University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Daniel D. Bikle, MD, PhD

Daniel D. Bikle, MD, PhD

Professor, Departments of Medicine and Dermatology, UCSF

Cancer Center Program Memberships

Non-aligned

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD. Deletion of Mediator 1 suppresses TGFß signaling leading to changes in epidermal lineages and regeneration. PLoS One. 2020; 15(8):e0238076.
    View on PubMed
  2. Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings NJ, Napoli N, Accili D, Binkley N, Landry DW, Giustina A. MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19. Eur J Endocrinol. 2020 Aug 01.
    View on PubMed
  3. Oda Y, Bikle DD. Vitamin D and calcium signaling in epidermal stem cells and their regeneration. World J Stem Cells. 2020 Jul 26; 12(7):604-611.
    View on PubMed
  4. Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z. p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling. J Cell Physiol. 2020 Apr 30.
    View on PubMed
  5. Xie Z, Wang X, Bikle DD. Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2020; 11:40.
    View on PubMed
  6. Bikle D, Christakos S. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020 04; 16(4):234-252.
    View on PubMed
  7. Bikle DD. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. J Endocr Soc. 2020 Feb 01; 4(2):bvz038.
    View on PubMed
  8. Bouillon R, Bikle D. Vitamin D Metabolism Revised: Fall of Dogmas. J Bone Miner Res. 2019 11; 34(11):1985-1992.
    View on PubMed
  9. Munson S, Wang Y, Chang W, Bikle DD. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011.
    View on PubMed
  10. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 08 01; 40(4):1109-1151.
    View on PubMed
  11. Bikle DD. Do sunscreens block vitamin D production? A critical review by an international panel of experts. Br J Dermatol. 2019 11; 181(5):884.
    View on PubMed
  12. Christakos S, Li S, De La Cruz J, Bikle DD. New developments in our understanding of vitamin metabolism, action and treatment. Metabolism. 2019 09; 98:112-120.
    View on PubMed
  13. Bikle DD, Schwartz J. Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2019; 10:317.
    View on PubMed
  14. Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD. The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner. JBMR Plus. 2019 Sep; 3(9):e10193.
    View on PubMed
  15. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S. Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome. Bone Rep. 2019 Jun; 10:100194.
    View on PubMed
  16. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab. 2018 09 01; 103(9):3278-3288.
    View on PubMed
  17. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 10; 84(10):2194-2207.
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  18. Bikle DD, Bouillon R. Vitamin D and bone and beyond. Bone Rep. 2018 Dec; 9:120-121.
    View on PubMed
  19. Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD. p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function. J Cell Physiol. 2018 01; 234(1):427-432.
    View on PubMed
  20. Oda Y, Hu L, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair. J Invest Dermatol. 2018 11; 138(11):2423-2431.
    View on PubMed

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