The McManus lab studies fundamental processes relating to the regulation of gene expression. We take high-throughput approaches, analyzing hundreds of thousands to millions of experiments at once, using unique and complex libraries coupled to deep sequencing. Our systems span from cell culture to in vivo models, focusing on a broad array of disease relevant tissues. From cancer to diabetes, we develop novel technologies to help us better understand how genes are regulated and how they function in cells. We aim to uncover the dark matter of the genome, to help unravel the beautiful genomic complexity of pathways and how genes interact in development and disease.
May 1, 2003 - March 31, 2020 - Diabetes Research Center, Co-Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: P30DK063720
September 23, 2014 - August 31, 2019 - Tracing Cell Lineages, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01CA195770
September 1, 2013 - August 31, 2018 - Genetic models for exRNA communication, Principal Investigator. Sponsor: NIH, Sponsor Award ID: U19CA179513
August 15, 2014 - March 31, 2018 - Empiric deconvolution of functional RNA elements, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM110251
Auburn University, Auburn, Alabama, B.S., 05/1991, Horticultural Science
University of Alabama at Birmingham, Ph.D., 12/2000, Biochem & Mol Genetics
Massachusetts Institute of Technology, Postdoctoral, 12/2004, Small RNA Biology