University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Thomas Kornberg, PhD

Thomas Kornberg, PhD

Professor, Department of Biochemistry and Biophysics, UCSF

Cancer Center Program Memberships

Cancer Genetics

Education

Juilliard School of Music
Columbia College, B.A., 1970, Biology
Columbia University, Ph.D., 1973, Biochemistry
Princeton University, postdoctoral, 1973-1975, Biochemistry
Cambridge MRC Laboratory of Molecular Biology, postdoctoral, 1975-1976, Developmental Genetics


Professional Experience

  • 1976-1977
    Assistant Professor, Molecular Biology Institute and Department of Chemistry, University of California, Los Angeles
  • 1986-present
    Assistant Professor, Associate Professor, Professor, Department of Biochemistry and Biophysics, University of California San Francisco

Honors & Awards

  • 1978
    American Cancer Society Career Development Award
  • 2001
    Member, American Academy of Arts and Sciences

Selected Publications

  1. Fereres S, Hatori R, Hatori M, Kornberg TB. Cytoneme-mediated signaling essential for tumorigenesis. PLoS Genet. 2019 Sep; 15(9):e1008415.
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  2. Zhang Q, Schepis A, Huang H, Yang J, Ma W, Torra J, Zhang SQ, Yang L, Wu H, Nonell S, Dong Z, Kornberg TB, Coughlin SR, Shu X. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals. J Am Chem Soc. 2019 Mar 20; 141(11):4526-4530.
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  3. Huang H, Liu S, Kornberg TB. Glutamate signaling at cytoneme synapses. Science. 2019 03 01; 363(6430):948-955.
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  4. Llano E, Pendás AM, Aza-Blanc P, Kornberg TB, López-Otín C. Withdrawal: Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development. J Biol Chem. 2019 01 25; 294(4):1428.
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  5. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):347.
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  6. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):334-346.e4.
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  7. Kornberg TB. Scripting a place in time. Dev Biol. 2019 03 01; 447(1):24-27.
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  8. Chen W, Huang H, Hatori R, Kornberg TB. Essential basal cytonemes take up Hedgehog in the Drosophila wing imaginal disc. Development. 2017 09 01; 144(17):3134-3144.
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  9. Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci Signal. 2017 May 02; 10(477).
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  10. Kornberg TB. Macrophages Help Cells Connect to Pattern Zebrafish Stripes. Dev Cell. 2017 03 27; 40(6):520-521.
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  11. Ali-Murthy Z, Kornberg TB. Correction: Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm. Elife. 2017 03 15; 6.
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  12. Kornberg TB. Distributing signaling proteins in space and time: the province of cytonemes. Curr Opin Genet Dev. 2017 Aug; 45:22-27.
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  13. Huang H, Kornberg TB. Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes. Elife. 2016 09 03; 5.
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  14. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58.
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  15. Ali-Murthy Z, Kornberg TB. Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm. Elife. 2016 Feb 17; 5.
    View on PubMed
  16. Kornberg TB. A Path to Pattern. Curr Top Dev Biol. 2016; 116:551-67.
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  17. Rao PR, Lin L, Huang H, Guha A, Roy S, Kornberg TB. Developmental compartments in the larval trachea of Drosophila. Elife. 2015 Oct 22; 4.
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  18. Kornberg TB, Gilboa L. Developmental biology: Nanotubes in the niche. Nature. 2015 Jul 16; 523(7560):292-3.
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  19. Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5.
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  20. Huang H, Kornberg TB. Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium. Elife. 2015 May 07; 4:e06114.
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