Research Summary

Johannes R. Kratz, M.D. is Director of Minimally Invasive and Robotic Thoracic Surgery and holds the Van Auken Endowed Chair in Thoracic Oncology. Kratz graduated magna cum laude from Harvard Medical School and holds a Masters in Philosophy from Stanford.

Kratz worked as research fellow in the Thoracic Oncology Lab from 2008-2011 where he played a pivotal role in the development of a prognostic assay for early-stage lung cancer patients. The novel assay was validated in an international clinical trial led by thoracic surgeons David M. Jablons, M.D. and Michael Mann, M.D. The assay better predicted risk of death in early-stage lung cancer patients versus conventional staging guidelines and later successfully identified Stage 1A lung cancer patients who had a very high likelihood of mortality after surgery. Kratz finished his clinical training as a clinical fellow in Thoracic Surgery at UCSF from 2014 - 2017.

Kratz has published numerous papers and has been the recipient of numerous awards and honors including the Partners Healthcare Resident/Fellow as Teacher Award, Willard M. Daggett Award, Edward Churchill Surgical Research Fellowship, Wyeth Scholarship of the American College of Surgeons, John E. Thayer Scholarship Award, Howard Hughes Medical Fellows Program Continued Support Award, Hellman Family Clinical-Translational Research Development Award, Howard Hughes Medical Student Research Fellowship, Michael DeBakey Research Scholarship, and designation as a Soma Weiss Scholar.

Research Funding

  • July 1, 2020 - June 30, 2022 - Immune Phenotypes of High-Risk Early Stage Lung Adenocarcinoma, Principal Investigator. Sponsor: American Association of Thoracic Surgery, Sponsor Award ID:
  • August 1, 2019 - July 31, 2021 - CoProject Pilot in Early-Stage Lung Cancer, Principal Investigator. Sponsor: Bakar ImmunoX Foundation, Sponsor Award ID:
  • June 3, 2020 - June 2, 2021 - COVID-19 Related Rapid Research Pilot Initiative, Principal Investigator. Sponsor: University of California, San Francisco, Sponsor Award ID:
  • October 19, 2019 - September 30, 2020 - Lung Cancer Tumor Immune Microenvironments, Principal Investigator. Sponsor: Helen Diller Family Comprehensive Cancer Center, Sponsor Award ID:

Education

Stanford University, Palo Alto, CA, B.A. (with Distinction), 06/1999, Philosophy
Stanford University, Palo Alto, CA, B.S. (with Honors with Distinction), 06/1999, Biological Sciences
Stanford University, Palo Alto, CA, M.A., 06/2000, Philosophy
Harvard Medical School, Boston, MA, M.D. (Magna cum laude), 06/2006
Massachusetts General Hospital, Boston, MA, Residency, 06/2014, General Surgery
University of California, San Francisco, CA, Post-Doctoral Research Fellowship, 06/2011, Thoracic Oncology
University of California, San Francisco, CA, Fellowship, 06/2017, Cardiothoracic Surgery

Honors & Awards

  • 2005
    Soma Weiss Scholar Award, Harvard Medical School
  • 2006
    John E. Thayer Scholarship Award, Harvard Medical School
  • 2010
    Willard M. Daggett Award, Massachusetts General Hospital
  • 2011
    President's Conference Selection, World Conference on Lung Cancer, International Association for the Study of Lung Cancer
  • 2012
    First Place, Oral Presentation, Harvard Medical School Surgery Research Conference, Harvard Medical School
  • 2012
    Partners HealthCare Resident/Fellow as Teacher Award (awarded to one resident among all specialties across all eleven Partners HealthCare hospitals), Partners HealthCare
  • 2017
    UCSF Health Exceptional Physician Award (awarded for Professionalism, Respect, Integrity, Diversity and Excellence), UCSF
  • 2018
    Van Auken Endowed Chair in Thoracic Oncology, University of California, San Francisco
  • 2019
    Hellman Family Clinical-Translational Research Development Award, Bakar ImmunoX Initiative
  • 2019
    Haile T. Debas Academy of Medical Educators Excellence in Teaching Award (awarded for Medical Student education), UCSF
  • 2019
    Michael DeBakey Research Scholarship (awarded to a single North American surgeon committed to pursuing an academic career in cardiothoracic surgery)

Selected Publications

  1. Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. bioRxiv. 2021 Jun 02.  View on PubMed
  2. Woodard GA, Fels Elliott DR, Yap A, Haro GJ, Kratz JR, Mann MJ, Jones KD, Jablons DM. Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity. Ann Surg Oncol. 2021 Sep; 28(9):4953-4959.  View on PubMed
  3. Li PJ, Roose JP, Jablons DM, Kratz JR. Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models. Cancers (Basel). 2021 Feb 09; 13(4).  View on PubMed
  4. Kratz JR, Nguyen TC. Commentary: Cardiothoracic surgery training: Global challenges without universal solutions. J Thorac Cardiovasc Surg. 2021 Jan 20.  View on PubMed
  5. G. Woodard, J. Kratz, G. Haro, M. Gubens, C. Blakely, K. Jones, M. Mann, D. Jablons. MO01.13 Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit from Adjuvant Chemotherapy. Journal of Thoracic Oncology. 2021 Jan 1; 16(1):s21.  View on PubMed
  6. Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Pgdme , Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I, Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar Mrcog S, Vidya R, Bhangu AA, COVIDSurg Collaborative . Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. J Clin Oncol. 2021 01 01; 39(1):66-78.  View on PubMed
  7. COVIDSurg Collaborative . Delaying surgery for patients with a previous SARS-CoV-2 infection. Br J Surg. 2020 Nov; 107(12):e601-e602.  View on PubMed
  8. Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG. Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. Cell. 2020 09 03; 182(5):1232-1251.e22.  View on PubMed
  9. Calixto-Hope G. Lucas, Johannes R. Kratz, Anatoly Urisman. Pulmonary Embolus of Benign Liver Tissue Following Partial Hepatectomy. AJSP Review and Reports. 2020 Jul 1; 25(4):e5-e7.  View on PubMed
  10. Haro GJ, Sheu B, Marcus SG, Sarin A, Campbell L, Jablons DM, Kratz JR. Perioperative Lung Resection Outcomes After Implementation of a Multidisciplinary, Evidence-based Thoracic ERAS Program. Ann Surg. 2019 Dec 05.  View on PubMed
  11. Haro GJ, Sheu B, Cook NR, Woodard GA, Mann MJ, Kratz JR. Comparison of Conventional TNM and Novel TNMB Staging Systems for Non-Small Cell Lung Cancer. JAMA Netw Open. 2019 12 02; 2(12):e1917062.  View on PubMed
  12. Greg J. Haro, Fang Yu Sheu, Stanley J. Rogers, David M. Jablons, Johannes R. Kratz. Esophagectomy Outcomes after Implementation of an Enhanced Recovery after Surgery Program. Journal of the American College of Surgeons. 2019 Oct 1; 229(4):s277.  View on PubMed
  13. G. Woodard, V. Ding, I. Kim, K. Jones, G. Chavez, G. Haro, J. Kratz, M. Mann, J. Rotow, C. Blakely, D. Jablons. MA06.09 Timing of Driver Mutation Development and the Genetic Evolution of Semi-Solid Lung Nodules into Early NSCLC. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s271-s272.  View on PubMed
  14. J. Rotow, A. Urisman, C. Mccoach, T. Jahan, T. Bivona, K. Jones, A. Gupta, H. Do, J. Riess, D. Aisner, R. Doebele, D. Jablons, J. Kratz, C. Blakely. P1.14-58 A Phase II Study to Evaluate Neoadjuvant Osimertinib for Surgically Resectable, EGFR-Mutant Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s578.  View on PubMed
  15. Jiang L, Tolani B, Yeh CC, Fan Y, Reza JA, Horvai AE, Xia E, Kratz JR, Jablons DM, Mann MJ. Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma. Cancer Manag Res. 2019; 11:8209-8218.  View on PubMed
  16. Kratz JR, Haro GJ, Cook NR, He J, Van Den Eeden SK, Woodard GA, Gubens MA, Jahan TM, Jones KD, Kim IJ, He B, Jablons DM, Mann MJ. Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. J Thorac Oncol. 2019 07; 14(7):1223-1232.  View on PubMed
  17. Lancaster EM, Jablons D, Kratz JR. Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development. Genet Test Mol Biomarkers. 2020 Feb; 24(2):59-66.  View on PubMed
  18. Joel L Ramirez, Johannes R Kratz. Quantitative Polymerase Chain Reaction for Companion Diagnostics and Precision Medicine Application. . 2019 Mar 6; 55-71.  View on PubMed
  19. Haro GJ, Seeley EJ, Jablons DM, Kratz JR. Central Airway Obstruction Due to Tracheal Glomus Tumor. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1):e43-e45.  View on PubMed
  20. Ramirez JL, Kratz JR, Wieselthaler GM. Giant right coronary artery aneurysm presenting as cardiac tamponade. Interact Cardiovasc Thorac Surg. 2018 11 01; 27(5):787-789.  View on PubMed

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