Research Summary

Dr. Amar Nijagal is a pediatric surgeon who specializes in caring for children with disorders of the liver and bile ducts.

Nijagal runs a research lab that investigates how the immune system affects the development of fetal organs. His research focuses on liver and bile duct development and how changes in the process contribute to congenital diseases.

Nijagal completed his medical degree and a residency in general surgery at UCSF, where he served as chief resident. He completed a postdoctoral research fellowship at the California Institute for Regenerative Medicine and a fellowship in general and thoracic pediatric surgery at Boston Children's Hospital.

Nijagal is a member of the American College of Surgeons, American Pediatric Surgical Association, UCSF Naffziger Surgical Society and Association for Academic Surgery.

Research Funding

  • July 1, 2019 - June 30, 2021 - The cooperative relationship between neutrophils and monocytes during neonatal liver inflammation: insight into the pathogenesis of biliary atresia, PI. Sponsor: Franklin H. Martin, MD, FACS Faculty Research Fellowship, American College of Surgeons, Sponsor Award ID: N/A
  • February 1, 2020 - January 31, 2021 - Single cell characterization and organoid development of pediatric choledochal cysts and hepatoblastoma to understand the link between liver development and hepatobiliary malignancy, PI. Sponsor: American Cancer Society, Sponsor Award ID: IRG-17-180-19
  • June 1, 2019 - May 31, 2020 - The Role of Monocytes During the Resolution of Perinatal Liver Inflammation, PI. Sponsor: UCSF Liver Center, Sponsor Award ID: NIH P30 DK026743
  • July 1, 2018 - June 30, 2019 - Investigating the Fetal Mechanisms of Liver and Bile Duct Repair: A Link to the Prenatal Origins of Biliary Atresia, PI. Sponsor: American Pediatric Surgical Association, Sponsor Award ID: N/A

Education

  • Duke University, B.A., 2000, Philosophy
  • University of California, San Francisco, M.D., 2006
  • University of California, Los Angeles, HHMI Medical Student Research Fellowship, 2004, Lymphocyte GPCR signaling
  • University of California, San Francisco, Internship, 2007, General Surgery
  • University of California, San Francisco, Residency, 2009, General Surgery
  • University of California, San Francisco, Postdoctoral Research Fellowship, 2012, Maternal-Fetal Immunology
  • University of California, San Francisco, Residency, 2014, General Surgery
  • Boston Children's Hospital, Fellowship, 2016, Pediatric General & Thoracic Surgery

Honors & Awards

  • 2011
    Judah Folkman Memorial Award- Best Podium Presentation, American Pediatric Surgical Association
  • 2012
    Judah Folkman Memorial Award- Best Podium Presentation, American Pediatric Surgical Association
  • 2013
    Medical Student Teaching Award, University of CA, San Francisco, Department of Surgery
  • 2014
    Medical Student Teaching Award, University of CA, San Francisco, Department of Surgery
  • 2014
    Esther Nusz Achievement Award, University of CA, San Francisco, Department of Surgery
  • 2018
    APSA Foundation Jay Grosfeld, MD Scholar Research Award, American Pediatric Surgical Association
  • 2019
    Franklin H. Martin, MD, FACS Faculty Research Fellowship, American College of Surgeons
  • 2019
    2019 UCSF Liver Center Pilot Award Recipient, UCSF Liver Center
  • 2020
    American Cancer Society Individual Research Grant, American Cancer Society
  • 2020
    Fellow of the American College of Surgeons, American College of Surgeons

Selected Publications

  1. Schwab ME, Braun HJ, Feldstein VA, Nijagal A The natural history of fetal gallstones: a case series and updated literature review.  View on PubMed
  2. Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.  View on PubMed
  3. Ramirez JL, Kuhrau CR, Wu B, Zarkowsky DS, Conte MS, Oskowitz AZ, Nijagal A, Vartanian SM Natural history of acute pediatric iliofemoral artery thrombosis treated with anticoagulation.  View on PubMed
  4. Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.  View on PubMed
  5. Subbaraj L, Beleniski F, Courtier J, Vartanian S, Nijagal A Congenital superior mesenteric artery aneurysm in a 6-week-old infant presenting with upper gastrointestinal bleeding.  View on PubMed
  6. Nijagal A, Perito ER Treating Biliary Atresia: The Challenge Continues.  View on PubMed
  7. Nijagal A, Perito ER Editorial: Treating Biliary Atresia: The Challenge Continues.  View on PubMed
  8. Wolf LL, Nijagal A, Flores A, Buchmiller TL Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature.  View on PubMed
  9. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.  View on PubMed
  10. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.  View on PubMed
  11. Nijagal A, MacKenzie TC Clinical implications of maternal-fetal cellular trafficking.  View on PubMed
  12. Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases.  View on PubMed
  13. Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC Alterations in maternal-fetal cellular trafficking after fetal surgery.  View on PubMed
  14. Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome.  View on PubMed
  15. Nijagal A, Flake AW, MacKenzie TC In utero hematopoietic cell transplantation for the treatment of congenital anomalies.  View on PubMed
  16. Nijagal A, Fleck S, MacKenzie TC Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance.  View on PubMed
  17. Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia.  View on PubMed
  18. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M Pancreatic mesenchyme regulates epithelial organogenesis throughout development.  View on PubMed
  19. Jelin EB, Etemadi M, Encinas J, Schecter SC, Chapin C, Wu J, Guevara-Gallardo S, Nijagal A, Gonzales KD, Ferrier WT, Roy S, Miniati D Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia.  View on PubMed
  20. Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC The maternal immune response inhibits the success of in utero hematopoietic cell transplantation.  View on PubMed

Go to UCSF Profiles, powered by CTSI