Research Summary

As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.

Research Funding

  • September 22, 2025 - September 21, 2029 - Genetic regulation of epithlial injury in ulcerative colitis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK141679
  • January 1, 2020 - August 31, 2025 - A20 and ABIN-1 cooperatively preserve intestinal integrity , Principal Investigator . Sponsor: Burroughs Wellcome Fund Career Awards for Medical Scientists, Sponsor Award ID: 1019583.01
  • January 16, 2020 - November 30, 2024 - Mechanisms of intestinal epithelial injury in intestinal inflammation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08DK123202
  • September 1, 2022 - August 31, 2023 - Tabula Sapiens , Intestine lead, co-investigator . Sponsor: Chan-Zuckerberg Biohub, Sponsor Award ID: unknown
  • March 1, 2021 - June 28, 2023 - AutoImmunoprofiler (AutoIPI) , IBD lead, co-Investigator . Sponsor: Eli Lilly, Sponsor Award ID: P0542258
  • July 1, 2019 - June 30, 2021 - Clinical cohort and corresponding cell atlas for patients with intestinal inflammation , Principal Investigator . Sponsor: Department of Medicine UCSF, Sponsor Award ID: DOM Cohort Grant

Education

Gastroenterology Fellowship, 2016 - Gastroenterology/Medicine, UCSF
Medicine Residency, 2012 - Medicine, Brigham and Women's Hospital
MD/PhD, 2010 - Medicine, Stanford University

Honors & Awards

  • Young Physician Scientist Award, American Society for Clinical Investigation, 2021
  • Recognition for Scientific Accomplishment as an Early Stage Investigator, DDW 2016, 2016
  • Resident Mentoring Award, Brigham and Women's Hospital, 2012
  • Hugh McDevitt Award, Stanford University, 2008

Selected Publications

  1. Donna Leet, Jing Jin, Charles Craik, Michael Kattah, Millie D. Long, Uma Mahadevan. Mo1835: POST-VACCINATION SARS-COV-2 NEUTRALIZING ANTIBODIES IN A COHORT OF PREGNANT WOMEN RECEIVING BIOLOGICS FOR INFLAMMATORY BOWEL DISEASE. Gastroenterology. 2025 May 1; 169(1):s-1179-s-1180. View on PubMed
  2. Rishika Chugh, Uma Mahadevan, Katy Tsai, Emily Pepe, David Oh, Michael Kattah. Su1929: INTESTINAL ULTRASOUND HAS A STRONG CORRELATION WITH ENDOSCOPIC FINDINGS IN PATIENTS WITH ICI ENTEROCOLITIS. View on PubMed
  3. Mei R, Pepe E, Oh DY, Tsai KK, Chugh R, Kattah MG. Symptomatic and Sonographic Improvement of Immune Checkpoint Inhibitor Enterocolitis With Risankizumab. Inflamm Bowel Dis. 2025 Apr 10; 31(4):1182-1183. View on PubMed
  4. Mennillo E, Lotstein ML, Lee G, Johri V, Ekstrand C, Tsui J, Hou J, Leet DE, He JY, Mahadevan U, Eckalbar W, Oh DY, Fragiadakis GK, Kattah MG, Combes AJ. Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks. bioRxiv. 2024 Nov 11. View on PubMed
  5. Rishika Chugh, Michael Kattah, Uma Mahadevan. Mo1866 REAL WORLD EFFICACY OF RISANKIZUMAB IN CROHN'S DISEASE PATIENTS WITH PRIOR EXPOSURE TO USTEKINUMAB. Gastroenterology. 2024 May 1; 166(5):s-1151. View on PubMed
  6. Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela K. Fragiadakis, Alexis Combes, Michael Kattah. Tu1756 TWO SPATIAL TRANSCRIPTOMIC PLATFORMS IDENTIFIED POTENTIAL PATHWAYS LINKED TO VEDOLIZUMAB RESPONSIVENESS IN ULCERATIVE COLITIS. Gastroenterology. 2024 May 1; 166(5):s-1408. View on PubMed
  7. He JY, Kim YJ, Mennillo E, Rusu I, Bain J, Rao AA, Andersen C, Law K, Yang H, Tsui J, Shen A, Davidson B, Kushnoor D, Shi Y, Fan F, Cheung A, Zhang L, Fong L, Combes AJ, Pisco AO, Kattah MG, Oh DY. Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis. J Immunother Cancer. 2024 Apr 19; 12(4). View on PubMed
  8. Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG. Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis. Nat Commun. 2024 Feb 19; 15(1):1493. View on PubMed
  9. Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah. VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS. Gastroenterology. 2024 Feb 1; 166(3):s96-s97. View on PubMed
  10. Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah. VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS. Inflammatory Bowel Diseases. 2024 Jan 25; 30(Supplement_1):s70-s70. View on PubMed
  11. Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG. Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis. bioRxiv. 2024 Jan 03. View on PubMed
  12. Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah Dorman, Faviola Bernard-Vazquez, Jared Bain, Ravi K. Patel, Christopher Andersen, Stanley Tamaki, Jessica Tsui, Kendall Beck, Najwa El-Nachef, Sara M. Lewin, Daniel Selvig, Jonathan P. Terdiman, Uma Mahadevan, David Oh, Gabriela K. Fragiadakis, Angela O. Pisco, Alexis Combes, Michael Kattah. 630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS. Gastroenterology. 2023 May 1; 164(6):s-124. View on PubMed
  13. Basta DW, Vong M, Beshimova A, Nakamura BN, Rusu I, Kattah MG, Shao L. A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Gastro Hep Adv. 2023; 2(1):96-107. View on PubMed
  14. Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U. Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro. Inflamm Bowel Dis. 2022 08 01; 28(8):1219-1228. View on PubMed
  15. Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. Intestinal inflammation alters the antigen-specific immune response to a skin commensal. Cell Rep. 2022 05 31; 39(9):110891. View on PubMed
  16. Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. Klein, Alexander Marson, Jessie A. Turnbaugh, Peter J. Turnbaugh, Barbara Malynn, Averil Ma, Michael Kattah. Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM. Gastroenterology. 2022 May 1; 162(7):s-995. View on PubMed
  17. Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5). View on PubMed
  18. Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U. Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2020 09; 65(9):2527-2532. View on PubMed
  19. Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS One. 2019; 14(7):e0218999. View on PubMed
  20. Hammami MB, Gill R, Thiruvengadam N, Oh DY, Beck K, Mahadevan U, Kattah MG. Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin. Dig Dis Sci. 2019 03; 64(3):685-688. View on PubMed

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