Research Summary

Young-Wook Jun, PhD, is an Associate Professor and he is the Director of the Nano-Probing Single Biomolecule Dynamics Laboratory in the Department of Otolaryngology - Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his PhD from the Korea Advanced Institute of Science and Technology in Seoul, South Korea, and he completed a postdoctoral from Yonsei University, Seoul, South Korea, followed by a postdoctoral from the University of California, Berkeley.

Dr. Jun's research interests include nanoprobing systems to investigate the single molecule dynamics of biomolecules involved in cellular developments such as gene regulation, cell-to-cell communications, and neuron circuit formation. His research on "Nanocrystal-Molecules as Probes for Monitoring the Dynamics of Biomolecular Machineries at the Single Molecule Level" will contribute to a foundation of a new field by providing a comprehensive understanding of the nanocrystal molecules including the fabrication, surface chemistry, scaling laws of magnetic, plasmonic, and charge coupling, and their behaviors in cells.

Dr. Jun has been invited to speak both national and internationally. He has contributed to over 40 articles, and 5 book chapters.

Research Funding

  • March 1, 2020 - February 28, 2025 - Spatiotemporal interrogation of molecular mechanobiololgy at the cell-cell interface with nanotechnology tools , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R35GM134948
  • April 15, 2021 - March 31, 2023 - Notch1 and APP signaling in cerebral microvascular dysfunction , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AG072232
  • September 15, 2017 - July 31, 2021 - Nanomodules for interrogating chemical, spatial, and mechanical dynamics of cell surface receptors , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM126542
  • January 1, 2018 - December 31, 2019 - In situ Investigation of dynamic protein-protein interactions in live cells via Magnetic Co-concentration (MCoC) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA224364
  • August 1, 2014 - July 31, 2019 - Spatiotemporal Control of Dynamic Notch Signaling with Subcellular Resolution , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM112081
  • July 1, 2017 - June 30, 2019 - Interrogation of mechanotransduction ion channels via nanoruler force microscopy and mechanogenetic nanomodules , Principal Investigator . Sponsor: NIH, Sponsor Award ID: 1R21NS103240-01
  • September 1, 2014 - June 30, 2017 - Spatial Mutation of Membrane Protein Assembly Dynamics Using Nano-Actuators , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21HL123329
  • March 1, 2014 - February 29, 2016 - Small, modular, and monovalent Quantum Dots for single molecule imaging of Notch , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21EB018044
  • March 15, 2012 - February 28, 2014 - Single Molecule Imaging of Guided Axonal Development using Plasmon Nanorulers , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21EB015088

Education

University of California, Berkeley, CA, Postdoc, 06/2010, Nanoscience
Yonsei University, Seoul, Korea, Postdoc, 06/2007, Nanochemistry
Korea Adv. Inst. Sci. & Tech., Daejeon, Korea, Ph.D., 02/2005, Materials Chemistry
Yonsei University, Seoul, Korea, B.A., 02/1999, Chemistry

Honors & Awards

  • 2005
    IUPAC Prize for Young Chemist: The Honorable Mention Award
  • 2010
    The Sandler Foundation New Innovator Research Award
  • 2011
    The Endowed Hemming Fellow
  • 2014
    The World’s Most Influential Scientific Minds
  • 2014
    Thomson Reuters Highly Cited Researchers
  • 2014
    BayBRAIN Initiative Award
  • 2016
    The Sandler Foundation New Frontier Research Award

Selected Publications

  1. Ko J, Kang M, Jun YJ Deep learning-based allergic rhinitis diagnosis using nasal endoscopy images.  View on PubMed
  2. Gao Z, Jung GY, Chou PI, Borkiewicz OJ, Newville M, Mishra R, Jun YS Photochemically Induced Co-oxidation of Aqueous Manganese and Cobalt and the Formation of Cobalt-Incorporated Manganese Oxides.  View on PubMed
  3. Zhu Y, Gupta P, Gholami Derami H, Huang YY, Singamaneni S, Jun YS Chemical Functional Groups Regulate Ion Concentrations and pHs in Nanopores.  View on PubMed
  4. Zhu Y, McWest L, Steefel CI, Wang Y, Li Q, Gao Z, Yang J, Jun YS Sulfate Promotes Compact CaCO3 Formation and Protects Portland Cement from Supercritical CO2 Attack.  View on PubMed
  5. Jung H, Lee B, Kim D, Gao Z, Chou PI, Jun YS Three Distinctive Steps for Heterogeneous Nucleation of Tunnel-Structured Mn Oxide on Quartz under Light Exposure.  View on PubMed
  6. Piraner DI, Abedi MH, Duran Gonzalez MJ, Chazin-Gray A, Lin A, Zhu I, Ravindran PT, Schlichthaerle T, Huang B, Bearchild TH, Lee D, Wyman S, Jun YW, Baker D, Roybal KT. Engineered receptors for soluble cellular communication and disease sensing. Nature. 2025 Feb; 638(8051):805-813.  View on PubMed
  7. Ilgen AG, Borguet E, Geiger FM, Gibbs JM, Grassian VH, Jun YS, Kabengi N, Kubicki JD Bridging molecular-scale interfacial science with continuum-scale models.  View on PubMed
  8. White MJ, Jacobs KA, Singh T, Mayo LN, Lin A, Chen CS, Jun YW, Kutys ML. Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. J Cell Biol. 2023 12 04; 222(12).  View on PubMed
  9. Xu Z, Cao H, Yoon S, Kang PK, Jun YS, Kneafsey T, Sheets JM, Cole D, Pyrak-Nolte LJ Gravity-driven controls on fluid and carbonate precipitation distributions in fractures.  View on PubMed
  10. Jeong S, Shin W, Park M, Lee JU, Lim Y, Noh K, Lee JH, Jun YW, Kwak M, Cheon J. Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo. Nano Lett. 2023 06 14; 23(11):5227-5235.  View on PubMed
  11. Bañuelos JL, Borguet E, Brown GE, Cygan RT, DeYoreo JJ, Dove PM, Gaigeot MP, Geiger FM, Gibbs JM, Grassian VH, Ilgen AG, Jun YS, Kabengi N, Katz L, Kubicki JD, Lützenkirchen J, Putnis CV, Remsing RC, Rosso KM, Rother G, Sulpizi M, Villalobos M, Zhang H Oxide- and Silicate-Water Interfaces and Their Roles in Technology and the Environment.  View on PubMed
  12. Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Georgakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner ZJ, Jun YW. Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling. Nat Cell Biol. 2022 12; 24(12):1739-1753.  View on PubMed
  13. Meher N, Seo K, Wang S, Bidkar AP, Fogarty M, Dhrona S, Huang X, Tang R, Blaha C, Evans MJ, Raleigh DR, Jun YW, VanBrocklin HF, Desai TA, Wilson DM, Ozawa T, Flavell RR. Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen. ACS Appl Mater Interfaces. 2021 Nov 24; 13(46):54739-54752.  View on PubMed
  14. Suh YC, Kim SH, Baek WY, Hong JW, Lee WJ, Jun YJ Super-thin ALT flap elevation using preoperative color doppler ultrasound planning: Identification of horizontally running pathway at the deep adipofascial layers.  View on PubMed
  15. Ryu YH, Moon SH, Kim KJ, Jun YJ, Oh DY, Kim SH, Rhie JW A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction.  View on PubMed
  16. Park J, Lee SY, Jeong H, Kang MG, Van Haute L, Minczuk M, Seo JK, Jun Y, Myung K, Rhee HW, Lee C The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.  View on PubMed
  17. Kwak M, Gu W, Jeong H, Lee H, Lee JU, An M, Kim YH, Lee JH, Cheon J, Jun YW. Small, Clickable, and Monovalent Magnetofluorescent Nanoparticles Enable Mechanogenetic Regulation of Receptors in a Crowded Live-Cell Microenvironment. Nano Lett. 2019 06 12; 19(6):3761-3769.  View on PubMed
  18. Pak CS, Park DH, Oh TS, Lee WJ, Jun YJ, Lee KA, Oh KS, Kwak KH, Rhie JW Comparison of the efficacy and safety of povidone-iodine foam dressing (Betafoam), hydrocellular foam dressing (Allevyn), and petrolatum gauze for split-thickness skin graft donor site dressing.  View on PubMed
  19. Kim JW, Jeong HK, Southard KM, Jun YW, Cheon J. Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time. Acc Chem Res. 2018 04 17; 51(4):839-849.  View on PubMed
  20. Xu T, Jiang Q, Ghim D, Liu KK, Sun H, Derami HG, Wang Z, Tadepalli S, Jun YS, Zhang Q, Singamaneni S Catalytically Active Bacterial Nanocellulose-Based Ultrafiltration Membrane.  View on PubMed

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