Research Summary

Dr. Krogan was born and raised in Regina, Saskatchewan, Canada, obtained his undergraduate degree from the University of Regina and his PhD from the University of Toronto. Dr. Krogan’s lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, the Krogan group is focused on studying cancer, infectious disease and psychiatric disorders.

Research Funding

  • November 1, 2024 - October 31, 2028 - CIRM Center for Neuropsychiatric Stem Cell Proteomics , Co-Investigator . Sponsor: CIRM, Sponsor Award ID: DISC4-16322
  • August 17, 2018 - May 31, 2028 - HPMI: Host Pathogen Mapping Initiative , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135990
  • September 15, 2022 - August 31, 2027 - The Cancer Cell Map Initiative v2.0 , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: 1U54CA274502
  • September 14, 2022 - August 31, 2027 - The Cancer Cell Map Initiative v2.0 , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54CA274502
  • July 15, 2022 - April 30, 2027 - HARC: HIV accessory and regulatory complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54AI170792
  • September 1, 2022 - November 30, 2026 - Bridge2AI: Cell Maps for AI (CM4AI) Data Generation Project , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: OT2OD032742
  • August 1, 2021 - May 31, 2026 - Host Pathogen Variation & TB Pathogenesis , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI162583
  • May 16, 2022 - April 30, 2026 - QCRG Pandemic Response Program , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U19AI171110
  • April 22, 2020 - August 31, 2025 - Childhood ?Omics? and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI152161
  • July 11, 2024 - June 30, 2025 - International West Africa Symposium and Workshop on Infectious Diseases , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R13AI186469
  • March 1, 2019 - February 28, 2025 - Novel VP30-host Interactions that Negatively Regulate Ebola Virus Infection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI143292
  • September 1, 2019 - August 31, 2024 - Combinatorial Regulation of Gene Networks During Cardiac Development and Disease , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL146366
  • September 15, 2019 - March 31, 2024 - Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: RF1AG059751
  • September 5, 2018 - June 30, 2023 - The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01MH115747
  • January 20, 2018 - December 31, 2022 - Fluomics: The Next Generation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI135972
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50GM082250
  • August 27, 2007 - August 31, 2022 - HARC Center: HIV Accessory and Regulatory Complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50AI150476
  • May 11, 2017 - April 30, 2022 - Research Center for Cancer Systems Biology: Cancer Cell Map Initiative , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54CA209891
  • February 15, 2019 - January 31, 2022 - CasCUT&RUN: An in vivo method to analyze locus-specific protein complexes driving transcription of target genes in cancer , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA235303
  • September 30, 2016 - August 31, 2021 - Linking tau proteostasis with neuronal activity in FTD , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U54NS100717
  • September 30, 2004 - June 30, 2021 - Intracellular pathogens and innate immunity , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI063302
  • August 1, 2015 - January 31, 2021 - Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI120694
  • December 1, 2015 - November 30, 2020 - Decoding the Chlamydia inclusion membrane protein-host protein interactome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI122747
  • June 24, 2015 - May 31, 2020 - Dengue Human Immunology Project Consortium (DHIPC) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI118610
  • September 1, 2010 - July 31, 2019 - Exploring Design Principles of Cellular Control Circuits , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50GM081879
  • September 1, 2014 - June 30, 2019 - Physical and Genetic Interaction Landscape of the Tyrosine Kinome , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM107671
  • August 1, 2008 - February 28, 2019 - Comparative Analysis of Genetic Interaction Networks , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084279
  • July 1, 2007 - July 31, 2018 - Transcriptional Networks During Cardiac Differentiation , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01HL089707
  • June 26, 2013 - May 31, 2018 - Multiscale analysis of influenza host-pathogen interactions: Fluomics , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI106754
  • December 15, 2015 - November 30, 2017 - Proteomics Analysis of Host-Pathogen Interactions in Histoplasma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI122064
  • July 13, 2011 - June 30, 2016 - Protein homeostasis mechanisms underlying enterovirus replication and evolution , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI091575
  • August 1, 2011 - May 31, 2016 - Integrating computation and genetics to quantify specificity in protein networks , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM098101
  • August 15, 2010 - July 31, 2015 - Global innate immune responses to HIV-1 infection , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI090935
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • June 1, 2008 - April 30, 2014 - Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM084448
  • September 25, 2008 - July 31, 2012 - Global Genetic Interaction Profiling in Prokaryotes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM085697

Education

University of Regina, Canada, BS, 1997, Chemistry
University of Regina, Canada, MSc, 1999, Biochemistry
University of Toronto, Canada, PhD, 2005, Medical Genetics

Honors & Awards

  • 1995-1996
    Canadian Cancer Society Award
  • 1997
    Society of Chemical Industry Merit Award
  • 1999-2001
    Natural Sciences and Engineering Research Council (NSERC) PGS-B Award
  • 2001-2004
    Canadian Institute of Health Research (CIHR) Doctoral Fellowship
  • 2004
    Hannah Farkas-Himsley and Alexander Memorial Award
  • 2005
    L. W. Macpherson Microbiology Award
  • 2008
    Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006
  • 2009-2012
    Searle Scholar, Searle Foundation
  • 2009-2014
    Keck Distinguished Young Scholar, W. M. Keck Foundation
  • 2012
    Alumni Crowning Achievement Award, University of Regina
  • 2014
    "40 under 40," Cell

Selected Publications

  1. Wang B, Vartak R, Hennick KM, Zaltsman Y, Naing ZZC, Polacco BJ, Bashir A, Eckhardt M, Bouhaddou M, Xu J, Sun N, Lasser MC, Zhou Y, McKetney J, Guiley KZ, Gniewek P, Chan U, Amirani N, Griffiths O, Chadha N, Tognatta R, Cakir M, Gordon M, Khare P, Drake S, Drury V, Burke DF, Gonzalez S, Alkhairy S, Thomas R, Lam S, Morris M, Bader E, Dos Santos M, Komarova AV, Bennett M, Ennis C, Castillo O, Lim Y, Martin R, Seyler M, Baum T, Krasnoff R, Wang G, Middya S, Wang S, Pham P, Arbelaez J, Pratt D, Bali S, Chag S, Kaye JA, Mahmood N, Spraggon L, Rolland T, Hervey-Jumper S, Fraser JS, Bourgeron T, Finkbeiner S, Demeret C, Swaney DL, Bandyopadhyay S, Ideker T, Beltrao P, Willsey HR, Hüttenhain R, Obernier K, Nowakowski TJ, State MW, Willsey AJ, Krogan NJ. Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology. Science. 2026 Aug 27; 393(6814):eady4523. View on PubMed
  2. Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Alvarez K, Lee A, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Thangaraj JL, Ayad NME, Rhodenhiser JA, Ten Hoeve J, Healy K, Digman M, Dillin A, Krogan NJ, Bertozzi CR, Kaufman DS, Sinha S, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, Weaver VM. The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism. Sci Adv. 2026 Aug 07; 12(32):eaeb1136. View on PubMed
  3. Kim NH, Lin Z, Nam S, Swaney DL, Krogan N, Kim YH, Therien MJ, DeGrado WF, Wells JA. A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells. bioRxiv. 2026 Jul 23. View on PubMed
  4. Krogsaeter EK, McKetney J, Li L, Liu I, Richards AL, Subramanyam V, Yin K, Gordon M, Mairal PB, Stevenson EJ, Qian H, Huang Y, Goodarzi H, Krogan NJ, Swaney DL. APOE4 disrupts the central dogma by arresting neuronal proteome dynamics. bioRxiv. 2026 Jul 22. View on PubMed
  5. Qian G, Kim J, Tiwari R, Polacco BJ, Forget A, Schaffer LV, Kim HK, Gao J, Zhou Y, Jang GM, Kelly MR, Zhao X, Foussard H, Zhang L, Krogan N, Ideker T, Chavez A. HIT-MAP: A scalable approach to multimodal mapping of subcellular organization. Cell Rep Methods. 2026 Jul 22; 101534. View on PubMed
  6. Nourreddine S, Doctor Y, Dailamy A, Lee YH, Hansen JN, Chinn R, Forget A, Polacco B, Muralidharan M, Sigaeva A, Sunder S, Pan E, Gao J, Chen JY, Clark T, Parker J, Obernier K, Metallo C, Ideker T, Lundberg E, Krogan N, Mali P. A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells. Nat Biotechnol. 2026 Jul 01. View on PubMed
  7. Matsui Y, Suryawanshi RK, Montano M, Taha TY, Khalid MM, Sun L, Khanna K, Tang J, Zhou Y, Kaake RM, Fang X, Maishan M, Matthay MA, Krogan NJ, Ott M. Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells. bioRxiv. 2026 Jun 11. View on PubMed
  8. Olwal CO, Rathore U, Makanani SK, Kaushal P, Ashley IA, Ummadi MR, Appiah V, Djomkam Zune AL, Blanc SF, Winters DM, Delgado Y, Muthoka K, Fabius JM, Eckhardt M, Kaake RM, Su M, Fregoso OI, Hultquist JF, Orang'o EO, Swaney DL, Kyei GB, Krogan NJ, Quashie PK, Bediako Y, Bouhaddou M. Paracrine signals from HIV-1-infected immune cells reprogram cervical cancer pathways. iScience. 2026 Jun 19; 29(6):116083. View on PubMed
  9. Raleigh D, Cady M, Aggarwal A, Stevers N, Zakimi N, Liu I, Mirchia K, Coukos J, Kongpracha P, Zhou Y, Nguyen M, Braman B, Leclair N, Phillips J, Chow K, Shamdasani-Sen S, Chantousti N, Choi B, Hong C, Toedebusch R, Englander R, Frankus J, Sinha D, Karner H, Rosenbluth J, Veer LVT, Choudhury A, Liu SJ, Krogan N, Costello J, Anczuków O, Toedebusch C, Dickinson P, Goodarzi H, Swaney D. A proteogenomic RNA processing mechanism drives sex differences in meningioma. Res Sq. 2026 Jun 02. View on PubMed
  10. Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Parthasarathy H, Gordon M, Malpotra S, Cupic A, Kehrer T, Dos Santos M, Benjamin R, Moen JM, Winters DM, Caval V, Rojc A, Mena I, Aslam S, Martinez-Romero C, Viñas IC, Khalil Z, Farrugia K, Villalón-Letelier F, Banerjee A, Tussia-Cohen D, Diallo A, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, San Felipe CJ, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi RK, Bonaventure B, Ibáñez C, Johnson JR, Juste J, Pache L, Stroud RM, Verba KA, Fraser JS, van Bakel H, Taha TY, Ott M, Hagai T, Jouvenet N, Demeret C, Polacco BJ, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ. Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential. Cell Host Microbe. 2026 Jun 10; 34(6):1100-1117.e13. View on PubMed
  11. Felipe CS, Verba KA, Krogan NJ, Grabe M, Fraser JS. Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules. bioRxiv. 2026 Apr 27. View on PubMed
  12. Gracias S, Le Seac'h E, Donaire-Carpio S, Vuillier F, Vendramini L, Moundib A, Temmam S, Rutkowska M, Donati F, Cupic A, Juste J, Martinez-Romero C, Morel N, Schwartz O, Krogan NJ, Miorin L, Müller MA, Demeret C, Munier S, Roingeard P, Batra J, Garcia-Sastre A, Caval V, Jouvenet N. Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells. PLoS Pathog. 2026 Apr; 22(4):e1013573. View on PubMed
  13. Rathore U, Dugan E, Thornton H, Kumar VE, Dajani R, Burdick RC, Young JM, Steinhart Z, Lao R, Delviks-Frankenberry KA, Choi W, Henriques WS, Echeverria I, Dann E, Dureja I, Pathak N, Arce MM, McKetney J, Umhoefer JM, Parulekar S, Schmidt R, Polacco BJ, Neidleman J, Montano M, Nguyen VQ, Sali A, Levy JA, Tenthorey JL, Cheng Y, Roan NR, Swaney DL, Kaake RM, Dodgson SE, Hiatt J, Pathak VK, Malik HS, Krogan NJ, Marson A. Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells. Cell. 2026 Jun 11; 189(12):3651-3668.e31. View on PubMed
  14. Stein CM, Benchek P, Mantshoyane L, Ciesielski T, McHenry ML, Wilson-Sesay H, Joloba M, Wampande E, Mc-Farland KAD, Roberts AW, Polacco B, Bennett M, Krogan N, Boom WH, Cox JS, Mayanja-Kizza H, Hawn TR, Williams SM. Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage. J Infect Dis. 2026 Apr 18. View on PubMed
  15. Vo PTT, Cicero J, Wang Z, Hakozaki H, Hoang TS, Rafael Adame-Garcia S, Ramms DJ, Sato K, Stevenson E, Zhou Y, Fan K, Swaney DL, Krogan NJ, Schöneberg J, Manor U, Gutkind JS. The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation. bioRxiv. 2026 Apr 06. View on PubMed
  16. Khalid MM, Chen IP, Soveg FS, Taha TY, Tabata T, Suryawanshi RK, Syed AM, Ciling A, McCavitt-Malvido M, Schulze-Gahmen U, Hayashi J, Kim IJ, Fong SW, Batra J, Kumar GR, Renia L, Ng LF, Krogan NJ, Doudna JA, Verdin E, Ott M. Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants. bioRxiv. 2026 Feb 03. View on PubMed
  17. Bild AH, Sangar MC, McQuerry JA, Ideker T, Kopetz S, Carey L, Nath A, Marcus D, Regier A, Rashid N, Barzilay R, Winer E, Salgia R, Malhotra J, Gentles A, Buetow K, Mahmood F, Markman DW, Eddy JA, ADAPT Consortium. The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy. Cancer Cell. 2026 Mar 09; 44(3):449-454. View on PubMed
  18. Lizzadro L, Li J, Taha TY, Degotte G, Detomasi TC, Zapatero-Belinchon FJ, Hantz ER, Huang S, Matsui Y, Henderson WR, McCann JT, Montano M, Rosecrans J, Torres Pomares DF, McGovern BL, Diaz-Tapia R, Benjamin J, Gordon ME, Suazo ID, Settineri NS, Diallo A, Krogan NJ, Shoichet BK, Verba KA, Albrecht R, García-Sastre A, White KM, Ott M, Craik CS, Renslo AR. Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models. J Med Chem. 2026 Jan 22; 69(2):1530-1551. View on PubMed
  19. Kim J, Correy GJ, Hall BW, Rachman MM, Mailhot O, Togo T, Gonciarz RL, Jaishankar P, Neitz RJ, Hantz ER, Doruk YU, Stevens MGV, Diolaiti ME, Reid R, Gopalkrishnan S, Krogan NJ, Renslo AR, Ashworth A, Shoichet BK, Fraser JS. Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens. bioRxiv. 2025 Dec 29. View on PubMed
  20. Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, Renslo AR. Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo. J Med Chem. 2026 Jan 08; 69(1):553-573. View on PubMed

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