Research Summary

My work focuses on understanding the mechanisms underlying pancreas development and disease, including diabetes and pancreatic cancer. My research on the role of embryonic signaling pathways in these processes has provided a glimpse into how tight regulation of these signaling events is imperative for proper organogenesis, maintenance of organ function, and prevention of pancreatic cancer. My lab has made important insights into how differentiated cells in the exocrine pancreas, namely duct and acinar cells, undergo a process of dedifferentiation during the early stages of neoplasia that can lead to pancreatic ductal adenocarcinoma (PDA), a particularly lethal cancer in humans.

Research Funding

  • September 20, 2018 - July 31, 2023 - Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus, Co-Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: UH3DK120004
  • May 1, 2015 - July 31, 2023 - Regulation of beta cell identity and dedifferentiation, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: R01DK105831
  • September 20, 2019 - May 31, 2023 - Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems, Co-Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: U01DK123559
  • September 20, 2018 - July 31, 2020 - Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus, Co-Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: UG3DK120004

Education

Biological-Technical Assistant (BTA) School, Bückeburg, Germany, Diploma, 1983-1985, Biology
Albert-Ludwigs University, Freiburg, Germany, Diploma/ Master Ph.D., 1986-1992, Cell & Molecular Biology
Max-Planck-Institute for Immunobiology, Freiburg, Germany, 1992-1995, Developmental Biology
Harvard University, Department of Molecular & Cell Biology and Howard Hughes Medical Institute, Cambridge, MA Postdoctoral Training, 1996-1999, Developmental Biology

Honors & Awards

  • 1994
    Graduate Student Research Award of the Hoechst AG, Frankfurt
  • 1995
    Post-doctoral Fellowship from the Max-Planck Society
  • 1996
    Post-doctoral Fellowship from the German Research Society (DFG)
  • 1997-1999
    Howard Hughes Medical Institute Postdoctoral Fellowship
  • 1999
    Sandler Program in Basic Sciences Junior Faculty Start-up Award
  • 2000
    Sandler Award in Basic Sciences
  • 2000
    Career Development Award, Juvenile Diabetes Foundation
  • 2004
    Guest-Professor, University of Ulm, Germany
  • 2006
    Scholar Award, Juvenile Diabetes Research Foundation
  • 2013-present
    Chair, CADO/NIH study section

Selected Publications

  1. de Klerk E, Hebrok M Stem Cell-Based Clinical Trials for Diabetes Mellitus.  View on PubMed
  2. Jacobson EF, Chen Z, Stoukides DM, Nair GG, Hebrok M, Tzanakakis ES Non-xenogeneic Expansion and Definitive Endoderm Differentiation of Human Pluripotent Stem Cells in an Automated Bioreactor.  View on PubMed
  3. Nair GG, Tzanakakis ES, Hebrok M Emerging routes to the generation of functional ß-cells for diabetes mellitus cell therapy.  View on PubMed
  4. Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M Loss of the transcription factor MAFB limits ß-cell derivation from human PSCs.  View on PubMed
  5. Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R LIN28B Impairs the Transition of hESC-Derived ß Cells from the Juvenile to Adult State.  View on PubMed
  6. Tong X, Dai C, Walker JT, Nair GG, Kennedy A, Carr RM, Hebrok M, Powers AC, Stein R Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.  View on PubMed
  7. Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors.  View on PubMed
  8. Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.  View on PubMed
  9. Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A mTORC1 to AMPK switching underlies ß-cell metabolic plasticity during maturation and diabetes.  View on PubMed
  10. Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet ß-Cell Function.  View on PubMed
  11. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells.  View on PubMed
  12. Harari N, Sakhneny L, Khalifa-Malka L, Busch A, Hertel KJ, Hebrok M, Landsman L Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.  View on PubMed
  13. Gopika Nair, Gopika Nair, Holger Russ, Matthias Hebrok Rapid generation of functional mature pancreatic islet-beta cells from human pluripotent stem cells.  View on PubMed
  14. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells.  View on PubMed
  15. Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.  View on PubMed
  16. Gaetano Faleo, Casey Ward, Audrey Parent, Gopika Nair, Wenhan Chang, Peter Stock, Matthias Hebrok, Qizhi Tang Co-Transplant of Parathyroid Gland and Stem Cell-Derived Insulin-Producing Cells Enhances Graft Survival through Release of Pro-Angiogenic and Pro-Survival Factors.  View on PubMed
  17. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.  View on PubMed
  18. Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G Synaptotagmin 4 Regulates Pancreatic ß Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.  View on PubMed
  19. Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M Replication confers ß cell immaturity.  View on PubMed
  20. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.  View on PubMed

Go to UCSF Profiles, powered by CTSI