University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Boris C. Bastian, MD, PhD

Boris C. Bastian, MD, PhD

Professor of Dermatology and Pathology, University of California, San Francisco
Gerson and Barbara Bass Bakar Distinguished Professor in Cancer Research, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I am a dermatologist and dermatopathologistwith expertise in diagnosing and treating patients with cutaneous neoplasms. I have expertise in molecular cancer genetics and molecular pathology and lead a research laboratory at the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco (UCSF). Since 1997 my research has focused on the molecular pathogenesis of melanoma and revealed the existence of distinct disease subtypes that differ in their underlying genetic alterations, epidemiology, anatomic distribution, clinical and microscopic appearance, evolution from precursor lesions, role of UV radiation, and cell of origin. The Bastian Lab also has contributed to the discovery of oncogenic alterations such as mutations in KIT, GNAQ, GNA11, HRAS, and a whole panel of oncogenic fusion genes of various receptor tyrosine and threonine kinases in various melanocytic neoplasms. I have developed clinical tests to assist pathologists with the diagnosis of histologically ambiguous lesions, which have been adopted word-wide. I have proposed a two-dimensional taxonomy of melanocytic neoplasia that has been adopted as the framework for the revised WHO Classification of Skin Tumors. I founded and direct the Clinical Cancer Genomics Laboratory at UCSF, which performs genomic analyses of tumor samples of patients seen at the UCSF Helen Diller Family Comprehensive Cancer Center and have additional clinical responsibilities in the in the Dermatopathology Section of the Departments of Dermatology and Pathology.

Education

Humboldt-Gymnasium, Solingen, Germany, Baccalaureate, 1980
University of Munich, Germany, M.D., 1988, Medicine
University of Munich, Germany, Dr. med., 1989, Laboratory Medicine
University of Wurzburg, Germany, Residency, 1994, Dermatology
University of California, San Francisco, Postdoctoral, 1999, Cancer Genetics


Professional Experience

  • 1986-1989
    Dissertation 'Development and Characterization of an enzymatic assay for human pancreatic phospholipase A2'
  • 1988-89
    Fellowship, Dept. of Hematology, Ludwig-Maximilian-University, Munich, Germany
  • 1989-1994
    Residency, Dermatology, Dept. of Dermatology, University of Würzburg, Germany
  • 1993
    German board certification for Dermatology
  • 1995
    German board certification Allergy and Immunology
  • 1994-1997
    Attending Physician, Dept. of Dermatology, University of Würzburg, Germany
  • 1995-1997
    Director of the Dermatopathology Section, Dept. of Dermatology, University of Würzburg, Germany
  • 1997-1999
    Postdoctoral Fellowship, Cancer Genetics Group, Cancer Center at UCSF
  • 1999-2002
    Assistant Clinical Professor, Dept. of Dermatology and Pathology, UCSF
  • 2002-2004
    Assistant Professor in Residence, Department of Dermatology and Assistant Clinical Professor, Department of Pathology, UCSF
  • 7/2004-2008
    Associate Professor in Residence, Department of Dermatology and Associate Clinical Professor, Department of Pathology, UCSF
  • 7/2008
    Professor in Residence, Department of Dermatology and Clinical Professor, Department of Pathology, UCSF
  • 9/2008
    Leader, Cutaneous Oncology Program, UCSF
  • 4/2010-8/11
    Chairman, Department of Pathology, and Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
  • 9/2011-present
    Professor of Dermatology and Pathology, University of California, San Francisco

Honors & Awards

  • 1995
    Graduate Stipend of the Novartis Foundation for Therapeutic Research
  • 1997
    Habilitandenstipendium of the German Research Society (Deutsche Forschungsgemeinschaft)
  • 2000
    American Melanoma Foundation Research Award
  • 2001
    American Skin Association Research Scientist Development Award
  • 2005
    Hermann Pinkus Lectureship and Award, American Society of Dermatopathology
  • 2006
    Stewart Trust Award
  • 2007
    Melanoma Research Foundation Individual Investigator Award
  • 2008
    Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research, American Skin Association
  • 2011-2013
    President, Society of Melanoma Research
  • 2011
    German National Academy of Science (Leopoldina)
  • 2012
    Helwig Award, American Society of Dermatopathology
  • 2012
    Scientific Leadership Award, Melanoma Research Foundation
  • 2014
    Lifetime Achievement Award, Society of Melanoma Research
  • 2015
    Stein Innovation Award, Research to Prevent Blindness
  • 2016
    Research Achievement Award in Melanoma and Skin Cancer Research, American Skin Association
  • 2017
    Lila and Murray Gruber Memorial Cancer Research Award, American Academy of Dermatology
  • 2017
    NCI Outstanding Investigator Award

Selected Publications

  1. Shain AH, Bastian BC. Author Correction: From melanocytes to melanomas. Nat Rev Cancer. 2020 May 07.
    View on PubMed
  2. Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway. Arch Pathol Lab Med. 2020 Apr; 144(4):500-522.
    View on PubMed
  3. Lee HJ, Pham T, Chang MT, Barnes D, Cai AG, Noubade R, Totpal K, Chen X, Tran C, Hagenbeek T, Wu X, Eastham-Anderson J, Tao J, Lee W, Bastian BC, Carbone M, Webster JD, Dey A. The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2020 Apr 15; 80(8):1656-1668.
    View on PubMed
  4. Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. Spitz melanoma is a distinct subset of spitzoid melanoma. Mod Pathol. 2020 Jan 03.
    View on PubMed
  5. Afshar AR, Pekmezci M, Bloomer MM, Cadenas NJ, Stevers M, Banerjee A, Roy R, Olshen AB, Van Ziffle J, Onodera C, Devine WP, Grenert JP, Bastian BC, Solomon DA, Damato BE. Next-Generation Sequencing of Retinoblastoma Identifies Pathogenic Alterations beyond RB1 Inactivation That Correlate with Aggressive Histopathologic Features. Ophthalmology. 2019 Dec 12.
    View on PubMed
  6. Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A. Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations. Mod Pathol. 2020 05; 33(5):846-857.
    View on PubMed
  7. Burbidge TE, Bastian BC, Guo D, Li H, Morris DG, Monzon JG, Leung G, Yang H, Cheng T. Association of Indoor Tanning Exposure With Age at Melanoma Diagnosis and BRAF V600E Mutations. J Natl Cancer Inst. 2019 11 01; 111(11):1228-1231.
    View on PubMed
  8. Fernandez KS, Turski ML, Shah AT, Bastian BC, Horvai A, Hardee S, Sweet-Cordero EA. Ewing sarcoma in a child with neurofibromatosis type 1. Cold Spring Harb Mol Case Stud. 2019 10; 5(5).
    View on PubMed
  9. Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC. Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7.
    View on PubMed
  10. Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. Targeted Genomic Profiling of Acral Melanoma. J Natl Cancer Inst. 2019 10 01; 111(10):1068-1077.
    View on PubMed
  11. Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL. MicroRNA Ratios Distinguish Melanomas from Nevi. J Invest Dermatol. 2020 01; 140(1):164-173.e7.
    View on PubMed
  12. Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas VR, Wolff AM, Fraser JS, Collisson EA, McCoach CE, Camidge DR, Pacheco J, Bazhenova L, Li T, Bivona TG, Blakely CM. Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. Clin Cancer Res. 2020 Jan 15; 26(2):439-449.
    View on PubMed
  13. Leachman SA, Hornyak TJ, Barsh G, Bastian BC, Brash DE, Cleaver JE, Cooper CD, D'Orazio JA, Fujita M, Holmen SL, Indra AK, Kraemer KH, Le Poole IC, Lo RS, Lund AW, Manga P, Pavan WJ, Setaluri V, Stemwedel CE, Kulesz-Martin MF. Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting. J Invest Dermatol. 2020 Feb; 140(2):269-274.
    View on PubMed
  14. Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, Xu Q, Rawson RV, Mukhopadhyay P, Dummer R, Levesque MP, Jönsson G, Wang X, Yeh I, Wu H, Joseph N, Bastian BC, Long GV, Spillane AJ, Shannon KF, Thompson JF, Saw RPM, Adams DJ, Si L, Pearson JV, Hayward NK, Waddell N, Mann GJ, Guo J, Scolyer RA. Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets. Nat Commun. 2019 07 18; 10(1):3163.
    View on PubMed
  15. Tsai KK, Khurana N, McCalmont T, Daud A, Bastian B, Yeh I. PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change. J Natl Compr Canc Netw. 2019 07 01; 17(7):778-783.
    View on PubMed
  16. Shain AH, Bagger MM, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC, Kiilgaard JF. The genetic evolution of metastatic uveal melanoma. Nat Genet. 2019 07; 51(7):1123-1130.
    View on PubMed
  17. Yeh I, Busam KJ, McCalmont TH, LeBoit PE, Pissaloux D, Alberti L, de la Fouchardière A, Bastian BC. Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion. Am J Surg Pathol. 2019 06; 43(6):737-746.
    View on PubMed
  18. Afshar AR, Damato BE, Stewart JM, Zablotska LB, Roy R, Olshen AB, Joseph NM, Bastian BC. Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis. Transl Vis Sci Technol. 2019 Mar; 8(2):18.
    View on PubMed
  19. Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V, Kuijjer ML, Arends MJ, Brenn T, Harms PW, Wood GA, Adams DJ. Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma. Nat Commun. 2019 01 21; 10(1):353.
    View on PubMed
  20. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2019 01; 29(1):85-96.
    View on PubMed

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