Research Funding

  • July 1, 2015 - June 30, 2021 - Molecular Correlates of progression in pancreatic cystic neoplasms, Site Principal Investigator, UCSF. Sponsor: NCI/NIH, Sponsor Award ID: U01
  • November 1, 2017 - November 1, 2020 - Minimally Invasive Classification of Pancreatic Cystic Neoplasms, Principal Investigator. Sponsor: V Foundation, Sponsor Award ID: T2017-013
  • February 1, 2017 - June 30, 2018 - Development of fluorogenic substrates for the diagnosis of pancreatic cysts, Principal Investigator. Sponsor: UCSF Clinical and Translational Sciences Institute, Sponsor Award ID: Catalyst Awards Program
  • January 1, 2015 - December 31, 2016 - Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R21CA185689

Education

Reed College, Portland, OR, B.A., 1977-1981, Biology
University of Pennsylvania School of Medicine, Philadelphia, PA, M.D., 1981-1985, Medicine

Honors & Awards

  • 1981
    Phi Beta Kappa National Honor Society
  • 1981
    Walter Croll Scholarship, University of Pennsylvania School of Medicine
  • 1983-85
    President, Alpha Omega Alpha National Medical Honor Society, University of Pennsylvania Chapter
  • 1989-90
    Claude E. Welch Research Fellowship Award, Department of Surgery, Mass General Hospital
  • 1990-91
    Claude E. Welch Research Fellowship Award, Department of Surgery, Mass General Hospital
  • 1995-96
    Nominated, Kaiser Award for Excellence in Teaching, UCSF School of Medicine
  • 1996-97
    Excellence in Teaching, UCSF Department of Surgery Chief Residents
  • 1998
    Clinical Teaching Award, UCSF School of Medicine, Class of 1998
  • 1999
    Nominated, Kaiser Award for Excellence in Teaching, Medical Students
  • 2001
    Excellence in Teaching Award, UCSF Department of Surgery Residents
  • 2004
    Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
  • 2004
    Kaiser Award for Excellence in Teaching Nomination, UCSF School of Medicine
  • 2008
    Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
  • 2009
    Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
  • 2010
    AGA Student Abstract Prize (Victoria Lyo), American Gastroenterological Association (AGA) Foundation
  • 2010
    Kaiser Award for Excellence in Teaching Nomination, UCSF School of Medicine
  • 2010
    Pancreas Club Warren Award (Victoria Lyo), Pancreas Club
  • 2010
    Howard Hughes Research Fellowship (Victoria Lyo), Howard Hughes Medical Institute
  • 2012
    Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
  • 2013
    Excellence in Teaching Award, UCSF School of Medicine, Surgical Clerkship
  • 2014
    Excellence in Teaching Award, UCSF Department of Surgery Chief Residents
  • 2015
    Excellence in Teaching Award, Inaugural, UCSF Department of Surgery Junior Residents

    • Ongoing Research Support

    • 7/2013-6/2014
      CTSI Phase 1, TI Catalyst: Early Diagnosis of Pancreatic Cancer Using a Non-Invasive Imaging Tool
    • 7/2013-6/2014
      UCSF RAP Cancer Pilot: Non-Invasive Imaging of Proteolytic Activity in the Pancreas: Towards Early Diagnosis of Pancreatic Cancer
    • 04/01/03-03/31/14
      R01 DK46285 (no cost extension) NIH: Neural Regulation of Pancreatic Function
      The major goals of this project are to examine the role of proteases, sensory nerves, tachykinins, ion channels, and neurokinin receptors in pancreatic inflammation and pain.

    Past Research Support (Selected)

    • 07/01/2009-06/30/12
      2T32DK07573-21 NIH: GI Training Grant
      The goal of this project is to provide 2 years of independent research training to fellows with academic career goals in the field of gastrointestinal surgery. Dr. Kirkwood has mentored 8 surgical research fellows in 17 years.
    • 02/01/10-01/31/11
      3R01DK046285-10S1 NIH: Neural Regulation of Pancreatic Function (Recovery Act Administrative Supplement)
      The purpose of this study is to further to examine the role of proteases, sensory nerves, tachykinins, ion channels, and neurokinin receptors in pancreatic inflammation and pain.
    • 07/01/2010-06/30/11
      Foundation - Greenwall Foundation (Co PI: Kirkwood, Lo) Ethics of Informed Consent for Innovative surgical procedures
      The purpose of this study is to develop an understanding of the ethical and legal issues that surround informed consent for innovative surgical procedures.
    • 04/01/08-03/31/13
      2 R01 DK046285-14 NIH: Neural Regulation of Pancreatic Function
      The major goals of this project are to examine the role of proteases, sensory nerves, tachykinins, ion channels, and neurokinin receptors in pancreatic inflammation and pain.

Selected Publications

  1. Thiruvengadam NR, Miranda J, Kim C, Behr S, Corvera C, Dai SC, Kirkwood K, Harris HW, Hirose K, Nakakura E, Ostroff JW, Kochman ML, Arain MA. Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis. Clin Transl Gastroenterol. 2021 04 27; 12(5):e00347.  View on PubMed
  2. Dittmar RL, Liu S, Tai MC, Rajapakshe K, Huang Y, Longton G, DeCapite C, Hurd MW, Paris PL, Kirkwood KS, Coarfa C, Maitra A, Brand RE, Killary AM, Sen S. Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer. Cancer Prev Res (Phila). 2021 Jul; 14(7):729-740.  View on PubMed
  3. Sharib J, Esserman L, Koay EJ, Maitra A, Shen Y, Kirkwood KS, Ozanne EM. Cost-effectiveness of consensus guideline based management of pancreatic cysts: The sensitivity and specificity required for guidelines to be cost-effective. Surgery. 2020 10; 168(4):601-609.  View on PubMed
  4. Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer. Clin Cancer Res. 2020 07 15; 26(14):3608-3615.  View on PubMed
  5. Wisneski AD, Carter J, Nakakura EK, Posselt A, Rogers SJ, Cello JP, Arain M, Kirkwood KS, Hirose K, Stewart L, Corvera CU. Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention. HPB (Oxford). 2020 10; 22(10):1496-1503.  View on PubMed
  6. Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biol Chem. 2019 11 26; 400(12):1629-1638.  View on PubMed
  7. Cao CX, Sharib JM, Blanco AM, Goldberg D, Bracci P, Mukhtar RA, Esserman LJ, Kirkwood KS. Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study. J Am Coll Surg. 2020 01; 230(1):53-63.e1.  View on PubMed
  8. Kim SS, Ko AH, Nakakura EK, Wang ZJ, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Kim GE. Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization? Am J Surg Pathol. 2019 03; 43(3):334-340.  View on PubMed
  9. Changala M, Laberge J, Kerlan R, Taylor A, Arain M, Kirkwood K. Managing Refractory Postoperative Fistulas as Chronic Wounds Using Video-Assisted Hydrodebridement (VAHD). J Gastrointest Surg. 2019 03; 23(3):608-612.  View on PubMed
  10. Sharib JM, Fonseca AL, Swords DS, Jaradeh K, Bracci PM, Firpo MA, Hatcher S, Scaife CL, Wang H, Kim GE, Mulvihill SJ, Maitra A, Koay EJ, Kirkwood KS. Surgical overtreatment of pancreatic intraductal papillary mucinous neoplasms: Do the 2017 International Consensus Guidelines improve clinical decision making? Surgery. 2018 12; 164(6):1178-1184.  View on PubMed
  11. Fonseca AL, Kirkwood K, Kim MP, Maitra A, Koay EJ. Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk. Pancreas. 2018 03; 47(3):272-279.  View on PubMed
  12. Kirkwood R, Damon L, Wang J, Hong E, Kirkwood K. Gangrenous cholecystitis: innovative laparoscopic techniques to facilitate subtotal fenestrating cholecystectomy when a critical view of safety cannot be achieved. Surg Endosc. 2017 12; 31(12):5258-5266.  View on PubMed
  13. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874.  View on PubMed
  14. Sharib J, Kirkwood K. Early and accurate diagnosis of pancreatic cancer? Oncotarget. 2016 12 27; 7(52):85676-85677.  View on PubMed
  15. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596.  View on PubMed
  16. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett. 2015 Jan 28; 356(2 Pt B):404-9.  View on PubMed
  17. Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW. Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants. Br J Pharmacol. 2014 Aug; 171(16):3814-26.  View on PubMed
  18. Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 01; 304(11):G1002-12.  View on PubMed
  19. Lee Char SJ, Hills NK, Lo B, Kirkwood KS. Informed consent for innovative surgery: a survey of patients and surgeons. Surgery. 2013 Apr; 153(4):473-80.  View on PubMed
  20. Lyo V, Cattaruzza F, Kim TN, Walker AW, Paulick M, Cox D, Cloyd J, Buxbaum J, Ostroff J, Bogyo M, Grady EF, Bunnett NW, Kirkwood KS. Active cathepsins B, L, and S in murine and human pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15; 303(8):G894-903.  View on PubMed

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