University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Zev Gartner, PhD

Zev Gartner, PhD

Associate Professor, Dept. of Pharmaceutical Chemistry

Cancer Center Program Memberships

Cancer Immunology

Research Summary

My lab aims to define the rules used by cells to self-organize into structurally ordered tissues, and to reveal how tissue structure guides the flow of chemical, mechanical, and electrical information between cells to coordinate collective decisions and behaviors. A better understanding of these processes will guide the development of new therapies for regenerative medicine and new strategies to block the progression of cancer. My lab’s multidisciplinary approach is uniquely suited to tackling these problems. We apply concepts and methods from chemistry, biology, and engineering, and develop new and enabling technologies when existing methods are insufficient for our experimental needs.

Education

University of California, Berkeley B.S. 1994-1999 Chemistry
Harvard University M.S. Ph.D. 1999-2004 Chemical Biology
University of California, Berkeley Postdoctoral 2005-2008 Chemical Biology


Professional Experience

  • 1998-1999
    Undergraduate Researcher, Laboratory of Professor Y. K. Shin
  • 1999-2004
    Graduate Student Researcher, Laboratory of Professor D. R. Liu
  • 2004
    Full Time Research Consultant, Ensemble Pharmaceuticals (formerly Ensemble Discovery)
  • 2005-2008
    Postdoctoral Researcher, Laboratory of Professor C. R. Bertozzi
  • 2008-present
    Assistant Professor, Dept. of Pharmaceutical Chemistry, University of California, San Francisco

Honors & Awards

  • 2000
    National Science Foundation Graduate Research Fellowship
  • 2003
    Bristol-Myers Squibb Fellowship
  • 2003
    Harvard Merit Fellowship
  • 2005
    IUPAC Prize for Young Chemists
  • 2006
    Jane Coffin Childs Postdoctoral Fellow
  • 2008
    Sandler Opportunity Award
  • 2010
    Kimmel Scholar Award
  • 2010
    Era of Hope Scholar Award
  • 2013
    NIH New Innovator Award
  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

  1. Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. Nat Methods. 2020 Jul 06.
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  2. Srivastava V, Huycke TR, Phong KT, Gartner ZJ. Organoid models for mammary gland dynamics and breast cancer. Curr Opin Cell Biol. 2020 Jun 11; 66:51-58.
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  3. Zhang JQ, Chang KC, Liu L, Gartner ZJ, Abate AR. High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing. J Vis Exp. 2020 May 21; (159).
    View on PubMed
  4. Zhang JQ, Siltanen CA, Liu L, Chang KC, Gartner ZJ, Abate AR. Linked optical and gene expression profiling of single cells at high-throughput. Genome Biol. 2020 02 24; 21(1):49.
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  5. Murrow LM, Gartner ZJ. Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development. Dev Cell. 2019 12 02; 51(5):545-547.
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  6. Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS. Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 05; 8(4).
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  7. Gartner Z, Hughes A. Getting the measure of living biomaterials. Nature. 2019 08; 572(7767):38-39.
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  8. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626.
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  9. OLIVIA A. CREASEY, DANIEL ELNATAN, JULIE B. SNEDDON, ZEV J. GARTNER. 2151-P: Quantification of Tissue Structure in Human and Mouse Islets. Diabetes. 2019 Jun 1; 68(Supplement 1):2151-p.
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  10. Lehmann R, Lee CM, Shugart EC, Benedetti M, Charo RA, Gartner Z, Hogan B, Knoblich J, Nelson CM, Wilson KM. Human organoids: a new dimension in cell biology. Mol Biol Cell. 2019 05 01; 30(10):1129-1137.
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  11. McGinnis CS, Murrow LM, Gartner ZJ. DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors. Cell Syst. 2019 04 24; 8(4):329-337.e4.
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  12. Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):11585-11590.
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  13. Gruber TD, Krishnamurthy C, Grimm JB, Tadross MR, Wysocki LM, Gartner ZJ, Lavis LD. Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. ACS Chem Biol. 2018 10 19; 13(10):2888-2896.
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  14. Hughes AJ, Mornin JD, Biswas SK, Beck LE, Bauer DP, Raj A, Bianco S, Gartner ZJ. Quanti.us: a tool for rapid, flexible, crowd-based annotation of images. Nat Methods. 2018 08; 15(8):587-590.
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  15. Siltanen CA, Cole RH, Poust S, Chao L, Tyerman J, Kaufmann-Malaga B, Ubersax J, Gartner ZJ, Abate AR. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology. Sci Rep. 2018 05 21; 8(1):7913.
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  16. Kim J, Han S, Lei A, Miyano M, Bloom J, Srivastava V, Stampfer MM, Gartner ZJ, LaBarge MA, Sohn LL. Characterizing cellular mechanical phenotypes with mechano-node-pore sensing. Microsyst Nanoeng. 2018; 4.
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  17. Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ. Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Rep. 2018 03 06; 22(10):2593-2600.
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  18. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 01 22; 44(2):165-178.e6.
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  19. Hu JL, Todhunter ME, LaBarge MA, Gartner ZJ. Opportunities for organoids as new models of aging. J Cell Biol. 2018 01 02; 217(1):39-50.
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  20. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889.
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