Research Summary

I am an academic neuro-oncologist involved in clinical care, clinical research and teaching. I have a PhD neuroscience as well as training in clinical trial development, implementation and analysis. As a member of the Division of Neuro-Oncology at UCSF, I have been involved in investigator-initiated, sponsored and multi-institutional consortium studies. With my strong background in basic science I am particularly interested in the development of phase I clinical trials testing novel treatment strategies for brain tumor patients.


Dartmouth College, Hanover NH, B.A., 06/2001, Molecular Biology
University of Rochester, Rochester NY, MA.S., 10/2005, Neuroscience
University of Rochester, Rochester NY, Ph.D., 06/2008, Neuroscience
University of Rochester, Rochester NY, M.D., 05/2011, Medicine
University of California San Francisco, Residency, 06/2015, Neurology
University of California San Francisco, Fellowship, 06/2016, Neuro-oncology

Honors & Awards

  • 2009
    Vincent du Vigneaud Award for thesis work unique in potential for stimulating and extending research in the field, among all disciplines
  • 2011
    American Academy of Neurology Medical Student Prize for Excellence in Neurology
  • 2016
    Voice of the Patient Pinnacle Award (Award for highest patient satisfaction, awarded to the Neuro-oncology Practice)

Selected Publications

  1. Bush NA, Chang SM, Berger MS. Current and future strategies for treatment of glioma. Neurosurg Rev. 2017 Jan; 40(1):1-14.  View on PubMed
  2. Scott BJ, Oberheim-Bush NA, Kesari S. Leptomeningeal metastasis in breast cancer - a systematic review. Oncotarget. 2016 Jan 26; 7(4):3740-7.  View on PubMed
  3. Takano T, He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M. Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia. 2014 Jan; 62(1):78-95.  View on PubMed
  4. Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell. 2013 Mar 07; 12(3):342-53.  View on PubMed
  5. Oberheim NA, Goldman SA, Nedergaard M. Heterogeneity of astrocytic form and function. Methods Mol Biol. 2012; 814:23-45.  View on PubMed
  6. Oberheim NA, Kim A, Farkas RL, Ruan DT, Schoeniger LO, Schiffhauer LM, Moalem J. Giant pancreatic tumor with clinical characteristics of insulinoma but without common pathologic features. Endocr Pract. 2011 Mar-Apr; 17(2):e12-6.  View on PubMed
  7. Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. Uniquely hominid features of adult human astrocytes. J Neurosci. 2009 Mar 11; 29(10):3276-87.  View on PubMed
  8. Ye ZC, Oberheim N, Kettenmann H, Ransom BR. Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. Glia. 2009 Feb; 57(3):258-69.  View on PubMed
  9. Takano T, Oberheim N, Cotrina ML, Nedergaard M. Astrocytes and ischemic injury. Stroke. 2009 Mar; 40(3 Suppl):S8-12.  View on PubMed
  10. Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M. Loss of astrocytic domain organization in the epileptic brain. J Neurosci. 2008 Mar 26; 28(13):3264-76.  View on PubMed
  11. Oberheim NA, Wang X, Goldman S, Nedergaard M. Astrocytic complexity distinguishes the human brain. Trends Neurosci. 2006 Oct; 29(10):547-53.  View on PubMed
  12. Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M. An astrocytic basis of epilepsy. Nat Med. 2005 Sep; 11(9):973-81.  View on PubMed

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