Research Summary

I am an Assistant Professor in the Department of Neurological Surgery at University of California, San Francisco (UCSF). Our lab focuses on identifying molecular mechanisms mediating immune suppression and evasion in brain tumors, with the goal of developing novel immunotherapeutics for these diseases. My recent research identified that protein phosphatase 2A negatively regulated T cell and macrophage mediated anti-tumor immunity, and further demonstrated that pharmacological inhibition of PP2A synergized with PD-1 blockade in multiple type of resistant tumors including glioblastoma. Based on those findings, a Phase I/II trial (NCT03027388) of PP2A inhibitor in recurrent glioblastoma is ongoing.

Research Funding

  • September 1, 2022 - August 31, 2027 - Regulation of Macrophage- and Microglia-mediated STING Signaling in Glioblastoma , Principal Investigator . Sponsor: NIH/NINDS, Sponsor Award ID: RO1NS126501
  • July 15, 2020 - July 15, 2024 - Targeting Protein Phosphatase 2A (PP2A) to Overcome Macrophage-Mediated Immunosuppression in Glioblastoma , Principal Investigator . Sponsor: DOD PRCRP, Sponsor Award ID: W81XWH-20-1-0428
  • September 1, 2021 - September 1, 2023 - Role of Aberrant Translational Quality Control in Tumorigenesis in Glioblastoma , Principal Investigator . Sponsor: Cancer Prevention and Research Institute of Texas, Sponsor Award ID: RP210068
  • October 1, 2021 - September 30, 2022 - Focused Ultrasound Induced Optogenetic Activation of CAR-Macrophage for Glioblastoma , Principal Investigator . Sponsor: MDAnderson-UT Austin Collaborative Pilot Project Grant, Sponsor Award ID:

Education

Ph.D., 06/2011 - Cancer Immunology, City of Hope

Honors & Awards

  • DOD Peer Reviewed Cancer Research Program Career Development Award, Department of Defense, 2020
  • Keystone Early Career Investigator Award, Keystone Conference, 2020
  • H.N. and Frances C. Berger Foundation Fellowship, City of Hope, 2008

Selected Publications

  1. Xue X, Li Q, Wang Y, Lu R, Han J, Zhang H, Xu X, Tao W, Ma T, Li Y, Wang H, Hua Y. Impaired corticospinal tract in chronic ankle instability: A diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) study at 7.0 Tesla. J Sci Med Sport. 2022 Aug; 25(8):649-654.  View on PubMed
  2. Huang Y, Wan Z, Tang Y, Xu J, Laboret B, Nallamothu S, Yang C, Liu B, Lu RO, Lu B, Feng J, Cao J, Hayflick S, Wu Z, Zhou B. Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism. Nat Commun. 2022 05 03; 13(1):2412.  View on PubMed
  3. Contreras-Trujillo H, Eerdeng J, Akre S, Jiang D, Contreras J, Gala B, Vergel-Rodriguez MC, Lee Y, Jorapur A, Andreasian A, Harton L, Bramlett CS, Nogalska A, Xiao G, Lee JW, Chan LN, Müschen M, Merchant AA, Lu R. Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses. Nat Commun. 2021 11 11; 12(1):6522.  View on PubMed
  4. Wu Z, Ho WS, Lu R. Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy. Neuromolecular Med. 2022 03; 24(1):18-22.  View on PubMed
  5. Ma H, Nie C, Chen Y, Li J, Xie Y, Tang Z, Gao Y, Ai S, Mao Y, Sun Q, Lu R. Therapeutic Targeting PLK1 by ON-01910.Na Is Effective in Local Treatment of Retinoblastoma. Oncol Res. 2021 Sep 07; 28(7):745-761.  View on PubMed
  6. Lu RO, Ho WS. Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer. Front Cell Dev Biol. 2020; 8:620788.  View on PubMed
  7. Chatterjee I, Lu R, Zhang Y, Zhang J, Dai Y, Xia Y, Sun J. Vitamin D receptor promotes healthy microbial metabolites and microbiome. Sci Rep. 2020 04 30; 10(1):7340.  View on PubMed
  8. Maggio D, Ho WS, Breese R, Walbridge S, Wang H, Cui J, Heiss JD, Gilbert MR, Kovach JS, Lu RO, Zhuang Z. Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma. J Neurooncol. 2020 Jun; 148(2):231-244.  View on PubMed
  9. Fan X, Wu C, Truitt LL, Espinoza DA, Sellers S, Bonifacino A, Zhou Y, Cordes SF, Krouse A, Metzger M, Donahue RE, Lu R, Dunbar CE. Clonal tracking of erythropoiesis in rhesus macaques. Haematologica. 2020 07; 105(7):1813-1824.  View on PubMed
  10. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Group. Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 Jul 04; 7(1):167.  View on PubMed
  11. Zhang J, Li K, Zhang Y, Lu R, Wu S, Tang J, Xia Y, Sun J. Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo. BMC Cancer. 2019 Jun 10; 19(1):555.  View on PubMed
  12. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Group. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 05 22; 7(1):131.  View on PubMed
  13. Espinoza DA, Fan X, Yang D, Cordes SF, Truitt LL, Calvo KR, Yabe IM, Demirci S, Hope KJ, Hong SG, Krouse A, Metzger M, Bonifacino A, Lu R, Uchida N, Tisdale JF, Wu X, DeRavin SS, Malech HL, Donahue RE, Wu C, Dunbar CE. Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque. Mol Ther. 2019 06 05; 27(6):1074-1086.  View on PubMed
  14. Zhang YG, Zhu X, Lu R, Messer JS, Xia Y, Chang EB, Sun J. Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy. Autophagy. 2019 11; 15(11):1935-1953.  View on PubMed
  15. Cao T, Liccardo D, LaCanna R, Zhang X, Lu R, Finck BN, Leigh T, Chen X, Drosatos K, Tian Y. Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice. Front Cell Dev Biol. 2019; 7:42.  View on PubMed
  16. Guo C, Liu F, Qi J, Ma J, Lin S, Zhang C, Zhang Q, Zhang H, Lu R, Li X. A Novel Synthetic Dihydroindeno[1,2-b] Indole Derivative (LS-2-3j) Reverses ABCB1- and ABCG2-Mediated Multidrug Resistance in Cancer Cells. Molecules. 2018 Dec 10; 23(12).  View on PubMed
  17. Tian J, Tang W, Xu M, Zhang C, Zhao P, Cao T, Shan X, Lu R, Guo W. Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder. Cell Physiol Biochem. 2018; 50(5):1726-1739.  View on PubMed
  18. Che X, Lu R, Fu Z, Sun Y, Zhu ZF, Li JP, Wang S, Jia J, Wang Q, Yao Z. Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9. Drug Des Devel Ther. 2018; 12:3357-3368.  View on PubMed
  19. Lin S, Liu K, Zhang Y, Jiang M, Lu R, Folts CJ, Gao X, Noble MD, Zhao T, Zhou Z, Lan X, Que J. Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma. Cell Signal. 2018 11; 51:222-232.  View on PubMed
  20. Danaher P, Warren S, Lu R, Samayoa J, Sullivan A, Pekker I, Wallden B, Marincola FM, Cesano A. Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA). J Immunother Cancer. 2018 06 22; 6(1):63.  View on PubMed

Go to UCSF Profiles, powered by CTSI