Research Summary

The Peng Lab is interested in how the mesenchymal compartment integrates extracellular cues to modify the niche, with a focus on the niche supporting resident tissue stem cells. We utilize complex murine genetic models and human specimen to interrogate how mesenchymal compartments maintain organ homeostasis, initiate disease, and drive tissue aging. Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

Research Funding

  • August 22, 2018 - June 30, 2022 - Maintenance of the alveolar niche in emphysema, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL142552
  • September 30, 2016 - June 30, 2021 - Defining the resident mesenchymal stem cell niche and function in vivo, Principal Investigator. Sponsor: NIH/NIA, Sponsor Award ID: DP2AG056034
  • September 1, 2014 - June 30, 2019 - The roles of Hedgehog signaling in pulmonary vascular development and remodeling, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: K08HL121146
  • August 22, 2018 - June 30, 2022 - Maintenance of the alveolar niche in emphysema, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL142552


University of Virginia, Charlottesville, VA, B.A., 05/2000, Biology/Sociology
Johns Hopkins University, Baltimore, MD, M.D., 05/2006, Medicine
Columbia University Medical Center, New York, NY, Residency, 06/2009, Internal Medicine
Hospital of the University of Pennsylvania, Philadelphia, PA, Fellowship, 12/2012, Pulmonary and Critical Care Medicine
University of Pennsylvania School of Medicine, Philadelphia, PA, Postdoctoral research, 07/2015 Cell and Developmental Biology

Honors & Awards

  • 2000
    Phi Beta Kappa, University of Virginia
  • 2003
    Clinical Research Training Program Scholar, National Institutes of Health
  • 2013
    Travel Award, Program Faculty, Keystone Symposia Conference, Lung Development, Cancer
  • and Disease
  • 2013
    Travel Award, Vascular Biology 2013, North American Vascular Biology Organization (NAVBO)
  • 2013
    Stanley E. Bradley Award for Outstanding Bench Research, Department of Medicine, University
  • of Pennsylvania
  • 2014
    Travel Award, Gordon Research Conference, Lung Development and Repair
  • 2014
    Travel Award, Moderator, Keystone Symposia Conference, Fibrosis: From Bench to Bedside
  • 2014
    Joe Rae Wright Outstanding Young Investigator Award, Federation of American Societies for
  • Experimental Biology (FASEB)
  • 2016
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2016
    NIH New Innovator Award

Selected Publications

  1. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.  View on PubMed
  2. Wang C, Cassandras M, Peng T The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance.  View on PubMed
  3. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.  View on PubMed
  4. Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.  View on PubMed
  5. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.  View on PubMed
  6. Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation.  View on PubMed
  7. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.  View on PubMed
  8. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development.  View on PubMed
  9. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.  View on PubMed
  10. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.  View on PubMed
  11. Peng T, Morrisey EE Development of the pulmonary vasculature: Current understanding and concepts for the future.  View on PubMed
  12. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM Plasma levels of S100A4 in portopulmonary hypertension.  View on PubMed
  13. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy.  View on PubMed
  14. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.  View on PubMed
  15. Akeju O, Peng T, Park JK Short hairpin RNA loop design for the facilitation of sequence verification.  View on PubMed
  16. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells.  View on PubMed

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