Research Summary

Dr. Chiung-Yu Huang is a Professor of Biostatistics at the Department of Epidemiology and Biostatistics at the University of California, San Francisco (UCSF) and serves as an Adjunct Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center. Dr. Huang is a Fellow of the American Statistical Association (ASA) and is well known for her contributions to methodology research, particularly in the areas of survival analysis, competing risks analysis, recurrent event analysis, outcome-dependent sampling, and the design and evaluation of vaccine efficacy trials.

Dr. Huang's recent work has focused on developing innovative statistical methodologies to improve analysis efficiency in small-scale studies by integrating external large databases, modeling and predicting the risk of recurrent events to identify high-risk individuals, and incorporating information on infecting pathogens in the analysis of vaccine trials with active or passive surveillance. Additionally, she has developed efficient statistical methods for analyzing survival data collected in prevalent cohort studies, benefit-risk assessment tools for evaluating treatment risks and benefits in patients with end-stage disease, and statistical methods that can account for informative clinic visits in the analysis of electronic health records.

In addition to her methodological research, Dr. Huang has extensive experience in collaborative research across a wide range of fields, including influenza, malaria, transplant, and cancer studies. During her tenure as a Mathematical Statistician at the National Institute of Allergy and Infectious Diseases (NIAID), she collaborated with both extramural and intramural scientists on the design, conduct, monitoring, analysis, and presentation of preclinical and clinical studies. She also served as a statistician to the NIAID Influenza Research Collaboration (NIRC) and the Mexican Emerging Infectious Disease Clinical Research Network (La Red), and received numerous awards for her collaborative research, including the prestigious NIAID Merit Award.

Since joining UCSF in 2017, Dr. Huang has served as the lead statistician for the Hematopoietic Malignancies Program at UCSF Helen Diller Family Comprehensive Cancer Center and the University of California Hematologic Malignancies Consortium (UCHMC). She also established and served as the core director of the UCSF Department of Surgery Biostatistics Research Core (2019-2024), which provides statistical support to surgery investigators in designing and conducting rigorous, high-quality research.

Research Funding

  • September 1, 2024 - August 31, 2029 - Improving causal inference in Alzheimer's Disease prevention research on modifiable risk factors: the Triangulation of Innovative Methods to End AD (TIME-AD) project , Co-leader of Analytics Core . Sponsor: NIH/NIA, Sponsor Award ID: P01AG082653
  • September 1, 2023 - May 31, 2028 - Cancer Center Support Grant – Biostatistics & Population Research Shared Resource , Co-Investigator . Sponsor: NIH/NCI, Sponsor Award ID: P30CA082103
  • August 1, 2022 - July 31, 2027 - The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation , Co-Investigator . Sponsor: NIH/NHLBI, Sponsor Award ID: U01HL163242
  • September 1, 2022 - August 31, 2025 - CF Statistical Expertise and Network (CF StatNet) Award , Statistician . Sponsor: Cystic Fibrosis Foundation, Sponsor Award ID: CFStatNet 003789Y7122
  • November 1, 2021 - January 31, 2025 - Mixed Data Meta-analysis: Integration of Individual Participant and Aggregate Data , Co-Investigator . Sponsor: PCORI, Sponsor Award ID: ME-2020C3-21269
  • June 15, 2018 - May 31, 2023 - Predicting post-transplant mortality and global functional health based on pre-transplant functional status in liver transplantation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AG059183
  • June 1, 2018 - May 31, 2023 - UCSF Liver Core Center, Biostatistics Core , Statistician . Sponsor: NIH/NIDDK, Sponsor Award ID: P30DK026743
  • August 5, 1999 - May 31, 2023 - Cancer Center Support Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30CA082103
  • September 1, 2021 - January 31, 2023 - Allergy, Immunology and Transplantation Research (UCSF Coordinating Center) , Statistician . Sponsor: NIH/NIAID, Sponsor Award ID: 3UM1AI109565-08S3
  • September 1, 2019 - July 31, 2022 - A novel natural history study of medullary thyroid carcinoma , Statistician . Sponsor: University of Texas M.D. Anderson Cancer Center, Sponsor Award ID: R01FD006650
  • July 1, 2015 - June 30, 2021 - Statistical Methods for Survival and Recurrent Event Data in Clinical Research , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA193888
  • July 1, 2015 - June 30, 2020 - Reprogramming the pancreatic tumor microenvironment with immunotherapy , Statistician/Principal Investigator (Subaward) . Sponsor: NIH/NCI, Sponsor Award ID: R01CA197296
  • September 1, 2017 - December 31, 2018 - Comparing Patient Centered Outcomes in the Management of Pain between Emergency Departments and Dedicated Acute Care Facilities for Adults with Sickle Cell disease , Statistician/Principal Investigator (Subaward) . Sponsor: PCORI, Sponsor Award ID: HIS-1403-11888

Education

National Tsing-Hua University, Hsinchu, Taiwan, B.S., 07/1994, Mathematics
National Tsing-Hua University, Hsinchu, Taiwan, M.S., 07/1996, Mathematics
Johns Hopkins University, Baltimore, Maryland, Ph.D., 05/2002, Biostatistics

Honors & Awards

  • Y.S. Chow Distinguished Lecture Award, Chinese Institute of Probability and Statistics, 2022
  • Elected Fellow, American Statistical Association, 2018
  • Distinguished Alumni Award, National Tainan Girls' Senior High School, Tainan, Taiwan, 2017
  • NIH Merit Award, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 2007
  • Margaret Merrell Award, Department of Biostatistics, Johns Hopkins University, Baltimore, MD, 2002

Selected Publications

  1. Qin J, Liu Y, Li M, Huang CY. Distribution-free prediction intervals under covariate shift, with an application to causal inference. Journal of the American Statistical Association. 2024.  View on PubMed
  2. Sheng Y, Qin J, Huang CY. Sequential data integration under dataset shift. Technometrics. 2024.  View on PubMed
  3. Far A, Bastani A, Lee A, Gologorskaya O, Huang CY, Pletcher MJ, Lai JC, Ge J. Evaluating the positive predictive value of code-based identification of cirrhosis and its complications utilizing GPT-4. Hepatology. 2024.  View on PubMed
  4. Szabo Yamashita T, Williams-Perez SM, Ehsan S, Mulder M, Kronenfeld D, Huang CY, Zhao H, Merriman K, Peterson SK, Hu MI, Zafereo M, Sosa JA, Grubbs EG. The Multi-Institutional Medullary Thyroid Cancer Collaborative Registry: Can a Rare Tumor Registry Accurately Represent the Real-World Patient Population? Thyroid. 2024 Sep; 34(9):1117-1125.  View on PubMed
  5. Wang M, Chiou SH, Ganger D, Ruck J, Huang CY, Kappus MR, King EA, Ladner DP, Rahimi RS, Duarte-Rojo A, Volk ML, Tevar AD, Verna EC, Lai JC. Liver transplantation provides survival benefit at all levels of frailty: From the Multicenter Functional Assessment in Liver Transplantation Study. Hepatology. 2024 Jul 24.  View on PubMed
  6. Wang M, Shui AM, Huang CY, Kappus MR, Rahimi R, Verna EC, Ruck J, King EA, Ladner DP, Tevar AD, Volk ML, Duarte-Rojo A, Ganger D, Lai JC. The liver frailty index enhances mortality risk prediction above and beyond MELD 3.0 alone. Liver Transpl. 2024 Jul 24.  View on PubMed
  7. Sheng Y, Sun Y, McCulloch CE, Huang CY. Scalable estimation for high velocity survival data able to accommodate adding covariates. Statistica Sinica. 2024; 3(34):1483-1503.  View on PubMed
  8. Wang M, Shui AM, Ruck J, Huang CY, Verna EC, King EA, Ladner DP, Ganger D, Kappus M, Rahimi R, Tevar AD, Duarte-Rojo A, Lai JC. Clinically relevant cut-points for changes in the Liver Frailty Index are associated with waitlist mortality in patients with cirrhosis. Liver Transpl. 2024 Oct 01; 30(10):991-1001.  View on PubMed
  9. Rubin JB, Loeb R, Fenton C, Huang CY, Keyhani S, Seal KH, Lai JC. The burden of significant pain in the cirrhosis population: Risk factors, analgesic use, and impact on health care utilization and clinical outcomes. Hepatol Commun. 2024 06 01; 8(6).  View on PubMed
  10. Reyes KR, Liu YC, Huang CY, Banerjee R, Martin T, Wong SW, Wolf JL, Arora S, Shah N, Chari A, Chung A. Salvage therapies including retreatment with BCMA-directed approaches after BCMA CAR-T relapses for multiple myeloma. Blood Adv. 2024 05 14; 8(9):2207-2216.  View on PubMed
  11. Huang MY, Qin J, Huang CY. Efficient data integration under prior probability shift. Biometrics. 2024 Mar 27; 80(2).  View on PubMed
  12. Calthorpe L, Chiou SH, Rubin J, Huang CY, Feng S, Lai J. A modified Hospital Frailty Risk Score for patients with cirrhosis undergoing abdominal operations. Hepatology. 2024 09 01; 80(3):595-604.  View on PubMed
  13. Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Kapse B, Greenland JR, Singer JP. Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction. medRxiv. 2024 Jan 23.  View on PubMed
  14. Vaziri S, McGarry ME, Huang CY, Cuneo AA, Willen SM, Iwanaga K, Neemuchwala F, Gibb ER, Chan M, Ly NP. Time to be blunt: Substance use in cystic fibrosis. Pediatr Pulmonol. 2024 Apr; 59(4):1015-1027.  View on PubMed
  15. Choi HH, Kim S, Shum DJ, Huang CY, Shui A, Fox RK, Khalili M. Assessing Adherence to US LI-RADS Follow-up Recommendations in Vulnerable Patients Undergoing Hepatocellular Carcinoma Surveillance. Radiol Imaging Cancer. 2024 01; 6(1):e230118.  View on PubMed
  16. Wang M, Shui AM, Ruck J, King E, Rahimi R, Kappus M, Volk ML, Ganger DR, Ladner DP, Duarte-Rojo A, Huang CY, Verna EC, Lai JC. The liver frailty index is a predictor of healthcare utilization after liver transplantation in older adults. Clin Transplant. 2024 01; 38(1):e15219.  View on PubMed
  17. Gutierrez SA, Pathak S, Raghu V, Shui A, Huang CY, Rhee S, McKenzie-Sampson S, Lai JC, Wadhwani SI. Neighborhood Income Is Associated with Health Care Use in Pediatric Short Bowel Syndrome. J Pediatr. 2024 Feb; 265:113819.  View on PubMed
  18. Patel S, Kim RG, Shui AM, Magee C, Lu M, Chen J, Tana M, Huang CY, Khalili M. Fatty Liver Education Promotes Physical Activity in Vulnerable Groups, Including Those With Unhealthy Alcohol Use. Gastro Hep Adv. 2024; 3(1):84-94.  View on PubMed
  19. Huang Y, Huang CY, Kim MO. Simultaneous selection and incorporation of consistent external aggregate information. Stat Med. 2023 12 30; 42(30):5630-5645.  View on PubMed
  20. Shifman HP, Huang CY, Beck AF, Bucuvalas J, Perito ER, Hsu EK, Ebel NH, Lai JC, Wadhwani SI. Association of state Medicaid expansion policies with pediatric liver transplant outcomes. Am J Transplant. 2024 Feb; 24(2):239-249.  View on PubMed

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