Research Funding

  • May 4, 2015 - April 30, 2020 - Improving risk allocation and developing novel therapies for children with T-ALL, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA193776
  • June 1, 2010 - May 31, 2015 - Interplay of Innate and Adaptive Immunity in Lupus Pathogenesis, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI089831
  • July 11, 2003 - June 30, 2007 - Role of CD45 in Hematopoiesis and Lymphomagenesis, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: K08CA098418
  • May 4, 2015 - April 30, 2020 - Improving risk allocation and developing novel therapies for children with T-ALL, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA193776

Education

University of Iowa, B.S August, 1988, Physiology
Washington University School of Medicine, Ph.D., May, 1997, Developmental Biology
Washington University School of Medicine, M.D., May, 1997, Medicine
University of California, San Francisco, Resident, 1997-99, Pediatrics
University of California, San Francisco, Fellow, 1999-03, Hematology/Oncology
University of California, San Francisco, Post-Doctoral Fellow,2001-2007,Immunology

Honors & Awards

  • 1987
    Mortar Board Honor Society, University of Iowa
  • 1988
    Honors Graduate, University of Iowa
  • 1988
    University of Iowa Homecoming Award for Excellence in Scholarship, Leadership, and Service
  • 1990
    Medical Scientist Training Program Fellowship, Washington University
  • 1990
    Edmond V. Cowdry Prize in Histology, Washington University
  • 1993
    Spencer T. and Ann W. Olin Foundation Medical Scientist Fellowship, Washington University
  • 1995
    Barbara Jackshik Award for Excellence in the Field of Cellular Regulation, Washington University
  • 1996
    American College of Physicians Award for Excellence in Physical Diagnosis
  • 1997
    American Medical Women's Association Janet M. Glasgow Memorial Achievement Citation, presented to women graduating in the top ten percent of their medical school class
  • 1997
    Missouri State Medical Association Award for Outstanding Achievement in Medicine
  • 1997
    Alpha Omega Alpha, Washington University School of Medicine
  • 1997
    UCSF Molecular Medicine Research Fellowship Program
  • 2001
    Molecular Oncology Investigator, University of California San Francisco Cancer Center
  • 2004
    FASEB Summer Protein Phosphatase Research Conference Poster Award
  • 2005
    Nominee, Department of Pediatrics Housestaff Teaching Award, UCSF
  • 2007-10
    Nominee, Fellow Mentoring Award, Department of Pediatrics, UCSF
  • 2008
    St. Baldrick's Foundation, Young Investigator Career Development Award
  • 2009
    Alex Lemonade Stand Young Investigator Career Development Award
  • 2010
    Histiocyte Society Nezelof Prize in Basic Science

Selected Publications

  1. Lin H, Scull BP, Goldberg BR, Abhyankar HA, Eckstein OE, Zinn DJ, Lubega J, Agrusa J, El Mallawaney N, Gulati N, Forbes L, Chinn I, Chakraborty R, Velasquez J, Goldman J, Bashir D, Lam F, Muscal E, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Meyer LK, Jeng M, Naqvi A, McClain K, Nguyen T, Wong H, Man TK, Jordan MB, Allen CE. IFN-? signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS. Blood Adv. 2021 Sep 14; 5(17):3457-3467.  View on PubMed
  2. Nguyen MC, Nguyen V, Le H, Nguyen DV, Nguyen ML, Hermiston ML, Bui CB, Loh AHP. Subcutaneous panniculitis-like T-cell lymphomas with homozygous inheritance of HAVCR2 mutations in Vietnamese pedigrees. Pediatr Blood Cancer. 2021 Aug 16; e29292.  View on PubMed
  3. Smith GA, Levinson AL, Galvin RT, Lalor LE, McCalmont T, Wang L, Geis MC, Odegaard K, Hupp M, Maguiness S, Turcotte LM, Cordoro KM, Hermiston ML. Concurrent Subcutaneous Panniculitis-like T-Cell Lymphoma and B-Cell Acute Lymphoblastic Leukemia in 2 Pediatric Patients. J Pediatr Hematol Oncol. 2021 08 01; 43(6):e791-e794.  View on PubMed
  4. Lauren K. Meyer, Ritu Roy, Benjamin J. Huang, Cristina Delgado-Martin, Tiffaney L. Vincent, Brent L. Wood, Yu Liu, Jinghui Zhang, Charles Grenfell Mullighan, Terzah M. Horton, Mignon L. Loh, Meenakshi Devidas, Elizabeth A. Raetz, Robert J. Hayashi, Stuart S. Winter, Kimberly P. Dunsmore, Stephen Hunger, David T. Teachey, Adam B. Olshen, Michelle L. Hermiston. Targeted gene expression classifier identifies pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients at high risk for end induction minimal residual disease positivity. Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):10002-10002.  View on PubMed
  5. K.J. Curran, V.A. Fabrizio, A. Mauguen, J.J. Boelens, C. Baggott, S. Prabhu, H. Placenta, C.L. Phillips, J. Rossoff, H. Stefanski, J. Talano, A. Moskop, S.P. Margossian, M.R. Verneris, G. Myers, N.A. Karras, P.A. Brown, M. Qayed, M. Hermiston, P. Satwani, C. Krupski, A. Keating, R. Wilcox, C.A. Rabik, V. Chinnabhandar, M. Kunicki, A. Goksenin, C. Mackall, T.W. Laetsch, L.M. Schultz. Fludarabine-exposure predicts disease control following CD19-specific car t cell (tisagenlecleucel); a report from pediatric real-world car consortium. Cytotherapy. 2021 May 1; 23(5):s27.  View on PubMed
  6. Chaturvedi V, Marsh RA, Zoref-Lorenz A, Owsley E, Chaturvedi V, Nguyen TC, Goldman JR, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Jeng M, Naqvi A, Allen CE, Wong HR, Jordan MB. T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis. Blood. 2021 Apr 29; 137(17):2337-2346.  View on PubMed
  7. Hermiston ML. Double trouble for Langerhans cell histiocytosis. Blood. 2021 04 01; 137(13):1705-1706.  View on PubMed
  8. Michael W Boyer, Sonali Chaudhury, Kara L Davis, Timothy Alan Driscoll, Stephan Grupp, Michelle Hermiston, Samuel John, Amy K Keating, Christina Kovacs, Andrea Magley, G. Doug Myers, Christine L Phillips, Mike A. Pulsipher, Das Purkayastha, Julie-An Talano, Olufolake A Adisa, Jennifer Willert. 149 Evaluating Efficacy and Safety of Tisagenlecleucel Reinfusion Following Loss of B-Cell Aplasia in Pediatric and Young Adult Patients with Acute Lymphoblastic Leukemia: HESTER Phase II Study. . 2021 Mar 1; 27(3):s141-s142.  View on PubMed
  9. David T. Teachey, Meenakshi Devidas, Brent L Wood, Zhiguo Chen, Robert James Hayashi, Robert D Annett, Barbara L Asselin, Keith J August, Steve Y Cho, Kimberly P. Dunsmore, Brian T. Fisher, Jason L. Freedman, Paul J. Galardy, Paul Harker-Murray, Michelle L. Hermiston, Terzah M Horton, Alok I Jaju, Allison Lam, Yoav H. Messinger, Rodney R. Miles, Maki Okada, Samir I Patel, Eric S. Schafer, Tal Schechter-Finkelstein, Kristin A. Shimano, Neelam Singh, Amii C. Steele, Maria L. Sulis, Sarah L Vargas, Stuart S. Winter, Charlotte Wood, Patrick Zweider McKay, Catherine M. Bollard, Mignon L. Loh, Stephen P. Hunger, Elizabeth A. Raetz. Cranial Radiation Can be Eliminated in Most Children with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Bortezomib Potentially Improves Survival in Children with T-Cell Lymphoblastic Lymphoma (T-LL): Results of Children's Oncology Group (COG) Trial AALL1231. Blood. 2020 Nov 5; 136(Supplement 1):11-12.  View on PubMed
  10. Michael W Boyer, Sonali Chaudhury, Kara L Davis, Timothy Alan Driscoll, Stephan A Grupp, Michelle Hermiston, Samuel John, Amy K Keating, Christina Kovacs, Andrea Magley, Gary Douglas Myers, Christine L Phillips, Michael A Pulsipher, Das Purkayastha, Julie-An Talano, Jennifer Willert. HESTER: A Phase II Study Evaluating Efficacy and Safety of Tisagenlecleucel Reinfusion in Pediatric and Young Adult Patients with Acute Lymphoblastic Leukemia Experiencing Loss of B-Cell Aplasia. Blood. 2020 Nov 5; 136(Supplement 1):23-24.  View on PubMed
  11. Alan S. Wayne, Gerard Michel, Daniel W. Lee, Andr√© Baruchel, Sonali Chaudhury, Patrick A. Brown, Michelle Hermiston, Joerg Krueger, Tong Shen, Kristy Tailford, Behzad Kharabi Masouleh. ZUMA-4: A Phase 1/2 Multicenter Study of KTE-X19 in Pediatric and Adolescent Patients With Relapsed/Refractory B Cell Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma. Blood. 2020 Nov 5; 136(Supplement 1):42-42.  View on PubMed
  12. Meyer LK, Verbist KC, Albeituni S, Scull BP, Bassett RC, Stroh AN, Tillman H, Allen CE, Hermiston ML, Nichols KE. JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation. Blood. 2020 08 06; 136(6):657-668.  View on PubMed
  13. Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM. Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434. J Clin Oncol. 2020 09 10; 38(26):3062-3070.  View on PubMed
  14. Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2020 02 03; 130(2):863-876.  View on PubMed
  15. Burke MJ, Kostadinov R, Sposto R, Gore L, Kelley SM, Rabik C, Trepel JB, Lee MJ, Yuno A, Lee S, Bhojwani D, Jeha S, Chang BH, Sulis ML, Hermiston ML, Gaynon P, Huynh V, Verma A, Gardner R, Heym KM, Dennis RM, Ziegler DS, Laetsch TW, Oesterheld JE, Dubois SG, Pollard JA, Glade-Bender J, Cooper TM, Kaplan JA, Farooqi MS, Yoo B, Guest E, Wayne AS, Brown PA. Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study. Clin Cancer Res. 2020 05 15; 26(10):2297-2307.  View on PubMed
  16. Lauren K. Meyer, Cristina Delgado-Martin, Phillip P. Sharp, Dustin McMinn, Christopher J. Kirk, Jack Taunton, Michelle L. Hermiston. Protein Translocation Inhibitors Overcome Cytokine-Induced Glucocorticoid Resistance in T-Cell Acute Lymphoblastic Leukemia. Blood. 2019 Nov 13; 134(Supplement_1):805-805.  View on PubMed
  17. Aleksandra S. Dain, Michelle L. Hermiston, Kristin A. Shimano, Sandhya Kharbanda, Alexis Melton, Jasmeen Dara, James N Huang, Christopher C. Dvorak. Role of Disease Mechanism in Hematopoietic Cell Transplantation Outcomes for Hemophagocytic Lymphohistiocytosis. Blood. 2019 Nov 13; 134(Supplement_1):3343-3343.  View on PubMed
  18. Lauren K. Meyer, Katherine Verbist, Sabrin Albeituni, Rachel Bassett, Michelle L. Hermiston, Kim E. Nichols. The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis. Blood. 2019 Nov 13; 134(Supplement_1):81-81.  View on PubMed
  19. Jordan MB, Allen CE, Greenberg J, Henry M, Hermiston ML, Kumar A, Hines M, Eckstein O, Ladisch S, Nichols KE, Rodriguez-Galindo C, Wistinghausen B, McClain KL. Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO). Pediatr Blood Cancer. 2019 11; 66(11):e27929.  View on PubMed
  20. Meyer LK, Delgado-Martin C, Maude SL, Shannon KM, Teachey DT, Hermiston ML. CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. PLoS One. 2019; 14(7):e0220026.  View on PubMed

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