Research Funding

  • September 18, 2018 - June 30, 2026 - Defining mechanisms driving salivary gland regeneration, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R35DE028255
  • September 30, 2017 - June 30, 2020 - Autonomic regulation of lacrimal stem cells, Principal Investigator. Sponsor: NIH/NEI, Sponsor Award ID: R01EY027392
  • August 1, 2015 - June 30, 2020 - Defining the role of the nervous system in aqueous-deficient dry eye, Principal Investigator. Sponsor: NIH/NEI, Sponsor Award ID: R01EY025980
  • February 1, 2019 - January 31, 2020 - 2018 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R13DE028494


University of New South Wales, Sydney, Australia, Ph.D., 4/2002, Biomedical Engineering
University of New South Wales, Sydney, Australia, B.S (Hon), 4/1998, Biochemistry

Honors & Awards

  • 1998
    Pacific Dunlop Postgraduate Scholarship
  • 1998
    Australian Postgraduate Award (APA)
  • 2005
    Australian Post-Doctoral Industrial Fellowship (APDI)
  • 2005
    UNSW Faculty of Engineering Research Grant
  • 2008
    NIH Pathway to Independence Award (K99/R00)
  • 2008
    Pathway to Independence Award (K99/R00)

Selected Publications

  1. Nnabue OE, Pletcher SD, Gurrola JG, Goldberg AN, Jordan KM, Knox SM, May AJ Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis.  View on PubMed
  2. Saitou M, Gaylord EA, Xu D, May AJ, Neznanova L, Nathan S, Grawe A, Chang J, Ryan W, Ruhl S, Knox SM, Gokcumen O Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.  View on PubMed
  3. Efraim Y, Chen FYT, Stashko C, Cheong KN, Gaylord E, McNamara N, Knox SM Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease.  View on PubMed
  4. SEAN DE LA O, LAUREN BYRNES, DANIEL M. WONG, SARAH KNOX, JULIE B. SNEDDON 2155-P: Peripheral Nervous System Innervation of the Developing Pancreas.  View on PubMed
  5. Sudiwala S, Knox SM The emerging role of cranial nerves in shaping craniofacial development.  View on PubMed
  6. Chen FY, Gaylord E, McNamara N, Knox S Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome.  View on PubMed
  7. May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.  View on PubMed
  8. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB Lineage dynamics of murine pancreatic development at single-cell resolution.  View on PubMed
  9. Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.  View on PubMed
  10. Emmerson E, Knox SM Salivary gland stem cells: A review of development, regeneration and cancer.  View on PubMed
  11. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement.  View on PubMed
  12. Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.  View on PubMed
  13. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM SOX2 regulates acinar cell development in the salivary gland.  View on PubMed
  14. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands.  View on PubMed
  15. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.  View on PubMed
  16. Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT miR-205 is a critical regulator of lacrimal gland development.  View on PubMed
  17. Mattingly A, Finley JK, Knox SM Salivary gland development and disease.  View on PubMed
  18. Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.  View on PubMed
  19. Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM Manipulating the murine lacrimal gland.  View on PubMed
  20. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.  View on PubMed

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