Research Summary

I am a physician-scientist whose research program focuses on mouse cancer modeling, molecular therapeutics, functional genomics, and biomarker discovery in hematologic cancers. My recent data indicate that targeting downstream Ras effector pathways and bromodomain and extraterminal (BET) proteins is highly synergistic in vivo and represents a novel approach for the treatment of pediatric acute myeloid leukemia (AML). Additional contributions to science include collaborations that have involved RAS/NF1-driven cancers and the implementation of computational pipelines for analyzing integrated (epi)genomic preclinical and clinical data. These collaborations include recent projects that incorporate primary samples from patients enrolled on North American Children's Oncology Group clinical trials, as well as early phase clinical trials. My overall goal is to develop new therapeutic strategies in AML to inform biology-driven, genetically stratified trials of innovative drug combinations.

Education

University of California, Berkeley, BS, 06/2005, Electrical Engineering and Computer Sciences
University of California, San Francisco, MD, 06/2010, Medicine
University of California, San Francisco, Residency, 06/2013, Pediatrics
University of California, San Francisco, Fellowship, 06/2016, Pediatric Hematology/Oncology

Honors & Awards

  • 2006
    UC Berkeley Outstanding Graduate Student Instructor Award
  • 2009
    Alpha Omega Alpha, Medical Honor Society
  • 2010
    UCSF School of Medicine Essential Core Teaching Award
  • 2011
    UCSF Pediatric Residency Ahmad Ghanea Bassiri Award Finalist
  • 2013
    UCSF Pediatric Residency Rudolph Award Finalist
  • 2014
    UCSF School of Medicine Core Clerkship Teaching Award
  • 2016
    St. Baldrick’s Foundation Fellowship Award
  • 2017
    Bleecher Junior Faculty Research Award
  • 2019
    Hyundai Hope on Wheels Scholar Award
  • 2020
    St. Baldrick's Foundation Scholar Award
  • 2020
    Rally Foundation Career Development Award

Selected Publications

  • Huang B, Smith JL, Wang YC, Taghizadeh K, Leonti AR, Ries RE, Liu Y, Kolekar P, Tarlock K, Gerbing R, Crowgey EL, Furlan SN, Shaw TI, Hagiwara K, Wei L, Cooper TM, Gamis AS, Aplenc R, Kolb EA, Farrar JE, Triche T, Alonzo TA, Ma X, Meshinchi S. CBFB-MYH11 Fusion Transcripts Distinguish Acute Myeloid Leukemias with Distinct Molecular Landscapes and Outcomes. Blood Adv. 2021 Sep 21; bloodadvances.2021004965.
  • Remsberg J, Suciu R, Zambetti N, Hanigan T, Firestone A, Inguva A, Long A, Ngo N, Lum K, Henry C, Richardson S, Predovic M, Huang B, Howell A, Niphakis M, Shannon K. ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 Apr 29. doi: 10.1038/s41589-021-00785-8.
  • Peretz C, McGary L, Kumar T, Jackson H, Jacob J, Durruthy-Durruthy R, Levis M, Perl A, Huang B, Smith C. Single cell DNA sequencing reveals complex mechanisms of resistance to quizartinib. Blood Adv. 2021 Mar 9;5(5):1437-1441.
  • Pucciarelli D, Angus SP, Huang B, Zhang C, Nakaoka HJ, Krishnamurthi G, Bandyopadhyay S, Clapp DW, Shannon K, Johnson GL, Nakamura JL. Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK. Mol Cancer Ther. 2020 Aug 26.
  • Zambetti NA, Firestone AJ, Remsberg JR, Huang B, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 May 14;135(20):1772-1782.
  • Wandler AM, Huang B, Craig J, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, and Shannon K. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 Feb 17.
  • Meyer LK, Huang B, Delgado-Martin C, Roy R, Hechmer A, Wandler AM, Vincent TL, Olshen A, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias. J Clin Invest. 2020 Jan 13. pii: 130189.
  • Huang B, Wandler A, Meyer L, Dail M, Daemen A, Sampath D, Li Q, Wang X, Wong JC, Nakitandwe J, Downing JR, Zhang J, Taylor B, Shannon K. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. PLoS Genet. 2019 Jun 14;15(6):e1008168.
  • Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang B, Firestone AJ, Young A, LaCap J, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. Cell. 2017 Feb 23;168(5):817-829.e15.
  • Delgado-Martin C, Meyer LK, Huang B, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey D, Hermiston ML. JAK/STAT Pathway Inhibition Overcomes IL7-induced Glucocorticoid Resistance in a Subset of Human T-cell AcuteLymphoblastic Leukemias. Leukemia. 2017 Dec;31(12):2568-2576.
  • Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 Cooperate in T-lineage Leukemogenesis and Modulate Responses to Targeted Agents. Proc Natl Acad Sci. 2010 Mar 16;107(11):5106-11.

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