September 18, 2018 - June 30, 2026 - Defining mechanisms driving salivary gland regeneration, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R35DE028255
September 30, 2017 - June 30, 2020 - Autonomic regulation of lacrimal stem cells, Principal Investigator. Sponsor: NIH/NEI, Sponsor Award ID: R01EY027392
August 1, 2015 - June 30, 2020 - Defining the role of the nervous system in aqueous-deficient dry eye, Principal Investigator. Sponsor: NIH/NEI, Sponsor Award ID: R01EY025980
February 1, 2019 - January 31, 2020 - 2018 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R13DE028494
Education
University of New South Wales, Sydney, Australia, Ph.D., 4/2002, Biomedical Engineering University of New South Wales, Sydney, Australia, B.S (Hon), 4/1998, Biochemistry
Honors & Awards
1998 Pacific Dunlop Postgraduate Scholarship
1998 Australian Postgraduate Award (APA)
2005 Australian Post-Doctoral Industrial Fellowship (APDI)
2005 UNSW Faculty of Engineering Research Grant
2008 NIH Pathway to Independence Award (K99/R00)
2008 Pathway to Independence Award (K99/R00)
Selected Publications
Saitou M, Gaylord EA, Xu D, May AJ, Neznanova L, Nathan S, Grawe A, Chang J, Ryan W, Ruhl S, Knox SM, Gokcumen O
Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.
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Efraim Y, Chen FYT, Stashko C, Cheong KN, Gaylord E, McNamara N, Knox SM
Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease.
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SEAN DE LA O, LAUREN BYRNES, DANIEL M. WONG, SARAH KNOX, JULIE B. SNEDDON
2155-P: Peripheral Nervous System Innervation of the Developing Pancreas.
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Sudiwala S, Knox SM
The emerging role of cranial nerves in shaping craniofacial development.
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Chen FY, Gaylord E, McNamara N, Knox S
Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome.
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May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM
Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.
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Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB
Lineage dynamics of murine pancreatic development at single-cell resolution.
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Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D
Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
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Emmerson E, Knox SM
Salivary gland stem cells: A review of development, regeneration and cancer.
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Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM
Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement.
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Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA
Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.
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Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM
SOX2 regulates acinar cell development in the salivary gland.
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Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO
Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands.
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Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM
Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
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Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT
miR-205 is a critical regulator of lacrimal gland development.
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Mattingly A, Finley JK, Knox SM
Salivary gland development and disease.
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Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM
Manipulating the murine lacrimal gland.
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Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM
Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
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Ophir D. Klein, Jeffrey O. Bush, Sarah M. Knox, Andrew H. Jheon, Dwight R. Cordero, Joan T. Richtsmeier
The society of craniofacial genetics and developmental biology 35th annual meeting.
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