University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
June MayLin Chan, ScD

June MayLin Chan, ScD

Program Director, Genitourinary Cancer Epidemiology and Population Sciences, Department of Urology, UCSF
Steven and Christine Burd-Safeway Distinguished Professor, UCSF

Cancer Center Program Memberships

Prostate Cancer

Research Summary

My main research interests are in understanding how diet, exercise, and genetics contribute to prostate cancer incidence, progression, and death. Our program aims to identify modifiable lifestyle risk factors for prostatecancer progression, use this information to better understand prostate cancer biology, and inform public health guidelines. I have worked in this area for ~20 years and was awarded the Steven & Christine Burd-Safeway Distinguished Professorship at UCSF (University of California San Francisco) in 2009 in recognition of my teaching, research, and service activities in prostate cancer. Our work is highly collaborative, and our clinical and translational studies work to identify risk-reduction strategies for men with or at high risk for prostate cancer, evaluate novel molecular markers of prostate cancer aggressiveness that may improve screening, diagnosis, or prognosis of clinically relevant disease, and improve cancer survivorship for the millions of men living with prostate cancer world wide.

I initiated the prospective Diet and Lifestyle Study within the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) in 2004; am PI of a randomized clinical trial examining an exercise intervention among men pursuing active surveillance for prostate cancer; co-PI on a large Dept. of Defense Translational Impact Award focused on improving risk stratification and decision support for men considering active surveillance for low risk prostate cancer; site co-PI for a global clinical trial of exercise among men with metastatic prostate cancer; and am mentoring two junior facultyon three distinct lifestyle intervention trials for cancer survivors. I have mentored ~22 pre-doctoral students, 8 fellows, and 6 faculty. I have worked closely with Dr. Carroll for 15+ yrs on research related to identifying and testing novel biomarkers to discern aggressive from lethal prostate cancer. In this proposal, we bring together expertise in lifestyle risk factors for lethal prostate cancer, experience in elucidating the molecular drivers for aggressive prostate cancer, and experience implementing prostate cancer registries and biobanks. We have assembled unique study and data resources to evaluate if/how lifestyle factors influence tumor and host inflammation, insulin regulation, and metabolism pathways to drive aggressive disease; examine if lifestyle changes may mitigate such drivers to prevent lethal prostate cancer; and begin to address these same hypothesis in African American men with prostate cancer.

Education

Harvard College, Cambridge, MA , B.A., 1994, Applied Math in Biology
Harvard School of Public Health, Boston, MA, ScD, 11/98, Epidemiology (Cancer)
Harvard School of Public Health, Boston, MA, 11/98-11/00, Postdoctoral Fellow-Epidemiology


Professional Experience

  • 1992-94, 1995-96
    Research Assistant, Department of Nutrition, Harvard School of Public Health
  • 1994-95
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1995-97
    National Research Service Award Fellowship, National Cancer Institute (NCI), Training Program in Cancer Epidemiology - pre-doctoral
  • 1997-98
    Teaching Fellow, Harvard School of Public Health
  • 1997- present
    Project Director, Prostate Cancer Survivors Follow-up, Harvard Sch. of Public Health
  • 1998-2000
    Postdoctoral Fellow, Depts of Epidemiology/Nutrition, Harvard Sch. Public Health; National Research Service Award Fellowship, NCI, Training Program in Cancer Epidemiology - post-doctoral
  • 1999
    Visiting Researcher, Dept. of Nutrition, National Public Health Institute, Helsinki, Finland
  • 1999
    Instructor of Medicine, Harvard Medical School
  • 2001-2007
    Assistant Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)
  • 2005-present
    Program Director, Genitourinary Cancer Epid. and Pop. Sci., Dept. of Urology, UCSF
  • 2007-present
    Associate Professor, In Residence, Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco (UCSF)
  • 2007-present
    Course Director & Epidemiology and Evidence-based Medicine Discipline Leader, Essential Core Curriculum, UCSF School of Medicine
  • 2012-present
    Professor, Departments of Epidemiology & Biostatistics and Urology, UCSF
  • 2013-2014
    Interim Division Chief, Genetic & Cancer Epidemiology, Dept. of Epid. & Biostats., UCSF

Honors & Awards

  • 1994-96
    Fulbright Scholar, Uppsala University, Sweden, Dept. of Medical Epidemiology
  • 1996 & 1997
    Pforzheimer Public Service Fellowship, Harvard University
  • 1998
    Society for Epidemiologic Research Abraham Lilienfeld Student Prize
  • 1998
    Association for the Cure of Cancer of the Prostate ("CaPCURE") - Young Investigator Award
  • 2000
    AACR-AFLAC Young Investigator Scholars in Cancer Research Award
  • 2001
    REAC Intramural award, UCSF
  • 2002
    AACR-California Department of Health Services Early Career Development Award in Gender-Related Cancer Research (prostate)
  • 2003
    Prostate Cancer Foundation ("CaPCURE") - Competitive Award (6/03 & 12/03)
  • UCSF Equal Opportunity Faculty Development Award
  • 2009
    Awarded Steven & Christine Burd-Safeway Distinguished Professorship, Urology, UCSF

Selected Publications

  1. Langlais CS, Cowan JE, Neuhaus J, Kenfield SA, Van Blarigan EL, Broering JM, Cooperberg MR, Carroll P, Chan JM. Obesity at diagnosis and prostate cancer prognosis and recurrence risk following primary treatment by radical prostatectomy. Cancer Epidemiol Biomarkers Prev. 2019 Aug 28.
    View on PubMed
  2. Herlemann A, Huang HC, Alam R, Tosoian JJ, Kim HL, Klein EA, Simko JP, Chan JM, Lane BR, Davis JW, Davicioni E, Feng FY, McCue P, Kim H, Den RB, Bismar TA, Carroll PR, Cooperberg MR. Decipher identifies men with otherwise clinically favorable-intermediate risk disease who may not be good candidates for active surveillance. Prostate Cancer Prostatic Dis. 2019 Aug 27.
    View on PubMed
  3. Zuniga KB, Chan JM, Ryan CJ, Kenfield SA. Diet and lifestyle considerations for patients with prostate cancer. Urol Oncol. 2019 Jul 18.
    View on PubMed
  4. Zuniga KB, Zhao S, Kenfield SA, Cedars B, Cowan JE, Van Blarigan EL, Broering JM, Carroll PR, Chan JM. Trends in Complementary and Alternative Medicine Use among Patients with Prostate Cancer. J Urol. 2019 May 15; 101097JU0000000000000336.
    View on PubMed
  5. Kornberg Z, Cooperberg MR, Cowan JE, Chan JM, Shinohara K, Simko JP, Tenggara I, Carroll PR. A 17-Gene Genomic Prostate Score as a Predictor of Adverse Pathology for Men on Active Surveillance. J Urol. 2019 Apr 26; 101097JU0000000000000290.
    View on PubMed
  6. Downer MK, Kenfield SA, Stampfer MJ, Wilson KM, Dickerman BA, Giovannucci EL, Rimm EB, Wang M, Mucci LA, Willett WC, Chan JM, Van Blarigan EL. Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study. J Clin Oncol. 2019 Jun 10; 37(17):1499-1511.
    View on PubMed
  7. Cedars BE, Washington SL, Cowan JE, Leapman M, Tenggara I, Chan JM, Cooperberg MR, Carroll PR. Stability of a 17-Gene Genomic Prostate Score in Serial Testing of Men on Active Surveillance of Early Stage Prostate Cancer. J Urol. 2019 Apr 08; 101097JU0000000000000271.
    View on PubMed
  8. Watts EL, Perez-Cornago A, Appleby PN, Albanes D, Ardanaz E, Black A, Bueno-de-Mesquita HB, Chan JM, Chen C, Chubb SAP, Cook MB, Deschasaux M, Donovan JL, English DR, Flicker L, Freedman ND, Galan P, Giles GG, Giovannucci EL, Gunter MJ, Habel LA, Häggström C, Haiman C, Hamdy FC, Hercberg S, Holly JM, Huang J, Huang WY, Johansson M, Kaaks R, Kubo T, Lane JA, Layne TM, Le Marchand L, Martin RM, Metter EJ, Mikami K, Milne RL, Morris HA, Mucci LA, Neal DE, Neuhouser ML, Oliver SE, Overvad K, Ozasa K, Pala V, Pernar CH, Pollak M, Rowlands MA, Schaefer CA, Schenk JM, Stattin P, Tamakoshi A, Thysell E, Touvier M, Trichopoulou A, Tsilidis KK, Van Den Eeden SK, Weinstein SJ, Wilkens L, Yeap BB, Key TJ, Allen NE, Travis RC. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies. Int J Cancer. 2019 Mar 15.
    View on PubMed
  9. Van Blarigan EL, Chan H, Van Loon K, Kenfield SA, Chan JM, Mitchell E, Zhang L, Paciorek A, Joseph G, Laffan A, Atreya CE, Fukuoka Y, Miaskowski C, Meyerhardt JA, Venook AP. Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial. BMC Cancer. 2019 Mar 11; 19(1):218.
    View on PubMed
  10. Zhao SG, Lehrer J, Chang SL, Das R, Erho N, Liu Y, Sjöström M, Den RB, Freedland SJ, Klein EA, Karnes RJ, Schaeffer EM, Xu M, Speers C, Nguyen PL, Ross AE, Chan JM, Cooperberg MR, Carroll PR, Davicioni E, Fong L, Spratt DE, Feng FY. The Immune Landscape of Prostate Cancer and Nomination of PD-L2 as a Potential Therapeutic Target. J Natl Cancer Inst. 2019 Mar 01; 111(3):301-310.
    View on PubMed
  11. Kornberg Z, Cowan JE, Westphalen AC, Cooperberg MR, Chan JM, Zhao S, Shinohara K, Carroll PR. Genomic Prostate Score, PI-RADS™ version 2 and Progression in Men with Prostate Cancer on Active Surveillance. J Urol. 2019 02; 201(2):300-307.
    View on PubMed
  12. Kenfield SA, Van Blarigan EL, Ameli N, Lavaki E, Cedars B, Paciorek AT, Monroy C, Tantum LK, Newton RU, Signorell C, Suh JH, Zhang L, Cooperberg MR, Carroll PR, Chan JM. Feasibility, Acceptability, and Behavioral Outcomes from a Technology-enhanced Behavioral Change Intervention (Prostate 8): A Pilot Randomized Controlled Trial in Men with Prostate Cancer. Eur Urol. 2019 Jan 09.
    View on PubMed
  13. Ahearn TU, Peisch S, Pettersson A, Ebot EM, Zhou CK, Graff RE, Sinnott JA, Fazli L, Judson GL, Bismar TA, Rider JR, Gerke T, Chan JM, Fiorentino M, Flavin R, Sesso HD, Finn S, Giovannucci EL, Gleave M, Loda M, Li Z, Pollak M, Mucci LA. Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease. Carcinogenesis. 2018 Dec 31; 39(12):1431-1437.
    View on PubMed
  14. Winters-Stone KM, Kenfield SA, Van Blarigan EL, Moe EL, Ramsdill JW, Daniel K, Macaire G, Paich K, Kessler ER, Kucuk O, Gillespie TW, Lyons KS, Beer TM, Broering JM, Carroll PR, Chan JM. Effect of Increasing Levels of Web-Based Behavioral Support on Changes in Physical Activity, Diet, and Symptoms in Men With Prostate Cancer: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2018 Nov 15; 7(11):e11257.
    View on PubMed
  15. Travis RC, Perez-Cornago A, Appleby PN, Albanes D, Joshu CE, Lutsey PL, Mondul AM, Platz EA, Weinstein SJ, Layne TM, Helzlsouer KJ, Visvanathan K, Palli D, Peeters PH, Bueno-de-Mesquita B, Trichopoulou A, Gunter MJ, Tsilidis KK, Sánchez MJ, Olsen A, Brenner H, Schöttker B, Perna L, Holleczek B, Knekt P, Rissanen H, Yeap BB, Flicker L, Almeida OP, Wong YYE, Chan JM, Giovannucci EL, Stampfer MJ, Ursin G, Gislefoss RE, Bjørge T, Meyer HE, Blomhoff R, Tsugane S, Sawada N, English DR, Eyles DW, Heath AK, Williamson EJ, Manjer J, Malm J, Almquist M, Marchand LL, Haiman CA, Wilkens LR, Schenk JM, Tangen CM, Black A, Cook MB, Huang WY, Ziegler RG, Martin RM, Hamdy FC, Donovan JL, Neal DE, Touvier M, Hercberg S, Galan P, Deschasaux M, Key TJ, Allen NE. A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk. Cancer Res. 2019 01 01; 79(1):274-285.
    View on PubMed
  16. Watts EL, Appleby PN, Perez-Cornago A, Bueno-de-Mesquita HB, Chan JM, Chen C, Cohn BA, Cook MB, Flicker L, Freedman ND, Giles GG, Giovannucci E, Gislefoss RE, Hankey GJ, Kaaks R, Knekt P, Kolonel LN, Kubo T, Le Marchand L, Luben RN, Luostarinen T, Männistö S, Metter EJ, Mikami K, Milne RL, Ozasa K, Platz EA, Quirós JR, Rissanen H, Sawada N, Stampfer M, Stanczyk FZ, Stattin P, Tamakoshi A, Tangen CM, Thompson IM, Tsilidis KK, Tsugane S, Ursin G, Vatten L, Weiss NS, Yeap BB, Allen NE, Key TJ, Travis RC. Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies. Eur Urol. 2018 11; 74(5):585-594.
    View on PubMed
  17. Downer MK, Allard CB, Preston MA, Wilson KM, Kenfield SA, Chan JM, Mucci LA, Giovannucci E, Stampfer MJ. Aspirin Use and Lethal Prostate Cancer in the Health Professionals Follow-up Study. Eur Urol Oncol. 2019 Mar; 2(2):126-134.
    View on PubMed
  18. Chan JM, Kenfield SA, Platz EA. Association of Statin Use With Overall and Cancer Survival. JAMA Oncol. 2018 Jul 01; 4(7):1016.
    View on PubMed
  19. Cooperberg MR, Erho N, Chan JM, Feng FY, Fishbane N, Zhao SG, Simko JP, Cowan JE, Lehrer J, Alshalalfa M, Kolisnik T, Chelliserry J, Margrave J, Aranes M, Plessis MD, Buerki C, Tenggara I, Davicioni E, Carroll PR. The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer. Eur Urol. 2018 10; 74(4):444-452.
    View on PubMed
  20. Mascarenhas MN, Chan JM, Vittinghoff E, Van Blarigan EL, Hecht F. Increasing Physical Activity in Mothers Using Video Exercise Groups and Exercise Mobile Apps: Randomized Controlled Trial. J Med Internet Res. 2018 May 18; 20(5):e179.
    View on PubMed

Go to UCSF Profiles, powered by CTSI