Research Summary

I am an Assistant Professor in the Department of Radiology and Biomedical Imaging at UCSF focused on developing MRI methods that provide novel information about tissue structure and function that are not accessible by other clinical imaging modalities. My background is primarily in MR pulse sequence development, including MR physics, RF pulse design, acquisition strategies, and reconstruction techniques, beginning in 2003 under the advising of Profs. Dwight Nishimura and John Pauly at Stanford University. I came to UCSF as a post-doc in 2007 under Prof. Daniel Vigneron and joined the faculty in 2011.

A major focus of my research program is hyperpolarized carbon-13 metabolic magnetic resonance imaging (MRI) methods, and I am part of the team at UCSF translating this modality into human studies of cancer. The technology has the potential to improve staging of cancer and monitoring treatment response by measuring real-time conversion in key metabolic pathways. I develop the MRI data acquisition and image reconstruction methodologies for these studies.

Research Funding

  • July 1, 2018 - June 30, 2022 - Imaging Metabolism and Cellular Transport in Cancer, Principal Investigator. Sponsor: American Cancer Society, Sponsor Award ID: 131715-RSG-18-005-01-CCE
  • April 15, 2018 - March 31, 2022 - MRI methods for high resolution imaging of the lung, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL136965
  • September 17, 2014 - May 31, 2018 - Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and Metabolism, Principal Investigator. Sponsor: NIH/NIBIB, Sponsor Award ID: R01EB016741
  • April 1, 2016 - March 31, 2018 - Novel Ultrashort Echo Time Sequences for Brain MRI, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R21NS089004

Education

Stanford University, Stanford, CA, B.S., 06/02, Electrical Engineering and Mathematics
Stanford University, Stanford, CA, M.S., 06/03, Electrical Engineering
Stanford University, Stanford, CA, Ph.D., 09/07, Electrical Engineering
University of California – San Francisco, San Francisco, CA, Postdoctoral, 09/07-08/11, Radiology and Biomedical Imaging

Honors & Awards

  • 1998
    IEEE Wescon Scholarship - 2nd Place
  • 1998
    RC Byrd Honors Scholarship
  • 2003
    National Science Foundation Graduate Fellowship - Honorable Mention
  • 2005
    International Society for Magnetic Resonance in Medicine Annual Meeting Poster Award – 2nd place, Pulse sequences category
  • 2006
    Myelin Imaging Conference Poster Award – Accompanied by proffered talk
  • 2009
    Surbeck Scholar Award – 2nd place
  • 2009
    Outstanding Poster Award – UCSF Dept. of Radiology and Biomedical Imaging Research Symposium
  • 2010
    Surbeck Scholar Award – 1st place
  • 2011
    Surbeck Scholar Award – 1st place
  • 2011
    International Society for Magnetic Resonance in Medicine (ISMRM) Junior Fellow
  • 2010,2011,2012
    Magnetic Resonance in Medicine (MRM) Distinguished Reviewer

Selected Publications

  1. Dwork N, Gordon JW, Tang S, O'Connor D, Hansen ESS, Laustsen C, Larson PEZ Di-chromatic interpolation of magnetic resonance metabolic images.  View on PubMed
  2. Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, Sriram R Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.  View on PubMed
  3. Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM Non-invasive assessment of telomere maintenance mechanisms in brain tumors.  View on PubMed
  4. Dwork N, Baron CA, Johnson EMI, O'Connor D, Pauly JM, Larson PEZ Fast variable density Poisson-disc sample generation with directional variation for compressed sensing in MRI.  View on PubMed
  5. Francesco Calivá, Andrew P. Leynes, Rutwik Shah, Upasana Upadhyay Bharadwaj, Sharmila Majumdar, Peder E. Z. Larson, Valentina Pedoia Proceedings of Machine Learning Research  View on PubMed
  6. Scholey JE, Chandramohan D, Naren T, Liu W, Larson PEZ, Sudhyadhom A Technical Note: A methodology for improved accuracy in stopping power estimation using MRI and CT.  View on PubMed
  7. Boucneau T, Fernandez B, Larson P, Darrasse L, Maître X Publisher Correction: 3D Magnetic Resonance Spirometry.  View on PubMed
  8. Murthy V, Smith RL, Tao DH, Lawhn-Heath CA, Korenchan DE, Larson PEZ, Flavell RR, Hope TA 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality.  View on PubMed
  9. Walker CM, Gordon JW, Xu Z, Michel KA, Li L, Larson PEZ, Vigneron DB, Bankson JA Slice profile effects on quantitative analysis of hyperpolarized pyruvate.  View on PubMed
  10. Ohliger MA, Gordon JW, Carvajal L, Larson PEZ, Ou JJ, Agarwal S, Zhu Z, Vigneron DB, von Morze C 55 Mn-based fiducial markers for rapid and automated RF coil localization for hyperpolarized 13 C MRI.  View on PubMed
  11. Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI.  View on PubMed
  12. Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma.  View on PubMed
  13. Boucneau T, Fernandez B, Larson P, Darrasse L, Maître X 3D Magnetic Resonance Spirometry.  View on PubMed
  14. Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI.  View on PubMed
  15. Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model.  View on PubMed
  16. Batsios G, Najac C, Cao P, Viswanath P, Subramani E, Saito Y, Gillespie AM, Yoshihara HAI, Larson P, Sando S, Ronen SM In vivo detection of ?-glutamyl-transferase up-regulation in glioma using hyperpolarized ?-glutamyl-[1-13C]glycine.  View on PubMed
  17. Ong F, Zhu X, Cheng JY, Johnson KM, Larson PEZ, Vasanawala SS, Lustig M Extreme MRI: Large-scale volumetric dynamic imaging from continuous non-gated acquisitions.  View on PubMed
  18. Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco.  View on PubMed
  19. Chandramohan D, Cao P, Han M, An H, Sunderland JJ, Kinahan PE, Laforest R, Hope TA, Larson PEZ Bone material analogues for PET/MRI phantoms.  View on PubMed
  20. Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner.  View on PubMed

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