Research Summary

Dr. Mi-Ok Kim has joined the HDFCCC as Director of the Biostatistics Core. The Core is responsible for providing support for protocol development, review and analysis for clinical studies, and statistical expertise for research collaborations with Cancer Center investigators in all disciplines across the spectrum of basic, clinical and population sciences. Dr. Kim will lead the Core and work directly with Cancer Center leadership on developing and implementing a strategic and integrated shared resource plan.

Dr. Kim joins us from Cincinnati Children’s Hospital Medical Center in Cincinnati, OH, where she directed the Biostatistics Unit for the Cancer and Blood Diseases Institute. Notable collaborations included Children's Tumor Foundation’s Neurofibromatosis (NF) Therapeutic Consortium that builds up a preclinical pipeline for screening candidate drug therapies in animal model systems. Dr. Kim also developed a research program in novel clinical trial designs that incorporate biomarker information and aim to optimize patient benefits. With the expertise in the trial design she served on the faculty for the American Association for Cancer Research (AACR) sponsored 2015 Methods in Cancer Biostatistics Workshop.

Dr. Kim will also join the Department of Epidemiology and Biostatistics as Professor of Biostatistics, continuing academic contributions to the field of biostatistics and providing biostatistical support broadly on campus. Trained as a mathematical statistician, Dr. Kim is an independent statistical method researcher with research interest in non- and semi-parametric statistics, and longitudinal and survival data analysis. She has been supported by NIH and National Science Foundation (NSF) awards, and published in prestigious journals such as the Annals of Statistics and the Journal of the American Statistical Association. Her recent research focuses on causal inference using structured data for comparative effectiveness research (CER) and patient-centered outcome research (PCOR). Registries, network databases and Electronic Health Record (EHR) often impose a hierarchical structure where subjects or patients are clustered, for example, by geographical area of residence, health care provider or health plan. The data structure is often associated with unmeasured characteristics of individuals or health care providers. Supported by the Patient-Centered Outcome Research Institute (PCORI), Dr. Kim and her research team study optimal handling of the complex data structure both in the treatment selection decision process and the outcome analysis in order to minimize bias and maximize efficiency of the causal inference. Application studies of the project include pediatric Crohn’s disease (CD) and kidney transplant study.

Research Funding

  • November 1, 2021 - October 31, 2024 - Mixed Data Meta-analysis: Integration of Individual Participant and Aggregate Data , PI . Sponsor: PCORI, Sponsor Award ID: ME-2020C3-21269
  • August 5, 1999 - May 31, 2023 - Cancer Center Support Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30CA082103
  • July 1, 2008 - December 31, 2018 - Risk Stratification & Identification of immunogenic and microbial markers of rapid disease progression in children with Crohn’s disease , Biostatistics Core Director . Sponsor: CCFA, Sponsor Award ID: Research Initiative Grant
  • January 1, 2015 - June 30, 2018 - Propensity Score-based Methods for CER Using Multilevel Data: What Works Best When , PI . Sponsor: PCORI, Sponsor Award ID: ME-1403-13922


MS: Statistics, University of Illinois, Urbana-Champaign, IL, 2000
PhD: Statistics, University of Illinois, Urbana-Champaign, IL, 2003

Honors & Awards

  • 1997
    Fellowship,University of Illinois at Urbana-Champaign
  • 2001
    First Prize,Capital One Financial Data Challenge Competition
  • 2002
    Norton Prize, Robert Bohrer Workshop for Student Papers in Statistics, University of Illinois at Urbana-Champaign
  • 2004
    Junior Faculty Travel Award,International Conference on Robust Statistics (ICORS)
  • 2008
    Travel Award, American Association for Cancer Research (AACR) Cancer Biostatistics Workshop

Selected Publications

  1. Cooch PB, Kim MO, Swami N, Tamma PD, Tabbutt S, Steurer MA, Wattier RL. Broad- Versus Narrow-Spectrum Perioperative Antibiotics and Outcomes in Pediatric Congenital Heart Disease Surgery: Analysis of the Vizient Clinical Data Base. J Pediatric Infect Dis Soc. 2023 Apr 28; 12(4):205-213.  View on PubMed
  2. Qureshy Z, Li H, Zeng Y, Rivera J, Cheng N, Peterson CN, Kim MO, Ryan WR, Ha PK, Bauman JE, Wang SJ, Long SR, Johnson DE, Grandis JR. STAT3 Activation as a Predictive Biomarker for Ruxolitinib Response in Head and Neck Cancer. Clin Cancer Res. 2022 11 01; 28(21):4737-4746.  View on PubMed
  3. Brown DM, Hernandez EA, Levin S, De Vaan M, Kim MO, Lynch C, Roth A, Brewster AL. Effect of Social Needs Case Management on Hospital Use Among Adult Medicaid Beneficiaries : A Randomized Study. Ann Intern Med. 2022 08; 175(8):1109-1117.  View on PubMed
  4. Borno HT, Kim MO, Hong JC, Yousefi S, Lin A, Tolstykh I, Zhang S, McKay RR, Harismendy O, Cinar P, Rugo H, Koshkin VS, Rabow M, Wang C, Bailey A, Small EJ. COVID-19 Outcomes Among Patients With Cancer: Observations From the University of California Cancer Consortium COVID-19 Project Outcomes Registry. Oncologist. 2022 05 06; 27(5):398-406.  View on PubMed
  5. Ginsburg AS, Braima de Sa A, Nankabirwa V, Co R, Murungi J, Kim MO, Brim R, Namiiro F, Namugga O, Hartigan-O'Connor DJ, Roberts SB, Flaherman V. Randomized controlled trial of early, small-volume formula supplementation among newborns: A study protocol. PLoS One. 2022; 17(2):e0263129.  View on PubMed
  6. Van Blarigan EL, Dhruva A, Atreya CE, Kenfield SA, Chan JM, Milloy A, Kim I, Steiding P, Laffan A, Zhang L, Piawah S, Fukuoka Y, Miaskowski C, Hecht FM, Kim MO, Venook AP, Van Loon K. Feasibility and Acceptability of a Physical Activity Tracker and Text Messages to Promote Physical Activity During Chemotherapy for Colorectal Cancer: Pilot Randomized Controlled Trial (Smart Pace II). JMIR Cancer. 2022 Jan 11; 8(1):e31576.  View on PubMed
  7. Yau C, Osdoit M, van der Noordaa M, Shad S, Wei J, de Croze D, Hamy AS, Laé M, Reyal F, Sonke GS, Steenbruggen TG, van Seijen M, Wesseling J, Martín M, Del Monte-Millán M, López-Tarruella S, I-SPY 2 Trial Consortium, Boughey JC, Goetz MP, Hoskin T, Gould R, Valero V, Edge SB, Abraham JE, Bartlett JMS, Caldas C, Dunn J, Earl H, Hayward L, Hiller L, Provenzano E, Sammut SJ, Thomas JS, Cameron D, Graham A, Hall P, Mackintosh L, Fan F, Godwin AK, Schwensen K, Sharma P, DeMichele AM, Cole K, Pusztai L, Kim MO, van 't Veer LJ, Esserman LJ, Symmans WF. Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients. Lancet Oncol. 2022 01; 23(1):149-160.  View on PubMed
  8. Jin N, Keam B, Cho J, Lee MJ, Kim HR, Torosyan H, Jura N, Ng PK, Mills GB, Li H, Zeng Y, Barbash Z, Tarcic G, Kang H, Bauman JE, Kim MO, VanLandingham NK, Swaney DL, Krogan NJ, Johnson DE, Grandis JR. Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. J Clin Invest. 2021 11 15; 131(22).  View on PubMed
  9. Shui AM, Kim P, Aribindi V, Huang CY, Kim MO, Rangarajan S, Schorger K, Aldrich JM, Lee H. Dynamic Risk Prediction for Hospital-Acquired Pressure Injury in Adult Critical Care Patients. Crit Care Explor. 2021 Nov; 3(11):e0580.  View on PubMed
  10. Digitale JC, Kim MO, Kuzniewicz MW, Newman TB. Update on Phototherapy and Childhood Cancer in a Northern California Cohort. Pediatrics. 2021 11; 148(5).  View on PubMed
  11. Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez-Morales D, Obernier K, Kreisberg JF, Kim M, Johnson DE, Jura N, Grandis JR, Gutkind JS, Ideker T, Krogan NJ. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science. 2021 Oct; 374(6563):eabf2911.  View on PubMed
  12. Kolodzie K, Cakmakkaya OS, Boparai ES, Tavakol M, Feiner JR, Kim MO, Newman TB, Niemann CU. Perioperative Normal Saline Administration and Delayed Graft Function in Patients Undergoing Kidney Transplantation: A Retrospective Cohort Study. Anesthesiology. 2021 10 01; 135(4):621-632.  View on PubMed
  13. Kim S, Ryan Cho H, Kim MO. Predictive generalized varying-coefficient longitudinal model. Stat Med. 2021 12 10; 40(28):6243-6259.  View on PubMed
  14. Bhola NE, Njatcha C, Hu L, Lee ED, Shiah JV, Kim MO, Johnson DE, Grandis JR. PD-L1 is upregulated via BRD2 in head and neck squamous cell carcinoma models of acquired cetuximab resistance. Head Neck. 2021 11; 43(11):3364-3373.  View on PubMed
  15. Sheng Y, Sun Y, Huang CY, Kim MO. Synthesizing external aggregated information in the penalized Cox regression under population heterogeneity. Stat Med. 2021 10 15; 40(23):4915-4930.  View on PubMed
  16. Sheng Y, Sun Y, Huang CY, Kim MO. Synthesizing external aggregated information in the presence of population heterogeneity: A penalized empirical likelihood approach. Biometrics. 2022 06; 78(2):679-690.  View on PubMed
  17. Baeg K, Harris C, Naparst MS, Ahn E, Thapi S, Martin J, Rustgi S, Mhango G, Wisnivesky J, Kim MK. Effect of treatment center volume on outcomes in gastroenteropancreatic neuroendocrine tumor patients. BMC Cancer. 2021 Feb 09; 21(1):146.  View on PubMed
  18. He Y, Kim S, Kim MO, Saber W, Ahn KW. Optimal treatment regimes for competing risk data using doubly robust outcome weighted learning with bi-level variable selection. Comput Stat Data Anal. 2021 Jun; 158.  View on PubMed
  19. Na Y, Hall A, Choi K, Hu L, Rose J, Coover RA, Miller A, Hennigan RF, Dombi E, Kim MO, Subramanian S, Ratner N, Wu J. MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK. Oncogene. 2021 02; 40(5):951-963.  View on PubMed
  20. Harun N, Liu C, Kim MO. Critical appraisal of Bayesian dynamic borrowing from an imperfectly commensurate historical control. Pharm Stat. 2020 09; 19(5):613-625.  View on PubMed

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