Research Summary

The long-term goal of the Mattis Lab is to understand molecular mechanisms in medical liver diseases especially non-alcoholic fatty liver disease. To better understand liver diseases, the laboratory is using patient fibroblast cell lines, reprogrammed to induced pluripotent stem cells (iPSCs) and differentiating these to liver cells including hepatocytes, cholangiocytes, and experimentally to other cellular lineages. Cell culture experiments underway in the Mattis lab focus on identifying unique pathways in these diseases that drive mechanisms of disease. Our lab has other small projects including cholangiocarcinoma and hepatocellular carcinoma deep sequencing and analysis.

Research Funding

  • June 1, 2023 - May 30, 2028 - Establishing patient-derived iPSCs as a platform for discovery research in NAFLD , MPI . Sponsor: NIDDK, Sponsor Award ID: RC2DK136052
  • February 1, 2024 - November 30, 2027 - Modeling and Characterization of NAFLD Phenotypes in a Severely Affected Family , PI . Sponsor: NIH/NIDDK, Sponsor Award ID: R01DK132129
  • June 8, 2021 - March 31, 2025 - Genetic Regulation of Nonalcoholic Fatty Liver Disease , MPI . Sponsor: NIH, Sponsor Award ID: R01DK130391
  • September 1, 2013 - July 31, 2019 - Regulation of Lipid Metabolism by miR-29a within Hepatocytes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08DK098270

Education

  • University of California, Berkeley, B.A., 1998, Molecular and Cell Biology
  • University of Illinois, Chicago, M.D., 2007, Medicine
  • University of Illinois, Urbana-Champaign, Ph.D., 2007, Biochemistry
  • University of California, San Francisco, 2009, Resident, Anatomic Pathology
  • University of California, San Francisco, 2009, Fellow, Surgical Pathology
  • University of California, San Francisco, 2010, Fellow, Liver/GI Pathology
  • University of California, San Francisco, 2014, Postdoctoral Fellow
  • California Institute for Regenerative Medicine, 2013, CIRM Clinical Fellow

Honors & Awards

  • 1998
    Biochemistry Trust Start-up Award, University of Illinois, Urbana-Champaign 
  • 1998-99
    Lycan Teaching Scholarship, University of Illinois, Urbana-Champaign 
  • 2007
    Alpha Omega Alpha Honor Medical Society, University of Illinois, Chicago 
  • 2010-13
    California Institute for Regenerative Medicine, Training Grant Award 
  • 2016
    UCSF Department of Pathology Start-up Award, San Francisco, California 

Selected Publications

  1. Kuang YL, Locatelli CAA, Qin Y, Zhang Y, Theusch E, Muñoz-Howell A, Sanchez G, Lu M, Nguyen MA, Yalamanchili T, Wang X, Nalula G, Mattis AN, Oni-Orisan A, Iribarren C, Krauss RM, Mulvihill EE, Medina MW. MIR192 Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion. bioRxiv. 2025 Mar 19.  View on PubMed
  2. Kim JJ, Kurial SNT, Choksi PK, Nunez M, Lunow-Luke T, Bartel J, Driscoll J, Her CL, Dhillon S, Yue W, Murti A, Mao T, Ramos JN, Tiyaboonchai A, Grompe M, Mattis AN, Syed SM, Wang BM, Maher JJ, Roll GR, Willenbring H. AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion. Nat Biotechnol. 2025 Jan 29.  View on PubMed
  3. Qin Y, Chhetri P, Theusch E, Lim G, Teker S, Kuang YL, Aziziraftar SK, Mehraban MH, Munoz-Howell A, Saxena V, Le Guillou D, Mattis AN, Maher JJ, Medina MW. Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells. bioRxiv. 2025 Jan 15.  View on PubMed
  4. Tuomivaara ST, Fisher SJ, Hall SC, Goin DE, Mattis AN, Den Besten PK. Fluoride-related changes in the fetal cord blood proteome; a pilot study. Environ Health. 2024 Jul 23; 23(1):66.  View on PubMed
  5. Hsu BY, Driscoll J, Human Cholangiocarcinogenesis Project, Tateno C, Mattis AN, Kelley RK, Willenbring H. Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas. Gastroenterology. 2024 Oct; 167(5):1029-1032.e7.  View on PubMed
  6. Lewis KA, Stroebel BM, Zhang L, Aouizerat B, Mattis AN, Flowers E. MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program. Int J Mol Sci. 2024 May 23; 25(11).  View on PubMed
  7. Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY. AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis. Sci Rep. 2024 03 03; 14(1):5205.  View on PubMed
  8. Tuomivaara ST, Goin DE, Fisher SJ, Hall SC, Mattis AN, Den Besten PK. Fluoride-related changes in the fetal cord blood proteome; a pilot study. Res Sq. 2024 Mar 01.  View on PubMed
  9. Lewis KA, Stroebel B, Zhang L, Aouizerat B, Mattis A, Flowers E. MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program. Res Sq. 2024 Jan 16.  View on PubMed
  10. Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA. Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease. Magn Reson Med. 2024 Apr; 91(4):1625-1636.  View on PubMed
  11. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28.  View on PubMed
  12. Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E. Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data. PLoS One. 2023; 18(4):e0271354.  View on PubMed
  13. Zhang R, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. DNA content abnormality frequently develops in the right/proximal colon in patients with primary sclerosing cholangitis and inflammatory bowel disease and is highly predictive of subsequent detection of dysplasia. Histopathology. 2023 Jul; 83(1):116-125.  View on PubMed
  14. Weng Y, Han S, Sekyi MT, Su T, Mattis AN, Chang TT. Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions. Stem Cells. 2023 03 02; 41(2):126-139.  View on PubMed
  15. Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract. Mod Pathol. 2023 05; 36(5):100117.  View on PubMed
  16. Pierce GF, Mattis AN. Transient expression of factor VIII and a chronic high-fat diet induces ER stress and late hepatocyte oncogenesis. Mol Ther. 2022 12 07; 30(12):3510-3512.  View on PubMed
  17. Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis. Front Med (Lausanne). 2022; 9:881848.  View on PubMed
  18. Muñoz A, Theusch E, Kuang YL, Nalula G, Peaslee C, Dorlhiac G, Landry MP, Streets A, Krauss RM, Iribarren C, Mattis AN, Medina MW. Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease. Cell Mol Gastroenterol Hepatol. 2022; 14(5):1174-1176.e6.  View on PubMed
  19. Bogliotti Y, Vander Roest M, Mattis AN, Gish RG, Peltz G, Anwyl R, Kivlighn S, Schuur ER. Clinical Application of Induced Hepatocyte-like Cells Produced from Mesenchymal Stromal Cells: A Literature Review. Cells. 2022 06 22; 11(13).  View on PubMed
  20. Fong S, Yates B, Sihn CR, Mattis AN, Mitchell N, Liu S, Russell CB, Kim B, Lawal A, Rangarajan S, Lester W, Bunting S, Pierce GF, Pasi KJ, Wong WY. Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A. Nat Med. 2022 04; 28(4):789-797.  View on PubMed

Go to UCSF Profiles, powered by CTSI