Research Summary

The Kampmann lab develops and applies innovative technologies to understand cellular and molecular mechanisms of aging-associated neurodegenerative diseases, and to discover new therapeutic strategies. A major focus of our research are Alzheimer's disease and related dementias.

We have pioneered a CRISPR-based functional genomics platform in human iPSC-derived neurons, glia and 3D assembloids, which enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells. We have also developed cell-type specific CRISPR screening approaches for mouse models of disease.

We use biochemistry, biophysics and cell biology to test mechanistic hypotheses generated by our functional genomics platform.

Major research questions are:

What controls protein aggregation in neurons, and why is it toxic? Why are some neuronal subtypes selectively vulnerable? Our main focus here is on the protein tau.

How do non-neuronal cells such as microglia and astrocytes contribute to disease? What controls their beneficial and toxic states and functions in disease?

Research Funding

  • September 1, 2021 - August 31, 2026 - Uncovering the genetic mechanisms of the Chromosome 17q21.31 Tau haplotype on neurodegeneration risk in FTD and PSP , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54NS123746
  • July 1, 2021 - June 30, 2026 - Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01AG072464
  • September 5, 2018 - June 30, 2023 - The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH115747
  • September 30, 2018 - May 31, 2023 - Systematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomics , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AG062359
  • September 30, 2016 - August 31, 2021 - Linking tau proteostasis with neuronal activity in FTD , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54NS100717
  • September 30, 2018 - June 30, 2020 - Uncovering mechanisms of selective vulnerability by CRISPR-based genetic screens , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56AG057528
  • September 30, 2015 - May 31, 2020 - Rewiring of the human protein homeostasis network in normal and disease contexts , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP2GM119139
  • August 1, 2015 - July 31, 2018 - Stress response networks in cancer: systematic mapping and therapeutic potential , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00CA181494
  • August 1, 2014 - July 31, 2015 - Stress response networks in cancer: systematic mapping and therapeutic potential , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99CA181494

Education

Marburg University, Germany, Pre-diploma, 06/00, Human Biology
Cambridge University, UK, B.A. (M.A.), First Class Honours, 06/03, Biochemistry
The Rockefeller University, Ph.D., 06/09, Biological Sciences (Cell Biology, Biophysics)
University of California, San Francisco, Postdoctoral Fellow, 07/15, Systems Biology

Honors & Awards

  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators
  • 2016
    Innovative Research Grant, Stand Up To Cancer
  • 2015
    New Innovator Award, NIH
  • 2015
    Allen Distinguished Investigator Award, Paul G. Allen Family Foundation
  • 2014
    Pathway to Independence Award (K99/R00), NIH
  • 2012
    Finalist, Deloitte QB3 Award for Innovation, California Institute for Quantitative Biosciences
  • 2012
    PBBR Postdoctoral Research Fellowship, Program for Breakthrough Biomedical Research, UCSF
  • 2010
    Postdoctoral Fellowship, Jane Coffin Childs Memorial Fund
  • 2006
    David Rockefeller Fellowship, The Rockefeller University
  • 2003
    Predoctoral Fellowship, Howard Hughes Medical Institute

Selected Publications

  1. Feringa FM, Koppes-den Hertog SJ, Wang LY, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward ME, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.  View on PubMed
  2. Ryan VH, Lawton S, Reyes JF, Hawrot J, Frankenfield AM, Seddighi S, Ramos DM, Epstein J, Faghri F, Johnson NL, Zou J, Kampmann M, Replogle J, Qi YA, Yuan H, Johnson K, Maric D, Hao L, Nalls MA, Ward ME Maintenance of neuronal TDP-43 expression requires axonal lysosome transport.  View on PubMed
  3. Veronica H Ryan, Sydney Lawton, Joel F Reyes, James Hawrot, Ashley M Frankenfield, Sahba Seddighi, Daniel M Ramos, Jacob Epstein, Faraz Faghri, Nicholas L Johnson, Jizhong Zou, Martin Kampmann, John Replogle, Yue Andy Qi, Hebao Yuan, Kory Johnson, Dragan Maric, Ling Hao, Mike A Nalls, Michael Emmerson Ward Maintenance of neuronal TDP-43 expression requires axonal lysosome transport.  View on PubMed
  4. Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Miller BL, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.  View on PubMed
  5. Ramani B, Rose IVL, Teyssier N, Pan A, Danner-Bocks S, Sanghal T, Yadanar L, Tian R, Ma K, Palop JJ, Kampmann M CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes.  View on PubMed
  6. Ramani B, Ehsani K, Kampmann M The Hsp40 co-chaperone DNAJC7 modifies polyglutamine but not polyglycine aggregation.  View on PubMed
  7. Sreekanth V, Jan M, Zhao KT, Lim D, Siriwongsup S, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies.  View on PubMed
  8. Ceesay S, Kampmann M, Votborg-Novél L, Hansson HS, Jensen RW, Carrasquilla M, Cisse H, Turner L, Dabbas U, Ntalla C, Bandermann S, Doumbo S, Doumtabe D, Ongoiba A, Kayentao K, Traore B, Crompton PD, Lavstsen T, Portugal S Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases.  View on PubMed
  9. Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M. CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning. Mol Psychiatry. 2025 Apr 06.  View on PubMed
  10. Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Wiseman RL, Lander GC Author Correction: DELE1 oligomerization promotes integrated stress response activation.  View on PubMed
  11. Krogsaeter EK, McKetney J, Valiente-Banuet L, Marquez A, Willis A, Cakir Z, Stevenson E, Jang GM, Rao A, Li E, Zhou A, Attili A, Chang TS, Kampmann M, Huang Y, Krogan NJ, Swaney DL. Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. bioRxiv. 2025 Mar 04.  View on PubMed
  12. Nakajo H, Cao R, Mula SA, McKetney J, Silva NJ, Shah M, Rose IVL, Kampmann M, Swaney DL, Kirst C, Molofsky AV Extracellular matrix proteolysis maintains synapse plasticity during brain development.  View on PubMed
  13. Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA. β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity. bioRxiv. 2025 Feb 25.  View on PubMed
  14. Meier S, Larsen ASG, Wanke F, Mercado N, Mei A, Takacs L, Mracsko ES, Collin L, Kampmann M, Roudnicky F, Jagasia R. An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models. Stem Cell Reports. 2025 Feb 11; 102420.  View on PubMed
  15. Boggess SC, Gandhi V, Tsai MC, Marzette E, Teyssier N, Yu-Ying Chou J, Hu X, Cramer A, Yadanar L, Shroff K, Jeong CG, Eidenschenk C, Hanson JE, Tian R, Kampmann M. A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity. bioRxiv. 2025 Feb 10.  View on PubMed
  16. Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Dräger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. Neuron. 2025 Mar 05; 113(5):701-718.e8.  View on PubMed
  17. Ramani B, Rose IVL, Teyssier N, Pan A, Danner-Bocks S, Sanghal T, Yadanar L, Tian R, Ma K, Palop JJ, Kampmann M. CRISPR screening by AAV episome-sequencing (CrAAVe-seq) is a highly scalable cell type-specific in vivo screening platform. bioRxiv. 2024 Dec 18.  View on PubMed
  18. Yin JA, Frick L, Scheidmann MC, Liu T, Trevisan C, Dhingra A, Spinelli A, Wu Y, Yao L, Vena DL, Knapp B, Guo J, De Cecco E, Ging K, Armani A, Oakeley EJ, Nigsch F, Jenzer J, Haegele J, Pikusa M, Täger J, Rodriguez-Nieto S, Bouris V, Ribeiro R, Baroni F, Bedi MS, Berry S, Losa M, Hornemann S, Kampmann M, Pelkmans L, Hoepfner D, Heutink P, Aguzzi A. Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes. Nat Biomed Eng. 2025 Jan; 9(1):127-148.  View on PubMed
  19. Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan SA, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N. Implementation and validation of single-cell genomics experiments in neuroscience. Nat Neurosci. 2024 Dec; 27(12):2310-2325.  View on PubMed
  20. Alexander V. Soloviev, Felipe Luiz Pereira, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Kun Leng, Martin Kampmann, Lea T. Grinberg. Exploring selective neuronal vulnerability in Alzheimer’s disease – key pathways are downregulated in vulnerable subpopulations of RORB and CDH9 excitatory neurons of the entorhinal cortex at Braak 0. Alzheimer's & Dementia. 2024 Dec 1; 20(Suppl 1):e091740.  View on PubMed

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