University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Isha Jain, PhD

Isha Jain, PhD

Assistant Researcher, Physiology, UCSF

Cancer Center Program Memberships

Cancer Genetics


Harvard University, Cambridge, MA, 2012, Chemical and Physical Biology
Massachusetts Institute of Technology, Cambridge, MA, PhD, Computer Science, Systems Biology

Professional Experience

  • 2017-2018
    Post-doctoral Fellow, Systems Medicine, Massachusetts General Hospital
  • 2018-present
    UCSF Sandler Faculty Fellow, Oxygen Metabolism; Physiology, UCSF

Honors & Awards

  • 2017
    Harold Weintraub Graduate Student Award
  • 2016
    Philanthropic Educational Organization National Scholar Award
  • 2011
    Barry Goldwater Scholarship
  • 2009
    Glamour Magazine's Top 10 College Women
  • 2008
    Discover Magazine's Top Five Scientists Under 20
  • 2007-2008
    Siemens Math, Science & Technology Competition, National Winner
  • 2008
    L'Oreal Women in Science, Invited Panelist
  • 2008
    Intel Science Talent Search Finalist
  • 2007
    Intel Science and Engineering Fair, First Place Award
  • 2004
    36th Int'l Metallographic Contest – First Prize, George Kehl Award
  • 2003
    First Prize, Nat'l Educators Workshop, Undergrad Research Poster Contest

Selected Publications

  1. Baik AH, Jain IH. Turning the Oxygen Dial: Balancing the Highs and Lows. Trends Cell Biol. 2020 May 05.
    View on PubMed
  2. Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK. Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism. Cell. 2020 Apr 30; 181(3):716-727.e11.
    View on PubMed
  3. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 Oct 01; 30(4):824-832.e3.
    View on PubMed
  4. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250.
    View on PubMed
  5. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61.
    View on PubMed
  6. Jain IH, Vijayan V, O'Shea EK. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13638-43.
    View on PubMed
  7. Vijayan V, Jain IH, O'Shea EK. A high resolution map of a cyanobacterial transcriptome. Genome Biol. 2011; 12(5):R47.
    View on PubMed
  8. Jain I, Iovine K. The making of a young scientist. Dev Dyn. 2008 Jun; 237(6):1535-6.
    View on PubMed
  9. Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Dev Biol. 2008 May 15; 317(2):541-8.
    View on PubMed
  10. Jain I, Stroka C, Yan J, Huang WM, Iovine MK. Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Dev Dyn. 2007 Sep; 236(9):2668-74.
    View on PubMed

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