Research Summary

Dr. Michael Mann is a cardiothoracic surgeon with particular interests in coronary bypass surgery, valve disease, aortic reconstruction, surgery for heart failure and thoracic cancer.

Mann's research interests include developing molecular therapies – treatments that target specific cells involved in disease – for disorders of the heart and lungs. While on the faculty at Harvard Medical School, he designed and directed the first clinical program for genetic manipulation during bypass surgery.

Mann earned his medical degree at the Stanford University School of Medicine. He completed a residency at Stanford Medicine and Brigham and Women's Hospital in Boston, followed by a fellowship at UCSF.

Research Funding

  • December 1, 2005 - April 30, 2017 - ERK Signaling and a Hybrid Surgical/Molecular Approach for Chronic Heart Failure , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL083118
  • April 1, 2006 - March 31, 2012 - The role of S1P signaling in surgical cardiac remodeling , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08HL079239
  • October 28, 1993 - January 1, 1900 - GROWTH FACTOR EXPRESSION IN VEIN GRAFT STENOSIS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: F32HL008850

Education

  • Residency, 2003 - Cardiothoracic Surgery, University of California, San Francisco
  • Residency, 2001 - General Surgery, Harvard Medical School/Brigham and Women's Hospital
  • M.D., 1991 - School of Medicine, Stanford University
  • AB, 1985 - Chemistry, Princeton University

Selected Publications

  1. Kristjansson AL, Mann MJ, Smith ML, Kogan SM, Lilly CL, James JE. Caffeine consumption and onset of alcohol use among early adolescents. Prev Med. 2022 10; 163:107208.  View on PubMed
  2. Kratz JR, Li JZ, Tsui J, Lee JC, Ding VW, Rao AA, Mann MJ, Chan V, Combes AJ, Krummel MF, Jablons DM. Genetic and immunologic features of recurrent stage I lung adenocarcinoma. Sci Rep. 2021 12 08; 11(1):23690.  View on PubMed
  3. Gupta AR, Woodard GA, Jablons DM, Mann MJ, Kratz JR. Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay. Future Oncol. 2021 Dec; 17(34):4785-4795.  View on PubMed
  4. Woodard GA, Kratz JR, Haro G, Gubens MA, Blakely CM, Jones KD, Mann MJ, Jablons DM. Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early-Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit From Adjuvant Chemotherapy. Clin Lung Cancer. 2021 11; 22(6):587-595.  View on PubMed
  5. Woodard GA, Fels Elliott DR, Yap A, Haro GJ, Kratz JR, Mann MJ, Jones KD, Jablons DM. Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity. Ann Surg Oncol. 2021 Sep; 28(9):4953-4959.  View on PubMed
  6. G. Woodard, J. Kratz, G. Haro, M. Gubens, C. Blakely, K. Jones, M. Mann, D. Jablons. MO01.13 Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit from Adjuvant Chemotherapy. Journal of Thoracic Oncology. 2021 Jan 1; 16(1):s21.  View on PubMed
  7. Haro GJ, Sheu B, Cook NR, Woodard GA, Mann MJ, Kratz JR. Comparison of Conventional TNM and Novel TNMB Staging Systems for Non-Small Cell Lung Cancer. JAMA Netw Open. 2019 12 02; 2(12):e1917062.  View on PubMed
  8. G. Woodard, V. Ding, I. Kim, K. Jones, G. Chavez, G. Haro, J. Kratz, M. Mann, J. Rotow, C. Blakely, D. Jablons. MA06.09 Timing of Driver Mutation Development and the Genetic Evolution of Semi-Solid Lung Nodules into Early NSCLC. Journal of Thoracic Oncology. 2019 Oct 1; 14(10):s271-s272.  View on PubMed
  9. Jiang L, Tolani B, Yeh CC, Fan Y, Reza JA, Horvai AE, Xia E, Kratz JR, Jablons DM, Mann MJ. Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma. Cancer Manag Res. 2019; 11:8209-8218.  View on PubMed
  10. Kratz JR, Haro GJ, Cook NR, He J, Van Den Eeden SK, Woodard GA, Gubens MA, Jahan TM, Jones KD, Kim IJ, He B, Jablons DM, Mann MJ. Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. J Thorac Oncol. 2019 07; 14(7):1223-1232.  View on PubMed
  11. G. Woodard, S. Wang, J. Kratz, G. Haro, M. Gubens, C. Blakely, T. Jahan, K. Jones, M. Mann, D. Jablons. P2.16-12 Expanded Data Confirm Molecular Testing Identifies Lung Adenocarcinoma Patients, Including Stage IA, Who Benefit from Adjuvant Chemotherapy. Journal of Thoracic Oncology. 2018 Oct 1; 13(10):s835.  View on PubMed
  12. G. Haro, J. Kratz, N. Cook, J. He, S. Van Den Eeden, G. Woodard, M. Gubens, T. Jahan, K. Jones, I. Kim, B. He, D. Jablons, M. Mann. P3.03-24 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging. Journal of Thoracic Oncology. 2018 Oct 1; 13(10):s919.  View on PubMed
  13. Greg J. Haro, Johannes R. Kratz, David M. Jablons, Michael J. Mann, Jasleen Kukreja. Propensity Matched Analysis of Perioperative Outcomes in Robotic-Assisted Thoracic Surgery, Video Assisted Thoracic Surgery, and Open Lung Resections. Journal of the American College of Surgeons. 2018 Oct 1; 227(4):s53.  View on PubMed
  14. Hoang NT, Acevedo LA, Mann MJ, Tolani B. A review of soft-tissue sarcomas: translation of biological advances into treatment measures. Cancer Manag Res. 2018; 10:1089-1114.  View on PubMed
  15. Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ. Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice. PLoS One. 2017; 12(12):e0188471.  View on PubMed
  16. Yeh CC, Fan Y, Yang YL, Mann MJ. Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect. J Biomed Sci. 2017 Nov 24; 24(1):89.  View on PubMed
  17. Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons DM. Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2018 01; 19(1):58-64.  View on PubMed
  18. Gavitt Woodard, Jane Crockard, Clara Zoon-Besselink, Johannes Kratz, Matthew Gubens, Thierry Jahan, Collin Blakely, Kirk Jones, Michael Mann, David Jablons. OA19.06 Adjuvant Chemotherapy Decisions Based on Molecular Risk Status Improves Outcomes in Early Stage, Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2017 Jan 1; 12(1):s320.  View on PubMed
  19. Johannes Kratz, Nancy Cook, Gavitt Woodard, Kirk Jones, Matthew Gubens, Thierry Jahan, Il-Jin Kim, Biao He, David Jablons, Michael Mann. P1.03-066 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer TNM Staging Topic: Staging. Journal of Thoracic Oncology. 2017 Jan 1; 12(1):s584-s585.  View on PubMed
  20. Fan Y, Yang YL, Yeh CC, Mann MJ. Spacial and Temporal Patterns of Gene Expression After Cardiac MEK1 Gene Transfer Improve Post-Infarction Remodeling Without Inducing Global Hypertrophy. J Cell Biochem. 2017 04; 118(4):775-784.  View on PubMed

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