Research Summary

As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.

Research Funding

  • January 1, 2020 - August 31, 2025 - A20 and ABIN-1 cooperatively preserve intestinal integrity , Principal Investigator . Sponsor: Burroughs Wellcome Fund Career Awards for Medical Scientists, Sponsor Award ID: 1019583.01
  • January 16, 2020 - November 30, 2024 - Mechanisms of intestinal epithelial injury in intestinal inflammation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08DK123202
  • September 1, 2022 - August 31, 2023 - Tabula Sapiens , Intestine lead, co-investigator . Sponsor: Chan-Zuckerberg Biohub, Sponsor Award ID:
  • March 1, 2021 - June 28, 2023 - AutoImmunoprofiler (AutoIPI) , IBD lead, co-Investigator . Sponsor: Eli Lilly, Sponsor Award ID: P0542258


Gastroenterology Fellowship, 2016 - Gastroenterology/Medicine, UCSF
Medicine Residency, 2012 - Medicine, Brigham and Women's Hospital
MD/PhD, 2010 - Medicine, Stanford University

Honors & Awards

  • Young Physician Scientist Award, American Society for Clinical Investigation, 2021
  • Recognition for Scientific Accomplishment as an Early Stage Investigator, DDW 2016, 2016
  • Resident Mentoring Award, Brigham and Women's Hospital, 2012
  • Hugh McDevitt Award, Stanford University, 2008

Selected Publications

  1. Mennillo E, Kim YJ, Rusu I, Lee G, Dorman LC, Bernard-Vazquez F, Bain JL, Patel R, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Naser M, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh D, Fragiadakis GK, Pisco A, Combes A, Kattah MG. Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis. bioRxiv. 2023 Jul 15.  View on PubMed
  2. Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah Dorman, Faviola Bernard-Vazquez, Jared Bain, Ravi K. Patel, Christopher Andersen, Stanley Tamaki, Jessica Tsui, Kendall Beck, Najwa El-Nachef, Sara M. Lewin, Daniel Selvig, Jonathan P. Terdiman, Uma Mahadevan, David Oh, Gabriela K. Fragiadakis, Angela O. Pisco, Alexis Combes, Michael Kattah. 630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS. Gastroenterology. 2023 May 1; 164(6):s-124.  View on PubMed
  3. Basta DW, Vong M, Beshimova A, Nakamura BN, Rusu I, Kattah MG, Shao L. A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Gastro Hep Adv. 2023; 2(1):96-107.  View on PubMed
  4. Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U. Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro. Inflamm Bowel Dis. 2022 08 01; 28(8):1219-1228.  View on PubMed
  5. Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. Intestinal inflammation alters the antigen-specific immune response to a skin commensal. Cell Rep. 2022 05 31; 39(9):110891.  View on PubMed
  6. Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. Klein, Alexander Marson, Jessie A. Turnbaugh, Peter J. Turnbaugh, Barbara Malynn, Averil Ma, Michael Kattah. Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM. Gastroenterology. 2022 May 1; 162(7):s-995.  View on PubMed
  7. Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5).  View on PubMed
  8. Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U. Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2020 09; 65(9):2527-2532.  View on PubMed
  9. Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS One. 2019; 14(7):e0218999.  View on PubMed
  10. Hammami MB, Gill R, Thiruvengadam N, Oh DY, Beck K, Mahadevan U, Kattah MG. Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin. Dig Dis Sci. 2019 03; 64(3):685-688.  View on PubMed
  11. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 07 31; 9(7):172.  View on PubMed
  12. Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A. A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. J Exp Med. 2018 07 02; 215(7):1839-1852.  View on PubMed
  13. Kidambi TD, Terdiman JP, El-Nachef N, Singh A, Kattah MG, Lee JK. Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy. Clin Gastroenterol Hepatol. 2019 03; 17(4):701-708.e1.  View on PubMed
  14. Nakamura BN, Glazier A, Kattah MG, Duong B, Jia Y, Campo D, Shao L. A20 regulates canonical wnt-signaling through an interaction with RIPK4. PLoS One. 2018; 13(5):e0195893.  View on PubMed
  15. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 04 03; 9(4):143.  View on PubMed
  16. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 03; 14(3):e1006806.  View on PubMed
  17. Kattah MG, Malynn BA, Ma A. Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. J Mol Biol. 2017 11 10; 429(22):3471-3485.  View on PubMed
  18. Michael Kattah, Jeffrey Milush, Trevor Burt, Uma Mahadevan. 332e Multiparameter Flow Cytometry Reveals Differences in B Cells Subsets among Infants Born to Mothers being Treated for IBD. Gastroenterology. 2017 Apr 1; 152(5):s86.  View on PubMed
  19. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420.  View on PubMed
  20. Michael Kattah, Ling Shao, Yenny Rosli, Michael Whang, Rommel Advincula, Barbara Malynn, Averil Ma. P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis. Inflammatory Bowel Diseases. 2017 Feb 1; 23(&NA;):s92.  View on PubMed

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