Research Summary
We are developing novel cancer-specific therapeutic targets within the non-coding genome to treat human glioma.Research Funding
- July 1, 2022 - June 30, 2027 - Functional long noncoding RNAs in neural development , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01NS124881
- October 1, 2009 - September 30, 2026 - Chromatin-based regulation of neural stem cells , Principal Investigator . Sponsor: VA, Sponsor Award ID: I01BX000252
- July 15, 2020 - April 30, 2025 - Understanding the neurodevelopmental role and mechanism of histone demethylase JMJD3 , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01NS112357
- March 15, 2022 - February 29, 2024 - A new model for understanding a brain tumor epigenetic driver , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21NS126978
Education
University of California, Berkeley, B.A., 05/1994, Biochemistry
The Rockefeller University, Ph.D., 06/2001, Neurobiology
Cornell Medical College, M.D., 06/2002, Medicine
University of California, San Francisco, Postdoctoral, 06/2007, Epigenetics/Stem cells
University of California, San Francisco, Residency, 06/2008, Neurological Surgery
Honors & Awards
- 1990
National Merit scholarship - 1990-1994
University of California, Regent's scholarship - 2009-2013
Sontag Foundation Distinguished Researcher Award - 2009-2014
NIH Director's New Innovator Award - 2010
Kavli Fellow, U.S. National Academy of Sciences
Selected Publications
- Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA. Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1. Science. 2020 Apr 3;368(6486):48-53.
View on PubMed - Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA. CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Genome Biol. 2020 Mar 31;21(1):83.
View on PubMed - Andersen RE, Hong SJ, Lim JJ, Cui M, Harpur BA, Hwang E, Delgado RN, Ramos AD, Liu SJ, Blencowe BJ, Lim DA. The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo. Dev Cell. 2019 May 20;49(4):632-642.e7.
View on PubMed - Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 Jan 6;355(6320):aah7111.
View on PubMed - Mueller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25;12(11):889.
View on PubMed - Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14;17:67.
View on PubMed - Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein AR, Lim DA. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell. 2015 Apr 2;16(4):439-447.
View on PubMed - Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim DA. Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis. Cell Rep. 2014 Sep 11;8(5):1290-9.
View on PubMed - Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA. Distinct and separable roles for EZH2 in neurogenic astroglia. Elife. 2014 May 27;3:e02439.
View on PubMed - Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim DA. Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo. Cell Stem Cell. 2013 May 2;12(5):616-28.
View on PubMed