Research Summary

Young-Wook Jun, PhD, is an Associate Professor and he is the Director of the Nano-Probing Single Biomolecule Dynamics Laboratory in the Department of Otolaryngology - Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his PhD from the Korea Advanced Institute of Science and Technology in Seoul, South Korea, and he completed a postdoctoral from Yonsei University, Seoul, South Korea, followed by a postdoctoral from the University of California, Berkeley.

Dr. Jun's research interests include nanoprobing systems to investigate the single molecule dynamics of biomolecules involved in cellular developments such as gene regulation, cell-to-cell communications, and neuron circuit formation. His research on "Nanocrystal-Molecules as Probes for Monitoring the Dynamics of Biomolecular Machineries at the Single Molecule Level" will contribute to a foundation of a new field by providing a comprehensive understanding of the nanocrystal molecules including the fabrication, surface chemistry, scaling laws of magnetic, plasmonic, and charge coupling, and their behaviors in cells.

Dr. Jun has been invited to speak both national and internationally. He has contributed to over 40 articles, and 5 book chapters.

Research Funding

  • March 1, 2020 - February 28, 2025 - Spatiotemporal interrogation of molecular mechanobiololgy at the cell-cell interface with nanotechnology tools, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R35GM134948
  • September 15, 2017 - July 31, 2021 - Nanomodules for interrogating chemical, spatial, and mechanical dynamics of cell surface receptors, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM126542
  • January 1, 2018 - December 31, 2019 - In situ Investigation of dynamic protein-protein interactions in live cells via Magnetic Co-concentration (MCoC), Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R21CA224364
  • August 1, 2014 - July 31, 2019 - Spatiotemporal Control of Dynamic Notch Signaling with Subcellular Resolution, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM112081

Education

University of California, Berkeley, CA, Postdoc, 06/2010, Nanoscience
Yonsei University, Seoul, Korea, Postdoc, 06/2007, Nanochemistry
Korea Adv. Inst. Sci. & Tech., Daejeon, Korea, Ph.D., 02/2005, Materials Chemistry
Yonsei University, Seoul, Korea, B.A., 02/1999, Chemistry

Honors & Awards

  • 2005
    IUPAC Prize for Young Chemist: The Honorable Mention Award
  • 2010
    The Sandler Foundation New Innovator Research Award
  • 2011
    The Endowed Hemming Fellow
  • 2014
    The World’s Most Influential Scientific Minds
  • 2014
    Thomson Reuters Highly Cited Researchers
  • 2014
    BayBRAIN Initiative Award
  • 2016
    The Sandler Foundation New Frontier Research Award

Selected Publications

  1. Kwak M, Gu W, Jeong H, Lee H, Lee JU, An M, Kim YH, Lee JH, Cheon J, Jun YW Small, Clickable, and Monovalent Magnetofluorescent Nanoparticles Enable Mechanogenetic Regulation of Receptors in a Crowded Live-Cell Microenvironment.  View on PubMed
  2. Kim JW, Jeong HK, Southard KM, Jun YW, Cheon J Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time.  View on PubMed
  3. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles.  View on PubMed
  4. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time.  View on PubMed
  5. Daeha Seo, Hyunjung Lee, Jung-uk Lee, Thomas Haas, Young-wook Jun Monovalent plasmonic nanoparticles for biological applications  View on PubMed
  6. Mabray MC, Lillaney P, Sze CH, Losey AD, Yang J, Kondapavulur S, Liu D, Saeed M, Patel A, Cooke D, Jun YW, El-Sayed I, Wilson M, Hetts SW In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.  View on PubMed
  7. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ Production and targeting of monovalent quantum dots.  View on PubMed
  8. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia.  View on PubMed
  9. Tajon C, Jun YW, Craik CS Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology.  View on PubMed
  10. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction.  View on PubMed
  11. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW Formation of targeted monovalent quantum dots by steric exclusion.  View on PubMed
  12. Hu Y, Jun YS Biotite dissolution in brine at varied temperatures and CO2 pressures: its activation energy and potential CO2 intercalation.  View on PubMed
  13. Sheikholeslami S, Jun YW, Jain PK, Alivisatos AP Coupling of optical resonances in a compositionally asymmetric plasmonic nanoparticle dimer.  View on PubMed
  14. Park J, Zheng H, Jun YW, Alivisatos AP Hetero-epitaxial anion exchange yields single-crystalline hollow nanoparticles.  View on PubMed
  15. Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level.  View on PubMed
  16. Zheng H, Smith RK, Jun YW, Kisielowski C, Dahmen U, Alivisatos AP Observation of single colloidal platinum nanocrystal growth trajectories.  View on PubMed
  17. Jun YW, Seo JW, Cheon J Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences.  View on PubMed
  18. Jun YW, Lee JH, Cheon J Chemical design of nanoparticle probes for high-performance magnetic resonance imaging.  View on PubMed
  19. Park JI, Jun YW, Choi JS, Cheon J Highly crystalline anisotropic superstructures via magnetic field induced nanoparticle assembly.  View on PubMed
  20. Yong-Min Huh, Eun-Sook Lee, Jae-Hyun Lee, Young-wook Jun, Pyung-Hwan Kim, Chae-Ok Yun, Joo-Hang Kim, Jin-Suck Suh, Jinwoo Cheon Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery  View on PubMed

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