Research Summary

Dr. Isaac Neuhaus is a dermatologic surgeon who specializes in Mohs micrographic surgery (a technique that maximizes preservation of normal tissue) and surgical reconstruction for skin cancer. He is an expert in laser surgery for treating a variety of vascular and pigmentary lesions, including extensive vascular malformations. He also performs cosmetic procedures, such as laser rejuvenation of photodamaged skin, Botox injections, soft tissue filler injections, chemical peels, sclerotherapy and liposuction.

In his research, Neuhaus studies skin cancer surgery and laser treatment.

Neuhaus earned a medical degree at the University of Florida. He completed a dermatology residency at UCSF, where he was chief resident, followed by a Mohs surgery and procedural dermatology fellowship, also at UCSF.

Neuhaus is a member of the American Society for Dermatologic Surgery, which awarded him its Cutting Edge Research Grant. He is past president of the California Society of Dermatology & Dermatologic Surgery, and he is a member of the American Academy of Dermatology, American College of Mohs Surgery and American Medical Association.

Education

Fellowship, 2005 - Mohs Micrographic Surgery and Procedural Dermatology, UCSF Medical Center
2000 - , University of Florida

Selected Publications

  1. Leboit PE, Patel DU, Cohen JN, Moss MI, Naik HB, Yates AE, Harris HW, Klufas DM, Kim EA, Neuhaus IM, Hansen SL, Kyle RL, Kelly M, Rosenblum MD, Lowe MM. The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa. Exp Dermatol. 2025 Feb; 34(2):e70057.  View on PubMed
  2. Ma MS, Zafar FS, Goldman MP, Munavalli GS, Zimmet SE, Nguyen TH, Mishra V, Cartee TV, Mann M, Hsu JTS, Silapunt S, Weiss RA, Weiss MA, Haq M, Ahmed A, Koza E, Shi VJ, Dave L, Yi M, Kang BY, Cahn B, Bae YSC, Kole LCS, Friedmann DP, Chow ML, Minkis K, Stücker M, Schlick CA, Hoss E, Hu JC, Kibbi N, Saikaly SK, Greywal T, Hooper D, Vashi NA, Boucher A, Ward KHM, Neuhaus IM, Ghareeb E, Luke J, Karen JK, Suggs A, Lucas J, Decker A, Brieva JC, Yoo SS, Suozzi K, Alam M. Development of an Objective Structured Assessment of Technical Skills for Sclerotherapy. J Am Acad Dermatol. 2025 Jan; 92(1):129-132.  View on PubMed
  3. Kumar S, Orcales F, Shih BB, Fang X, Yin C, Yates A, Dimitrion P, Neuhaus I, Johnson C, Adrianto I, Wiala A, Hamzavi I, Zhou L, Naik H, Posch C, Mi QS, Liao W. Cellular indexing of transcriptomes and epitopes (CITE-Seq) in hidradenitis suppurativa identifies dysregulated cell types in peripheral blood and facilitates diagnosis via machine learning. Res Sq. 2024 Sep 09.  View on PubMed
  4. Leboit PE, Patel DU, Cohen JN, Moss MI, Naik HB, Yates AE, Harris HW, Klufas DM, Kim EA, Neuhaus IM, Hansen SL, Kyle RL, Kelly M, Rosenblum MD, Lowe MM. A Novel Whole Tissue Explant Model of Hidradenitis Suppurativa. bioRxiv. 2024 Jul 23.  View on PubMed
  5. Dirr MA, Ahmed A, Schlessinger DI, Haq M, Shi V, Koza E, Ma M, Christensen RE, Ibrahim SA, Schmitt J, Johannsen L, Asai Y, Baldwin HE, Berardesca E, Berman B, Vieira AC, Chien AL, Cohen DE, Del Rosso JQ, Dosal J, Drake LA, Feldman SR, Fleischer AB, Friedman A, Graber E, Harper JC, Helfrich YR, Jemec GB, Johnson SM, Katta R, Lio P, Maier LE, Martin G, Nagler AR, Neuhaus IM, Palamar M, Parish LC, Rosen T, Shumack SP, Solomon JA, Tanghetti EA, Webster GF, Weinkle A, Weiss JS, Wladis EJ, Maher IA, Sobanko JF, Cartee TV, Cahn BA, Alam M, IMPROVED-COS Rosacea Working Group, Kang BY, Iyengar S, Anvery N, Alpsoy E, Bewley A, Dessinioti C, Egeberg A, Engin B, Gollnick HPM, Ioannides D, Kim HS, Lazaridou E, Li J, Lim HG, Micali G, de Oliveira CMM, Noguera-Morel L, Parodi A, Reinholz M, Suh DH, Sun Q, van Zuuren EJ, Wollina U, Zhou Y, Zip C, Poon E, Pearlman R. Rosacea Core Domain Set for Clinical Trials and Practice: A Consensus Statement. JAMA Dermatol. 2024 Jun 01; 160(6):658-666.  View on PubMed
  6. Lyubetskaya A, Rabe B, Fisher A, Lewin A, Neuhaus I, Brett C, Brett T, Pereira E, Golhar R, Kebede S, Font-Tello A, Mosure K, Van Wittenberghe N, Mavrakis KJ, MacIsaac K, Chen BJ, Drokhlyansky E. Assessment of spatial transcriptomics for oncology discovery. Cell Rep Methods. 2022 11 21; 2(11):100340.  View on PubMed
  7. Gulati A, Grekin R, Neuhaus I, Saylor D, Yu S, Park A, Seth R, Knott PD. Long-Term Appearance-Related Outcomes of Facial Reconstruction After Skin Cancer Resection. Facial Plast Surg Aesthet Med. 2023 Jul-Aug; 25(4):344-350.  View on PubMed
  8. Knott PD, Alemi SA, Han M, Seth R, Park AM, Heaton CM, Grekin RC, Arron ST, Neuhaus I, Yu SS, Saylor DK, Zhu BZ. Skin Color Match in Head and Neck Reconstructive Surgery. Laryngoscope. 2022 09; 132(9):1753-1759.  View on PubMed
  9. Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 11; 599(7886):667-672.  View on PubMed
  10. Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD. Layilin Anchors Regulatory T Cells in Skin. J Immunol. 2021 10 01; 207(7):1763-1775.  View on PubMed
  11. Lohman ME, Grekin RC, North JP, Neuhaus IM. Impact of second-opinion dermatopathology reviews on surgical management of malignant neoplasms. J Am Acad Dermatol. 2021 May; 84(5):1385-1392.  View on PubMed
  12. Alam M, Harikumar V, Kang BY, Ibrahim SA, Kibbi N, Owen JL, Maher IA, Cartee TV, Sobanko JF, Reynolds KA, Bolotin D, Waldman AH, Minkis K, Petersen B, Council ML, Nehal KS, Xu YG, Jiang SB, Somani AK, Bichakjian CK, Huang CC, Eisen DB, Ozog DM, Lee EH, Samie FH, Neuhaus IM, Bordeaux JS, Wang JV, Leitenberger JJ, Mann MW, Lawrence N, Zeitouni NC, Golda N, Behshad R, Ibrahim SF, Yu SS, Shin TM, Stebbins WG, Worley B. Development of international clinical practice guidelines: benefits, limitations, and alternative forms of international collaboration. Arch Dermatol Res. 2022 07; 314(5):483-486.  View on PubMed
  13. Alam M, Harikumar V, Ibrahim SA, Kang BY, Maher IA, Cartee TV, Sobanko JF, Kibbi N, Owen JL, Reynolds KA, Bolotin D, Waldman AH, Minkis K, Petersen B, Council ML, Nehal KS, Xu YG, Jiang SB, Somani AK, Bichakjian CK, Huang CC, Eisen DB, Ozog DM, Lee EH, Samie FH, Neuhaus IM, Bordeaux JS, Wang JV, Leitenberger JJ, Mann MW, Lawrence N, Zeitouni NC, Golda N, Behshad R, Ibrahim SF, Yu SS, Shin TM, Stebbins WG, Worley B. Principles for developing and adapting clinical practice guidelines and guidance for pandemics, wars, shortages, and other crises and emergencies: the PAGE criteria. Arch Dermatol Res. 2022 05; 314(4):393-398.  View on PubMed
  14. Harikumar V, Worley B, Ibrahim SA, Kang BY, Maher IA, Cartee TV, Sobanko JF, Kibbi N, Owen JL, Reynolds KA, Bolotin D, Waldman AH, Minkis K, Petersen B, Council ML, Nehal KS, Xu YG, Jiang SB, Somani AK, Huang CC, Eisen DB, Ozog DM, Lee EH, Samie FH, Neuhaus IM, Leitenberger JJ, Mann MW, Lawrence N, Zeitouni NC, Golda N, Behshad R, Ibrahim SF, Yu SS, Shin TM, Stebbins WG, Alam M. Broad versus narrow clinical practice guidelines: avoiding rules for the high risk 1. Arch Dermatol Res. 2022 05; 314(4):385-387.  View on PubMed
  15. Aljabban J, Syed S, Syed S, Rohr M, Weisleder N, McElhanon KE, Hasan L, Safeer L, Hoffman K, Aljabban N, Mukhtar M, Adapa N, Allarakhia Z, Panahiazar M, Neuhaus I, Kim S, Hadley D, Jarjour W. Investigating genetic drivers of dermatomyositis pathogenesis using meta-analysis. Heliyon. 2020 Sep; 6(9):e04866.  View on PubMed
  16. Yu WY, Waalboer-Spuij R, Bremer R, Lu B, Aroyan C, Crow L, Grekin R, Neuhaus I, Yu S, Arron ST, Hollestein LM. Validation of the English Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire. Dermatol Surg. 2020 03; 46(3):327-334.  View on PubMed
  17. Yu WY, Lu B, Tan D, Aroyan C, Shinkai K, Leslie KS, Fox LP, Yu S, Neuhaus IM, Grekin RC, Arron ST. Effect of Topical Brimonidine on Alcohol-Induced Flushing in Asian Individuals: A Randomized Clinical Trial. JAMA Dermatol. 2020 02 01; 156(2):182-185.  View on PubMed
  18. Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 12 19; 4(24).  View on PubMed
  19. Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M. Sebaceous carcinoma: evidence-based clinical practice guidelines. Lancet Oncol. 2019 12; 20(12):e699-e714.  View on PubMed
  20. Worley B, Owen JL, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw S, Cartee TV, Chandra S, Cho N, Choi J, Council ML, Eisen DB, Golda N, Huang CC, Ibrahim SF, Jiang SIB, Kim J, Lacutoure M, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann M, Minkis K, Mittal B, Nehal KS, Neuhaus I, Ozog DM, Petersen B, Samie F, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas V, Tse D, Waldman A, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Poon E, Alam M. Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma: Informed by a Systematic Review. JAMA Dermatol. 2019 Sep 01; 155(9):1059-1068.  View on PubMed

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