July 1, 2015 - June 30, 2021 - Molecular Correlates of progression in pancreatic cystic neoplasms, Site Principal Investigator, UCSF. Sponsor: NCI/NIH, Sponsor Award ID: U01
November 1, 2017 - November 1, 2020 - Minimally Invasive Classification of Pancreatic Cystic Neoplasms, Principal Investigator. Sponsor: V Foundation, Sponsor Award ID: T2017-013
February 1, 2017 - June 30, 2018 - Development of fluorogenic substrates for the diagnosis of pancreatic cysts, Principal Investigator. Sponsor: UCSF Clinical and Translational Sciences Institute, Sponsor Award ID: Catalyst Awards Program
January 1, 2015 - December 31, 2016 - Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R21CA185689
Education
Reed College, Portland, OR, B.A., 1977-1981, Biology University of Pennsylvania School of Medicine, Philadelphia, PA, M.D., 1981-1985, Medicine
Honors & Awards
1981 Phi Beta Kappa National Honor Society
1981 Walter Croll Scholarship, University of Pennsylvania School of Medicine
1983-85 President, Alpha Omega Alpha National Medical Honor Society, University of Pennsylvania Chapter
1989-90 Claude E. Welch Research Fellowship Award, Department of Surgery, Mass General Hospital
1990-91 Claude E. Welch Research Fellowship Award, Department of Surgery, Mass General Hospital
1995-96 Nominated, Kaiser Award for Excellence in Teaching, UCSF School of Medicine
1996-97 Excellence in Teaching, UCSF Department of Surgery Chief Residents
1998 Clinical Teaching Award, UCSF School of Medicine, Class of 1998
1999 Nominated, Kaiser Award for Excellence in Teaching, Medical Students
2001 Excellence in Teaching Award, UCSF Department of Surgery Residents
2004 Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
2004 Kaiser Award for Excellence in Teaching Nomination, UCSF School of Medicine
2008 Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
2009 Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
2010 AGA Student Abstract Prize (Victoria Lyo), American Gastroenterological Association (AGA) Foundation
2010 Kaiser Award for Excellence in Teaching Nomination, UCSF School of Medicine
2010 Pancreas Club Warren Award (Victoria Lyo), Pancreas Club
2010 Howard Hughes Research Fellowship (Victoria Lyo), Howard Hughes Medical Institute
2012 Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
2013 Excellence in Teaching Award, UCSF School of Medicine, Surgical Clerkship
2014 Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
2015 Excellence in Teaching Award, Inaugural, UCSF Department of Surgery Junior Residents
Ongoing Research Support
7/2013-6/2014 CTSI Phase 1, TI Catalyst: Early Diagnosis of Pancreatic Cancer Using a Non-Invasive Imaging Tool
7/2013-6/2014 UCSF RAP Cancer Pilot: Non-Invasive Imaging of Proteolytic Activity in the Pancreas: Towards Early Diagnosis of Pancreatic Cancer
04/01/03-03/31/14 R01 DK46285 (no cost extension) NIH: Neural Regulation of Pancreatic Function The major goals of this project are to examine the role of proteases, sensory nerves, tachykinins, ion channels, and neurokinin receptors in pancreatic inflammation and pain.
Past Research Support (Selected)
07/01/2009-06/30/12 2T32DK07573-21 NIH: GI Training Grant The goal of this project is to provide 2 years of independent research training to fellows with academic career goals in the field of gastrointestinal surgery. Dr. Kirkwood has mentored 8 surgical research fellows in 17 years.
02/01/10-01/31/11 3R01DK046285-10S1 NIH: Neural Regulation of Pancreatic Function (Recovery Act Administrative Supplement) The purpose of this study is to further to examine the role of proteases, sensory nerves, tachykinins, ion channels, and neurokinin receptors in pancreatic inflammation and pain.
07/01/2010-06/30/11 Foundation - Greenwall Foundation (Co PI: Kirkwood, Lo) Ethics of Informed Consent for Innovative surgical procedures The purpose of this study is to develop an understanding of the ethical and legal issues that surround informed consent for innovative surgical procedures.
04/01/08-03/31/13 2 R01 DK046285-14 NIH: Neural Regulation of Pancreatic Function The major goals of this project are to examine the role of proteases, sensory nerves, tachykinins, ion channels, and neurokinin receptors in pancreatic inflammation and pain.
Selected Publications
Sharib J, Esserman L, Koay EJ, Maitra A, Shen Y, Kirkwood KS, Ozanne EM
Cost-effectiveness of consensus guideline based management of pancreatic cysts: The sensitivity and specificity required for guidelines to be cost-effective.
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Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ
Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.
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Wisneski AD, Carter J, Nakakura EK, Posselt A, Rogers SJ, Cello JP, Arain M, Kirkwood KS, Hirose K, Stewart L, Corvera CU
Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.
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Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS
The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.
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Cao CX, Sharib JM, Blanco AM, Goldberg D, Bracci P, Mukhtar RA, Esserman LJ, Kirkwood KS
Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study.
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Kim SS, Ko AH, Nakakura EK, Wang ZJ, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Kim GE
Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?
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Changala M, Laberge J, Kerlan R, Taylor A, Arain M, Kirkwood K
Managing Refractory Postoperative Fistulas as Chronic Wounds Using Video-Assisted Hydrodebridement (VAHD).
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Sharib JM, Fonseca AL, Swords DS, Jaradeh K, Bracci PM, Firpo MA, Hatcher S, Scaife CL, Wang H, Kim GE, Mulvihill SJ, Maitra A, Koay EJ, Kirkwood KS
Surgical overtreatment of pancreatic intraductal papillary mucinous neoplasms: Do the 2017 International Consensus Guidelines improve clinical decision making?
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Fonseca AL, Kirkwood K, Kim MP, Maitra A, Koay EJ
Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk.
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Kirkwood R, Damon L, Wang J, Hong E, Kirkwood K
Gangrenous cholecystitis: innovative laparoscopic techniques to facilitate subtotal fenestrating cholecystectomy when a critical view of safety cannot be achieved.
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Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS
Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.
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Sharib J, Kirkwood K
Early and accurate diagnosis of pancreatic cancer?
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Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH
Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?
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Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S
Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions.
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Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW
Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.
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Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS
Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice.
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Lee Char SJ, Hills NK, Lo B, Kirkwood KS
Informed consent for innovative surgery: a survey of patients and surgeons.
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Lyo V, Cattaruzza F, Kim TN, Walker AW, Paulick M, Cox D, Cloyd J, Buxbaum J, Ostroff J, Bogyo M, Grady EF, Bunnett NW, Kirkwood KS
Active cathepsins B, L, and S in murine and human pancreatitis.
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Minter RM, Angelos P, Coimbra R, Dale P, de Vera ME, Hardacre J, Hawkins W, Kirkwood K, Matthews JB, McLoughlin J, Peralta E, Schmidt M, Zhou W, Schwarze ML
Ethical management of conflict of interest: proposed standards for academic surgical societies.
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Ceppa EP, Lyo V, Grady EF, Knecht W, Grahn S, Peterson A, Bunnett NW, Kirkwood KS, Cattaruzza F
Serine proteases mediate inflammatory pain in acute pancreatitis.
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