I am an Assistant Professor in the Department of Neurological Surgery at University of California, San Francisco (UCSF). Our lab focuses on identifying molecular mechanisms mediating immune suppression and evasion in brain tumors, with the goal of developing novel immunotherapeutics for these diseases. My recent research identified that protein phosphatase 2A negatively regulated T cell and macrophage mediated anti-tumor immunity, and further demonstrated that pharmacological inhibition of PP2A synergized with PD-1 blockade in multiple type of resistant tumors including glioblastoma. Based on those findings, a Phase I/II trial (NCT03027388) of PP2A inhibitor in recurrent glioblastoma is ongoing.
September 1, 2022 - August 31, 2027 - Regulation of Macrophage- and Microglia-mediated STING Signaling in Glioblastoma , Principal Investigator . Sponsor: NIH/NINDS, Sponsor Award ID: RO1NS126501
July 15, 2020 - July 15, 2024 - Targeting Protein Phosphatase 2A (PP2A) to Overcome Macrophage-Mediated Immunosuppression in Glioblastoma , Principal Investigator . Sponsor: DOD PRCRP, Sponsor Award ID: W81XWH-20-1-0428
September 1, 2021 - September 1, 2023 - Role of Aberrant Translational Quality Control in Tumorigenesis in Glioblastoma , Principal Investigator . Sponsor: Cancer Prevention and Research Institute of Texas, Sponsor Award ID: RP210068
October 1, 2021 - September 30, 2022 - Focused Ultrasound Induced Optogenetic Activation of CAR-Macrophage for Glioblastoma , Principal Investigator . Sponsor: MDAnderson-UT Austin Collaborative Pilot Project Grant, Sponsor Award ID: