University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Patrick Ha, MD

Patrick Ha, MD

Distinguished Professor, Department of Otolaryngology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I have been heavily involved in the field salivary gland cancer research since my postdoctoral experience during residency in the lab of Drs. David Sidransky and Joseph Califano. I joined the Johns Hopkins Department of Otolaryngology as a faculty member in 2006 and chose to focus my research efforts on salivary gland tumors, with several NIH and foundation grants awarded since 2007. My focus is on the epigenetic mechanisms of adenoid cystic carcinoma, and the pathways that might lead to its development. I have published many peer-reviewed studies on this topic and have formed many collaborations throughout the country. I recently moved to the University of California San Francisco to lead the Division of Head and Neck Surgical Oncology and will continue in my research there. As a head and neck surgeon, I bring additional clinical expertise which can offer access to tissue and patients, as well as an understanding of the relevant translational questions.

Education

Harvard College, BA, 1991-95, Biology
Johns Hopkins School of Medicine, MD, 1995-99, Medicine
Johns Hopkins Department of Otolaryngology, Residency, 1999-2006, Otolaryngology
Johns Hopkins Department of Otolaryngology, Postdoctoral Fellowship, 2000-2002, Molecular Genetics
Johns Hopkins Department of Otolaryngology, Advanced training, 2006, Head and Neck Surgery

Honors & Awards

  • 1999
    Elected Alpha Omega Alpha, Johns Hopkins School of Medicine
  • 2001
    Greater Baltimore Medical Center Resident Research Forum award winner
  • 2005
    Recipient of the Henkel Chief Resident Teacher of the Year Award
  • 2005
    Recipient of the Greater Baltimore Medical Center Outstanding Resident Award 2005
  • 2006
    Tilghman Travel Fellowship recipient for training in endoscopic laser surgery
  • 2007/10
    Recipient of the Otolaryngology Faculty Teaching Award
  • 2011-15
    Voted Baltimore Magazine Top Doc in Head and Neck Surgical Oncology

Selected Publications

  1. Wai KC, Xu MJ, Lee RH, El-Sayed IH, George JR, Heaton CM, Knott PD, Park AM, Ryan WR, Seth R, Ha PK. Head and neck surgery during the coronavirus-19 pandemic: The University of California San Francisco experience. Head Neck. 2020 Oct 23.
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  2. Madeleine P. Strohl, Patrick K. Ha, Robert R. Flavell, Sue S. Yom. Position Emission Tomography/Computed Tomography (PET/CT) in Surgical Planning for Head and Neck Cancer. Seminars in Nuclear Medicine. 2020 Aug 1.
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  3. Park S, Vora M, van Zante A, Humtsoe J, Kim HS, Yom S, Agarwal S, Ha P. Clinicopathologic implications of Myb and Beta-catenin expression in adenoid cystic carcinoma. J Otolaryngol Head Neck Surg. 2020 Jul 10; 49(1):48.
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  4. Windon M, Fakhry C, Rooper L, Ha P, Schoppy D, Miles B, Koch W, Vosler P, Eisele D, D'Souza G. The Role of Age and Merkel Cell Polyomavirus in Oral Cavity Cancers. Otolaryngol Head Neck Surg. 2020 Jun 23; 194599820932553.
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  5. Chang CF, Ei-Sayed IH, George JR, Heaton CM, Ryan WR, Susko MS, Yom SS, Ha PK. Modified technique of submandibular gland transfer followed by intensity modulated radiotherapy to reduce xerostomia in head and neck cancer patients. Head Neck. 2020 Sep; 42(9):2340-2347.
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  6. Susko MS, Lazar AA, Dhar S, Chan JW, Shiao SL, Chapman CH, Johnson J, Quivey JM, Ryan WR, Heaton CM, Ha PK, Yom SS. Improved Tumor Control Related to Radiotherapy Technological Development for Hypopharyngeal Cancer. Laryngoscope. 2020 May 12.
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  7. Ochoa E, Larson AR, Han M, Webb KL, Stanford-Moore GB, El-Sayed IH, George JR, Ha PK, Heaton CM, Ryan WR. Patient-Reported Quality of Life After Resection With Primary Closure for Oral Tongue Carcinoma. Laryngoscope. 2020 May 07.
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  8. Rooper LM, Windon MJ, Hernandez T, Miles B, Ha PK, Ryan WR, Van Zante A, Eisele DW, D'Souza G, Fakhry C, Westra WH. HPV-positive Squamous Cell Carcinoma of the Larynx, Oral Cavity, and Hypopharynx: Clinicopathologic Characterization With Recognition of a Novel Warty Variant. Am J Surg Pathol. 2020 05; 44(5):691-702.
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  9. M.J. Windon, G. D'Souza, T. Waterboer, L. Rooper, W.H. Westra, T. Troy, D.M. Pardoll, M. Tan, S. Yavvari, A.P. Kiess, B. Miles, W. Mydlarz, P. Ha, N. Bender, D. Eisele, C. Fakhry. Risk Factors for Human Papillomavirus-Positive Nonoropharyngeal Squamous Cell Carcinoma. International Journal of Radiation Oncology • Biology • Physics. 2020 Apr 1; 106(5):1158.
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  10. Windon MJ, D'Souza G, Waterboer T, Rooper L, Westra WH, Troy T, Pardoll D, Tan M, Yavvari S, Kiess AP, Miles B, Mydlarz WK, Ha PK, Bender N, Eisele DW, Fakhry C. Risk factors for human papillomavirus-positive nonoropharyngeal squamous cell carcinoma. Head Neck. 2020 Aug; 42(8):1954-1962.
    View on PubMed
  11. Wai KC, Strohl MP, van Zante A, Ha PK. Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma. Cells. 2020 02 22; 9(2).
    View on PubMed
  12. Formeister EJ, Baum R, Knott PD, Seth R, Ha P, Ryan W, El-Sayed I, George J, Larson A, Plonowska K, Heaton C. Machine Learning for Predicting Complications in Head and Neck Microvascular Free Tissue Transfer. Laryngoscope. 2020 Jan 28.
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  13. Fakhry C, Waterboer T, Westra WH, Rooper LM, Windon M, Troy T, Koch W, Gourin CG, Bender N, Yavvari S, Kiess AP, Miles BA, Ryan WR, Ha PK, Eisele DW, D'Souza G. Distinct biomarker and behavioral profiles of human papillomavirus-related oropharynx cancer patients by age. Oral Oncol. 2020 02; 101:104522.
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  14. Ho AS, Ochoa A, Jayakumaran G, Zehir A, Valero Mayor C, Tepe J, Makarov V, Dalin MG, He J, Bailey M, Montesion M, Ross JS, Miller VA, Chan L, Ganly I, Dogan S, Katabi N, Tsipouras P, Ha P, Agrawal N, Solit DB, Futreal PA, El Naggar AK, Reis-Filho JS, Weigelt B, Ho AL, Schultz N, Chan TA, Morris LG. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest. 2019 10 01; 129(10):4276-4289.
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  15. Jon Mallen-St. Clair, Patrick Ha. Molecular Genetics of Salivary Gland Cancer. . 2019 Sep 13; 1-6.
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  16. Larson AR, Kemmer J, Formeister E, El-Sayed I, Ha P, George J, Ryan W, Chan E, Heaton C. Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma. Laryngoscope. 2020 07; 130(7):1715-1720.
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  17. Mathios D, Hwang T, Xia Y, Phallen J, Rui Y, See AP, Maxwell R, Belcaid Z, Casaos J, Burger PC, McDonald KL, Gallia GL, Cope L, Kai M, Brem H, Pardoll DM, Ha P, Green JJ, Velculescu VE, Bettegowda C, Park CK, Lim M. Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types. Int J Cancer. 2019 12 15; 145(12):3425-3435.
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  18. Ando M, Saito Y, Xu G, Bui NQ, Medetgul-Ernar K, Pu M, Fisch K, Ren S, Sakai A, Fukusumi T, Liu C, Haft S, Pang J, Mark A, Gaykalova DA, Guo T, Favorov AV, Yegnasubramanian S, Fertig EJ, Ha P, Tamayo P, Yamasoba T, Ideker T, Messer K, Califano JA. Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. Nat Commun. 2019 May 29; 10(1):2415.
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  19. Strohl MP, Chen JP, Ha PK, Seth R, Yom SS, Heaton CM. Can Early Dental Extractions Reduce Delays in Postoperative Radiation for Patients With Advanced Oral Cavity Carcinoma? J Oral Maxillofac Surg. 2019 Nov; 77(11):2215-2220.
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  20. Ando M, Saito Y, Xu G, Bui NQ, Medetgul-Ernar K, Pu M, Fisch K, Ren S, Sakai A, Fukusumi T, Liu C, Haft S, Pang J, Mark A, Gaykalova DA, Guo T, Favorov AV, Yegnasubramanian S, Fertig EJ, Ha P, Tamayo P, Yamasoba T, Ideker T, Messer K, Califano JA. Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. Nat Commun. 2019 05 16; 10(1):2188.
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