Research Summary

Dr. Krogan was born and raised in Regina, Saskatchewan, Canada, obtained his undergraduate degree from the University of Regina and his PhD from the University of Toronto. Dr. Krogan’s lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, the Krogan group is focused on studying cancer, infectious disease and psychiatric disorders.

Research Funding

  • September 15, 2022 - August 31, 2027 - The Cancer Cell Map Initiative v2.0 , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: 1U54CA274502
  • July 15, 2022 - April 30, 2027 - HARC: HIV accessory and regulatory complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54AI170792
  • August 1, 2021 - May 31, 2026 - Host Pathogen Variation & TB Pathogenesis , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI162583
  • September 1, 2022 - August 31, 2025 - Building an Interpretable Genomic Translator Using Maps of Cell Architecture , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: OT2OD032742
  • May 16, 2022 - April 30, 2025 - QCRG Pandemic Response Program , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI171110
  • April 22, 2020 - March 31, 2025 - Childhood ?Omics? and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI152161
  • September 1, 2019 - August 31, 2024 - Combinatorial Regulation of Gene Networks During Cardiac Development and Disease , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL146366
  • September 15, 2019 - March 31, 2024 - Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: RF1AG059751
  • March 1, 2019 - February 29, 2024 - Novel VP30-host Interactions that Negatively Regulate Ebola Virus Infection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI143292
  • September 5, 2018 - June 30, 2023 - The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH115747
  • January 20, 2018 - December 31, 2022 - Fluomics: The Next Generation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135972
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50AI150476
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50GM082250
  • August 17, 2018 - July 31, 2022 - HPMI: Host Pathogen Mapping Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135990
  • May 11, 2017 - April 30, 2022 - Research Center for Cancer Systems Biology: Cancer Cell Map Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54CA209891
  • February 15, 2019 - January 31, 2022 - CasCUT&RUN: An in vivo method to analyze locus-specific protein complexes driving transcription of target genes in cancer , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA235303
  • September 30, 2016 - August 31, 2021 - Linking tau proteostasis with neuronal activity in FTD , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54NS100717
  • September 30, 2004 - June 30, 2021 - Intracellular pathogens and innate immunity , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI063302
  • August 1, 2015 - January 31, 2021 - Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI120694
  • December 1, 2015 - November 30, 2020 - Decoding the Chlamydia inclusion membrane protein-host protein interactome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI122747
  • June 24, 2015 - May 31, 2020 - Dengue Human Immunology Project Consortium (DHIPC) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI118610
  • September 1, 2010 - July 31, 2019 - Exploring Design Principles of Cellular Control Circuits , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50GM081879
  • September 1, 2014 - June 30, 2019 - Physical and Genetic Interaction Landscape of the Tyrosine Kinome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM107671
  • August 1, 2008 - February 28, 2019 - Comparative Analysis of Genetic Interaction Networks , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084279
  • July 1, 2007 - July 31, 2018 - Transcriptional Networks During Cardiac Differentiation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL089707
  • June 26, 2013 - May 31, 2018 - Multiscale analysis of influenza host-pathogen interactions: Fluomics , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI106754
  • December 15, 2015 - November 30, 2017 - Proteomics Analysis of Host-Pathogen Interactions in Histoplasma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI122064
  • July 13, 2011 - June 30, 2016 - Protein homeostasis mechanisms underlying enterovirus replication and evolution , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI091575
  • August 1, 2011 - May 31, 2016 - Integrating computation and genetics to quantify specificity in protein networks , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM098101
  • August 15, 2010 - July 31, 2015 - Global innate immune responses to HIV-1 infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI090935
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • June 1, 2008 - April 30, 2014 - Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084448
  • September 25, 2008 - July 31, 2012 - Global Genetic Interaction Profiling in Prokaryotes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM085697

Education

University of Regina, Canada, BS, 1997, Chemistry
University of Regina, Canada, MSc, 1999, Biochemistry
University of Toronto, Canada, PhD, 2005, Medical Genetics

Honors & Awards

  • 1995-1996
    Canadian Cancer Society Award
  • 1997
    Society of Chemical Industry Merit Award
  • 1999-2001
    Natural Sciences and Engineering Research Council (NSERC) PGS-B Award
  • 2001-2004
    Canadian Institute of Health Research (CIHR) Doctoral Fellowship
  • 2004
    Hannah Farkas-Himsley and Alexander Memorial Award
  • 2005
    L. W. Macpherson Microbiology Award
  • 2008
    Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006
  • 2009-2012
    Searle Scholar, Searle Foundation
  • 2009-2014
    Keck Distinguished Young Scholar, W. M. Keck Foundation
  • 2012
    Alumni Crowning Achievement Award, University of Regina
  • 2014
    "40 under 40," Cell

Selected Publications

  1. Giddins M, Kratz AF, De Los Santos MB, Forget A, Tiwari R, Jang G, Blazejewski T, Qin C, Huang Y, Lao YH, Falconer T, Leong KW, Krogan N, Staller M, Wang H, Wei L, Chavez A Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity.  View on PubMed
  2. Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, Kongpracha P, Bali S, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.  View on PubMed
  3. Ferle PE, Krause N, Koliwer J, Völker JM, Becker F, Hillebrand A, Schröder LF, Jäger S, Edassery S, Liu D, Krogan NJ, Savas JN, Fischer von Mollard G, Schwake M The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5.  View on PubMed
  4. Jimeno J, Varona JF, Lopez-Martin JA, Izquierdo-Useros N, Molina Molina E, Guisado-Vasco P, Sachse M, Risco C, Losada A, Fudio S, Luepke E, Nieto A, Gomez J, Aviles P, Cuevas C, Bouhaddou M, Sola I, Krogan NJ, Enjuanes L, Fernandez-Sousa JM, GarcÍa-Sastre A, White K Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor.  View on PubMed
  5. Stein CM, Benchek P, Mantshoyane L, Ciesielski T, McHenry ML, Wilson-Sesay H, Joloba M, Wampande E, Dill Mc-Farland KA, Roberts AW, Polacco B, Bennett M, Krogan N, Boom WH, Cox JS, Mayanja-Kizza H, Hawn TR, Williams SM Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage.  View on PubMed
  6. Chin J, Abeydeera N, Repasy T, Rivera-Lugo R, Mitchell G, Nguyen VQ, Zheng W, Richards A, Stevenson E, Swaney DL, Krogan NJ, Ernst JD, Cox JS, Budzik JM Mycobacterium tuberculosis triggers reduced inflammatory cytokine responses and virulence in mice lacking Tax1bp1.  View on PubMed
  7. Pessina P, Nevo M, Shi J, Kodali S, Casas E, Cui Y, Richards AL, Park EJ, Chen X, Levin-Ferreyra F, Rivera Tostado A, Stevenson E, Krogan NJ, Swaney DL, Ying Q, Chen Q, Brumbaugh J, Di Stefano B Selective RNA sequestration in biomolecular condensates directs cell fate transitions.  View on PubMed
  8. Krogsaeter EK, McKetney J, Valiente-Banuet L, Marquez A, Willis A, Cakir Z, Stevenson E, Jang GM, Rao A, Li E, Zhou A, Attili A, Chang TS, Kampmann M, Huang Y, Krogan NJ, Swaney DL Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.  View on PubMed
  9. Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, Renslo AR Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.  View on PubMed
  10. Wang B, Tran MN, Wang S, Liu Y, Olfson E, Wang G, Sun N, Dea J, Olwal CO, Bertolace L, Bloch MH, Cappi C, Chang YC, Chavira D, Coffey BJ, Falkenstein MJ, Frank AC, Franklin ME, Garayalde S, Garrido H, Grados M, Hatem R, Howell AL, Khim S, Kuckertz JM, Le MM, Libby A, McCarty RJ, McNamara ME, McNeil D, Miguel EC, Nasello C, Nguyen B, Norbu T, Oh L, Ordway A, Paciotti C, Peskin VA, Pittenger C, Simpson HB, Martin HS, Tischfield MA, Xing J, Zakrzewski JJ, Tourette International Collaborative Genetics (TIC Genetics), Dietrich A, Gilbert DL, Hoekstra PJ, Kim YS, Kuperman S, Rosen A, Zinner SH, Bouhaddou M, King RA, Rouleau G, Ressler KJ, Mathews CA, Krogan NJ, Sestan N, Tischfield JA, Lee AM, Heiman GA, Fernandez TV, Willsey AJ, State MW Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.  View on PubMed
  11. Shriver LP, Polacco BJ, Eckhardt M, Chang MW, Martínez-Romero C, Adkins-Travis K, Cahalane C, Haas K, Stein DA, Fourati S, Martin-Sancho L, Metreveli G, Johnson JR, Muñoz-Moreno R, Newton BW, Kaake RM, Zhou Y, Jimenez-Morales D, VonDollen J, Verschueren E, Swaney DL, Nguyen TT, Stevenson EJ, Stancliffe E, Patti GJ, Albrecht R, Moulton HM, Pache L, Sekaly RP, Benner C, Hultquist JF, Chanda SK, Garcia-Sastre A, Krogan NJ Integrative multi-omics analysis in vivo identifies influenza virus host factors.  View on PubMed
  12. Uwase G, Luthra P, Vogel OA, Batra J, La Rosa BA, Sheehan KCF, Khatavkar O, Payton JE, Davey RA, Krogan NJ, Basler CF, Leung DW, Amarasinghe GK Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.  View on PubMed
  13. CJ San Felipe, Jyoti Batra, Monita Muralidharan, Shivali Malpotra, Durga Anand, Rachel Bauer, Kliment A Verba, Danielle L Swaney, Nevan J Krogan, Michael Grabe, James S Fraser Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.  View on PubMed
  14. San Felipe CJ, Batra J, Muralidharan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.  View on PubMed
  15. Akinsanya K, AlQuraishi M, Boija A, Chodera J, Cichonska A, Ghassemi M, Head M, Jin W, Kibbe WA, Krogan N, LeVine MV, Moult J, Stuart L, Tourassi G, Zou J, Barzilay R, Elemento O Redefining druggable targets with artificial intelligence.  View on PubMed
  16. Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Gordon M, Malpotra S, Cupic A, Kehrer T, Moen JM, Winters DM, Rojc A, Mena I, Aslam S, Martinez-Romero C, Conde Viñas I, Khalil Z, Farrugia K, Banerjee A, Tussia-Cohen D, Santos MD, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, Felipe CS, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi R, Ibáñez C, Juste J, Pache L, Taha TY, Jouvenet N, Verba KA, Fraser JS, Demeret C, Stroud RM, van Bakel H, Ott M, Hagai T, Polacco B, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication.  View on PubMed
  17. Uwase G, Luthra P, Vogel OA, Batra J, La Rosa BA, Sheehan KCF, Khatavkar O, Payton JE, Davey RA, Krogan NJ, Basler CF, Leung DW, Amarasinghe GK Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.  View on PubMed
  18. Wang S, Kovalski JR, Zapatero-Belinchón FJ, Bennett M, Kuzuoglu-Öztürk D, Li Q, Stevenson E, Liu J, Krogan NJ, Ott M, Swaney DL, Ruggero D, Lou K, Shokat KM Programmable translational inhibition by a molecular glue-oligonucleotide conjugate.  View on PubMed
  19. Vasudevan HN, Arang N, Sacconi Nunez M, Kennedy P, Payne E, Mohabeer S, Chien J, Wright A, Sale MJ, Krogan NJ, Forget A, McCormick F A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system.  View on PubMed
  20. Meyerhöfer N, Krogan NJ, Polacco BJ, Blumenthal DB Inference of differential kinase interaction networks with KINference.  View on PubMed

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