University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Peder Larson, PhD

Peder Larson, PhD

Assistant Professor-in-Residence, Department of Radiology and Biomedical Imaging, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

I am an Assistant Professor in the Department of Radiology and Biomedical Imaging at UCSF focused on developing MRI methods that provide novel information about tissue structure and function that are not accessible by other clinical imaging modalities. My background is primarily in MR pulse sequence development, including MR physics, RF pulse design, acquisition strategies, and reconstruction techniques, beginning in 2003 under the advising of Profs. Dwight Nishimura and John Pauly at Stanford University. I came to UCSF as a post-doc in 2007 under Prof. Daniel Vigneron and joined the faculty in 2011.
A major focus of my research program is hyperpolarized carbon-13 metabolic magnetic resonance imaging (MRI) methods, and I am part of the team at UCSF translating this modality into human studies of cancer. The technology has the potential to improve staging of cancer and monitoring treatment response by measuring real-time conversion in key metabolic pathways. I develop the MRI data acquisition and image reconstruction methodologies for these studies.

Education

Stanford University, Stanford, CA, B.S., 06/02, Electrical Engineering and Mathematics
Stanford University, Stanford, CA, M.S., 06/03, Electrical Engineering
Stanford University, Stanford, CA, Ph.D., 09/07, Electrical Engineering
University of California – San Francisco, San Francisco, CA, Postdoctoral, 09/07-08/11, Radiology and Biomedical Imaging


Professional Experience

  • 2002-2003
    Teaching Assistant, Department of Electrical Engineering, Stanford University, Stanford, CA
  • 2003-2007
    Research Assistant, Department of Electrical Engineering, Stanford University, Stanford, CA
  • 2007-2011
    Postdoctoral Scholar, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA
  • 2011-present
    Assistant Professor-in-Residence, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA

Honors & Awards


  • 1998
    IEEE Wescon Scholarship - 2nd Place
  • 1998
    RC Byrd Honors Scholarship
  • 2003
    National Science Foundation Graduate Fellowship - Honorable Mention
  • 2005
    International Society for Magnetic Resonance in Medicine Annual Meeting Poster Award – 2nd place, Pulse sequences category
  • 2006
    Myelin Imaging Conference Poster Award – Accompanied by proffered talk
  • 2009
    Surbeck Scholar Award – 2nd place
  • 2009
    Outstanding Poster Award – UCSF Dept. of Radiology and Biomedical Imaging Research Symposium
  • 2010
    Surbeck Scholar Award – 1st place
  • 2011
    Surbeck Scholar Award – 1st place
  • 2011
    International Society for Magnetic Resonance in Medicine (ISMRM) Junior Fellow
  • 2010,2011,2012
    Magnetic Resonance in Medicine (MRM) Distinguished Reviewer

Selected Publications

  1. Dharshan Chandramohan, Peng Cao, Misung Han, Hongyu An, John J. Sunderland, Paul E. Kinahan, Richard Laforest, Thomas A. Hope, Peder E. Z. Larson. Bone Material Analogues for PET/MRI Phantoms. . 2019 Oct 24.
    View on PubMed
  2. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil M, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 Oct 08; 309:106617.
    View on PubMed
  3. Frank Ong, Xucheng Zhu, Joseph Y. Cheng, Kevin M. Johnson, Peder E. Z. Larson, Shreyas S. Vasanawala, Michael Lustig. Extreme MRI: Large-Scale Volumetric Dynamic Imaging from Continuous Non-Gated Acquisitions. . 2019 Sep 30.
    View on PubMed
  4. Zhu X, Chan M, Lustig M, Johnson KM, Larson PEZ. Iterative motion-compensation reconstruction ultra-short TE (iMoCo UTE) for high-resolution free-breathing pulmonary MRI. Magn Reson Med. 2019 Sep 30.
    View on PubMed
  5. Cao P, Liu J, Tang S, Leynes AP, Lupo JM, Xu D, Larson PEZ. Technical Note: Simultaneous segmentation and relaxometry for MRI through multitask learning. Med Phys. 2019 Oct; 46(10):4610-4621.
    View on PubMed
  6. Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB. Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain. IEEE Trans Med Imaging. 2019 Jul 02.
    View on PubMed
  7. Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR. Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging. Magn Reson Med. 2019 Sep; 82(3):959-972.
    View on PubMed
  8. Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology. 2019 May; 291(2):273-284.
    View on PubMed
  9. Walker CM, Fuentes D, Larson PEZ, Kundra V, Vigneron DB, Bankson JA. Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate. Magn Reson Med. 2019 Jun; 81(6):3754-3762.
    View on PubMed
  10. Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW. Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies. J Magn Reson. 2019 Apr; 301:73-79.
    View on PubMed
  11. Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging. NMR Biomed. 2019 03; 32(3):e4052.
    View on PubMed
  12. Maryam Vareth, Janine Lupo, Peder Larson, Sarah Nelson. Inside Cover Image, Volume 31, Issue 11. . 2018 Nov 1; 31(11):e4033.
    View on PubMed
  13. Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB. Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients. Magn Reson Med. 2019 04; 81(4):2702-2709.
    View on PubMed
  14. Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ. Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport. Magn Reson Med. 2019 03; 81(3):2001-2010.
    View on PubMed
  15. Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB. Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed. 2018 11; 31(11):e3997.
    View on PubMed
  16. Tang S, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ. A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13 C MRI. Magn Reson Med. 2019 02; 81(2):839-851.
    View on PubMed
  17. Yang J, Liu J, Wiesinger F, Menini A, Zhu X, Hope TA, Seo Y, Larson PEZ. Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI. Phys Med Biol. 2018 09 10; 63(18):185002.
    View on PubMed
  18. Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9).
    View on PubMed
  19. Vareth M, Lupo J, Larson P, Nelson S. A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors. NMR Biomed. 2018 11; 31(11):e3929.
    View on PubMed
  20. Autry AW, Hashizume R, James CD, Larson PEZ, Vigneron DB, Park I. Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging. Contrast Media Mol Imaging. 2018; 2018:3215658.
    View on PubMed

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