peer-reviewed studies on this topic and have formed many collaborations throughout the country. I recently moved to the University of California San Francisco to lead the Division of Head and Neck Surgical Oncology and will continue in my research there. As a head and neck surgeon, I bring additional clinical expertise which can offer access to tissue and patients, as well as an understanding of the relevant translational questions.

Research Funding

  • September 1, 2012 - August 31, 2017 - Integrated pathway analysis of altered driver genes in adenoid cystic carcinoma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE023227
  • July 13, 2012 - June 30, 2014 - array-based screening for the expression and regulation of tumor supressor genes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03DE022591
  • July 1, 2007 - December 30, 2012 - The role of promoter hypermethylation in adenoid cystic carcinoma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08DE018463

Education

Harvard College, BA, 1991-95, Biology
Johns Hopkins School of Medicine, MD, 1995-99, Medicine
Johns Hopkins Department of Otolaryngology, Residency, 1999-2006, Otolaryngology
Johns Hopkins Department of Otolaryngology, Postdoctoral Fellowship, 2000-2002, Molecular Genetics
Johns Hopkins Department of Otolaryngology, Advanced training, 2006, Head and Neck Surgery

Honors & Awards

  • 1999
    Elected Alpha Omega Alpha, Johns Hopkins School of Medicine
  • 2001
    Greater Baltimore Medical Center Resident Research Forum award winner
  • 2005
    Recipient of the Henkel Chief Resident Teacher of the Year Award
  • 2005
    Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005
  • 2006
    Tilghman Travel Fellowship recipient for training in endoscopic laser surgery
  • 2007/10
    Recipient of the Otolaryngology Faculty Teaching Award
  • 2011-15
    Voted Baltimore Magazine Top Doc in Head and Neck Surgical Oncology

Selected Publications

  1. Madeleine P. Strohl, Patrick K. Ha, Kaveh Zakeri, Nancy Lee. De-intensification Strategies for Head and Neck Cancer. . 2022 Sep 10; 1-12.  View on PubMed
  2. Mukherjee A, Ha P, Wai KC, Naara S. The Role of ECM Remodeling, EMT, and Adhesion Molecules in Cancerous Neural Invasion: Changing Perspectives. Adv Biol (Weinh). 2022 Sep; 6(9):e2200039.  View on PubMed
  3. Joseph O. Humtsoe, Leilani Jones, Shorook Naara, Francesca Zammarchi, Nicole Spardy Burr, Patrick H. van Berkel, Patrick K. Ha, Hyunseok Kang. Abstract LB084: AXL as a therapeutic target in adenoid cystic carcinoma: preclinical evaluation of AXL targeting antibody-drug conjugate (ADCT-601). Cancer Research. 2022 Jun 15; 82(12_Supplement):lb084-lb084.  View on PubMed
  4. Cheung CK, Chew J, Wai K, Calkins SM, Ha PK, Ryan WR, Cunha A, Yom SS, Hsu IC, Chan JW. Feasibility of accelerated image-guided high-dose-rate interstitial brachytherapy with inverse planning simulated annealing (IPSA-HDRBT) for post-operative treatment of pathologically node-negative squamous cell carcinomas of the oral tongue. Brachytherapy. 2022 Sep-Oct; 21(5):686-691.  View on PubMed
  5. Humtsoe JO, Kim HS, Jones L, Cevallos J, Boileau P, Kuo F, Morris LGT, Ha P. Development and Characterization of MYB-NFIB Fusion Expression in Adenoid Cystic Carcinoma. Cancers (Basel). 2022 Apr 30; 14(9).  View on PubMed
  6. Guix I, Liu Q, Pujana MA, Ha P, Piulats J, Linares I, Guedea F, Mao JH, Lazar A, Chapman J, Yom SS, Ashworth A, Barcellos-Hoff MH. Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy. Clin Cancer Res. 2022 04 01; 28(7):1372-1382.  View on PubMed
  7. Scott-Wittenborn N, D'Souza G, Tewari S, Rooper L, Troy T, Drake V, Bigelow EO, Windon MJ, Ryan WR, Ha PK, Kiess AP, Miles B, Westra WH, Mydlarz WK, Eisele DW, Fakhry C. Prevalence of human papillomavirus in head and neck cancers at tertiary care centers in the United States over time. Cancer. 2022 05 01; 128(9):1767-1774.  View on PubMed
  8. Li H, Peyser ND, Zeng Y, Ha PK, Johnson DE, Grandis JR. NSAIDs Overcome PIK3CA Mutation-Mediated Resistance to EGFR Inhibition in Head and Neck Cancer Preclinical Models. Cancers (Basel). 2022 Jan 20; 14(3).  View on PubMed
  9. Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, Immunoprofiler Consortium, Cai C, Zhan J, Davis KC, Kelley RK, Chapman JS, Atreya CE, Patel A, Daud AI, Ha P, Diaz AA, Kratz JR, Collisson EA, Fragiadakis GK, Erle DJ, Boissonnas A, Asthana S, Chan V, Krummel MF. Discovering dominant tumor immune archetypes in a pan-cancer census. Cell. 2022 01 06; 185(1):184-203.e19.  View on PubMed
  10. Stanford-Moore GB, Sola AM, Chan J, El-Sayed I, George J, Ha P, Ryan WR, Heaton CM. Adjuvant therapy improves survival in pT4aN0 oral cavity squamous cell carcinoma with bone invasion. Am J Otolaryngol. 2022 Mar-Apr; 43(2):103303.  View on PubMed
  11. Zebolsky AL, George E, Gulati A, Wai KC, Carpenter P, Van Zante A, Ha PK, Heaton CM, Ryan WR. Risk of Pathologic Extranodal Extension and Other Adverse Features After Transoral Robotic Surgery in Patients With HPV-Positive Oropharynx Cancer. JAMA Otolaryngol Head Neck Surg. 2021 12 01; 147(12):1080-1088.  View on PubMed
  12. Cognetti DM, Johnson JM, Curry JM, Kochuparambil ST, McDonald D, Mott F, Fidler MJ, Stenson K, Vasan NR, Razaq MA, Campana J, Ha P, Mann G, Ishida K, Garcia-Guzman M, Biel M, Gillenwater AM. Phase 1/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma. Head Neck. 2021 12; 43(12):3875-3887.  View on PubMed
  13. Drake V, Bigelow E, Fakhry C, Windon M, Rooper LM, Ha P, Miles B, Gourin C, Mandal R, Mydlarz W, London N, Vosler PS, Yavvari S, Troy T, Waterboer T, Eisele DW, D'Souza G. Biologic and behavioral associations of estrogen receptor alpha positivity in head and neck squamous cell carcinoma. Oral Oncol. 2021 10; 121:105461.  View on PubMed
  14. Lee RH, Salesky M, Benjamin T, El-Sayed IH, George JR, Ha PK, Ryan WR, Heaton CM. Impact of Smoking and Primary Tumor Subsite on Recurrence in HPV-Associated Oropharyngeal Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2022 04; 166(4):704-711.  View on PubMed
  15. Fakhry C, Tewari SR, Zhang L, Windon MJ, Bigelow EO, Drake VE, Rooper LM, Troy T, Ha P, Miles BA, Mydlarz WK, Eisele DW, D'Souza G. RTOG-0129 risk groups are reproducible in a prospective multicenter heterogeneously treated cohort. Cancer. 2021 10 01; 127(19):3523-3530.  View on PubMed
  16. Wai KC, Kang H, Ha PK. Molecular Markers that Matter in Salivary Malignancy. Otolaryngol Clin North Am. 2021 Jun; 54(3):613-627.  View on PubMed
  17. Brodie KD, Zebolsky AL, Ochoa E, Ha PK, Heaton CM, El-Sayed IH, Ryan WR. A prospective study of patient-reported xerostomia-related outcomes after parotidectomy. Laryngoscope Investig Otolaryngol. 2021 Aug; 6(4):683-689.  View on PubMed
  18. Ryan WR, Xu MJ, Ochoa E, Plonowska-Hirschfeld KA, Zebolsky AL, Ha PK, Bewley AF, Mallen-St Clair J, Joshi AS, Coffey CS, Faraji F, MacDonald BV, Houlton JJ, Gobillot TA, Curry JM, Philips R, Hackman TG, Richmon JD, Holcomb AJ, Coughlin AM, Panwar A, Smith RB, Herberg ME, Fakhry C, Cognetti DM. Oncologic outcomes of human papillomavirus-associated oropharynx carcinoma treated with surgery alone: A 12-institution study of 344 patients. Cancer. 2021 09 01; 127(17):3092-3106.  View on PubMed
  19. Plonowska-Hirschfeld KA, Fung M, Glastonbury C, Ha PK. Parapharyngeal tuberculoid mass: A rare complication of Bacillus Calmette-Guérin therapy for urothelial carcinoma in situ. Clin Case Rep. 2021 Jun; 9(6):e04172.  View on PubMed
  20. Geiger JL, Ismaila N, Beadle B, Caudell JJ, Chau N, Deschler D, Glastonbury C, Kaufman M, Lamarre E, Lau HY, Licitra L, Moore MG, Rodriguez C, Roshal A, Seethala R, Swiecicki P, Ha P. Management of Salivary Gland Malignancy: ASCO Guideline. J Clin Oncol. 2021 06 10; 39(17):1909-1941.  View on PubMed

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