Research SummaryMy research examines the socio-cultural and institutional dimensions of inequities in cancer care. As an anthropologist, I specialize in ethnographic approaches, but use a range of mixed qualitative and quantitative methods and community-based participatory research to investigate issues affecting vulnerable and medically underserved populations across the cancer continuum and in the context of the translation of new genomic technologies to clinical settings. My research program primarily focuses on 1) the translation of hereditary cancer services to underrepresented populations and under resourced settings and 2) the participation of vulnerable populations in cancer clinical research. In both these areas, I am particularly interested in identifying and addressing the challenges of effectively communicating with low-income, low-health literacy, and limited-English-proficient (LEP) populations in both clinical and community settings.
I am currently site PI/Co-Investigator on the CHARM (Cancer Health Assessments Reaching Many) study (MPI Goddard/Wilfond), one of the seven clinical project of the CSER consortium (funded by NHGRI, NCI and NIMHD). The Clinical Sequencing Evidence-Generating Research (CSER) consortium, now in its second funding cycle, is investigating the effectiveness of integrating genomic (exome or genome) sequencing into the clinical care of diverse and medically underserved individuals in a variety of healthcare settings and disease states. The goal of CHARM is to examine the utility of exome sequencing for cancer screening and how it affects care in diverse populations. My role includes leading the intervention development for a RCT comparing the ARIA genetic counseling model (Accessible, Relational, Inclusive, Actionable) and usual care genetic counseling for the return of exome sequence results with historically underserved patients. Also, for the CHARM study, I am leading the development and evaluation of an intervention to teach professional health care interpreters about exome sequencing, and to examine interpreters’ impact on the communication dynamic as well as LEP patient understanding and follow-up care.
I am also PI of the ELSI (ethical, legal social issues) study of the WISDOM trial, a pragmatic, preference sensitive RCT of risk-based breast cancer screening. This study is ethnographic and involves both empirical and normative bioethics methods to examine the ethical and social issues that arise in the context of precision population medicine (co-PI Barbara Koenig).
Most recently, I received funding with Dr. Kim Rhoads (MPI) for a study Mapping Mutographs and Epigenetic Changes in the Bayview Hunters Point Historical Cohort. This study combines CBPR, ethnographic and mapping methods to understand the relationship between a deeply toxic environment and the health of multigenerational African American families in the Bayview Hunters Point neighborhood.
- January 12, 2017 - December 31, 2021 - Precision Genomics in the WISDOM Pragmatic Clinical Trial: An Embedded ELSI Study of Risk-based Breast Cancer Screening, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA211999
- June 14, 2013 - May 31, 2021 - Exome sequencing in Diverse Populations in Colorado & Oregon, Co-Investigator. Sponsor: NIH, Sponsor Award ID: U01HG007292
- April 12, 2016 - March 31, 2021 - Comparison of 3 Modes of Genetic Counseling in High-Risk Public Hospital Patients, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA197784
- January 20, 2021 - January 20, 2021 - Engaging Underserved Women in Health Research, . Sponsor: California Breast Cancer Research Program, Sponsor Award ID: 20BB-2100
Wesleyan University, Middletown, Connecticut, B.A., 1988, Anthropology
University of California, Santa Cruz, M.A., 1993, Cultural Anthropology
University of California, Santa Cruz, Ph.D., 1999, Cultural Anthropology
Yale University, Center for International & Area Studies, Post-Doctoral Fellowship, 2001, Migration, Globalization, & Citizenship
Honors & Awards
Graduate Fellowship Honorable Mention, National Science Foundation
Wenner-Gren Foundation for Anthropological Research Dissertation Research Fellowship
Spencer Foundation Dissertation Writing Fellowship
Advanced Studies Fellowship, Anthropology and Education Institute, Spencer Foundation
Best Published Paper Award Nomination, Asian/PI Caucus, American Public Health Association
Best Abstract, first-time presenter at Genomics Forum, American Public Health Association
Mentored Community-Academic Team, Community-Based Participatory Research for Health Equity Institute, NIMHHD (Grant # 1R13MD007620-01), San Francisco State University, San Francisco, CA
UCSF CORO Leadership Training Institute
National Society for Genetic Counselors Best Abstract Award: “Adapting Evidenced Based Strategies for Effective Communication in Cancer Genetic Counseling"
National Society for Genetic Counselors Best Trainee Paper Award for mentee Daniella Karmara, Journal of Genetic Counseling "Cancer counseling of low-income limited English proficient Latina women using medical interpreters: Implications for shared decision making"
- Development and early implementation of an Accessible, Relational, Inclusive and Actionable approach to genetic counseling: The ARIA model. View on PubMed
- Biesecker BB, Lillie SE, Amendola LM, Donohue KE, East KM, Foreman AKM, Gilmore MJ, Greve V, Liangolou B, O'Daniel JM, Odgis JA, Rego S, Rolf B, Scollon S, Suckiel SA, Zepp J, Joseph G A review and definition of 'usual care' in genetic counseling trials to standardize use in research. View on PubMed
- Leslie Riddle, Laura M. Amendola, Marian J. Gilmore, Claudia Guerra, Barbara Biesecker, Tia L. Kauffman, Katherine Anderson, Alan F. Rope, Michael C. Leo, Mikaella Caruncho, Gail P. Jarvik, Benjamin Wilfond, Katrina A.B. Goddard, Galen Joseph Development and early implementation of an Accessible, Relational, Inclusive and Actionable approach to genetic counseling: the ARIA model. View on PubMed
- Katrina A.B. Goddard, Frank A.N. Angelo, Sara L. Ackerman, Jonathan S. Berg, Barbara B. Biesecker, Maria I. Danila, Kelly M. East, Lucia A. Hindorff, Carol R. Horowitz, Jessica Ezzell Hunter, Galen Joseph, Sara J. Knight, Amy McGuire, Kristin R. Muessig, Jeffrey Ou, Simon Outram, Elizabeth J. Rahn, Michelle A. Ramos, Christine Rini, Jill O. Robinson, Hadley Stevens Smith, Margaret Waltz, Sandra Soo-Jin Lee Lessons Learned about Harmonizing Survey Measures for the CSER Consortium. View on PubMed
- Kraft SA, McMullen C, Lindberg NM, Bui D, Shipman K, Anderson K, Joseph G, Duenas DM, Porter KM, Kauffman TL, Koomas A, Ransom CL, Jackson P, Goddard KAB, Wilfond BS, Lee SS Integrating stakeholder feedback in translational genomics research: an ethnographic analysis of a study protocol's evolution. View on PubMed
- Van Blarigan EL, Chan H, Van Loon K, Kenfield SA, Chan JM, Mitchell E, Zhang L, Paciorek A, Joseph G, Laffan A, Atreya CE, Fukuoka Y, Miaskowski C, Meyerhardt JA, Venook AP Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial. View on PubMed
- Nickell A, Stewart SL, Burke NJ, Guerra C, Cohen E, Lawlor C, Colen S, Cheng J, Joseph G Engaging limited English proficient and ethnically diverse low-income women in health research: A randomized trial of a patient navigator intervention. View on PubMed
- Joseph G, Lee R, Pasick RJ, Guerra C, Schillinger D, Rubin S Effective communication in the era of precision medicine: A pilot intervention with low health literacy patients to improve genetic counseling communication. View on PubMed
- Lara-Otero K, Weil J, Guerra C, Cheng JKY, Youngblom J, Joseph G Genetic Counselor and Healthcare Interpreter Perspectives on the Role of Interpreters in Cancer Genetic Counseling. View on PubMed
- Amendola LM, Berg JS, Horowitz CR, Angelo F, Bensen JT, Biesecker BB, Biesecker LG, Cooper GM, East K, Filipski K, Fullerton SM, Gelb BD, Goddard KAB, Hailu B, Hart R, Hassmiller-Lich K, Joseph G, Kenny EE, Koenig BA, Knight S, Kwok PY, Lewis KL, McGuire AL, Norton ME, Ou J, Parsons DW, Powell BC, Risch N, Robinson M, Rini C, Scollon S, Slavotinek AM, Veenstra DL, Wasserstein MP, Wilfond BS, Hindorff LA, Plon SE, Jarvik GP The Clinical Sequencing Evidence-Generating Research Consortium: Integrating Genomic Sequencing in Diverse and Medically Underserved Populations. View on PubMed
- Atreya CE, Kubo A, Borno HT, Rosenthal B, Campanella M, Rettger JP, Joseph G, Allen IE, Venook AP, Altschuler A, Dhruva A Being Present: A single-arm feasibility study of audio-based mindfulness meditation for colorectal cancer patients and caregivers. View on PubMed
- Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan T Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook, Erin Van Blarigan Effect of physical activity trackers and daily text messages on quality-of-life in colorectal survivors (Smart Pace): A pilot randomized controlled trial. View on PubMed
- Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook, Erin Van Blarigan Effect of physical activity trackers and daily text messages on quality-of-life in colorectal survivors (Smart Pace): A pilot randomized controlled trial. View on PubMed
- Erin Van Blarigan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Hilary Chan, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook Self-monitoring and reminder text messages to increase physical activity after colorectal cancer (CRC): A pilot randomized controlled trial. View on PubMed
- Cheng JKY, Guerra C, Pasick RJ, Schillinger D, Luce J, Joseph G Cancer genetic counseling communication with low-income Chinese immigrants. View on PubMed
- Joseph G, Pasick RJ, Schillinger D, Luce J, Guerra C, Cheng JKY Erratum to: Information Mismatch: Cancer Risk Counseling with Diverse Underserved Patients. View on PubMed
- Kamara D, Weil J, Youngblom J, Guerra C, Joseph G Cancer Counseling of Low-Income Limited English Proficient Latina Women Using Medical Interpreters: Implications for Shared Decision-Making. View on PubMed
- Joseph G, Pasick RJ, Schillinger D, Luce J, Guerra C, Cheng JKY Information Mismatch: Cancer Risk Counseling with Diverse Underserved Patients. View on PubMed
- G Joseph, RJ Pasick, D Schillinger, J Luce, JKY Cheng, C Guerra Effective Cancer Risk Communication to Prevent Disparities in the Era of Precision Medicine. View on PubMed
- Berg JS, Agrawal PB, Bailey DB, Beggs AH, Brenner SE, Brower AM, Cakici JA, Ceyhan-Birsoy O, Chan K, Chen F, Currier RJ, Dukhovny D, Green RC, Harris-Wai J, Holm IA, Iglesias B, Joseph G, Kingsmore SF, Koenig BA, Kwok PY, Lantos J, Leeder SJ, Lewis MA, McGuire AL, Milko LV, Mooney SD, Parad RB, Pereira S, Petrikin J, Powell BC, Powell CM, Puck JM, Rehm HL, Risch N, Roche M, Shieh JT, Veeraraghavan N, Watson MS, Willig L, Yu TW, Urv T, Wise AL Newborn Sequencing in Genomic Medicine and Public Health. View on PubMed