Research Summary

The Peng Lab is interested in how fibroblasts integrates extracellular cues to modify the tissue niche, with a particular focus on fibroblasts that support tissue-resident stem cells and immune cells. We utilize complex murine genetic models and human specimen to interrogate how fibroblasts maintain organ homeostasis, initiate disease, and drive tissue aging. Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

Research Funding

  • February 1, 2021 - December 31, 2024 - Mesenchymal modulation of epithelial metaplasia in lung fibrosis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL155622
  • August 22, 2018 - June 30, 2022 - Maintenance of the alveolar niche in emphysema , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL142552
  • September 30, 2016 - June 30, 2021 - Defining the resident mesenchymal stem cell niche and function in vivo , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP2AG056034
  • September 1, 2014 - June 30, 2019 - The roles of Hedgehog signaling in pulmonary vascular development and remodeling , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K08HL121146

Education

University of Virginia, Charlottesville, VA, B.A., 05/2000, Biology/Sociology
Johns Hopkins University, Baltimore, MD, M.D., 05/2006, Medicine
Columbia University Medical Center, New York, NY, Residency, 06/2009, Internal Medicine
Hospital of the University of Pennsylvania, Philadelphia, PA, Fellowship, 12/2012, Pulmonary and Critical Care Medicine
University of Pennsylvania School of Medicine, Philadelphia, PA, Postdoctoral research, 07/2015 Cell and Developmental Biology

Honors & Awards

  • 2000
    Phi Beta Kappa, University of Virginia
  • 2003
    Clinical Research Training Program Scholar, National Institutes of Health
  • 2013
    Travel Award, Program Faculty, Keystone Symposia Conference, Lung Development, Cancer
  • and Disease
  • 2013
    Travel Award, Vascular Biology 2013, North American Vascular Biology Organization (NAVBO)
  • 2013
    Stanley E. Bradley Award for Outstanding Bench Research, Department of Medicine, University
  • of Pennsylvania
  • 2014
    Travel Award, Gordon Research Conference, Lung Development and Repair
  • 2014
    Travel Award, Moderator, Keystone Symposia Conference, Fibrosis: From Bench to Bedside
  • 2014
    Joe Rae Wright Outstanding Young Investigator Award, Federation of American Societies for
  • Experimental Biology (FASEB)
  • 2016
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2016
    NIH New Innovator Award

Selected Publications

  1. Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir. Immunity. 2023 Feb 16.  View on PubMed
  2. Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science. 2022 10 14; 378(6616):192-201.  View on PubMed
  3. Allen NC, Reyes NS, Lee JY, Peng T. Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche. Front Cell Dev Biol. 2022; 10:932723.  View on PubMed
  4. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol. 2022 01; 24(1):10-23.  View on PubMed
  5. Kathiriya JJ, Peng T. An inflammatory switch for stem cell plasticity. Nat Cell Biol. 2021 09; 23(9):928-929.  View on PubMed
  6. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020 11; 22(11):1295-1306.  View on PubMed
  7. Wang C, Cassandras M, Peng T. The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance. J Dev Biol. 2019 Jul 09; 7(3).  View on PubMed
  8. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 03 19; 50(3):707-722.e6.  View on PubMed
  9. Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell. 2019 06; 18(3):e12914.  View on PubMed
  10. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358.  View on PubMed
  11. Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 11 22; 17(9):2312-2325.  View on PubMed
  12. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82.  View on PubMed
  13. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79.  View on PubMed
  14. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/�-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 05; 13(6):720-33.  View on PubMed
  15. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92.  View on PubMed
  16. Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8.  View on PubMed
  17. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60.  View on PubMed
  18. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5.  View on PubMed
  19. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52.  View on PubMed
  20. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158.  View on PubMed

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