University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Daniel D. Bikle, MD, PhD

Daniel D. Bikle, MD, PhD

Professor, Departments of Medicine and Dermatology, UCSF

Cancer Center Program Memberships



Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Professional Experience

  • 1974-1972
    Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
  • 1979-1982
    Assistant Professor of Medicine, University of California, San Francisco, CA
  • 1979-present
    Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
  • 1986-1992
    Associate Professor of Medicine, University of California, San Francisco, CA
  • 1991-present
    Professor of Medicine, University of California, San Francisco, CA
  • 1993-present
    Professor of Dermatology, University of California, San Francisco, CA

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  • (Selected from a total of 232)
  • Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E 1989 Bone res-ponse to normal weightbearing after a period of skeletal unloading. Am J Physiol 257:E606-610.
  • Patterson-Buckendahl P, Globus RK, Bikle DD, Cone CE, Morey-Holton E 1989 Effect of simulated weightlessness on rat osteocalcin and bone calcium. Amer J Physiol 257:R1103-9, 1989.
  • Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E 1990 Different responses to trabecular and cortical bone to 1,25(OH)2D3 infusion. Am J Physiol 259:E715-22.
  • Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E 1993 Skeletal unloading decreases the production of 1,25 dihydroxyvitamin D. Amer J Physiol 264: E712-716.
  • Bikle DD, Harris J, Halloran BP, Roberts Jr. CT, LeRoith D, Morey-Holton E 1994 Expression of the genes for the insulin like growth factors and their receptors in bone during skeletal growth. Amer J Physiol 267: E278-E286.
  • Bikle DD, Harris J, Halloran BP, Morey-Holton E 1994 Skeletal unloading induces resistance to insulin like growth factor 1. J Bone Miner Res 9: 1789-1796.
  • Bikle DD, Morey-Holton E, Doty SB, Currier PA, Tanner SJ, Halloran BP 1994 Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J Bone Miner Res 9: 1777-1787.
  • Bikle DD, Harris J, Halloran BP, Morey-Holton E 1994 Altered skeletal pattern of gene expression in response to space flight: comparison to the response to hindlimb elevation. Amer J Physiol 267: E822-E827.
  • Bikle DD, Halloran BP, Morey-Holton E 1994 Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astron 33:119-129.
  • Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E 1995 The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology 136: 2099-2109.
  • Halloran BP, Bikle DD, Harris J, Autry CP, Currier P, Tanner S, Patterson-Buckendahl P, Morey-Holton E 1995 Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res 10: 1168-1176.
  • Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E 1997 Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res 12:1068-1074.
  • Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD, 1997. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Amer J Physiol 273:E1133. E1139.
  • Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E 1999. Bone and mineral changes induced by skeletal unloading in the mature male rat. Amer J Physiol 276:E62-E62
  • Kostenuik PJ, Harris J, Halloran B, Turner R, Morey-Holton E, Bikle DD 1999. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone an to insulin-like growth factor-I. J Bone Min Res 14:21-32
  • Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD. 2001. Osteoblasts in culture respond to pulsatile fluid flow with short-term increases in PGE2 production but no change in cell proliferation or mineralization. J Appl Physiol 90:1849-1854.
  • Bikle DD, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B. 2001. The skeletal structure of insulin-like growth factor-I deficient mice. J Bone Min Res 16:2320-2329.
  • Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. 2002. Insulin like growth factor-I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Min Res. 17:1570-78, 2002.
  • Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM 2002. Mechanical and chemical characteristics of mineral produced by bFGF-treated bone marrow stromal cells in vitro. Tiss Engineer 8:931-939.
  • Bikle DD, Sakata T, Halloran BP 2003. The Impact of Skeletal Unloading on Bone Formation. Grav Space Biol Bull 16:45-52
  • Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD 2003. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calc Tiss Internl 73: 147-152.
  • Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD 2003. Skeletal unloading induces resistance to insulin-like growth factor-I on bone formation. Bone 32:669-682
  • Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD 2004. Skeletal unloading induces resistance to IGF-I by inhibiting activation of the IGF-I signaling pathways. J Bone Min Res 19:436-446.
  • Huang JC, Sakata T, Pfleger LV, Bencsik M, Halloran BP, Bikle DD, and Nissenson RA. 2004 Effects of Parathyroid Hormone on RANKL and OPG Gene Expression During Osteoblast Differentiation. J Bone Min Res 19: 235-244.
  • Rodriguez L, Tu C, Cheng Z, Chen T-H, Bikle D, Shoback D, Chang W 2005 Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology 146: 5294-5302
  • Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD 2006 Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol 189: 279-282
  • Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD.2006 Insulin-Like Growth Factor-I Is Essential For Embryonic Bone Development. Endocrinology 147:4753-4762