Research Summary

I am a Professor in the Department of Laboratory Medicine and the Helen Diller Family Comprehenive Cancer Center at the University of California San Francisco. I am a board-certified hematopathologist with 17 years in active practice diagnosing lymphomas, leukemias, and other hematologic disorders. As a past chair of the Hematopathology subcommittee of the National Cancer Institute’s Mouse Models of Human Cancers Consortium, I am an internationally recognized expert in the characteri¬zation and classification of hematopoietic neoplasms in mice as well as in humans. I am also a noted researcher in the molecular pathogenesis of leukemia, including in the role of MYC in hematologic malignancy. My hematopathology training and research background combine to facilitate consultations and collaborations with investigators at UCSF, nationally, and internationally. I use my expertise in the pathology of humans and mice, as well as my experience in clinical pathology/laboratory medicine, to direct the mouse pathology core of the UCSF HDFCCC.

Research Funding

  • June 1, 2014 - May 31, 2020 - Impact of low IL-10 levels at birth and leukemia risk , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA185058
  • September 25, 2009 - June 30, 2019 - Center for Integrative Research on Childhood Leukemia and the Environment , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50ES018172
  • February 1, 2013 - January 31, 2016 - Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA173028
  • April 1, 2002 - January 31, 2014 - Molecular Mechanisms of Leukemogenesis by PMLRAR alpha , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA095274

Education

Harvard College, Cambridge, MA, A.B., 1986, Biochemical Sciences
University of California San Francisco, M.D., 1991, Medicine
Laboratory Medicine Residency, UCSF, 1991-1993, Laboratory Medicine
Hematopathology Fellowship, UCSF, 1997-1998, Hematopathology

Honors & Awards

  • 1986
    Summa Cum Laude, Phi Beta Kappa
  • 1986
    Joseph L. Barrett Award for Teaching, Harvard University
  • 1993
    National Committee for Clinical Laboratory Standards, Honored Graduate Award
  • 1993
    UCSF Molecular Medicine Training Program
  • 1993
    American Cancer Society Physician Research Training Award
  • 1994
    Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians
  • 1997
    Burroughs Wellcome Fund Career Award
  • 2000
    32nd Edward Mallinckrodt Jr. Scholar Award
  • 2001
    Medical Student Teaching Award, Excellence for Small Group Instruction
  • 2002
    Department of Laboratory Medicine Resident Teaching Award
  • 2004
    Leukemia & Lymphoma Society Scholar Award
  • 2007
    Mentor Award, UCSF Department of Pediatrics

Selected Publications

  1. Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J. Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia. Cytogenet Genome Res. 2022 Jun 08; 1-5.  View on PubMed
  2. Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X. Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children. Haematologica. 2022 May 31.  View on PubMed
  3. Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL. Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis. Am J Hematol. 2022 06 01; 97(6):E198-E201.  View on PubMed
  4. Fitch BA, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Kogan SC. Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia. Blood Adv. 2022 01 08; 6(3):854-865.  View on PubMed
  5. Schwartz JB, Kogan SC, Fang MC. Preventing Bleeding With Direct-Acting Oral Anticoagulants. J Am Coll Cardiol. 2021 10 19; 78(16):e127.  View on PubMed
  6. Morales CE, Stieglitz E, Kogan SC, Loh ML, Braun BS. Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia. Blood Adv. 2021 09 28; 5(18):3587-3591.  View on PubMed
  7. Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1526-1535.  View on PubMed
  8. Xu K, Li S, Whitehead TP, Pandey P, Kang AY, Morimoto LM, Kogan SC, Metayer C, Wiemels JL, de Smith AJ. Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1517-1525.  View on PubMed
  9. Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB. Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. Res Pract Thromb Haemost. 2021 May; 5(4):e12528.  View on PubMed
  10. Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Kogan SC. In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system. Clin Sci (Lond). 2021 04 30; 135(8):1053-1063.  View on PubMed
  11. Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL. Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016. Am J Epidemiol. 2021 04 06; 190(4):519-527.  View on PubMed
  12. Kogan SC. PML-RARα: changing myeloid networks. Blood. 2021 03 18; 137(11):1439-1440.  View on PubMed
  13. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21).  View on PubMed
  14. Gloria Mas Martin, Na Man, Daniel Karl, Concepcion Martinez, Stephanie Duffort, Hidehiro Itonaga, Adnan K Mookhtiar, Daniel Bilbao, Kranthi Kunkalla, Alfredo M Valencia, Clayton Collings, Cigall Kadoch, Francisco Vega, Scott C. Kogan, Stephen Nimer. The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks. Blood. 2020 Nov 5; 136(Supplement 1):13-13.  View on PubMed
  15. Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL. History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System. Am J Epidemiol. 2020 10 01; 189(10):1076-1085.  View on PubMed
  16. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 10; 90:65-71.e1.  View on PubMed
  17. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 05 14; 135(20):1772-1782.  View on PubMed
  18. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 08; 34(8):2025-2037.  View on PubMed
  19. Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica. 2019 11; 104(11):e514-e516.  View on PubMed
  20. Esnault C, Rahmé R, Rice KL, Berthier C, Gaillard C, Quentin S, Maubert AL, Kogan S, de Thé H. FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias. Blood. 2019 03 28; 133(13):1495-1506.  View on PubMed

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