Research Funding

  • September 24, 2014 - August 31, 2019 - Antibody Research Technology Center, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P41CA196276
  • February 1, 2013 - January 31, 2018 - Generation of therapeutic antibodies to serotype F botulism, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI104579
  • June 20, 2012 - May 31, 2017 - Trispecific monoclonal antibody for botulinum neurotoxin intoxication therapy, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R33AI101539
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource, Co-Investigator. Sponsor: NIH, Sponsor Award ID: P41RR001614

Education

University of California, Berkeley, Biochemistry
University of California, San Francisco, M.D., 1979, Medicine
Medical Research Council, Laboratory of Molecular Biology, Cambridge, England, Ph.D., 1992, Molecular Biology

Honors & Awards

  • (1975)
    Phi Beta Kappa
  • (1979)
    Alpha Omega Alpha
  • (1994)
    Beckman Young Investigator Award
  • (1995, 1996)
    CaPCURE Research Award

Selected Publications

  1. Snow DM, Cobb RR, Martinez J, Finger-Baker I, Collins L, Terpening S, Syar ES, Niemuth N, Kobs D, Barnewall R, Farr-Jones S, Marks JD, Tomic MT A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model.  View on PubMed
  2. Kamoun W, Swindell E, Pien C, Luus L, Cain J, Pham M, Kandela I, Huang ZR, Tipparaju SK, Koshkaryev A, Askoxylakis V, Kirpotin DB, Bloom T, Mino-Kenudson M, Marks JD, Zalutskaya A, Bshara W, Morrison C, Drummond DC Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed Nanotherapeutic.  View on PubMed
  3. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL Cryo-EM Reveals Integrin-Mediated TGF-ß Activation without Release from Latent TGF-ß.  View on PubMed
  4. Fan Y, Barash JR, Conrad F, Lou J, Tam C, Cheng LW, Arnon SS, Marks JD The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA.  View on PubMed
  5. Snow DM, Riling K, Kimbler A, Espinoza Y, Wong D, Pham K, Martinez Z, Kraus CN, Conrad F, Garcia-Rodriguez C, Cobb RR, Marks JD, Tomic MT Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins.  View on PubMed
  6. Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, Dugast AS, Zhang H, Depis F, Feau S, Jakubowski A, Qiao W, Craig G, Razlog M, Qiu J, Zhou Y, Marks JD, Croft M, Drummond DC, Raue A Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity.  View on PubMed
  7. Espinoza Y, Wong D, Ahene A, Der K, Martinez Z, Pham J, Cobb RR, Farr-Jones S, Marks JD, Tomic MT Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats.  View on PubMed
  8. Tomic MT, Espinoza Y, Martinez Z, Pham K, Cobb RR, Snow DM, Earnhart CG, Pals T, Syar ES, Niemuth N, Kobs DJ, Farr-Jones S, Marks JD Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model.  View on PubMed
  9. Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, Wilton JH, Geddie ML, Suchy J, Grabow S, Kohli N, Reynolds CP, Blaydes R, Zhou Y, Sawyer AJ, Marks JD, Drummond DC Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models.  View on PubMed
  10. Lou J, Marks JD Botulinum Neurotoxins (BoNTs)-Antibody and Vaccine.  View on PubMed
  11. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells.  View on PubMed
  12. Wijesuriya SD, Pongo E, Tomic M, Zhang F, Garcia-Rodriquez C, Conrad F, Farr-Jones S, Marks JD, Horwitz AH Antibody engineering to improve manufacturability.  View on PubMed
  13. Garcia-Rodriguez C, Razai A, Geren IN, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes.  View on PubMed
  14. Lou J, Wen W, Conrad F, Meng Q, Dong J, Sun Z, Garcia-Rodriguez C, Farr-Jones S, Cheng LW, Henderson TD, Brown JL, Smith TJ, Smith LA, Cormier A, Marks JD A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A.  View on PubMed
  15. Zhou Y, Zou H, Yau C, Zhao L, Hall SC, Drummond DC, Farr-Jones S, Park JW, Benz CC, Marks JD Discovery of internalizing antibodies to basal breast cancer cells.  View on PubMed
  16. Fan Y, Garcia-Rodriguez C, Lou J, Wen W, Conrad F, Zhai W, Smith TJ, Smith LA, Marks JD A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes.  View on PubMed
  17. Geddie ML, Kohli N, Kirpotin DB, Razlog M, Jiao Y, Kornaga T, Rennard R, Xu L, Schoerberl B, Marks JD, Drummond DC, Lugovskoy AA Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting.  View on PubMed
  18. Peyton C, Yang E, Msall ME, Adde L, Støen R, Fjørtoft T, Bos AF, Einspieler C, Zhou Y, Schreiber MD, Marks JD, Drobyshevsky A White Matter Injury and General Movements in High-Risk Preterm Infants.  View on PubMed
  19. Fan Y, Barash JR, Lou J, Conrad F, Marks JD, Arnon SS Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H.  View on PubMed
  20. Krombach JW, Marks JD, Dubowitz G, Radke OC Development and Implementation of Checklists for Routine Anesthesia Care: A Proposal for Improving Patient Safety.  View on PubMed

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