Research Summary

Dr. Chiung-Yu Huang is a Professor of Biostatistics at the Department of Epidemiology and Biostatistics at the University of California, San Francisco (UCSF) and serves as an Adjunct Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center. Dr. Huang is a Fellow of the American Statistical Association (ASA) and Institute of Mathematical Statistics (IMS). She is well known for her contributions to methodology research, particularly in the areas of survival analysis, competing risks analysis, recurrent event analysis, outcome-dependent sampling, and the design and evaluation of vaccine efficacy trials.

Dr. Huang's recent work has focused on developing innovative statistical methodologies to improve analysis efficiency in small-scale studies by integrating external large databases, modeling and predicting the risk of recurrent events to identify high-risk individuals, and incorporating information on infecting pathogens in the analysis of vaccine trials with active or passive surveillance. Additionally, she has developed efficient statistical methods for analyzing survival data collected in prevalent cohort studies, benefit-risk assessment tools for evaluating treatment risks and benefits in patients with end-stage disease, and statistical methods that can account for informative clinic visits in the analysis of electronic health records.

In addition to her methodological research, Dr. Huang has extensive experience in collaborative research across a wide range of fields, including influenza, malaria, transplant, and cancer studies. During her tenure as a Mathematical Statistician at the National Institute of Allergy and Infectious Diseases (NIAID), she collaborated with both extramural and intramural scientists on the design, conduct, monitoring, analysis, and presentation of preclinical and clinical studies. She also served as a statistician to the NIAID Influenza Research Collaboration (NIRC) and the Mexican Emerging Infectious Disease Clinical Research Network (La Red), and received numerous awards for her collaborative research, including the prestigious NIAID Merit Award.

Since joining UCSF in 2017, Dr. Huang has served as the lead statistician for the Hematopoietic Malignancies Program at UCSF Helen Diller Family Comprehensive Cancer Center and the University of California Hematologic Malignancies Consortium (UCHMC). She also established and served as the core director of the UCSF Department of Surgery Biostatistics Research Core (2019-2024), which provides statistical support to surgery investigators in designing and conducting rigorous, high-quality research.

Research Funding

  • September 1, 2024 - August 31, 2029 - Improving causal inference in Alzheimer's Disease prevention research on modifiable risk factors: the Triangulation of Innovative Methods to End AD (TIME-AD) project , Co-lead of Analytics Core . Sponsor: NIH/NIA, Sponsor Award ID: P01AG082653
  • August 1, 2025 - May 31, 2029 - Statistical Methods for Information Synthesizing Using Multiple Existing Longitudinal Cohort Studies , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01HL173153
  • September 1, 2023 - May 31, 2028 - Cancer Center Support Grant – Biostatistics & Population Research Shared Resource , Co-Investigator . Sponsor: NIH/NCI, Sponsor Award ID: P30CA082103
  • August 1, 2022 - July 31, 2027 - The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation , Co-Investigator . Sponsor: NIH/NHLBI, Sponsor Award ID: U01HL163242
  • September 1, 2022 - August 31, 2025 - CF Statistical Expertise and Network (CF StatNet) Award , Statistician . Sponsor: Cystic Fibrosis Foundation, Sponsor Award ID: CFStatNet 003789Y7122
  • November 1, 2021 - January 31, 2025 - Mixed Data Meta-analysis: Integration of Individual Participant and Aggregate Data , Co-Investigator . Sponsor: PCORI, Sponsor Award ID: ME-2020C3-21269
  • June 15, 2018 - May 31, 2023 - Predicting post-transplant mortality and global functional health based on pre-transplant functional status in liver transplantation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AG059183
  • June 1, 2018 - May 31, 2023 - UCSF Liver Core Center, Biostatistics Core , Statistician . Sponsor: NIH/NIDDK, Sponsor Award ID: P30DK026743
  • August 5, 1999 - May 31, 2023 - Cancer Center Support Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30CA082103
  • September 1, 2021 - January 31, 2023 - Allergy, Immunology and Transplantation Research (UCSF Coordinating Center) , Statistician . Sponsor: NIH/NIAID, Sponsor Award ID: 3UM1AI109565-08S3
  • September 1, 2019 - July 31, 2022 - A novel natural history study of medullary thyroid carcinoma , Statistician . Sponsor: University of Texas M.D. Anderson Cancer Center, Sponsor Award ID: R01FD006650
  • July 1, 2015 - June 30, 2021 - Statistical Methods for Survival and Recurrent Event Data in Clinical Research , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA193888
  • July 1, 2015 - June 30, 2020 - Reprogramming the pancreatic tumor microenvironment with immunotherapy , Statistician/Principal Investigator (Subaward) . Sponsor: NIH/NCI, Sponsor Award ID: R01CA197296
  • September 1, 2017 - December 31, 2018 - Comparing Patient Centered Outcomes in the Management of Pain between Emergency Departments and Dedicated Acute Care Facilities for Adults with Sickle Cell disease , Statistician/Principal Investigator (Subaward) . Sponsor: PCORI, Sponsor Award ID: HIS-1403-11888

Education

National Tsing-Hua University, Hsinchu, Taiwan, B.S., 07/1994, Mathematics
National Tsing-Hua University, Hsinchu, Taiwan, M.S., 07/1996, Mathematics
Johns Hopkins University, Baltimore, Maryland, Ph.D., 05/2002, Biostatistics

Honors & Awards

  • Frank Wilcoxon Award, American Society for Quality, 2025
  • Elected Fellow, Institute of Mathematical Statistics, 2025
  • Y.S. Chow Distinguished Lecture Award, Chinese Institute of Probability and Statistics, 2022
  • Elected Fellow, American Statistical Association, 2018
  • Distinguished Alumni Award, National Tainan Girls' Senior High School, Tainan, Taiwan, 2017
  • NIH Merit Award, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 2007
  • Margaret Merrell Award, Department of Biostatistics, Johns Hopkins University, Baltimore, MD, 2002

Selected Publications

  1. Huang Y, Kim HJ, Huang CY, Kim MO Bayesian random-effects meta-analysis integrating individual participant data and aggregate data  View on PubMed
  2. Sun Y, Chiou SY, Huang CY. Global and episode-specific prediction of recurrent events using longitudinal health informatics data. Journal of the American Statistical Association. 2025.  View on PubMed
  3. Qin J, Liu Y, Li M, Huang CY. Distribution-free prediction intervals under covariate shift, with an application to causal inference. Journal of the American Statistical Association. 2025.  View on PubMed
  4. Gutierrez SA, Raghu V, Oliveira SB, Nguyen V, Shui AM, Sudan DL, Cole C, Huang CY, Rhee S, Lai JC, Wadhwani SI Central line-associated bloodstream infection rates in pediatric short bowel syndrome in the United States: A retrospective cohort study from 2016 to 2023.  View on PubMed
  5. Ge J, Lee A, Gologorskaya O, Far AT, Bastani A, Huang CY, Pletcher MJ, Lai JC Characterizing practice variations in the care of hospitalized patients with cirrhosis across the University of California Health.  View on PubMed
  6. Hennessy MA, Cimino-Mathews A, Carter JM, Kachergus JM, Ma Y, Leal JP, Solnes LB, Denbow R, Abramson VG, Carey LA, Rimawi M, Specht J, Storniolo AM, Valero V, Vaklavas C, Winer EP, Krop IE, Wolff AC, Wahl RL, Perez EA, Huang CY, Stearns V, Thompson EA, Connolly RM. Multiplex Spatial Proteomic Analysis of HER2-Positive Breast Tumors Reveals Unique Molecular and Immunologic Features Associated With Treatment Response. JCO Precis Oncol. 2025 Apr; 9:e2400546.  View on PubMed
  7. Tan CR, Asoori S, Huang CY, Brunaldi L, Popat R, Kastritis E, Martinez-Lopez J, Bansal R, Silva Corraes AM, Chhabra S, Parrondo R, Ailawadhi S, Fotiou D, Dimopoulos MA, Yong K, Mactier C, Lau C, Corona M, Marin AJS, Mian H, Durie BG, Usmani SZ, Martin TG, Lin Y. Real-world evaluation of teclistamab for the treatment of relapsed/refractory multiple myeloma (RRMM): an International Myeloma Working Group Study. Blood Cancer J. 2025 Apr 03; 15(1):53.  View on PubMed
  8. Sheng Y, Qin J, Huang CY. Sequential data integration under dataset shift. Technometrics. 2024; 66(4):662–670.  View on PubMed
  9. Lai M, Fenton C, Rubin J, Huang CY, Pletcher M, Lai JC, Cullaro G, Ge J Clinical Sentiment Analysis by Large Language Models Enhances the Prediction of Hepatorenal Syndrome in Decompensated Cirrhosis.  View on PubMed
  10. Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Kapse B, Greenland JR, Singer JP Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.  View on PubMed
  11. Far AT, Bastani A, Lee A, Gologorskaya O, Huang CY, Pletcher MJ, Lai JC, Ge J. Evaluating the positive predictive value of code-based identification of cirrhosis and its complications utilizing GPT-4. Hepatology. 2024 Oct 08.  View on PubMed
  12. Seijo L, Gao Y, Betancourt L, Venado A, Hays SR, Kukreja J, Calabrese DR, Greenland JR, Singer JP. Improvements in Patient-Reported Functioning after Lung Transplant is Associated with Improved Quality of Life and Survival. medRxiv. 2024 Aug 06.  View on PubMed
  13. Szabo Yamashita T, Williams-Perez SM, Ehsan S, Mulder M, Kronenfeld D, Huang CY, Zhao H, Merriman K, Peterson SK, Hu MI, Zafereo M, Sosa JA, Grubbs EG. The Multi-Institutional Medullary Thyroid Cancer Collaborative Registry: Can a Rare Tumor Registry Accurately Represent the Real-World Patient Population? Thyroid. 2024 Sep; 34(9):1117-1125.  View on PubMed
  14. Wang M, Chiou SH, Ganger D, Ruck J, Huang CY, Kappus MR, King EA, Ladner DP, Rahimi RS, Duarte-Rojo A, Volk ML, Tevar AD, Verna EC, Lai JC. Liver transplantation provides survival benefit at all levels of frailty: From the Multicenter Functional Assessment in Liver Transplantation Study. Hepatology. 2025 Apr 01; 81(4):1269-1275.  View on PubMed
  15. Wang M, Shui AM, Huang CY, Kappus MR, Rahimi R, Verna EC, Ruck J, King EA, Ladner DP, Tevar AD, Volk ML, Duarte-Rojo A, Ganger D, Lai JC. The Liver Frailty Index enhances mortality risk prediction above and beyond MELD 3.0 alone. Liver Transpl. 2024 Dec 01; 30(12):1326-1329.  View on PubMed
  16. Sheng Y, Sun Y, McCulloch CE, Huang CY. Scalable estimation for high velocity survival data able to accommodate adding covariates. Statistica Sinica. 2024; 3(34):1483-1503.  View on PubMed
  17. Wang M, Shui AM, Ruck J, Huang CY, Verna EC, King EA, Ladner DP, Ganger D, Kappus M, Rahimi R, Tevar AD, Duarte-Rojo A, Lai JC. Clinically relevant cut-points for changes in the Liver Frailty Index are associated with waitlist mortality in patients with cirrhosis. Liver Transpl. 2024 Oct 01; 30(10):991-1001.  View on PubMed
  18. Rubin JB, Loeb R, Fenton C, Huang CY, Keyhani S, Seal KH, Lai JC. The burden of significant pain in the cirrhosis population: Risk factors, analgesic use, and impact on health care utilization and clinical outcomes. Hepatol Commun. 2024 06 01; 8(6).  View on PubMed
  19. Reyes KR, Liu YC, Huang CY, Banerjee R, Martin T, Wong SW, Wolf JL, Arora S, Shah N, Chari A, Chung A. Salvage therapies including retreatment with BCMA-directed approaches after BCMA CAR-T relapses for multiple myeloma. Blood Adv. 2024 05 14; 8(9):2207-2216.  View on PubMed
  20. Huang MY, Qin J, Huang CY. Efficient data integration under prior probability shift. Biometrics. 2024 Mar 27; 80(2).  View on PubMed

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