Research Summary

Dr. Krogan was born and raised in Regina, Saskatchewan, Canada, obtained his undergraduate degree from the University of Regina and his PhD from the University of Toronto. Dr. Krogan’s lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, the Krogan group is focused on studying cancer, infectious disease and psychiatric disorders.

Research Funding

  • September 15, 2022 - August 31, 2027 - The Cancer Cell Map Initiative v2.0 , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: 1U54CA274502
  • July 15, 2022 - April 30, 2027 - HARC: HIV accessory and regulatory complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54AI170792
  • August 1, 2021 - May 31, 2026 - Host Pathogen Variation & TB Pathogenesis , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI162583
  • September 1, 2022 - August 31, 2025 - Building an Interpretable Genomic Translator Using Maps of Cell Architecture , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: OT2OD032742
  • May 16, 2022 - April 30, 2025 - QCRG Pandemic Response Program , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI171110
  • April 22, 2020 - March 31, 2025 - Childhood ?Omics? and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI152161
  • September 1, 2019 - August 31, 2024 - Combinatorial Regulation of Gene Networks During Cardiac Development and Disease , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL146366
  • September 15, 2019 - March 31, 2024 - Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: RF1AG059751
  • March 1, 2019 - February 29, 2024 - Novel VP30-host Interactions that Negatively Regulate Ebola Virus Infection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI143292
  • September 5, 2018 - June 30, 2023 - The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH115747
  • January 20, 2018 - December 31, 2022 - Fluomics: The Next Generation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135972
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50GM082250
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50AI150476
  • August 17, 2018 - July 31, 2022 - HPMI: Host Pathogen Mapping Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135990
  • May 11, 2017 - April 30, 2022 - Research Center for Cancer Systems Biology: Cancer Cell Map Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54CA209891
  • February 15, 2019 - January 31, 2022 - CasCUT&RUN: An in vivo method to analyze locus-specific protein complexes driving transcription of target genes in cancer , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA235303
  • September 30, 2016 - August 31, 2021 - Linking tau proteostasis with neuronal activity in FTD , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54NS100717
  • September 30, 2004 - June 30, 2021 - Intracellular pathogens and innate immunity , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI063302
  • August 1, 2015 - January 31, 2021 - Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI120694
  • December 1, 2015 - November 30, 2020 - Decoding the Chlamydia inclusion membrane protein-host protein interactome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI122747
  • June 24, 2015 - May 31, 2020 - Dengue Human Immunology Project Consortium (DHIPC) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI118610
  • September 1, 2010 - July 31, 2019 - Exploring Design Principles of Cellular Control Circuits , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50GM081879
  • September 1, 2014 - June 30, 2019 - Physical and Genetic Interaction Landscape of the Tyrosine Kinome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM107671
  • August 1, 2008 - February 28, 2019 - Comparative Analysis of Genetic Interaction Networks , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084279
  • July 1, 2007 - July 31, 2018 - Transcriptional Networks During Cardiac Differentiation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL089707
  • June 26, 2013 - May 31, 2018 - Multiscale analysis of influenza host-pathogen interactions: Fluomics , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI106754
  • December 15, 2015 - November 30, 2017 - Proteomics Analysis of Host-Pathogen Interactions in Histoplasma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI122064
  • July 13, 2011 - June 30, 2016 - Protein homeostasis mechanisms underlying enterovirus replication and evolution , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI091575
  • August 1, 2011 - May 31, 2016 - Integrating computation and genetics to quantify specificity in protein networks , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM098101
  • August 15, 2010 - July 31, 2015 - Global innate immune responses to HIV-1 infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI090935
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • June 1, 2008 - April 30, 2014 - Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084448
  • September 25, 2008 - July 31, 2012 - Global Genetic Interaction Profiling in Prokaryotes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM085697

Education

University of Regina, Canada, BS, 1997, Chemistry
University of Regina, Canada, MSc, 1999, Biochemistry
University of Toronto, Canada, PhD, 2005, Medical Genetics

Honors & Awards

  • 1995-1996
    Canadian Cancer Society Award
  • 1997
    Society of Chemical Industry Merit Award
  • 1999-2001
    Natural Sciences and Engineering Research Council (NSERC) PGS-B Award
  • 2001-2004
    Canadian Institute of Health Research (CIHR) Doctoral Fellowship
  • 2004
    Hannah Farkas-Himsley and Alexander Memorial Award
  • 2005
    L. W. Macpherson Microbiology Award
  • 2008
    Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006
  • 2009-2012
    Searle Scholar, Searle Foundation
  • 2009-2014
    Keck Distinguished Young Scholar, W. M. Keck Foundation
  • 2012
    Alumni Crowning Achievement Award, University of Regina
  • 2014
    "40 under 40," Cell

Selected Publications

  1. Krogsaeter EK, McKetney J, Valiente-Banuet L, Marquez A, Willis A, Cakir Z, Stevenson E, Jang GM, Rao A, Li E, Zhou A, Attili A, Chang TS, Kampmann M, Huang Y, Krogan NJ, Swaney DL. Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. bioRxiv. 2025 Mar 04.  View on PubMed
  2. Serrano LR, Pelin A, Arrey TN, Damoc NE, Richards AL, Zhou Y, Lancaster NM, Peters-Clarke TM, Pashkova A, Jang GM, Eckhardt M, Quarmby ST, Zeller M, Hermanson D, Stewart H, Hock C, Makarov A, Zabrouskov V, Krogan NJ, Coon JJ, Swaney DL. Affinity Purification Mass Spectrometry on the Orbitrap-Astral Mass Spectrometer Enables High-Throughput Protein-Protein Interaction Mapping. J Proteome Res. 2025 Mar 02.  View on PubMed
  3. Turnham RE, Pitea A, Jang GM, Xu Z, Lim HC, Choi AL, Von Dollen J, Levin RS, Webber JT, McCarthy E, Hu J, Li X, Che L, Singh A, Yoon A, Chan GKL, Kelley RK, Swaney DL, Zhang W, Bandyopadhyay S, Theis FJ, Eckhardt M, Chen X, Shokat KM, Ideker T, Krogan NJ, Gordan JD. HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma. Cancer Res. 2025 Feb 17; 85(4):660-674.  View on PubMed
  4. An Z, Fan QW, Wang L, Yoda H, Barata MJ, Jimenez-Morales D, Phillips JJ, Swaney DL, Stevenson E, Lee E, Krogan N, Weiss WA. EGFR and EGFRvIII coopt host defense pathways promoting progression in glioblastoma. Neuro Oncol. 2025 Feb 10; 27(2):383-397.  View on PubMed
  5. Mohammed AM, Olwal CO, Fossati A, Nyakoe NK, Fabius JM, Gordon M, Polacco BJ, Swaney DL, Awandare GA, Krogan NJ, Bouhaddou M, Bediako Y. Malaria exposure remodels the plasma proteome of Ghanaian children. BMC Infect Dis. 2025 Feb 03; 25(1):157.  View on PubMed
  6. Chin J, Abeydeera N, Repasy T, Rivera-Lugo R, Mitchell G, Nguyen VQ, Zheng W, Richards A, Swaney DL, Krogan NJ, Ernst JD, Cox JS, Budzik JM. Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages. bioRxiv. 2024 Dec 16.  View on PubMed
  7. Arce MM, Umhoefer JM, Arang N, Kasinathan S, Freimer JW, Steinhart Z, Shen H, Pham MTN, Ota M, Wadhera A, Dajani R, Dorovskyi D, Chen YY, Liu Q, Zhou Y, Swaney DL, Obernier K, Shy BR, Carnevale J, Satpathy AT, Krogan NJ, Pritchard JK, Marson A. Central control of dynamic gene circuits governs T cell rest and activation. Nature. 2025 Jan; 637(8047):930-939.  View on PubMed
  8. Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation. PLoS Pathog. 2024 Nov; 20(11):e1012741.  View on PubMed
  9. Greenblatt JF, Alberts BM, Krogan NJ. Discovery and significance of protein-protein interactions in health and disease. Cell. 2024 Nov 14; 187(23):6501-6517.  View on PubMed
  10. Nourreddine S, Doctor Y, Dailamy A, Forget A, Lee YH, Chinn B, Khaliq H, Polacco B, Muralidharan M, Pan E, Zhang Y, Sigaeva A, Hansen JN, Gao J, Parker JA, Obernier K, Clark T, Chen JY, Metallo C, Lundberg E, Ideker T, Krogan N, Mali P. A PERTURBATION CELL ATLAS OF HUMAN INDUCED PLURIPOTENT STEM CELLS. bioRxiv. 2024 Nov 04.  View on PubMed
  11. Kaushal P, Ummadi MR, Jang GM, Delgado Y, Makanani SK, Alba K, Winters DM, Blanc SF, Xu J, Polacco B, Zhou Y, Stevenson E, Eckhardt M, Zuliani-Alvarez L, Kaake R, Swaney DL, Krogan NJ, Bouhaddou M. Protocol for mapping differential protein-protein interaction networks using affinity purification-mass spectrometry. STAR Protoc. 2024 Dec 20; 5(4):103286.  View on PubMed
  12. Shehu D, Kim MO, Rosendo J, Krogan N, Morgan DO, Guglielmo BJ. Institutional Conversion to Energy-Efficient Ultra-Low Freezers Decreases Carbon Footprint and Reduces Energy Costs. Biopreserv Biobank. 2024 Sep 25.  View on PubMed
  13. Eaton CD, Avalos L, Liu SJ, Chen Z, Zakimi N, Casey-Clyde T, Bisignano P, Lucas CG, Stevenson E, Choudhury A, Vasudevan HN, Magill ST, Young JS, Krogan NJ, Villanueva-Meyer JE, Swaney DL, Raleigh DR. MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features. Nat Commun. 2024 Sep 09; 15(1):7873.  View on PubMed
  14. Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Zapatero-Belinchón FJ, McCavittMalvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Richards AL, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS. The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2. bioRxiv. 2024 Aug 29.  View on PubMed
  15. Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K. Fibrin drives thromboinflammation and neuropathology in COVID-19. Nature. 2024 Sep; 633(8031):905-913.  View on PubMed
  16. Schynkel T, Snippenberg WV, Verniers K, Jang GM, Krogan NJ, Mestdagh P, Vandekerckhove L, Trypsteen W. Interactome of the HIV-1 proteome and human host RNA. EMBO Rep. 2024 Sep; 25(9):4078-4090.  View on PubMed
  17. Nageshan RK, Krogan N, Cooper JP. Parallel genetic screens identify nuclear envelope homeostasis as a key determinant of telomere entanglement resolution in fission yeast. G3 (Bethesda). 2024 Jul 08; 14(7).  View on PubMed
  18. Zhong X, Li Q, Polacco BJ, Patil T, Marley A, Foussard H, Khare P, Vartak R, Xu J, DiBerto JF, Roth BL, Eckhardt M, von Zastrow M, Krogan NJ, Hüttenhain R. A proximity proteomics pipeline with improved reproducibility and throughput. Mol Syst Biol. 2024 Aug; 20(8):952-971.  View on PubMed
  19. Nageshan RK, Ortega R, Krogan N, Cooper JP. Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown. Nat Commun. 2024 Jun 03; 15(1):4707.  View on PubMed
  20. Kelly LM, Rutter JC, Lin KH, Ling F, Duchmann M, Latour E, Arang N, Pasquer H, Ho Nhat D, Charles J, Killarney ST, Ang HX, Namor F, Culeux C, Lombard B, Loew D, Swaney DL, Krogan NJ, Brunel L, Carretero É, Verdié P, Amblard M, Fodil S, Huynh T, Sebert M, Adès L, Raffoux E, Fenouille N, Itzykson R, Lobry C, Benajiba L, Forget A, Martin AR, Wood KC, Puissant A. Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule. Nat Cancer. 2024 Jul; 5(7):1082-1101.  View on PubMed

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