University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Patrick Ha, MD

Patrick Ha, MD

Distinguished Professor, Department of Otolaryngology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I have been heavily involved in the field salivary gland cancer research since my postdoctoral experience during residency in the lab of Drs. David Sidransky and Joseph Califano. I joined the Johns Hopkins Department of Otolaryngology as a faculty member in 2006 and chose to focus my research efforts on salivary gland tumors, with several NIH and foundation grants awarded since 2007. My focus is on the epigenetic mechanisms of adenoid cystic carcinoma, and the pathways that might lead to its development. I have published many peer-reviewed studies on this topic and have formed many collaborations throughout the country. I recently moved to the University of California San Francisco to lead the Division of Head and Neck Surgical Oncology and will continue in my research there. As a head and neck surgeon, I bring additional clinical expertise which can offer access to tissue and patients, as well as an understanding of the relevant translational questions.

Education

Harvard College, BA, 1991-95, Biology
Johns Hopkins School of Medicine, MD, 1995-99, Medicine
Johns Hopkins Department of Otolaryngology, Residency, 1999-2006, Otolaryngology
Johns Hopkins Department of Otolaryngology, Postdoctoral Fellowship, 2000-2002, Molecular Genetics
Johns Hopkins Department of Otolaryngology, Advanced training, 2006, Head and Neck Surgery


Professional Experience

  • 1999 – 2000
    Surgical Internship, Johns Hopkins Department of Surgery
  • 2000 – 2002
    Research Fellow, Head and Neck Cancer Division, Johns Hopkins Department of Otolaryngology
  • 2002 – 2005
    Resident, Johns Hopkins Department of Otolaryngology
  • 2006 – 2006
    Assistant, Johns Hopkins Department of Otolaryngology
  • 2006 – 2010
    Assistant Professor, Johns Hopkins Department of Otolaryngology
  • 2010 – 2015
    Associate Professor, Johns Hopkins Department of Otolaryngology
  • 2015 -
    Distinguished Professor, University of California San Francisco Department of Otolaryngology

Honors & Awards

  • 1999
    Elected Alpha Omega Alpha, Johns Hopkins School of Medicine
  • 2001
    Greater Baltimore Medical Center Resident Research Forum award winner
  • 2005
    Recipient of the Henkel Chief Resident Teacher of the Year Award
  • 2005
    Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005
  • 2006
    Tilghman Travel Fellowship recipient for training in endoscopic laser surgery
  • 2007/10
    Recipient of the Otolaryngology Faculty Teaching Award
  • 2011-15
    Voted Baltimore Magazine Top Doc in Head and Neck Surgical Oncology

Selected Publications

  1. Windon MJ, D'Souza G, Waterboer T, Rooper L, Westra WH, Troy T, Pardoll D, Tan M, Yavvari S, Kiess AP, Miles B, Mydlarz WK, Ha PK, Bender N, Eisele DW, Fakhry C. Risk factors for human papillomavirus-positive nonoropharyngeal squamous cell carcinoma. Head Neck. 2020 Feb 26.
    View on PubMed
  2. Wai KC, Strohl MP, van Zante A, Ha PK. Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma. Cells. 2020 Feb 22; 9(2).
    View on PubMed
  3. Formeister EJ, Baum R, Knott PD, Seth R, Ha P, Ryan W, El-Sayed I, George J, Larson A, Plonowska K, Heaton C. Machine Learning for Predicting Complications in Head and Neck Microvascular Free Tissue Transfer. Laryngoscope. 2020 Jan 28.
    View on PubMed
  4. Rooper LM, Windon MJ, Hernandez T, Miles B, Ha PK, Ryan WR, Van Zante A, Eisele DW, D'Souza G, Fakhry C, Westra WH. HPV-positive Squamous Cell Carcinoma of the Larynx, Oral Cavity, and Hypopharynx: Clinicopathologic Characterization With Recognition of a Novel Warty Variant. Am J Surg Pathol. 2020 Jan 13.
    View on PubMed
  5. Fakhry C, Waterboer T, Westra WH, Rooper LM, Windon M, Troy T, Koch W, Gourin CG, Bender N, Yavvari S, Kiess AP, Miles BA, Ryan WR, Ha PK, Eisele DW, D'Souza G. Distinct biomarker and behavioral profiles of human papillomavirus-related oropharynx cancer patients by age. Oral Oncol. 2020 Feb; 101:104522.
    View on PubMed
  6. Ho AS, Ochoa A, Jayakumaran G, Zehir A, Valero Mayor C, Tepe J, Makarov V, Dalin MG, He J, Bailey M, Montesion M, Ross JS, Miller VA, Chan L, Ganly I, Dogan S, Katabi N, Tsipouras P, Ha P, Agrawal N, Solit DB, Futreal PA, El Naggar AK, Reis-Filho JS, Weigelt B, Ho AL, Schultz N, Chan TA, Morris LG. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest. 2019 Oct 01; 129(10):4276-4289.
    View on PubMed
  7. Jon Mallen-St. Clair, Patrick Ha. Molecular Genetics of Salivary Gland Cancer. . 2019 Sep 13; 1-6.
    View on PubMed
  8. Larson AR, Kemmer J, Formeister E, El-Sayed I, Ha P, George J, Ryan W, Chan E, Heaton C. Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma. Laryngoscope. 2019 Aug 14.
    View on PubMed
  9. Mathios D, Hwang T, Xia Y, Phallen J, Rui Y, See AP, Maxwell R, Belcaid Z, Casaos J, Burger PC, McDonald KL, Gallia GL, Cope L, Kai M, Brem H, Pardoll DM, Ha P, Green JJ, Velculescu VE, Bettegowda C, Park CK, Lim M. Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types. Int J Cancer. 2019 12 15; 145(12):3425-3435.
    View on PubMed
  10. Ando M, Saito Y, Xu G, Bui NQ, Medetgul-Ernar K, Pu M, Fisch K, Ren S, Sakai A, Fukusumi T, Liu C, Haft S, Pang J, Mark A, Gaykalova DA, Guo T, Favorov AV, Yegnasubramanian S, Fertig EJ, Ha P, Tamayo P, Yamasoba T, Ideker T, Messer K, Califano JA. Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. Nat Commun. 2019 May 29; 10(1):2415.
    View on PubMed
  11. Strohl MP, Chen JP, Ha PK, Seth R, Yom SS, Heaton CM. Can Early Dental Extractions Reduce Delays in Postoperative Radiation for Patients With Advanced Oral Cavity Carcinoma? J Oral Maxillofac Surg. 2019 Nov; 77(11):2215-2220.
    View on PubMed
  12. Ando M, Saito Y, Xu G, Bui NQ, Medetgul-Ernar K, Pu M, Fisch K, Ren S, Sakai A, Fukusumi T, Liu C, Haft S, Pang J, Mark A, Gaykalova DA, Guo T, Favorov AV, Yegnasubramanian S, Fertig EJ, Ha P, Tamayo P, Yamasoba T, Ideker T, Messer K, Califano JA. Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. Nat Commun. 2019 05 16; 10(1):2188.
    View on PubMed
  13. Raghavan K, Wen KW, Small EJ, Ha P, Flavell RR. Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT. Clin Nucl Med. 2019 May; 44(5):e367-e369.
    View on PubMed
  14. Binnewies M, Mujal AM, Pollack JL, Combes AJ, Hardison EA, Barry KC, Tsui J, Ruhland MK, Kersten K, Abushawish MA, Spasic M, Giurintano JP, Chan V, Daud AI, Ha P, Ye CJ, Roberts EW, Krummel MF. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019 04 18; 177(3):556-571.e16.
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  15. Xu MJ, Plonowska KA, Gurman ZR, Humphrey AK, Ha PK, Wang SJ, El-Sayed IH, Heaton CM, George JR, Yom SS, Algazi AP, Ryan WR. Treatment modality impact on quality of life for human papillomavirus-associated oropharynx cancer. Laryngoscope. 2020 Feb; 130(2):E48-E56.
    View on PubMed
  16. Wang L, Zhang SK, Ma Y, Ha PK, Wang ZM. Papillary cystadenoma of the parotid gland: A case report. World J Clin Cases. 2019 Feb 06; 7(3):366-372.
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  17. Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 02 04; 216(2):419-427.
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  18. Chan JW, Yeh I, El-Sayed IH, Algazi AP, Glastonbury CM, Ha PK, Yom SS, van Zante A. Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site. Head Neck. 2019 06; 41(6):E82-E85.
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  19. Jonathan P. Giurintano, Patrick K. Ha. Should Margin Sampling Be Obtained from the Specimen or from the Resection Bed in Oral Cavity Cancer?. Difficult Decisions in Head and Neck Oncologic Surgery. 2019 Jan 1; 31-39.
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  20. Wu TJ, Ha PK, El-Sayed IH, George JR, Heaton CM, Ryan WR, Russell MD. Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease. Head Neck. 2019 03; 41(3):715-721.
    View on PubMed

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