University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Scott C. Kogan, MD

Scott C. Kogan, MD

Professor, Department of Laboratory Medicine, UCSF

Cancer Center Program Memberships

Hematopoietic Malignancies

Research Summary

I am a Professor in the Department of Laboratory Medicine and the Helen Diller Family Comprehenive Cancer Center at the University of California San Francisco. I am a board-certified hematopathologist with 17 years in active practice diagnosing lymphomas, leukemias, and other hematologic disorders. As a past chair of the Hematopathology subcommittee of the National Cancer Institute’s Mouse Models of Human Cancers Consortium, I am an internationally recognized expert in the characteri¬zation and classification of hematopoietic neoplasms in mice as well as in humans. I am also a noted researcher in the molecular pathogenesis of leukemia, including in the role of MYC in hematologic malignancy. My hematopathology training and research background combine to facilitate consultations and collaborations with investigators at UCSF, nationally, and internationally. I use my expertise in the pathology of humans and mice, as well as my experience in clinical pathology/laboratory medicine, to direct the mouse pathology core of the UCSF HDFCCC.

Education

Harvard College, Cambridge, MA, A.B., 1986, Biochemical Sciences
University of California San Francisco, M.D., 1991, Medicine
Laboratory Medicine Residency, UCSF, 1991-1993, Laboratory Medicine
Hematopathology Fellowship, UCSF, 1997-1998, Hematopathology

Honors & Awards

  • 1986
    Summa Cum Laude, Phi Beta Kappa
  • 1986
    Joseph L. Barrett Award for Teaching, Harvard University
  • 1993
    National Committee for Clinical Laboratory Standards, Honored Graduate Award
  • 1993
    UCSF Molecular Medicine Training Program
  • 1993
    American Cancer Society Physician Research Training Award
  • 1994
    Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians
  • 1997
    Burroughs Wellcome Fund Career Award
  • 2000
    32nd Edward Mallinckrodt Jr. Scholar Award
  • 2001
    Medical Student Teaching Award, Excellence for Small Group Instruction
  • 2002
    Department of Laboratory Medicine Resident Teaching Award
  • 2004
    Leukemia & Lymphoma Society Scholar Award
  • 2007
    Mentor Award, UCSF Department of Pediatrics

Selected Publications

  1. Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL. Trends in Acute Lymphoblastic Leukemia Incidence in the US from 2000-2016: an Increased Risk in Latinos Across All Age Groups. Am J Epidemiol. 2020 Oct 09.
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  2. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Alzamora MDP, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein O, Tuveson D, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 Sep 29.
    View on PubMed
  3. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 Sep 15.
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  4. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 May 14; 135(20):1772-1782.
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  5. Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL. History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a U.S. Integrated Health Care System. Am J Epidemiol. 2020 Apr 23.
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  6. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 Aug; 34(8):2025-2037.
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  7. Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica. 2019 11; 104(11):e514-e516.
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  8. Esnault C, Rahmé R, Rice KL, Berthier C, Gaillard C, Quentin S, Maubert AL, Kogan S, de Thé H. FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias. Blood. 2019 03 28; 133(13):1495-1506.
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  9. Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC. Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv. 2018 10 09; 2(19):2462-2466.
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  10. Jacquot C, Wool GD, Kogan SC. Dilute Russell viper venom time interpretation and clinical correlation: A two-year retrospective institutional review. Int J Lab Hematol. 2019 Feb; 41(1):80-86.
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  11. Yang T, Cui H, Wen M, Zuber J, Kogan SC, Wei G. TCEA1 regulates the proliferative potential of mouse myeloid cells. Exp Cell Res. 2018 09 15; 370(2):551-560.
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  12. Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ. Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. Cell Mol Gastroenterol Hepatol. 2018; 6(4):405-427.
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  13. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. Mol Ther. 2018 07 05; 26(7):1685-1693.
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  14. Lehmann-Che J, Bally C, Letouzé E, Berthier C, Yuan H, Jollivet F, Ades L, Cassinat B, Hirsch P, Pigneux A, Mozziconacci MJ, Kogan S, Fenaux P, de Thé H. Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia. Nat Commun. 2018 05 24; 9(1):2047.
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  15. Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D. Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice. Blood. 2018 02 08; 131(6):636-648.
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  16. Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN. Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation? Cancer Genet. 2017 Oct; 216-217:74-78.
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  17. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2017 03 23; 129(12):1680-1684.
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  18. Cyril Jacquot, Geoffrey D. Wool, Scott C. Kogan. Dilute Russell Viper Venom Time Interpretation and Clinical Correlation: A Two-Year Retrospective Institutional Review. Blood. 2016 Dec 2; 128(22):2609-2609.
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  19. Scott C. Kogan, Huimin Geng, Ritu Roy, Encarnacion Montecino-Rodriguez, Coline M Gaillard, Kamir Hiam, Henrik Bengtsson, David Casero, Adam B Olshen, Kenneth Dorshkind. Genetic Subtypes of Human Pediatric ALLs Show Gene Expression Differences That Parallel Those Observed in Mouse B1 and B2 Progenitors, Suggesting Divergent Developmental Origins. Blood. 2016 Dec 2; 128(22):1741-1741.
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  20. Sangeetha Surianarayanan, Coline M Gaillard, Trevor Bentley, Matthew R. Warr, Briana Fitch, Huimin Geng, Emmanuelle Passegue, Hugues de Thé, Scott C. Kogan. Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia. Blood. 2016 Dec 2; 128(22):1518-1518.
    View on PubMed

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