Research Funding

  • September 7, 2018 - August 31, 2023 - Redesigning a Neuron's Breath: A Modern Twist to Classical Oxygen Biology , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP5OD026398

Education

Harvard University, Cambridge, MA, 2012, Chemical and Physical Biology
Massachusetts Institute of Technology, Cambridge, MA, PhD, 2017, Computer Science, Systems Biology

Honors & Awards

  • 2017
    Harold Weintraub Graduate Student Award
  • 2016
    Philanthropic Educational Organization National Scholar Award
  • 2011
    Barry Goldwater Scholarship
  • 2009
    Glamour Magazine's Top 10 College Women
  • 2008
    Discover Magazine's Top Five Scientists Under 20
  • 2007-2008
    Siemens Math, Science & Technology Competition, National Winner
  • 2008
    L'Oreal Women in Science, Invited Panelist
  • 2008
    Intel Science Talent Search Finalist
  • 2007
    Intel Science and Engineering Fair, First Place Award
  • 2004
    36th Int'l Metallographic Contest – First Prize, George Kehl Award
  • 2003
    First Prize, Nat'l Educators Workshop, Undergrad Research Poster Contest

Selected Publications

  1. Blume SY, Garg A, Martí-Mateos Y, Midha AD, Chew BTL, Lin B, Yu C, Dick R, Lee PS, Situ E, Sarwaikar R, Green E, Ramanan V, Grotenbreg G, Hoek M, Sinz C, Jain IH. HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity. Cell. 2025 Feb 12.  View on PubMed
  2. Ostrowski MS, Yang MG, McNally CP, Abdulhay NJ, Wang S, Renduchintala K, Irkliyenko I, Biran A, Chew BTL, Midha AD, Wong EV, Sandoval J, Jain IH, Groth A, Nora EP, Goodarzi H, Ramani V. The single-molecule accessibility landscape of newly replicated mammalian chromatin. Cell. 2025 Jan 09; 188(1):237-252.e19.  View on PubMed
  3. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Sci Adv. 2023 Dec 08; 9(49):eadj4884.  View on PubMed
  4. Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Mol Cell. 2023 03 16; 83(6):942-960.e9.  View on PubMed
  5. Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH. Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism. Cell Metab. 2023 03 07; 35(3):504-516.e5.  View on PubMed
  6. Flanigan WR, Jain IH. The Goldilocks Oxygen Principle: not too little and not too much. Nat Cardiovasc Res. 2022 Dec; 1(12):1101-1103.  View on PubMed
  7. Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM. Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer. Cancer Discov. 2022 09 02; 12(9):2198-2219.  View on PubMed
  8. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 01 01; 371(6524):52-57.  View on PubMed
  9. Baik AH, Jain IH. Turning the Oxygen Dial: Balancing the Highs and Lows. Trends Cell Biol. 2020 07; 30(7):516-536.  View on PubMed
  10. Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK. Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism. Cell. 2020 04 30; 181(3):716-727.e11.  View on PubMed
  11. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 10 01; 30(4):824-832.e3.  View on PubMed
  12. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250.  View on PubMed
  13. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61.  View on PubMed
  14. Jain IH, Vijayan V, O'Shea EK. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13638-43.  View on PubMed
  15. Vijayan V, Jain IH, O'Shea EK. A high resolution map of a cyanobacterial transcriptome. Genome Biol. 2011; 12(5):R47.  View on PubMed
  16. Jain I, Iovine K. The making of a young scientist. Dev Dyn. 2008 Jun; 237(6):1535-6.  View on PubMed
  17. Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Dev Biol. 2008 May 15; 317(2):541-8.  View on PubMed
  18. Jain I, Stroka C, Yan J, Huang WM, Iovine MK. Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Dev Dyn. 2007 Sep; 236(9):2668-74.  View on PubMed

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