Education

11/2015 - Hematology/Oncology Fellowship, UCSF
10/2012 - Internal Medicine Residency, Stanford University Hospital and Clinics
MD, 06/2009 - , Stanford University School of Medicine
BS, 05/2000 - Neuroscience, Davidson College

Selected Publications

  1. Jacob S, Christofferson A, Fisch S, Norwood P, Castillo P, Yu H, Hirst G, Soliman H, Nanda R, Mukhtar RA, Ewing C, Majure M, Melisko M, Rugo HS, Esserman L, Price E, Chien AJ. Regional lymph node changes on breast MRI in patients with early-stage breast cancer receiving neoadjuvant chemo-immunotherapy. Breast Cancer Res Treat. 2025 Jan; 209(1):147-159.  View on PubMed
  2. K.H. Natsuhara, M. Vella, S.C. Behr, L. Quintal, J. Chien, M.E. Melisko, M. Majure, G.C. Buckle, A.H. Ko, H.S. Rugo. 381P Treatment rechallenge after grade 1 trastuzumab-deruxtecan related interstitial lung disease: A real-world experience. Annals of Oncology. 2024 Sep 1; 35:s378.  View on PubMed
  3. Huppert LA, Fisch S, Tsopurashvili E, Somepalle SS, Salans M, Vasudevan HN, Jo Chien A, Majure M, Rugo HS, Balassanian R, Boreta L, Melisko ME. Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study. Breast Cancer Res Treat. 2024 Aug; 206(3):625-636.  View on PubMed
  4. Samantha Catherine Fisch, Elene Tsopurashvili, Sai Sahitha Somepalle, Mia Salans, Harish Vasudevan, Amy Jo Chien, Melanie Majure, Hope S. Rugo, Ronald Balassanian, Lauren Boreta, Michelle E. Melisko, Laura Ann Huppert. A single center retrospective cohort study of patients with metastatic breast cancer and leptomeningeal disease: Updated survival data and subgroup analyses by breast cancer subtype. Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):1108-1108.  View on PubMed
  5. Laura Huppert, Lindy Her, Christine Hodgdon, Susie Brain, Carol Simmons, Jo Chien, Melanie Majure, Hope Rugo, Mark Jesus Magbanua, Ron Balassanian, Michelle Melisko. Abstract PS11-03: Comparison of next-generation sequencing (NGS) results from the cerebrospinal fluid, peripheral blood, and systemic metastatic tumor tissue of patients with metastatic breast cancer (MBC) and leptomeningeal disease (LMD). Cancer Research. 2024 May 2; 84(9_Supplement):ps11-03-ps11-03.  View on PubMed
  6. Saya Jacob, Samantha Fisch, Carolyn Face, Laura Huppert, Zoe Quandt, Laura Quintal, Michelle Melisko, Melanie Majure, Jo Chien, Anne Blaes, Hope Rugo. Abstract PS14-03: Delayed and post-treatment immune toxicities in patients with breast cancer receiving immune checkpoint inhibitors. Cancer Research. 2024 May 2; 84(9_Supplement):ps14-03-ps14-03.  View on PubMed
  7. Umashankar S, Li M, Blevins K, Kim MO, Majure M, Park J, Huppert LA, Melisko M, Rugo HS, Esserman L, Chien AJ. Characterizing attitudes related to future child-bearing in young women diagnosed with early-stage breast cancer. Breast Cancer Res Treat. 2024 Apr; 204(3):509-520.  View on PubMed
  8. Gumusay O, Huppert LA, Magbanua MJM, Wabl CA, Assefa M, Chien AJ, Melisko ME, Majure MC, Moasser M, Park J, Rugo HS. A phase Ib/II study of eribulin in combination with cyclophosphamide in patients with advanced breast cancer. Breast Cancer Res Treat. 2024 Jan; 203(2):197-204.  View on PubMed
  9. Saya Jacob, Zoe Quandt, Michelle E. Melisko, Melanie Majure, Amy Jo Chien, Anne Hudson Blaes, Diane Heditsian, Laura Esserman, Hope S. Rugo. Delayed immune toxicities in patients with breast cancer receiving immune checkpoint inhibitors. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):e24091-e24091.  View on PubMed
  10. Laura Ann Huppert, Elene Tsopurashvili, Sai Sahitha Somepalle, Amy Jo Chien, Melanie Majure, Hope S. Rugo, Ronald Balassanian, Michelle E. Melisko. Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: A single center retrospective cohort study. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):1108-1108.  View on PubMed
  11. Laura Ann Huppert, Amelia S Gliwa, Madeline Tait, Laura Quintal, Stephanie Starzinski, Alexander Cheung, Mark M. Moasser, Melanie Majure, Michelle E. Melisko, Hope S. Rugo, Pamela N. Munster, Michael J. Campbell, Lawrence Fong, Amy Jo Chien. Phase Ib study of talimogene laherparepvec (T-VEC) in combination with chemotherapy (CT) or endocrine therapy (ET) in patients with metastatic, unresectable, or locoregionally recurrent HER2-negative breast cancer (BC). Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):1091-1091.  View on PubMed
  12. Huppert LA, Walker Z, Li M, Kim MO, Callan J, Brandman D, Majure M, Melisko ME, Rugo HS, Behr S, Chien AJ. Clinical characteristics and outcomes in patients with metastatic breast cancer and pseudocirrhosis: a single center retrospective cohort study. Breast Cancer Res Treat. 2023 Jan; 197(1):137-148.  View on PubMed
  13. Laura Ann Huppert, Zak Walker, Moming Li, Mi-Ok Kim, Jennie Callan, Melanie Majure, Michelle E. Melisko, Hope S. Rugo, Spencer Behr, Amy Jo Chien. Clinical and radiographic characteristics of patients with metastatic breast cancer and pseudocirrhosis: A single-center retrospective cohort study. Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):1101-1101.  View on PubMed
  14. Yee D, Isaacs C, Wolf DM, Yau C, Haluska P, Giridhar KV, Forero-Torres A, Jo Chien A, Wallace AM, Pusztai L, Albain KS, Ellis ED, Beckwith H, Haley BB, Elias AD, Boughey JC, Kemmer K, Yung RL, Pohlmann PR, Tripathy D, Clark AS, Han HS, Nanda R, Khan QJ, Edmiston KK, Petricoin EF, Stringer-Reasor E, Falkson CI, Majure M, Mukhtar RA, Helsten TL, Moulder SL, Robinson PA, Wulfkuhle JD, Brown-Swigart L, Buxton M, Clennell JL, Paoloni M, Sanil A, Berry S, Asare SM, Wilson A, Hirst GL, Singhrao R, Asare AL, Matthews JB, Hylton NM, DeMichele A, Melisko M, Perlmutter J, Rugo HS, Fraser Symmans W, Van't Veer LJ, Berry DA, Esserman LJ. Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer. NPJ Breast Cancer. 2021 Oct 05; 7(1):131.  View on PubMed
  15. Saumya Umashankar, Moming Li, Mi-Ok Kim, Hope S. Rugo, Michelle E. Melisko, Melanie Majure, John Park, Laura Esserman, Amy Jo Chien. Characterizing attitudes related to child-bearing in young women diagnosed with early breast cancer (EBC). Journal of Clinical Oncology. 2021 Oct 1; 39(28_suppl):165-165.  View on PubMed
  16. Ozge Gumusay, Mark Jesus M. Magbanua, Melanie C. Majure, Travis Deal, Jonathan R. Renslo, Chiara A. Wabl, Michelle E. Melisko, A. Jo Chien, Andrei Goga, Mark M. Moasser, John W. Park, Jimmy Hwang, Hope S. Rugo. Abstract PS2-19: Circulating tumor cell (CTC) enumeration in a phase II trial of pazopanib in addition to endocrine therapy in patients with hormone resistant advanced breast cancer (ABC). Cancer Research. 2021 Feb 15; 81(4_Supplement):ps2-19-ps2-19.  View on PubMed
  17. Amy Jo Chien, Amelia S Gliwa, Siti Rahmaputri, Heidi F Dittrich, Melanie Catherine Majure, Hope S. Rugo, Michelle E. Melisko, Pamela N. Munster, John W. Park, Mark M. Moasser, Mehrdad Matloubian, Tasha Lea, Julia Rohrberg, Gregor Krings, Andrei Goga. A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):1076-1076.  View on PubMed
  18. Ozge Gumusay, Jonathan R. Renslo, Chiara A. Wabl, Amy Jo Chien, Michelle E. Melisko, Melanie Catherine Majure, Siti D. Rahmaputri, Mark Moasser, John Park, Hope S. Rugo. A phase Ib/II study of eribulin with cyclophosphamide (EC) in patients (pts) with advanced breast cancer (ABC). Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):e13079-e13079.  View on PubMed
  19. Ozge Gumusay, Melanie Catherine Majure, Travis Deal, Jonathan R. Renslo, Chiara A. Wabl, Michelle E. Melisko, Amy Jo Chien, Andrei Goga, Mark Moasser, John Park, Jimmy Hwang, Hope S. Rugo. Pazopanib (PZ) plus endocrine therapy as treatment for hormone resistant advanced breast cancer (ABC). Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):1068-1068.  View on PubMed
  20. Nanda R, Liu MC, Yau C, Shatsky R, Pusztai L, Wallace A, Chien AJ, Forero-Torres A, Ellis E, Han H, Clark A, Albain K, Boughey JC, Jaskowiak NT, Elias A, Isaacs C, Kemmer K, Helsten T, Majure M, Stringer-Reasor E, Parker C, Lee MC, Haddad T, Cohen RN, Asare S, Wilson A, Hirst GL, Singhrao R, Steeg K, Asare A, Matthews JB, Berry S, Sanil A, Schwab R, Symmans WF, van 't Veer L, Yee D, DeMichele A, Hylton NM, Melisko M, Perlmutter J, Rugo HS, Berry DA, Esserman LJ. Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial. JAMA Oncol. 2020 05 01; 6(5):676-684.  View on PubMed

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