Research Summary

The Kampmann lab develops and applies innovative technologies to understand cellular and molecular mechanisms of aging-associated neurodegenerative diseases, and to discover new therapeutic strategies. A major focus of our research are Alzheimer's disease and related dementias.

We have pioneered a CRISPR-based functional genomics platform in human iPSC-derived neurons, glia and 3D assembloids, which enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells. We have also developed cell-type specific CRISPR screening approaches for mouse models of disease.

We use biochemistry, biophysics and cell biology to test mechanistic hypotheses generated by our functional genomics platform.

Major research questions are:

What controls protein aggregation in neurons, and why is it toxic? Why are some neuronal subtypes selectively vulnerable? Our main focus here is on the protein tau.

How do non-neuronal cells such as microglia and astrocytes contribute to disease? What controls their beneficial and toxic states and functions in disease?

Research Funding

  • September 1, 2021 - August 31, 2026 - Uncovering the genetic mechanisms of the Chromosome 17q21.31 Tau haplotype on neurodegeneration risk in FTD and PSP , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54NS123746
  • July 1, 2021 - June 30, 2026 - Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01AG072464
  • September 5, 2018 - June 30, 2023 - The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH115747
  • September 30, 2018 - May 31, 2023 - Systematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomics , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AG062359
  • September 30, 2016 - August 31, 2021 - Linking tau proteostasis with neuronal activity in FTD , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54NS100717
  • September 30, 2018 - June 30, 2020 - Uncovering mechanisms of selective vulnerability by CRISPR-based genetic screens , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56AG057528
  • September 30, 2015 - May 31, 2020 - Rewiring of the human protein homeostasis network in normal and disease contexts , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP2GM119139
  • August 1, 2015 - July 31, 2018 - Stress response networks in cancer: systematic mapping and therapeutic potential , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00CA181494
  • August 1, 2014 - July 31, 2015 - Stress response networks in cancer: systematic mapping and therapeutic potential , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99CA181494

Education

Marburg University, Germany, Pre-diploma, 06/00, Human Biology
Cambridge University, UK, B.A. (M.A.), First Class Honours, 06/03, Biochemistry
The Rockefeller University, Ph.D., 06/09, Biological Sciences (Cell Biology, Biophysics)
University of California, San Francisco, Postdoctoral Fellow, 07/15, Systems Biology

Honors & Awards

  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators
  • 2016
    Innovative Research Grant, Stand Up To Cancer
  • 2015
    New Innovator Award, NIH
  • 2015
    Allen Distinguished Investigator Award, Paul G. Allen Family Foundation
  • 2014
    Pathway to Independence Award (K99/R00), NIH
  • 2012
    Finalist, Deloitte QB3 Award for Innovation, California Institute for Quantitative Biosciences
  • 2012
    PBBR Postdoctoral Research Fellowship, Program for Breakthrough Biomedical Research, UCSF
  • 2010
    Postdoctoral Fellowship, Jane Coffin Childs Memorial Fund
  • 2006
    David Rockefeller Fellowship, The Rockefeller University
  • 2003
    Predoctoral Fellowship, Howard Hughes Medical Institute

Selected Publications

  1. Meier S, Larsen ASG, Wanke F, Mercado N, Mei A, Takacs L, Mracsko ES, Collin L, Kampmann M, Roudnicky F, Jagasia R. An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models. Stem Cell Reports. 2025 Feb 11; 102420.  View on PubMed
  2. Boggess SC, Gandhi V, Tsai MC, Marzette E, Teyssier N, Yu-Ying Chou J, Hu X, Cramer A, Yadanar L, Shroff K, Jeong CG, Eidenschenk C, Hanson JE, Tian R, Kampmann M. A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity. bioRxiv. 2025 Feb 10.  View on PubMed
  3. Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Dräger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. Neuron. 2025 Mar 05; 113(5):701-718.e8.  View on PubMed
  4. Ramani B, Rose IVL, Teyssier N, Pan A, Danner-Bocks S, Sanghal T, Yadanar L, Tian R, Ma K, Palop JJ, Kampmann M. CRISPR screening by AAV episome-sequencing (CrAAVe-seq) is a highly scalable cell type-specific in vivo screening platform. bioRxiv. 2024 Dec 18.  View on PubMed
  5. Yin JA, Frick L, Scheidmann MC, Liu T, Trevisan C, Dhingra A, Spinelli A, Wu Y, Yao L, Vena DL, Knapp B, Guo J, De Cecco E, Ging K, Armani A, Oakeley EJ, Nigsch F, Jenzer J, Haegele J, Pikusa M, Täger J, Rodriguez-Nieto S, Bouris V, Ribeiro R, Baroni F, Bedi MS, Berry S, Losa M, Hornemann S, Kampmann M, Pelkmans L, Hoepfner D, Heutink P, Aguzzi A. Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes. Nat Biomed Eng. 2025 Jan; 9(1):127-148.  View on PubMed
  6. Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan SA, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N. Implementation and validation of single-cell genomics experiments in neuroscience. Nat Neurosci. 2024 Dec; 27(12):2310-2325.  View on PubMed
  7. Alexander V. Soloviev, Felipe Luiz Pereira, Renata Elaine Paraizo Leite, Claudia Kimie Suemoto, Kun Leng, Martin Kampmann, Lea T. Grinberg. Exploring selective neuronal vulnerability in Alzheimer’s disease – key pathways are downregulated in vulnerable subpopulations of RORB and CDH9 excitatory neurons of the entorhinal cortex at Braak 0. Alzheimer's & Dementia. 2024 Dec 1; 20(Suppl 1):e091740.  View on PubMed
  8. Steven C Boggess, Vaidehi Gandhi, Ming-Chi Tsai, Yu-Ying Chou, Jesse E. Hanson, Martin Kampmann. Uncovering mechanisms of hyperexcitability in tauopathies with functional genomics. Alzheimer's & Dementia. 2024 Dec 1; 20(Suppl 1):e083573.  View on PubMed
  9. Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Draeger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. bioRxiv. 2024 Nov 24.  View on PubMed
  10. Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M. CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning. bioRxiv. 2024 Nov 17.  View on PubMed
  11. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv. 2024 Nov 04.  View on PubMed
  12. Ryan VH, Lawton S, Reyes JF, Hawrot J, Frankenfield AM, Seddighi S, Ramos DM, Faghri F, Johnson NL, Zou J, Kampmann M, Replogle J, Yuan H, Johnson KR, Maric D, Hao L, Nalls MA, Ward ME. Maintenance of neuronal TDP-43 expression requires axonal lysosome transport. bioRxiv. 2024 Oct 01.  View on PubMed
  13. Bakulin A, Teyssier NB, Kampmann M, Khoroshkin M, Goodarzi H. pyPAGE: A framework for Addressing biases in gene-set enrichment analysis-A case study on Alzheimer's disease. PLoS Comput Biol. 2024 Sep; 20(9):e1012346.  View on PubMed
  14. Novy B, Dagunts A, Weishaar T, Holland EE, Adoff H, Hutchinson E, De Maria M, Kampmann M, Tsvetanova NG, Lobingier BT. An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation. Nat Chem Biol. 2025 Mar; 21(3):360-370.  View on PubMed
  15. Leng K, Rooney B, McCarthy F, Xia W, Rose IVL, Bax S, Chin M, Fathi S, Herrington KA, Leonetti M, Kao A, Fancy SPJ, Elias JE, Kampmann M. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes. J Neuroinflammation. 2024 Aug 08; 21(1):198.  View on PubMed
  16. Feringa FM, Hertog SJK, Wang L, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward M, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R. The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4. bioRxiv. 2024 Jul 03.  View on PubMed
  17. Ramadoss GN, Namaganda SJ, Hamilton JR, Sharma R, Chow KG, Macklin BL, Sun M, Liu JC, Fellmann C, Watry HL, Jin J, Perez BS, Sandoval Espinoza CR, Matia MP, Lu SH, Judge LM, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR. Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes. bioRxiv. 2024 Jun 26.  View on PubMed
  18. Mohl GA, Dixon G, Marzette E, McKetney J, Samelson AJ, Serras CP, Jin J, Li A, Boggess SC, Swaney DL, Kampmann M. The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways. bioRxiv. 2024 Jun 06.  View on PubMed
  19. Priya Choudhry, Corynn Kasap, Bonell Patiño-Escobar, Olivia Gugliemini, Huimin Geng, Vishesh Sarin, Amrik Kang, Audrey Kishishita, Sham Rampersaud, Letitia Sarah, Yu-Hsiu T. Lin, Neha Paranjape, Poornima Ramkumar, Jonathan C. Patton, Makeba Marcoulis, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron Hann, Benjamin G. Barwick, Martin Kampmann, Arun P. Wiita. Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma. . 2024 Jun 1; 100025.  View on PubMed
  20. Rose K, Jepson T, Shukla S, Maya-Romero A, Kampmann M, Xu K, Hurley JH. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2315690121.  View on PubMed

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