Research Funding

  • August 14, 2025 - July 31, 2030 - A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AT013724
  • September 1, 2025 - June 30, 2030 - Mechanisms of Oxygen Toxicity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL179702
  • August 1, 2025 - May 31, 2030 - Understanding and Treating NAXD Deficiency Using Vitamin B3-Based Approaches , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01NS142087
  • September 26, 2024 - August 31, 2025 - A Translatable Form of Hypoxia Therapy for Impaired Mitochondrial Proteostasis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56AG088161
  • September 7, 2018 - August 31, 2023 - Redesigning a Neuron's Breath: A Modern Twist to Classical Oxygen Biology , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP5OD026398

Education

Harvard University, Cambridge, MA, 2012, Chemical and Physical Biology
Massachusetts Institute of Technology, Cambridge, MA, PhD, 2017, Computer Science, Systems Biology

Honors & Awards

  • 2017
    Harold Weintraub Graduate Student Award
  • 2016
    Philanthropic Educational Organization National Scholar Award
  • 2011
    Barry Goldwater Scholarship
  • 2009
    Glamour Magazine's Top 10 College Women
  • 2008
    Discover Magazine's Top Five Scientists Under 20
  • 2007-2008
    Siemens Math, Science & Technology Competition, National Winner
  • 2008
    L'Oreal Women in Science, Invited Panelist
  • 2008
    Intel Science Talent Search Finalist
  • 2007
    Intel Science and Engineering Fair, First Place Award
  • 2004
    36th Int'l Metallographic Contest – First Prize, George Kehl Award
  • 2003
    First Prize, Nat'l Educators Workshop, Undergrad Research Poster Contest

Selected Publications

  1. Desousa BR, Abe Y, Kampmann M, Jain IH. The Disease Gene THAP12 is a Transcriptional Regulator of Mitochondrial ETC Complex I. bioRxiv. 2026 Jul 17. View on PubMed
  2. Garg A, Desousa BR, Roy R, Flis A, Blume SY, Abe Y, Melo AA, Cupo RR, Grigorean G, Southworth DR, Shorter J, Jain IH. Hypoxia rescues complex 1-associated disease caused by proteostatic defects. Nat Metab. 2026 Jul 08. View on PubMed
  3. Garg A, Blume SY, Huynh H, Barrios AM, Karabulut OO, Zhao Q, Midha AD, Turner AW, Resnick BV, Chen X, Agrawal A, Kim J, Chen L, Ran Q, Ryan AM, Larson RC, Negahban M, Nelson SCK, Yang AC, Traglia M, Thomas R, Sun R, Paredes M, Corces MR, Lin H, Jain IH. Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. Cell. 2026 Apr 30; 189(9):2648-2662.e19. View on PubMed
  4. Martí-Mateos Y, Safari Z, Bevers S, Midha AD, Flanigan WR, Joshi T, Huynh H, Desousa BR, Blume SY, Baik AH, Rogers S, Issaian AV, Doctor A, D'Alessandro A, Jain IH. Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude. Cell Metab. 2026 Mar 03; 38(3):529-545.e8. View on PubMed
  5. Midha AD, Chew BTL, Choi BMH, Suh JM, Carpenter C, Baik AH, Joshi TA, Blume SY, Haribowo AG, Ruivo P, Flanigan WR, Garg A, Zhang DD, Subramanyam V, Shuere R, Seo Y, VanBrocklin H, Goodarzi H, Jain IH. Systemic hypoxia suppresses solid tumor growth. bioRxiv. 2026 Feb 10. View on PubMed
  6. Flanigan WR, Midha AD, Blume SY, Marti-Mateos Y, Costa MW, Huang Y, Baik AH, Huynh H, Susarla G, Bennett NK, Nowak RA, Srivastava D, Nakamura K, Jain IH. Genome-wide CRISPRi screen identifies basigin loss as protective in cardiac hypoxia. bioRxiv. 2026 Jan 27. View on PubMed
  7. Upadhyay V, Ortega EF, Ramirez Hernandez LA, Alexander M, Kaur G, Trepka K, Rock RR, Shima RT, Cheshire WC, Alipanah-Lechner N, Calfee CS, Matthay MA, Lee JV, Goga A, Jain IH, Turnbaugh PJ. Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury. bioRxiv. 2025 Mar 25. View on PubMed
  8. Blume SY, Garg A, Martí-Mateos Y, Midha AD, Chew BTL, Lin B, Yu C, Dick R, Lee PS, Situ E, Sarwaikar R, Green E, Ramanan V, Grotenbreg G, Hoek M, Sinz C, Jain IH. HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity. Cell. 2025 Mar 20; 188(6):1580-1588.e11. View on PubMed
  9. Ostrowski MS, Yang MG, McNally CP, Abdulhay NJ, Wang S, Renduchintala K, Irkliyenko I, Biran A, Chew BTL, Midha AD, Wong EV, Sandoval J, Jain IH, Groth A, Nora EP, Goodarzi H, Ramani V. The single-molecule accessibility landscape of newly replicated mammalian chromatin. Cell. 2025 Jan 09; 188(1):237-252.e19. View on PubMed
  10. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Sci Adv. 2023 12 08; 9(49):eadj4884. View on PubMed
  11. Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Mol Cell. 2023 03 16; 83(6):942-960.e9. View on PubMed
  12. Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH. Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism. Cell Metab. 2023 03 07; 35(3):504-516.e5. View on PubMed
  13. Flanigan WR, Jain IH. The Goldilocks Oxygen Principle: not too little and not too much. Nat Cardiovasc Res. 2022 Dec; 1(12):1101-1103. View on PubMed
  14. Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM. Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer. Cancer Discov. 2022 09 02; 12(9):2198-2219. View on PubMed
  15. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 01 01; 371(6524):52-57. View on PubMed
  16. Baik AH, Jain IH. Turning the Oxygen Dial: Balancing the Highs and Lows. Trends Cell Biol. 2020 07; 30(7):516-536. View on PubMed
  17. Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK. Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism. Cell. 2020 04 30; 181(3):716-727.e11. View on PubMed
  18. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 10 01; 30(4):824-832.e3. View on PubMed
  19. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. View on PubMed
  20. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61. View on PubMed

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