The McManus lab studies fundamental processes relating to the regulation of gene expression. We take high-throughput approaches, analyzing hundreds of thousands to millions of experiments at once, using unique and complex libraries coupled to deep sequencing. Our systems span from cell culture to in vivo models, focusing on a broad array of disease relevant tissues. From cancer to diabetes, we develop novel technologies to help us better understand how genes are regulated and how they function in cells. We aim to uncover the dark matter of the genome, to help unravel the beautiful genomic complexity of pathways and how genes interact in development and disease.
September 15, 2017 - August 31, 2023 - Illuminating Druggable Dark Matter , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U24DK116214
August 10, 2017 - July 31, 2022 - The Cancer Target Discovery and Development Network at UCSF , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA217882
August 1, 2017 - July 31, 2022 - Functional Networks for Persister Cell Sensitivities , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA212767
September 15, 2018 - August 31, 2021 - Bay Area CRISPR Reporters , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U42OD026647
Auburn University, Auburn, Alabama, B.S., 05/1991, Horticultural Science
University of Alabama at Birmingham, Ph.D., 12/2000, Biochem & Mol Genetics
Massachusetts Institute of Technology, Postdoctoral, 12/2004, Small RNA Biology