Research Funding

  • December 18, 2009 - November 30, 2011 - Role of regulation of eukaryotic DNA replication in preserving genome stability, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM059704
  • June 28, 2002 - June 27, 2003 - Yeast Chromosome Structure, Replication and Segregation, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R13CA094910
  • December 18, 2009 - November 30, 2011 - Role of regulation of eukaryotic DNA replication in preserving genome stability, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM059704
  • June 28, 2002 - June 27, 2003 - Yeast Chromosome Structure, Replication and Segregation, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R13CA094910

Education

University of Chicago, Chicago, IL, B.S., M.S., 1980, Chemistry Johns Hopkins University School of Medicine, Baltimore, MD, M.D., Ph.D., 1988, Medicine/Molecular Biology

Honors & Awards

  • 1977
    United States Presidential Scholar
  • 1979
    Phi Beta Kappa
  • 1979-1980
    National Science Foundation Graduate Fellow
  • 1987
    Michael A. Shanoff Research Award for Ph.D. Thesis, Johns Hopkins University School of Medicine
  • 1989-1990
    Squibb Fellow, Life Sciences Research Foundation
  • 1990-1997
    Markey Scholar Award
  • 1994-1999
    Rita Allen Scholar
  • 1995-1998
    Searle Scholar
  • 1998
    Distinction in Teaching Award, UCSF

Selected Publications

  1. Bui DT, Li JJ. DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis. Genetics. 2019 06; 212(2):445-460.  View on PubMed
  2. Hanlon SL, Li JJ. Re-replication of a centromere induces chromosomal instability and aneuploidy. PLoS Genet. 2015 Apr; 11(4):e1005039.  View on PubMed
  3. Richardson CD, Li JJ. Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. PLoS Genet. 2014 Jun; 10(6):e1004358.  View on PubMed
  4. Finn KJ, Li JJ. Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. PLoS Genet. 2013; 9(1):e1003192.  View on PubMed
  5. Green BM, Finn KJ, Li JJ. Loss of DNA replication control is a potent inducer of gene amplification. Science. 2010 Aug 20; 329(5994):943-6.  View on PubMed
  6. Moses AM, Liku ME, Li JJ, Durbin R. Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17713-8.  View on PubMed
  7. Green BM, Morreale RJ, Ozaydin B, Derisi JL, Li JJ. Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell. 2006 May; 17(5):2401-14.  View on PubMed
  8. Liku ME, Nguyen VQ, Rosales AW, Irie K, Li JJ. CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication. Mol Biol Cell. 2005 Oct; 16(10):5026-39.  View on PubMed
  9. Green BM, Li JJ. Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol Biol Cell. 2005 Jan; 16(1):421-32.  View on PubMed

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