University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Peder Larson, PhD

Peder Larson, PhD

Assistant Professor-in-Residence, Department of Radiology and Biomedical Imaging, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

I am an Assistant Professor in the Department of Radiology and Biomedical Imaging at UCSF focused on developing MRI methods that provide novel information about tissue structure and function that are not accessible by other clinical imaging modalities. My background is primarily in MR pulse sequence development, including MR physics, RF pulse design, acquisition strategies, and reconstruction techniques, beginning in 2003 under the advising of Profs. Dwight Nishimura and John Pauly at Stanford University. I came to UCSF as a post-doc in 2007 under Prof. Daniel Vigneron and joined the faculty in 2011.
A major focus of my research program is hyperpolarized carbon-13 metabolic magnetic resonance imaging (MRI) methods, and I am part of the team at UCSF translating this modality into human studies of cancer. The technology has the potential to improve staging of cancer and monitoring treatment response by measuring real-time conversion in key metabolic pathways. I develop the MRI data acquisition and image reconstruction methodologies for these studies.

Education

Stanford University, Stanford, CA, B.S., 06/02, Electrical Engineering and Mathematics
Stanford University, Stanford, CA, M.S., 06/03, Electrical Engineering
Stanford University, Stanford, CA, Ph.D., 09/07, Electrical Engineering
University of California – San Francisco, San Francisco, CA, Postdoctoral, 09/07-08/11, Radiology and Biomedical Imaging


Professional Experience

  • 2002-2003
    Teaching Assistant, Department of Electrical Engineering, Stanford University, Stanford, CA
  • 2003-2007
    Research Assistant, Department of Electrical Engineering, Stanford University, Stanford, CA
  • 2007-2011
    Postdoctoral Scholar, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA
  • 2011-present
    Assistant Professor-in-Residence, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA

Honors & Awards


  • 1998
    IEEE Wescon Scholarship - 2nd Place
  • 1998
    RC Byrd Honors Scholarship
  • 2003
    National Science Foundation Graduate Fellowship - Honorable Mention
  • 2005
    International Society for Magnetic Resonance in Medicine Annual Meeting Poster Award – 2nd place, Pulse sequences category
  • 2006
    Myelin Imaging Conference Poster Award – Accompanied by proffered talk
  • 2009
    Surbeck Scholar Award – 2nd place
  • 2009
    Outstanding Poster Award – UCSF Dept. of Radiology and Biomedical Imaging Research Symposium
  • 2010
    Surbeck Scholar Award – 1st place
  • 2011
    Surbeck Scholar Award – 1st place
  • 2011
    International Society for Magnetic Resonance in Medicine (ISMRM) Junior Fellow
  • 2010,2011,2012
    Magnetic Resonance in Medicine (MRM) Distinguished Reviewer

Selected Publications

  1. Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J. Simultaneous metabolic and perfusion imaging using hyperpolarized 13C MRI can evaluate early and dose-dependent responses to radiotherapy in a prostate cancer mouse model. Int J Radiat Oncol Biol Phys. 2020 Apr 24.
    View on PubMed
  2. Batsios G, Najac C, Cao P, Viswanath P, Subramani E, Saito Y, Gillespie AM, Yoshihara HAI, Larson P, Sando S, Ronen SM. In vivo detection of ?-glutamyl-transferase up-regulation in glioma using hyperpolarized ?-glutamyl-[1-13C]glycine. Sci Rep. 2020 Apr 10; 10(1):6244.
    View on PubMed
  3. Ong F, Zhu X, Cheng JY, Johnson KM, Larson PEZ, Vasanawala SS, Lustig M. Extreme MRI: Large-scale volumetric dynamic imaging from continuous non-gated acquisitions. Magn Reson Med. 2020 Apr 09.
    View on PubMed
  4. Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D. Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco. NMR Biomed. 2020 Mar 19; e4280.
    View on PubMed
  5. Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ. A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner. Magn Reson Med. 2020 Feb 21.
    View on PubMed
  6. Gordon JW, Chen HY, Dwork N, Tang S, Larson PEZ. Fast Imaging for Hyperpolarized MR Metabolic Imaging. J Magn Reson Imaging. 2020 Feb 10.
    View on PubMed
  7. Chandramohan D, Cao P, Han M, An H, Sunderland JJ, Kinahan PE, Laforest R, Hope TA, Larson PEZ. Bone material analogues for PET/MRI phantoms. Med Phys. 2020 Feb 08.
    View on PubMed
  8. Milshteyn E, Reed GD, Gordon JW, von Morze C, Cao P, Tang S, Leynes AP, Larson PEZ, Vigneron DB. Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence. J Magn Reson. 2020 Mar; 312:106691.
    View on PubMed
  9. Guglielmetti C, Boucneau T, Cao P, Van der Linden A, Larson PEZ, Chaumeil MM. Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging. Neuroimage. 2020 Mar; 208:116415.
    View on PubMed
  10. Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. Prostate Cancer Prostatic Dis. 2019 Nov 04.
    View on PubMed
  11. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 12; 309:106617.
    View on PubMed
  12. Zhu X, Chan M, Lustig M, Johnson KM, Larson PEZ. Iterative motion-compensation reconstruction ultra-short TE (iMoCo UTE) for high-resolution free-breathing pulmonary MRI. Magn Reson Med. 2020 Apr; 83(4):1208-1221.
    View on PubMed
  13. Cao P, Liu J, Tang S, Leynes AP, Lupo JM, Xu D, Larson PEZ. Technical Note: Simultaneous segmentation and relaxometry for MRI through multitask learning. Med Phys. 2019 Oct; 46(10):4610-4621.
    View on PubMed
  14. Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB. Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain. IEEE Trans Med Imaging. 2020 02; 39(2):320-327.
    View on PubMed
  15. Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR. Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging. Magn Reson Med. 2019 09; 82(3):959-972.
    View on PubMed
  16. Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology. 2019 05; 291(2):273-284.
    View on PubMed
  17. Walker CM, Fuentes D, Larson PEZ, Kundra V, Vigneron DB, Bankson JA. Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate. Magn Reson Med. 2019 06; 81(6):3754-3762.
    View on PubMed
  18. Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW. Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies. J Magn Reson. 2019 04; 301:73-79.
    View on PubMed
  19. Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging. NMR Biomed. 2019 03; 32(3):e4052.
    View on PubMed
  20. Maryam Vareth, Janine Lupo, Peder Larson, Sarah Nelson. Inside Cover Image, Volume 31, Issue 11. NMR in Biomedicine. 2018 Nov 1; 31(11):e4033.
    View on PubMed

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