Research Summary

Dr. Kavita K. Mishra is an internationally renowned expert radiation oncologist focused on the treatment of uveal melanomas with proton beam radiotherapy as well as plaque brachytherapy. She earned her undergraduate degree in Biology at Harvard University, followed by her medical degree at the UCSF School of Medicine. She then completed a masters degree at the Harvard School of Public Health. Dr. Mishra finished her residency in radiation oncology at the UCSF Medical Center and thereafter joined the faculty at UCSF.

Dr. Mishra specializes in the use of proton beam radiation and plaque brachytherapy to treat malignant and benign conditions of the eye. Dr. Mishra believes in a multidisciplinary approach to ocular oncology care with the aim to provide the most efficacious and individualized therapy for her patients. She is active in the national and international ocular oncology community, is the Co-Chair of PTCOG Ocular (Particle Therapy Co-Operative Group) - the largest collection of proton beam ocular radiation therapy institutions, and has multiple significant research publications and oral presentations globally in her areas of expertise.

Her current research protocols are focused on the clinical outcomes of uveal melanoma patients, particularly with respect to tumor control, preservation of the eye, and quality of life issues. She hopes to continue using a unified, team-oriented approach to maintain excellent outcomes for patients undergoing modern proton beam, plaque therapy, and external beam radiation techniques for ocular malignancies.

Research Funding

  • June 23, 2022 - June 23, 2022 - Long-Term Investigation of Proton Beam Radiation Therapy, Helium Ion, and Plaque Therapy Techniques for Treatment of Uveal Melanoma and Other Ocular Tumors , Principal Investigator . Sponsor: , Sponsor Award ID:
  • June 23, 2022 - June 23, 2022 - Millimeter scale particle dosimeter for cancer radiotherapy , Co-Investigator . Sponsor: , Sponsor Award ID:

Education

Residency, 2008 - Radiation Oncology, University of California, San Francisco
M.P.H., 2003 - Masters in Public Health, Harvard School of Public Health
M.D., 2002 - Medicine, University of California, San Francisco
A.B., 1998 - Biology, Harvard University

Honors & Awards

  • Faculty Scholar, Osher Center for Integrative Medicine, University of California San Francisco, 2020
  • Highest ranked scientific abstract, Particle Therapy Co-Operative Group, 2015
  • RSNA Roentgen Resident/Fellow Research Award, University of California San Francisco, 2008
  • Class Speaker, UCSF School of Medicine Commencement, University of California San Francisco, 2002
  • Rainer Scholarship for International Health Research, University of California San Francisco, 1999
  • Harvard College Scholar, Dean's List, Harvard University, 1998
  • First Class Marshal, Harvard Class of 1998, Harvard University, 1998

Selected Publications

  1. Mishra KK, Victorson D, Mehta DH, Vago DR. Personalized Mind-Body Medicine in Integrative Oncology: Meeting the Moment with Each Patient. J Integr Complement Med. 2022 May 12.  View on PubMed
  2. Lee K, Scholey J, Norman EB, Daftari IK, Mishra KK, Faddegon BA, Maharbiz MM, Anwar M. A Millimeter-scale Single Charged Particle Dosimeter for Cancer Radiotherapy. IEEE J Solid-State Circuits. 2020 Nov; 55(11):2947-2958.  View on PubMed
  3. Mishra KK, Scholey JE, Daftari IK, Afshar A, Tsai T, Park S, Quivey JM, Char DH. Oral isotretinoin and topical retinoid use in a series of young patients with ocular melanoma. Am J Ophthalmol Case Rep. 2020 Sep; 19:100787.  View on PubMed
  4. Mishra KK, Afshar A, Thariat J, Shih HA, Scholey JE, Daftari IK, Kacperek A, Pica A, Hrbacek J, Dendale R, Mazal A, Heufelder J, Char DH, Sauerwein WAG, Weber DC, Damato BE. Practice Considerations for Proton Beam Radiation Therapy of Uveal Melanoma During the Coronavirus Disease Pandemic: Particle Therapy Co-Operative Group Ocular Experience. Adv Radiat Oncol. 2020 Jul-Aug; 5(4):682-686.  View on PubMed
  5. Mukkamala LK, Mishra K, Daftari I, Moshiri A, Park SS. Phase I/II randomized study of proton beam with anti-VEGF for exudative age-related macular degeneration: long-term results. Eye (Lond). 2020 12; 34(12):2271-2279.  View on PubMed
  6. Lu JE, Welch RJ, Mishra KK, Daftari IK, Park SS. Ultrasonography and transillumination for uveal melanoma localisation in proton beam treatment planning. Eye (Lond). 2019 12; 33(12):1904-1910.  View on PubMed
  7. Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L. National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. Int J Radiat Oncol Biol Phys. 2018 05 01; 101(1):152-168.  View on PubMed
  8. Daftari IK, Quivey JM, Chang JS, Mishra KK. Technical Note: Feasibility study of titanium markers in choroidal melanoma localization for proton beam radiation therapy. Med Phys. 2018 Mar; 45(3):1036-1039.  View on PubMed
  9. Von Bargen EC, Grimes CL, Mishra K, Wang R, Haviland MJ, Hacker MR, Carnevale JA, Estes AJ, Elkadry EA. Prevalence of occult pre-malignant or malignant pathology at the time of uterine morcellation for benign disease. Int J Gynaecol Obstet. 2017 May; 137(2):123-128.  View on PubMed
  10. Osmanovic S, Moisseiev E, Mishra KK, Daftari I, Moshiri A, Morse L, Park SS. Phase I/II Randomized Study of Proton Beam with Anti-Vascular Endothelial Growth Factor for Exudative Age-Related Macular Degeneration: One-Year Results. Ophthalmol Retina. 2017 May - Jun; 1(3):217-226.  View on PubMed
  11. Polishchuk AL, Mishra KK, Weinberg V, Daftari IK, Nguyen JM, Cole TB, Quivey JM, Phillips TL, Char DH. Temporal Evolution and Dose-Volume Histogram Predictors of Visual Acuity After Proton Beam Radiation Therapy of Uveal Melanoma. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):91-97.  View on PubMed
  12. Mishra KK, Daftari IK. Proton therapy for the management of uveal melanoma and other ocular tumors. Chin Clin Oncol. 2016 Aug; 5(4):50.  View on PubMed
  13. Mishra KK, Chiu-Tsao ST, Orton CG. Point/Counterpoint. Particle therapy is ideal for the treatment of ocular melanomas. Med Phys. 2016 Feb; 43(2):631-4.  View on PubMed
  14. Hrbacek J, Mishra KK, Kacperek A, Dendale R, Nauraye C, Auger M, Herault J, Daftari IK, Trofimov AV, Shih HA, Chen YE, Denker A, Heufelder J, Horwacik T, Swakon J, Hoehr C, Duzenli C, Pica A, Goudjil F, Mazal A, Thariat J, Weber DC. Practice Patterns Analysis of Ocular Proton Therapy Centers: The International OPTIC Survey. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):336-343.  View on PubMed
  15. Roach M, Schulte R, Mishra K, Faddegon B, Barani I, Lazar A, Blakely EA. New Clinical and Research Programs in Particle Beam Radiation Therapy: The University of California San Francisco Perspective. Int J Part Ther. 2016; 2(3):471-473.  View on PubMed
  16. Mishra KK, Quivey JM, Daftari IK, Weinberg V, Castro JR, Phillips TL, Char DH. In Reply to Kamrava and McCannel. Int J Radiat Oncol Biol Phys. 2015 Sep 01; 93(1):216-7.  View on PubMed
  17. Mishra KK, Quivey JM, Daftari IK, Weinberg V, Cole TB, Patel K, Castro JR, Phillips TL, Char DH. Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):376-83.  View on PubMed
  18. Seider MI, Stewart PJ, Mishra KK, Damato BE. Uveal melanoma gene expression profile test result provided for uveal metastasis. Ophthalmic Surg Lasers Imaging Retina. 2014 Sep-Oct; 45(5):441-2.  View on PubMed
  19. Mishra KK, Daftari IK, Weinberg V, Cole T, Quivey JM, Castro JR, Phillips TL, Char DH. Risk factors for neovascular glaucoma after proton beam therapy of uveal melanoma: a detailed analysis of tumor and dose-volume parameters. Int J Radiat Oncol Biol Phys. 2013 Oct 01; 87(2):330-6.  View on PubMed
  20. Newmann SJ, Mishra K, Onono M, Bukusi EA, Cohen CR, Gage O, Odeny R, Schwartz KD, Grossman D. Providers' Perspectives on Provision of Family Planning to HIV-Positive Individuals in HIV Care in Nyanza Province, Kenya. AIDS Res Treat. 2013; 2013:915923.  View on PubMed

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