University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Karla Kerlikowske, MD

Karla Kerlikowske, MD

Professor, Departments of Medicine and Epidemiology/Biostatistics, UCSF

Cancer Center Program Memberships

Breast Oncology

Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine


Professional Experience

  • 1988-89
    Medicine Internship, University of California San Francisco, San Francisco, CA
  • 1989-91
    Primary Care Medicine Residency, University of California San Francisco, San Francisco, CA
  • 1991-93
    Fellow in General Internal Medicine, Veterans Affairs Medical Center, San Francisco, CA
  • 1991-93
    Clinical Instructor, Assistant Physician, UCSF Department of Medicine, San Francisco, CA
  • 1993-1999
    Associate Director, Women's Clinic, Veterans Affairs Medical Center, San Francisco, CA
  • 1999-present
    Director, Women's Clinic, Veterans Affairs Medical Center, San Francisco, CA
  • 1994-present
    Assistant Professor In Residence, UCSF Department of Medicine, San Francisco, CA
  • 1994-present
    Assistant Professor In Residence, UCSF Department of Epidemiology & Biostatistics, San Francisco, CA
  • 2000-present
    Associate Professor, In Residence, Department of Medicine, Univ. of California, San Francisco
  • 2000-present
    Associate Professor, In Residence, Department of Epidemiology & Biostatistics, Univ. of California, San Francisco
  • 2000-present
    Professor, In Residence, Department of Epidemiology & Biostatistics, Univ. of California, San Francisco

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians

Selected Publications

  1. Kerlikowske K, Sprague BL, Tosteson ANA, Wernli KJ, Rauscher GH, Johnson D, Buist DSM, Onega T, Henderson LM, O'Meara ES, Miglioretti DL. Strategies to Identify Women at High Risk of Advanced Breast Cancer During Routine Screening for Discussion of Supplemental Imaging. JAMA Intern Med. 2019 Jul 01.
    View on PubMed
  2. Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe B, Lee V, Kerlikowske K, Shepherd J. Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study. Cancer Imaging. 2019 Jun 22; 19(1):41.
    View on PubMed
  3. Wernli KJ, Ichikawa L, Kerlikowske K, Buist DSM, Brandzel SD, Bush M, Johnson D, Henderson LM, Nekhlyudov L, Onega T, Sprague BL, Lee JM, Lehman CD, Miglioretti DL. Surveillance Breast MRI and Mammography: Comparison in Women with a Personal History of Breast Cancer. Radiology. 2019 Jun 04; 182475.
    View on PubMed
  4. Kerlikowske K, Miglioretti DL, Vachon CM. Discussions of Dense Breasts, Breast Cancer Risk, and Screening Choices in 2019. JAMA. 2019 May 31.
    View on PubMed
  5. Engmann NJ, Scott CG, Jensen MR, Winham S, Miglioretti DL, Ma L, Brandt K, Mahmoudzadeh A, Whaley DH, Hruska C, Wu F, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Combined effect of volumetric breast density and body mass index on breast cancer risk. Breast Cancer Res Treat. 2019 May 25.
    View on PubMed
  6. Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, Brandt KR, Visscher DW, Shepherd JA, Tamimi RM, Vachon CM, Kerlikowske K. Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype. Breast Cancer Res. 2019 Apr 03; 21(1):48.
    View on PubMed
  7. Lee JM, Arao RF, Sprague BL, Kerlikowske K, Lehman CD, Smith RA, Henderson LM, Rauscher GH, Miglioretti DL. Performance of Screening Ultrasonography as an Adjunct to Screening Mammography in Women Across the Spectrum of Breast Cancer Risk. JAMA Intern Med. 2019 Mar 18.
    View on PubMed
  8. Miglioretti DL, Abraham L, Lee CI, Buist DSM, Herschorn SD, Sprague BL, Henderson LM, Tosteson ANA, Kerlikowske K. Digital Breast Tomosynthesis: Radiologist Learning Curve. Radiology. 2019 Apr; 291(1):34-42.
    View on PubMed
  9. Tice JA, Bissell MCS, Miglioretti DL, Gard CC, Rauscher GH, Dabbous FM, Kerlikowske K. Validation of the breast cancer surveillance consortium model of breast cancer risk. Breast Cancer Res Treat. 2019 Jun; 175(2):519-523.
    View on PubMed
  10. Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe B, Lee V, Strand F, Kerlikowske K, Shepherd J. Derived mammographic masking measures based on simulated lesions predict the risk of interval cancer after controlling for known risk factors: a case-case analysis. Med Phys. 2019 Mar; 46(3):1309-1316.
    View on PubMed
  11. Miglioretti DL, Lee JM, Kerlikowske K. Re: "Linkage of the ACR National Mammography Database to the Network of State Cancer Registries: Proof of Concept Evaluation by the ACR National Mammography Database Committee". J Am Coll Radiol. 2019 02; 16(2):135-136.
    View on PubMed
  12. Arasu VA, Miglioretti DL, Sprague BL, Alsheik NH, Buist DSM, Henderson LM, Herschorn SD, Lee JM, Onega T, Rauscher GH, Wernli KJ, Lehman CD, Kerlikowske K. Population-Based Assessment of the Association Between Magnetic Resonance Imaging Background Parenchymal Enhancement and Future Primary Breast Cancer Risk. J Clin Oncol. 2019 Jan 09; JCO1800378.
    View on PubMed
  13. Sprague BL, Kerlikowske K, Bowles EJA, Rauscher GH, Lee CI, Tosteson ANA, Miglioretti DL. Trends in Clinical Breast Density Assessment From the Breast Cancer Surveillance Consortium. J Natl Cancer Inst. 2019 Jan 08.
    View on PubMed
  14. Drukker K, Giger ML, Joe BN, Kerlikowske K, Greenwood H, Drukteinis JS, Niell B, Fan B, Malkov S, Avila J, Kazemi L, Shepherd J. Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set. Radiology. 2019 Mar; 290(3):621-628.
    View on PubMed
  15. Karliner LS, Kaplan C, Livaudais-Toman J, Kerlikowske K. Mammography facilities serving vulnerable women have longer follow-up times. Health Serv Res. 2019 Feb; 54 Suppl 1:226-233.
    View on PubMed
  16. Kontos D, Winham SJ, Oustimov A, Pantalone L, Hsieh MK, Gastounioti A, Whaley DH, Hruska CB, Kerlikowske K, Brandt K, Conant EF, Vachon CM. Radiomic Phenotypes of Mammographic Parenchymal Complexity: Toward Augmenting Breast Density in Breast Cancer Risk Assessment. Radiology. 2019 Jan; 290(1):41-49.
    View on PubMed
  17. Lee CI, Zhu W, Onega TL, Germino J, O'Meara ES, Lehman CD, Henderson LM, Haas JS, Kerlikowske K, Sprague BL, Rauscher GH, Tosteson ANA, Alford-Teaster J, Wernli KJ, Miglioretti DL. The Effect of Digital Breast Tomosynthesis Adoption on Facility-Level Breast Cancer Screening Volume. AJR Am J Roentgenol. 2018 Nov; 211(5):957-963.
    View on PubMed
  18. Lee JM, Abraham L, Lam DL, Buist DSM, Kerlikowske K, Miglioretti DL, Houssami N, Lehman CD, Henderson LM, Hubbard RA. Cumulative Risk Distribution for Interval Invasive Second Breast Cancers After Negative Surveillance Mammography. J Clin Oncol. 2018 Jul 10; 36(20):2070-2077.
    View on PubMed
  19. Kerlikowske K, Scott CG, Mahmoudzadeh AP, Ma L, Winham S, Jensen MR, Wu FF, Malkov S, Pankratz VS, Cummings SR, Shepherd JA, Brandt KR, Miglioretti DL, Vachon CM. Automated and Clinical Breast Imaging Reporting and Data System Density Measures Predict Risk for Screen-Detected and Interval Cancers: A Case-Control Study. Ann Intern Med. 2018 Jun 05; 168(11):757-765.
    View on PubMed
  20. Buist DSM, Abraham L, Lee CI, Lee JM, Lehman C, O'Meara ES, Stout NK, Henderson LM, Hill D, Wernli KJ, Haas JS, Tosteson ANA, Kerlikowske K, Onega T. Breast Biopsy Intensity and Findings Following Breast Cancer Screening in Women With and Without a Personal History of Breast Cancer. JAMA Intern Med. 2018 Apr 01; 178(4):458-468.
    View on PubMed

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