Research Summary

Dr. Chiung-Yu Huang is Professor of Biostatistics at the Department of Epidemiology and Biostatistics and an elected Fellow of the American Statistical Association (ASA). She is a Member of the UCSF Helen Diller Family Comprehensive Cancer Center and an Adjunct Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center. She is recognized for her novel methodology research in survival analysis, competing risks analysis, recurrent event analysis, outcome-dependent sampling, and design and evaluation of vaccine efficacy trials. Dr. Huang’s recent methodology contributions include (1) methods for combining information from external large databases, such as disease registries, to improve efficiency in the analysis of relatively small-scale studies that collect more detailed patient-level information. The importance of such methods has been recognized as we have now entered the big data era; (2) methods to better model, estimate, and predict the risk of recurrent events to identify individuals who are at a high risk of experiencing recurrent events, allowing one to target these individuals for more intensive monitoring and treatment; (3) statistical methods for analyzing vaccine trials with active or passive surveillance by incorporating information about infecting pathogens collected at the time of infection; (4) efficient statistical methods for survival data collected in prevalent cohort studies. (5) benefit-risk assessment tools for evaluating treatment risks and benefit in cancer patients with end-stage disease; (6) statistical methods that can properly account for informative clinic visits in the analysis of electronic health records.

In addition to statistical method research, Dr. Huang has a rich experience in collaborative research across a wide range of areas, including influenza, malaria, transplant, and cancer studies. During her service as a Mathematical Statistician at NIAID, NIH (2004-2013), she worked closely with both extramural and intramural NIH scientists on the design, conduct, monitoring, analysis, and presentation of preclinical and clinical studies. She served as a statistician to the NIAID Influenza Research Collaboration (NIRC) and the Mexican Emerging Infectious Disease Clinical Research Network (La Red), and was a statistical reviewer to the Infectious Disease Clinical Research Program (IDCRP) and several intramural laboratories within NIAID. She has received numerous awards for her collaborative research, including the prestigious NIAID Merit Award. Prior to joining UCSF, she was an Associate Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center (2013-2017), where she served as the lead statistician to the Breast and Ovarian Cancer Program. She also worked closely with the Transplant and Oncology Infectious Diseases Programs in modeling and characterizing morbidities attributable to infections occurring after solid organ transplants (SOT) and hematopoietic stem cell transplants (HSCT). Since joining UCSF in 2017, she has been serving as the lead statistician to the Hematopoietic Malignancies Program at UCSF Helen Diller Family Comprehensive Cancer Center and is the primary statistician to the University of California Hematologic Malignancies Consortium (UCHMC).

Research Funding

  • November 1, 2021 - January 31, 2025 - Mixed Data Meta-analysis: Integration of Individual Participant and Aggregate Data , Co-Investigator . Sponsor: PCORI, Sponsor Award ID: ME-2020C3-21269
  • June 1, 2018 - May 31, 2023 - UCSF Liver Core Center, Biostatistics Core , Statistician . Sponsor: NIH/NIDDK, Sponsor Award ID: P30DK026743
  • September 1, 2019 - July 31, 2022 - A novel natural history study of medullary thyroid carcinoma , Statistician . Sponsor: University of Texas M.D. Anderson Cancer Center, Sponsor Award ID: R01FD006650
  • September 1, 2021 - January 31, 2022 - Allergy, Immunology and Transplantation Research (UCSF Coordinating Center) , Statistician . Sponsor: NIH/NIAID, Sponsor Award ID: 3UM1AI109565-08S3

Education

National Tsing-Hua University, Hsinchu, Taiwan, B.S., 07/1994, Mathematics
National Tsing-Hua University, Hsinchu, Taiwan, M.S., 07/1996, Mathematics
Johns Hopkins University, Baltimore, Maryland, Ph.D., 05/2002, Biostatistics

Honors & Awards

  • 1991
    Invited Contestant, Asian Pacific Mathematics Olympiad (APMO)
  • 1991
    College admission for gifted students under Taiwan’s Special Education Act
  • 1991-1995
    Four-Year College Scholarship for Gifted Students in Mathematics and Sciences, Taiwanese Ministry of Education
  • 1992, 1993, 1994
    President’s Academic Awards (3 times), National Tsing-Hua University
  • 1994
    Graduated first in class from the Department of Mathematics, National Tsing-Hua University, Taiwan (completed a bachelor's degree in three years and admitted into graduate school without entrance exam)
  • 1997-2002
    Five-year departmental scholarship, Department of Biostatistics, Johns Hopkins University
  • 2002
    Margaret Merrell Award for Excellence in Research, Department of Biostatistics, Johns Hopkins University
  • 2004
    NIH Travel Award, ENAR Young Investigators Meeting
  • 2003-2005
    Grant-in-Aid of Research, Artistry, and Scholarship, University of Minnesota
  • 2005
    Performance Award for special achievement, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, NIH
  • 2005, 2006, 2007, 2008, 2010, 2011
    Special Act or Service Award, National Institute of Allergy and Infectious Diseases, NIH
  • 2007
    NIAID Merit Award, National Institute of Allergy and Infectious Diseases, NIH

Selected Publications

  1. Chang MR, Ke H, Coherd CD, Wang Y, Mashima K, Kastrunes GM, Huang CY, Marasco WA. Analysis of a SARS-CoV-2 convalescent cohort identified a common strategy for escape of vaccine-induced anti-RBD antibodies by Beta and Omicron variants. EBioMedicine. 2022 May 06; 80:104025.  View on PubMed
  2. Ha NB, Montano-Loza AJ, Carey EJ, Lin S, Shui AM, Huang CY, Dunn MA, Lai JC. Sarcopenic visceral obesity is associated with increased post-liver transplant mortality in acutely ill patients with cirrhosis. Am J Transplant. 2022 Apr 29.  View on PubMed
  3. Kambhampati S, Sheng Y, Huang CY, Bylsma S, Lo M, Kennedy V, Natsuhara K, Martin T, Wolf J, Shah N, Wong SW. Infectious complications in patients with relapsed refractory multiple myeloma after BCMA CAR T-cell therapy. Blood Adv. 2022 Apr 12; 6(7):2045-2054.  View on PubMed
  4. Castro-Pearson S, Sur A, Lee CH, Huang CY, Luo X. BivRec: an R package for the nonparametric and semiparametric analysis of bivariate alternating recurrent events. BMC Med Res Methodol. 2022 04 03; 22(1):92.  View on PubMed
  5. Shifman HP, Rasnick E, Huang CY, Beck AF, Bucuvalas J, Lai JC, Wadhwani SI. Association of Primary Care Shortage Areas with Adverse Outcomes after Pediatric Liver Transplant. J Pediatr. 2022 Mar 15.  View on PubMed
  6. Kelly YM, Zarinsefat A, Tavakol M, Shui AM, Huang CY, Roberts JP. Consent to organ offers from public health service "Increased Risk" donors decreases time to transplant and waitlist mortality. BMC Med Ethics. 2022 03 05; 23(1):20.  View on PubMed
  7. Banerjee R, Huang CY, Dunn L, Knoche J, Ryan C, Brassil K, Jackson L, Patel D, Lo M, Arora S, Wong SW, Wolf J, Martin Iii T, Dhruva A, Shah N. Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study. JMIR Form Res. 2022 Mar 04; 6(3):e33701.  View on PubMed
  8. Huang LW, Sheng Y, Andreadis C, Logan AC, Mannis GN, Smith CC, Gaensler KML, Martin TG, Damon LE, Huang CY, Olin RL. Patterns and Predictors of Functional Decline after Allogeneic Hematopoietic Cell Transplantation in Older Adults. Transplant Cell Ther. 2022 Mar 03.  View on PubMed
  9. Sun Y, Chiou SH, Marr KA, Huang CY. Statistical inference on shape- and size-indexes for counting processes. Biometrika. 2022; 109:195–208.  View on PubMed
  10. Chirikova E, McConnell RJ, O'Kane P, Yauseyenka V, Little MP, Minenko V, Drozdovitch V, Veyalkin I, Hatch M, Chan JM, Huang CY, Mabuchi K, Cahoon EK, Rozhko A, Zablotska LB. Association between exposure to radioactive iodine after the Chernobyl accident and thyroid volume in Belarus 10-15 years later. Environ Health. 2022 01 07; 21(1):5.  View on PubMed
  11. Sait AS, Chiang TP, Marr KA, Massie AB, Cochran W, Shah P, Brennan DC, Thomas AG, Mehta Steinke S, Permpalung N, Shoham S, Merlo C, Jain T, Boyarsky B, Charnaya O, Gurakar A, Sharma K, Durand CM, Werbel WA, Huang CY, Ostrander D, Desai N, Kim MY, Alasfar S, Bloch EM, Tobian AAR, Garonzik-Wang J, Segev DL, Avery RK. Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics. Transplant Direct. 2022 Jan; 8(1):e1268.  View on PubMed
  12. Kennedy VE, Wong C, Huang CY, Kambhampati S, Wolf J, Martin TG, Shah N, Wong SW. Macrophage activation syndrome-like (MAS-L) manifestations following BCMA-directed CAR T cells in multiple myeloma. Blood Adv. 2021 12 14; 5(23):5344-5348.  View on PubMed
  13. Bernards S, Hirose R, Yao FY, Jin C, Dodge JL, Huang CY, Mehta N. The Impact of Median Model for End-Stage Liver Disease at Transplant Minus 3 National Policy on Waitlist Outcomes in Patients With and Without Hepatocellular Carcinoma. Liver Transpl. 2022 03; 28(3):376-385.  View on PubMed
  14. Wong SW, Shah N, Ledergor G, Martin T, Wolf J, Shui AM, Huang CY, Martinez-Lopez J. Early Dynamics and Depth of Response in Multiple Myeloma Patients Treated With BCMA CAR-T Cells. Front Oncol. 2021; 11:783703.  View on PubMed
  15. Lai JC, Shui AM, Duarte-Rojo A, Ganger DR, Rahimi RS, Huang CY, Yao F, Kappus M, Boyarsky B, McAdams-Demarco M, Volk ML, Dunn MA, Ladner DP, Segev DL, Verna EC, Feng S, from the Multi-Center Functional Assessment in Liver Transplantation (FrAILT) Study. Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study. Hepatology. 2021 Dec 04.  View on PubMed
  16. Yap A, Shui A, Gosnell J, Huang CY, Sosa JA, Roman S. Accuracy of the lymph node yield in surgery for papillary thyroid cancer in children. World Journal of Surgery. 2021; 45(10):3092-3098.  View on PubMed
  17. Tam AH, Jung Y, Young R, Huang CY, Wolf J, Shah N, Wong SW, Martin TG, Lo M. Evaluation of subcutaneous daratumumab injections in the ambulatory care setting. J Oncol Pharm Pract. 2021 Oct 14; 10781552211046911.  View on PubMed
  18. Kelly JD, Badio M, Drew C, Wilson B, Cooper JB, Glayweon M, Johnson K, Moses JS, Gayedu-Dennis D, Torres JM, Oldenburg CE, Davidson MC, Huang CY, Steward WT, Sneller MC, Rutherford GW, Reilly C, Fallah MP, Weiser SD. Triangulating Evidence to Infer Pathways that Influence Ebola Virus Disease-Related Stigma and Clinical Findings among Survivors: An Observational Cohort Study. Am J Trop Med Hyg. 2021 09 27; 105(6):1563-1568.  View on PubMed
  19. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Ann Am Thorac Soc. 2021 09; 18(9):1464-1474.  View on PubMed
  20. Moksud N, Loo LWM, Yang J, Huang CY, Haiman CA, Le Marchand L, Wilkens LR, Cheng I. Cholesterol lowering drug use and breast cancer survival: the Multiethnic Cohort Study. Breast Cancer Res Treat. 2021 Nov; 190(1):165-173.  View on PubMed

Go to UCSF Profiles, powered by CTSI