Research Summary

Dr. Chiung-Yu Huang is Professor of Biostatistics at the Department of Epidemiology and Biostatistics and an elected Fellow of the American Statistical Association (ASA). She is a Member of the UCSF Helen Diller Family Comprehensive Cancer Center and an Adjunct Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center. She is recognized for her novel methodology research in survival analysis, competing risks analysis, recurrent event analysis, outcome-dependent sampling, and design and evaluation of vaccine efficacy trials. Dr. Huang’s recent methodology contributions include (1) methods for combining information from external large databases, such as disease registries, to improve efficiency in the analysis of relatively small-scale studies that collect more detailed patient-level information. The importance of such methods has been recognized as we have now entered the big data era; (2) methods to better model, estimate, and predict the risk of recurrent events to identify individuals who are at a high risk of experiencing recurrent events, allowing one to target these individuals for more intensive monitoring and treatment; (3) statistical methods for analyzing vaccine trials with active or passive surveillance by incorporating information about infecting pathogens collected at the time of infection; (4) efficient statistical methods for survival data collected in prevalent cohort studies. (5) benefit-risk assessment tools for evaluating treatment risks and benefit in cancer patients with end-stage disease; (6) statistical methods that can properly account for informative clinic visits in the analysis of electronic health records.

In addition to statistical method research, Dr. Huang has a rich experience in collaborative research across a wide range of areas, including influenza, malaria, transplant, and cancer studies. During her service as a Mathematical Statistician at NIAID, NIH (2004-2013), she worked closely with both extramural and intramural NIH scientists on the design, conduct, monitoring, analysis, and presentation of preclinical and clinical studies. She served as a statistician to the NIAID Influenza Research Collaboration (NIRC) and the Mexican Emerging Infectious Disease Clinical Research Network (La Red), and was a statistical reviewer to the Infectious Disease Clinical Research Program (IDCRP) and several intramural laboratories within NIAID. She has received numerous awards for her collaborative research, including the prestigious NIAID Merit Award. Prior to joining UCSF, she was an Associate Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center (2013-2017), where she served as the lead statistician to the Breast and Ovarian Cancer Program. She also worked closely with the Transplant and Oncology Infectious Diseases Programs in modeling and characterizing morbidities attributable to infections occurring after solid organ transplants (SOT) and hematopoietic stem cell transplants (HSCT). Since joining UCSF in 2017, she has been serving as the lead statistician to the Hematopoietic Malignancies Program at UCSF Helen Diller Family Comprehensive Cancer Center and is the primary statistician to the University of California Hematologic Malignancies Consortium (UCHMC).

Research Funding

  • August 1, 2022 - July 31, 2027 - The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation , Co-Investigator . Sponsor: NIH/NHLBI, Sponsor Award ID: U01HL163242
  • September 1, 2022 - August 31, 2025 - CF Statistical Expertise and Network (CF StatNet) Award , Statistician . Sponsor: Cystic Fibrosis Foundation, Sponsor Award ID: CFStatNet 003789Y7122
  • November 1, 2021 - January 31, 2025 - Mixed Data Meta-analysis: Integration of Individual Participant and Aggregate Data , Co-Investigator . Sponsor: PCORI, Sponsor Award ID: ME-2020C3-21269
  • June 15, 2018 - May 31, 2023 - Predicting post-transplant mortality and global functional health based on pre-transplant functional status in liver transplantation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AG059183

Education

National Tsing-Hua University, Hsinchu, Taiwan, B.S., 07/1994, Mathematics
National Tsing-Hua University, Hsinchu, Taiwan, M.S., 07/1996, Mathematics
Johns Hopkins University, Baltimore, Maryland, Ph.D., 05/2002, Biostatistics

Honors & Awards

  • 1991
    Invited Contestant, Asian Pacific Mathematics Olympiad (APMO)
  • 1991
    College admission for gifted students under Taiwan’s Special Education Act
  • 1991-1995
    Four-Year College Scholarship for Gifted Students in Mathematics and Sciences, Taiwanese Ministry of Education
  • 1992, 1993, 1994
    President’s Academic Awards (3 times), National Tsing-Hua University
  • 1994
    Graduated first in class from the Department of Mathematics, National Tsing-Hua University, Taiwan (completed a bachelor's degree in three years and admitted into graduate school without entrance exam)
  • 1997-2002
    Five-year departmental scholarship, Department of Biostatistics, Johns Hopkins University
  • 2002
    Margaret Merrell Award for Excellence in Research, Department of Biostatistics, Johns Hopkins University
  • 2004
    NIH Travel Award, ENAR Young Investigators Meeting
  • 2003-2005
    Grant-in-Aid of Research, Artistry, and Scholarship, University of Minnesota
  • 2005
    Performance Award for special achievement, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, NIH
  • 2005, 2006, 2007, 2008, 2010, 2011
    Special Act or Service Award, National Institute of Allergy and Infectious Diseases, NIH
  • 2007
    NIAID Merit Award, National Institute of Allergy and Infectious Diseases, NIH

Selected Publications

  1. Lai JC, Shui AM, Duarte-Rojo A, Rahimi RS, Ganger DR, Verna EC, Volk ML, Kappus M, Ladner DP, Boyarsky B, Segev DL, Gao Y, Huang CY, Singer JP. Association of Frailty With Health-Related Quality of Life in Liver Transplant Recipients. JAMA Surg. 2022 Dec 14.  View on PubMed
  2. Sheng Y, Sun Y, McCulloch CE, Huang CY. Scalable estimation for high velocity survival data able to accommodate adding covariates. Statistica Sinica. 2022.  View on PubMed
  3. Cheng YW, McLean R, Sewell JL, Huang CY, Khalili M. Inflammatory bowel disease type influences development of elevated liver enzymes. JGH Open. 2022 Dec; 6(12):846-853.  View on PubMed
  4. Huang MY, Huang CY. Improved semiparametric estimation of the proportional rate model with recurrent event data. Biometrics. 2022 Oct 31.  View on PubMed
  5. Cheng YJ, Liu YC, Tsai CY, Huang CY. Semiparametric estimation of the transformation model by leveraging external aggregate data in the presence of population heterogeneity. Biometrics. 2022 Oct 31.  View on PubMed
  6. Greenberg AL, Karimzada MM, Brian R, Yap A, Luu HY, Ahmed S, Huang CY, Waits SA, Hirose R, Alseidi A, Rapp JH, O'Sullivan PS, Chern H, Syed SM. Assessment of Surgeon Performance of Advanced Open Surgical Skills Using a Microskills-Based Novel Curriculum. JAMA Netw Open. 2022 09 01; 5(9):e2229787.  View on PubMed
  7. Chung A, Banbury B, Vignali M, Huang CY, Asoori S, Johnson R, Kurtz T, Arora S, Wong SW, Shah N, Martin TG, Wolf JL. Antibody and T-cell responses by ultra-deep T-cell receptor immunosequencing after COVID-19 vaccination in patients with plasma cell dyscrasias. Br J Haematol. 2022 Nov; 199(4):520-528.  View on PubMed
  8. Conroy PC, Wilhelm A, Calthorpe L, Ullmann TM, Davis S, Huang CY, Shen WT, Gosnell J, Duh QY, Roman S, Sosa JA. Endocrine surgeons are performing more thyroid lobectomies for low-risk differentiated thyroid cancer since the 2015 ATA guidelines. Surgery. 2022 11; 172(5):1392-1400.  View on PubMed
  9. Raychaudhuri S, Charli-Joseph Y, Huang CY, Mintz MA, Pincus LB, Ai WZ. Association of a Dominant T-Cell Clone in Peripheral Blood With Time to Systemic Treatment in Patients With Stage IB Mycosis Fungoides. JAMA Dermatol. 2022 08 01; 158(8):954-956.  View on PubMed
  10. Sun Y, Chiou SY, Wu CO, McGarry M, Huang CY. Dynamic risk prediction triggered by intermediate events using survival tree ensembles. Annals of Applied Statistics. 2022.  View on PubMed
  11. Chiou SY, Xu G, Yan J, Huang CY. Regression modeling for recurrent events possibly with an informative terminal event using R package reReg. Journal of Statistical Software. 2022; 105(5):1-34.  View on PubMed
  12. Qin J, Sun Y, Yuan A, Huang CY. . Maximum likelihood estimation for shape-restricted single-index hazard models. Journal of Data Science. 2022.  View on PubMed
  13. Ha NB, Montano-Loza AJ, Carey EJ, Lin S, Shui AM, Huang CY, Dunn MA, Lai JC. Sarcopenic visceral obesity is associated with increased post-liver transplant mortality in acutely ill patients with cirrhosis. Am J Transplant. 2022 09; 22(9):2195-2202.  View on PubMed
  14. Chang MR, Ke H, Coherd CD, Wang Y, Mashima K, Kastrunes GM, Huang CY, Marasco WA. Analysis of a SARS-CoV-2 convalescent cohort identified a common strategy for escape of vaccine-induced anti-RBD antibodies by Beta and Omicron variants. EBioMedicine. 2022 Jun; 80:104025.  View on PubMed
  15. Kambhampati S, Sheng Y, Huang CY, Bylsma S, Lo M, Kennedy V, Natsuhara K, Martin T, Wolf J, Shah N, Wong SW. Infectious complications in patients with relapsed refractory multiple myeloma after BCMA CAR T-cell therapy. Blood Adv. 2022 04 12; 6(7):2045-2054.  View on PubMed
  16. Castro-Pearson S, Sur A, Lee CH, Huang CY, Luo X. BivRec: an R package for the nonparametric and semiparametric analysis of bivariate alternating recurrent events. BMC Med Res Methodol. 2022 04 03; 22(1):92.  View on PubMed
  17. Shifman HP, Rasnick E, Huang CY, Beck AF, Bucuvalas J, Lai JC, Wadhwani SI. Association of Primary Care Shortage Areas with Adverse Outcomes after Pediatric Liver Transplant. J Pediatr. 2022 07; 246:103-109.e2.  View on PubMed
  18. Kelly YM, Zarinsefat A, Tavakol M, Shui AM, Huang CY, Roberts JP. Consent to organ offers from public health service "Increased Risk" donors decreases time to transplant and waitlist mortality. BMC Med Ethics. 2022 03 05; 23(1):20.  View on PubMed
  19. Banerjee R, Huang CY, Dunn L, Knoche J, Ryan C, Brassil K, Jackson L, Patel D, Lo M, Arora S, Wong SW, Wolf J, Martin Iii T, Dhruva A, Shah N. Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study. JMIR Form Res. 2022 Mar 04; 6(3):e33701.  View on PubMed
  20. Kennedy VE, Huang CY, Kaplan LD, Andreadis C, Ai WZ, Olin RL. Geriatric assessment in adults age 50 years and older undergoing autologous hematopoietic cell transplantation for lymphoma. J Geriatr Oncol. 2022 06; 13(5):644-647.  View on PubMed

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