Research Summary

Dr. Isaac Neuhaus is a dermatologic surgeon who specializes in Mohs micrographic surgery (a technique that maximizes preservation of normal tissue) and surgical reconstruction for skin cancer. He is an expert in laser surgery for treating a variety of vascular and pigmentary lesions, including extensive vascular malformations. He also performs cosmetic procedures, such as laser rejuvenation of photodamaged skin, Botox injections, soft tissue filler injections, chemical peels, sclerotherapy and liposuction.

In his research, Neuhaus studies skin cancer surgery and laser treatment.

Neuhaus earned a medical degree at the University of Florida. He completed a dermatology residency at UCSF, where he was chief resident, followed by a Mohs surgery and procedural dermatology fellowship, also at UCSF.

Neuhaus is a member of the American Society for Dermatologic Surgery, which awarded him its Cutting Edge Research Grant. He is past president of the California Society of Dermatology & Dermatologic Surgery, and he is a member of the American Academy of Dermatology, American College of Mohs Surgery and American Medical Association.

Education

Fellowship, 2005 - Mohs Micrographic Surgery and Procedural Dermatology, UCSF Medical Center
2000 - , University of Florida

Selected Publications

  1. Lyubetskaya A, Rabe B, Fisher A, Lewin A, Neuhaus I, Brett C, Brett T, Pereira E, Golhar R, Kebede S, Font-Tello A, Mosure K, Van Wittenberghe N, Mavrakis KJ, MacIsaac K, Chen BJ, Drokhlyansky E. Assessment of spatial transcriptomics for oncology discovery. Cell Rep Methods. 2022 Nov 21; 2(11):100340.  View on PubMed
  2. Gulati A, Grekin R, Neuhaus I, Saylor D, Yu S, Park A, Seth R, Knott PD. Long-Term Appearance-Related Outcomes of Facial Reconstruction After Skin Cancer Resection. Facial Plast Surg Aesthet Med. 2023 Jul-Aug; 25(4):344-350.  View on PubMed
  3. Knott PD, Alemi SA, Han M, Seth R, Park AM, Heaton CM, Grekin RC, Arron ST, Neuhaus I, Yu SS, Saylor DK, Zhu BZ. Skin Color Match in Head and Neck Reconstructive Surgery. Laryngoscope. 2022 09; 132(9):1753-1759.  View on PubMed
  4. Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 11; 599(7886):667-672.  View on PubMed
  5. Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD. Layilin Anchors Regulatory T Cells in Skin. J Immunol. 2021 10 01; 207(7):1763-1775.  View on PubMed
  6. Lohman ME, Grekin RC, North JP, Neuhaus IM. Impact of second-opinion dermatopathology reviews on surgical management of malignant neoplasms. J Am Acad Dermatol. 2021 May; 84(5):1385-1392.  View on PubMed
  7. Alam M, Harikumar V, Kang BY, Ibrahim SA, Kibbi N, Owen JL, Maher IA, Cartee TV, Sobanko JF, Reynolds KA, Bolotin D, Waldman AH, Minkis K, Petersen B, Council ML, Nehal KS, Xu YG, Jiang SB, Somani AK, Bichakjian CK, Huang CC, Eisen DB, Ozog DM, Lee EH, Samie FH, Neuhaus IM, Bordeaux JS, Wang JV, Leitenberger JJ, Mann MW, Lawrence N, Zeitouni NC, Golda N, Behshad R, Ibrahim SF, Yu SS, Shin TM, Stebbins WG, Worley B. Development of international clinical practice guidelines: benefits, limitations, and alternative forms of international collaboration. Arch Dermatol Res. 2022 07; 314(5):483-486.  View on PubMed
  8. Alam M, Harikumar V, Ibrahim SA, Kang BY, Maher IA, Cartee TV, Sobanko JF, Kibbi N, Owen JL, Reynolds KA, Bolotin D, Waldman AH, Minkis K, Petersen B, Council ML, Nehal KS, Xu YG, Jiang SB, Somani AK, Bichakjian CK, Huang CC, Eisen DB, Ozog DM, Lee EH, Samie FH, Neuhaus IM, Bordeaux JS, Wang JV, Leitenberger JJ, Mann MW, Lawrence N, Zeitouni NC, Golda N, Behshad R, Ibrahim SF, Yu SS, Shin TM, Stebbins WG, Worley B. Principles for developing and adapting clinical practice guidelines and guidance for pandemics, wars, shortages, and other crises and emergencies: the PAGE criteria. Arch Dermatol Res. 2022 05; 314(4):393-398.  View on PubMed
  9. Harikumar V, Worley B, Ibrahim SA, Kang BY, Maher IA, Cartee TV, Sobanko JF, Kibbi N, Owen JL, Reynolds KA, Bolotin D, Waldman AH, Minkis K, Petersen B, Council ML, Nehal KS, Xu YG, Jiang SB, Somani AK, Huang CC, Eisen DB, Ozog DM, Lee EH, Samie FH, Neuhaus IM, Leitenberger JJ, Mann MW, Lawrence N, Zeitouni NC, Golda N, Behshad R, Ibrahim SF, Yu SS, Shin TM, Stebbins WG, Alam M. Broad versus narrow clinical practice guidelines: avoiding rules for the high risk 1. Arch Dermatol Res. 2022 05; 314(4):385-387.  View on PubMed
  10. Aljabban J, Syed S, Syed S, Rohr M, Weisleder N, McElhanon KE, Hasan L, Safeer L, Hoffman K, Aljabban N, Mukhtar M, Adapa N, Allarakhia Z, Panahiazar M, Neuhaus I, Kim S, Hadley D, Jarjour W. Investigating genetic drivers of dermatomyositis pathogenesis using meta-analysis. Heliyon. 2020 Sep; 6(9):e04866.  View on PubMed
  11. Yu WY, Waalboer-Spuij R, Bremer R, Lu B, Aroyan C, Crow L, Grekin R, Neuhaus I, Yu S, Arron ST, Hollestein LM. Validation of the English Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire. Dermatol Surg. 2020 03; 46(3):327-334.  View on PubMed
  12. Yu WY, Lu B, Tan D, Aroyan C, Shinkai K, Leslie KS, Fox LP, Yu S, Neuhaus IM, Grekin RC, Arron ST. Effect of Topical Brimonidine on Alcohol-Induced Flushing in Asian Individuals: A Randomized Clinical Trial. JAMA Dermatol. 2020 02 01; 156(2):182-185.  View on PubMed
  13. Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 12 19; 4(24).  View on PubMed
  14. Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M. Sebaceous carcinoma: evidence-based clinical practice guidelines. Lancet Oncol. 2019 12; 20(12):e699-e714.  View on PubMed
  15. Worley B, Owen JL, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw S, Cartee TV, Chandra S, Cho N, Choi J, Council ML, Eisen DB, Golda N, Huang CC, Ibrahim SF, Jiang SIB, Kim J, Lacutoure M, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann M, Minkis K, Mittal B, Nehal KS, Neuhaus I, Ozog DM, Petersen B, Samie F, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas V, Tse D, Waldman A, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Poon E, Alam M. Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma: Informed by a Systematic Review. JAMA Dermatol. 2019 Sep 01; 155(9):1059-1068.  View on PubMed
  16. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 10 23; 25(4):871-883.  View on PubMed
  17. Zhang B, Zhao S, Neuhaus I. canvasDesigner: a versatile interactive high-resolution scientific multi-panel visualization toolkit. Bioinformatics. 2018 10 01; 34(19):3419-3420.  View on PubMed
  18. Wang X, Tilford C, Neuhaus I, Mintier G, Guo Q, Feder JN, Kirov S. CRISPR-DAV: CRISPR NGS data analysis and visualization pipeline. Bioinformatics. 2017 Dec 01; 33(23):3811-3812.  View on PubMed
  19. Valdebran M, Neuhaus I, North J. Pseudocarcinomatous Epithelial Hyperplasia Induced by Imiquimod: A Mimic of Cutaneous Squamous Cell Carcinoma. Dermatol Surg. 2017 06; 43(6):874-876.  View on PubMed
  20. Chaudhari S, Leon A, Levin E, Neuhaus I, Liao W. Case Report of Multiple Keratoacanthomas and Squamous Cell Carcinomas in a Patient Receiving Pembrolizumab. J Drugs Dermatol. 2017 May 01; 16(5):513-515.  View on PubMed

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