Research Summary
Since the beginning of the AIDS epidemic, I have been involved in studying the role of macrophages in the pathogenesis of a wide variety of diseases, including neurodegenerative diseases and cancer. The primary model systems for these studies revolved around the study of HIV-infected macrophages and their influence on the brain, as well as in lymphoma. Through the study of HIV, I have gained important insight into the pathogenesis of other non-HIV diseases that seem to operate in the same manner as those associated with HIV infection. A critical component of the studies performed over the past 30 years was the creation of the ACSR, a central NCI-sponsored program of which I have been the PI since 1994. Access to well-preserved tissues from patients with a wide variety of AIDS-related conditions has allowed the discovery of fundamental mechanisms of disease that would never have been made otherwise. Through study of ACSR specimen sets, we have discovered that HIV-infected macrophages persist in tissues long after the blood has been cleared of infectious HIV. In fact, recent evidence suggests that infected macrophages play central roles in the pathogenesis of major post-cART diseases, such as cancer and heart disease. The current ACSR program will continue to expand investigator access to biospecimens for HIV-associated cancer research.
Research Funding
September 18, 2019 - August 31, 2024 - Pathogenesis of the cART unresponsive Kaposi?s sarcoma tumor niche, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA239263
September 23, 2013 - August 31, 2024 - AIDS and Cancer Specimen Resource (ACSR), Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: UM1CA181255
September 4, 2013 - July 31, 2018 - Molecular Features of and Approach to the HIV CNS Reservoir Post cART, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: R01MH100984
May 24, 2007 - October 31, 2013 - Macrophage Targeted Therapy for HAD and HIV Disease, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: U19MH081835
Education
University of Minnesota, B.S., 1974, Biology Medicine
Stanford University School of Medicine, M.D., 1980, Medicine
Stanford University School of Medicine, Ph.D., 1981, Cancer Biology
Honors & Awards
- 1990
Outstanding Speaker Award, American Association for Clinical Chemistry - 1999-2000
Mercatur Scholar, University of Heidelberg, Germany
Selected Publications
- Markazi A, Bracci PM, McGrath M, Gao SJ
Pseudomonas aeruginosa Stimulates Inflammation and Enhances Kaposi's Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin.
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- Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL
Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency.
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- Maguire A, Chen X, Wisner L, Malasi S, Ramsower C, Kendrick S, Barrett MT, Glinsmann-Gibson B, McGrath M, Rimsza LM
Enhanced DNA repair and genomic stability identify a novel HIV-related diffuse large B-cell lymphoma signature.
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- Lamers SL, Fogel GB, Nolan DJ, Barbier AE, Rose R, Singer EJ, Gonzalez-Perez MP, McGrath MS
Emerging Patterns in HIV-1 gp120 Variable Domains in Anatomical Tissues in the Absence of a Plasma Viral Load.
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- Jin X, Xu H, McGrath MS
Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes.
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- Nolan DJ, Rose R, Rodriguez PH, Salemi M, Singer EJ, Lamers SL, McGrath MS
The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy.
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- Lamers SL, Fogel GB, Liu ES, Barbier AE, Rodriguez CW, Singer EJ, Nolan DJ, Rose R, McGrath MS
Brain-specific HIV Nef identified in multiple patients with neurological disease.
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- Rose R, Nolan DJ, Maidji E, Stoddart CA, Singer EJ, Lamers SL, McGrath MS
Eradication of HIV from Tissue Reservoirs: Challenges for the Cure.
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- Lakritz JR, Yalamanchili S, Polydefkis MJ, Miller AD, McGrath MS, Williams KC, Burdo TH
An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy.
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- Walker JA, Miller AD, Burdo TH, McGrath MS, Williams KC
Direct Targeting of Macrophages With Methylglyoxal-Bis-Guanylhydrazone Decreases SIV-Associated Cardiovascular Inflammation and Pathology.
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- Lamers SL, Fogel GB, Liu ES, Nolan DJ, Salemi M, Barbier AE, Rose R, Singer EJ, McGrath MS
Predicted coreceptor usage at end-stage HIV disease in tissues derived from subjects on antiretroviral therapy with an undetectable plasma viral load.
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- Cope FO, Abbruzzese B, Sanders J, Metz W, Sturms K, Ralph D, Blue M, Zhang J, Bracci P, Bshara W, Behr S, Maurer T, Williams K, Walker J, Beverly A, Blay B, Damughatla A, Larsen M, Mountain C, Neylon E, Parcel K, Raghuraman K, Ricks K, Rose L, Sivakumar A, Streck N, Wang B, Wasco C, Williams A, Schlesinger LS, Azad A, Rajaram MVS, Jarjour W, Young N, Rosol T, McGrath M
Corrigendum to the inextricable axis of targeted diagnostic imaging and therapy: An immunological natural history approach [Nucl Med Biol 43 (2016) 215-225].
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- Lamers SL, Rose R, Maidji E, Agsalda-Garcia M, Nolan DJ, Fogel GB, Salemi M, Garcia DL, Bracci P, Yong W, Commins D, Said J, Khanlou N, Hinkin CH, Sueiras MV, Mathisen G, Donovan S, Shiramizu B, Stoddart CA, McGrath MS, Singer EJ
HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.
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- Rose R, Lamers SL, Nolan DJ, Maidji E, Faria NR, Pybus OG, Dollar JJ, Maruniak SA, McAvoy AC, Salemi M, Stoddart CA, Singer EJ, McGrath MS
HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer.
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- Lamers SL, Rose R, Nolan DJ, Fogel GB, Barbier AE, Salemi M, McGrath MS
HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi's Sarcoma during AIDS.
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- Lamers SL, Fogel GB, Liu ES, Salemi M, McGrath MS
On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition.
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- Cope FO, Abbruzzese B, Sanders J, Metz W, Sturms K, Ralph D, Blue M, Zhang J, Bracci P, Bshara W, Behr S, Maurer T, Williams K, Walker J, Beverly A, Blay B, Damughatla A, Larsen M, Mountain C, Neylon E, Parcel K, Raghuraman K, Ricks K, Rose L, Sivakumar A, Streck N, Wang B, Wasco C, Schlesinger LS, Azad A, Rajaram MVS, Jarjour W, Young N, Rosol T, Williams A, McGrath M
The inextricable axis of targeted diagnostic imaging and therapy: An immunological natural history approach.
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- Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart CA, McGrath MS
The meningeal lymphatic system: a route for HIV brain migration?
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- Fogel GB, Lamers SL, Liu ES, Salemi M, McGrath MS
Identification of dual-tropic HIV-1 using evolved neural networks.
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- Jin X, McGrath MS, Xu H
Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone.
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