My laboratory is interested in the logic of cell signaling systems: understanding how the networks of signaling proteins found in eukaryotic cells have evolved to allow cells to make complex behavioral decisions. We use two broad approaches to attack this problem. First we use biochemistry, cell biology, genetics, and computational biology to dissect the mechanisms of signaling proteins and networks. We are particularly interested in understanding how nature's toolkit of modular domains are recombined through evolution to generate new and diverse response behaviors. Second, we use synthetic biology: the redesign of biological systems. In particular, we are using various methods to create novel or modified signaling proteins and pathways, both to systematically understand network structure/function relationships and to develop engineered research tools and novel biotechnological and therapeutic applications.
September 10, 2021 - August 31, 2026 - Synthetic circuits that drive infiltration of therapeutic T cells into immunologically cold tumors , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA265697
April 1, 2021 - March 31, 2026 - Synthetic epigenetic circuits: tunable cell fate switches controlled by dynamic and combinatorial inputs , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA253017
December 1, 2020 - November 30, 2025 - Recognizing the tumor ecosystem: Integrating stromal and cancer antigen signals to achieve precision recognition of solid tumors by CAR T cells , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA249018
September 24, 2019 - August 31, 2024 - UCSF Center for Synthetic Immunology: Tools to Reprogram the Immune System to Combat Cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54CA244438
Harvard University, Cambridge, MA, AB, 1986, Chemistry
Mass. Institute of Technology, Cambridge, MA, PhD, 1991, Biochem & Biophysics
Yale University, New Haven, CT, Postdoc, 1992-1996, Biophysics & Biochem