University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Zev Gartner, PhD

Zev Gartner, PhD

Associate Professor, Dept. of Pharmaceutical Chemistry

Cancer Center Program Memberships

Cancer Immunology

Research Summary

My lab aims to define the rules used by cells to self-organize into structurally ordered tissues, and to reveal how tissue structure guides the flow of chemical, mechanical, and electrical information between cells to coordinate collective decisions and behaviors. A better understanding of these processes will guide the development of new therapies for regenerative medicine and new strategies to block the progression of cancer. My lab’s multidisciplinary approach is uniquely suited to tackling these problems. We apply concepts and methods from chemistry, biology, and engineering, and develop new and enabling technologies when existing methods are insufficient for our experimental needs.

Education

University of California, Berkeley B.S. 1994-1999 Chemistry
Harvard University M.S. Ph.D. 1999-2004 Chemical Biology
University of California, Berkeley Postdoctoral 2005-2008 Chemical Biology


Professional Experience

  • 1998-1999
    Undergraduate Researcher, Laboratory of Professor Y. K. Shin
  • 1999-2004
    Graduate Student Researcher, Laboratory of Professor D. R. Liu
  • 2004
    Full Time Research Consultant, Ensemble Pharmaceuticals (formerly Ensemble Discovery)
  • 2005-2008
    Postdoctoral Researcher, Laboratory of Professor C. R. Bertozzi
  • 2008-present
    Assistant Professor, Dept. of Pharmaceutical Chemistry, University of California, San Francisco

Honors & Awards

  • 2000
    National Science Foundation Graduate Research Fellowship
  • 2003
    Bristol-Myers Squibb Fellowship
  • 2003
    Harvard Merit Fellowship
  • 2005
    IUPAC Prize for Young Chemists
  • 2006
    Jane Coffin Childs Postdoctoral Fellow
  • 2008
    Sandler Opportunity Award
  • 2010
    Kimmel Scholar Award
  • 2010
    Era of Hope Scholar Award
  • 2013
    NIH New Innovator Award
  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

  1. Gartner Z, Hughes A. Getting the measure of living biomaterials. Nature. 2019 Aug; 572(7767):38-39.
    View on PubMed
  2. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626.
    View on PubMed
  3. Lehmann R, Lee CM, Shugart EC, Benedetti M, Charo RA, Gartner Z, Hogan B, Knoblich J, Nelson CM, Wilson KM. Human organoids: a new dimension in cell biology. Mol Biol Cell. 2019 05 01; 30(10):1129-1137.
    View on PubMed
  4. McGinnis CS, Murrow LM, Gartner ZJ. DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors. Cell Syst. 2019 Apr 24; 8(4):329-337.e4.
    View on PubMed
  5. Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):11585-11590.
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  6. Gruber TD, Krishnamurthy C, Grimm JB, Tadross MR, Wysocki LM, Gartner ZJ, Lavis LD. Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. ACS Chem Biol. 2018 10 19; 13(10):2888-2896.
    View on PubMed
  7. Hughes AJ, Mornin JD, Biswas SK, Beck LE, Bauer DP, Raj A, Bianco S, Gartner ZJ. Quanti.us: a tool for rapid, flexible, crowd-based annotation of images. Nat Methods. 2018 08; 15(8):587-590.
    View on PubMed
  8. Siltanen CA, Cole RH, Poust S, Chao L, Tyerman J, Kaufmann-Malaga B, Ubersax J, Gartner ZJ, Abate AR. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology. Sci Rep. 2018 05 21; 8(1):7913.
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  9. Kim J, Han S, Lei A, Miyano M, Bloom J, Srivastava V, Stampfer MM, Gartner ZJ, LaBarge MA, Sohn LL. Characterizing cellular mechanical phenotypes with mechano-node-pore sensing. Microsyst Nanoeng. 2018; 4.
    View on PubMed
  10. Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ. Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Rep. 2018 03 06; 22(10):2593-2600.
    View on PubMed
  11. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 01 22; 44(2):165-178.e6.
    View on PubMed
  12. Hu JL, Todhunter ME, LaBarge MA, Gartner ZJ. Opportunities for organoids as new models of aging. J Cell Biol. 2018 01 02; 217(1):39-50.
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  13. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889.
    View on PubMed
  14. Cole RH, Tang SY, Siltanen CA, Shahi P, Zhang JQ, Poust S, Gartner ZJ, Abate AR. Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8728-8733.
    View on PubMed
  15. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2017 06 15; 169(7):1357.
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  16. Gartner ZJ, Prescher JA, Lavis LD. Unraveling cell-to-cell signaling networks with chemical biology. Nat Chem Biol. 2017 05 17; 13(6):564-568.
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  17. Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 03 23; 169(1):108-119.e20.
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  18. Murrow LM, Weber RJ, Gartner ZJ. Dissecting the stem cell niche with organoid models: an engineering-based approach. Development. 2017 03 15; 144(6):998-1007.
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  19. Weber RJ, Desai TA, Gartner ZJ. Non-autonomous cell proliferation in the mammary gland and cancer. Curr Opin Cell Biol. 2017 04; 45:55-61.
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  20. Shahi P, Kim SC, Haliburton JR, Gartner ZJ, Abate AR. Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding. Sci Rep. 2017 03 14; 7:44447.
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